At Inotiv, you have access to specialized in vivo models to help you drive your program forward. Our goal is to provide you with preclinical (efficacy and toxicity) data to support the advancement of your biologic and small molecule from discovery to First-in-Human. We work with you to customize your study design to effectively reach your project’s goal. If you do not see a capability you need listed below, please contact us as we are continuously developing new models.
Our capabilities include the following:
- In vitro services
- Ex vivo analysis
- Pathology services
- In vivo research of specific toxicology, pharmacokinetic, and pharmacological models
- Established pharmacology models
- PK/TK modeling and simulation
| Rodent (mouse and rat) | Pig |
| Rabbit | Canine |
| Guinea pig | Sheep, goats, cattle, horses |
| Ferret | Non-human primates |
Our in vitro services deliver solutions that facilitate your decision-making process.
- Primary cell lines (neurons, astrocytes, oligodendrocytes)
- Established cell lines and novel modalities (osteoblasts, HEK, Hela, etc.)
- Models of aging, neurodegeneration, injury, stroke, mitochondrial health and more
- Customized model development
- Metabolic stability/permeability assessment (including drug transporter assessment, permeability)
- Protein binding/tissue binding
- Mass spectrometry (LC-MS/MS) based analysis
Click here for a more comprehensive list of our DMPK services
We offer a wide array of ex vivo services, providing you with the data needed to efficiently make informed decisions.
- Multiplexing offers an extensive list of analytes and can tailor any Luminex® profile to meet your needs
- ELISA analysis
- Fluorescent activated cell sorting (FACS)
- Blood, plasma, serum analysis
- Pharmacokinetic (PK) modeling
- Stability
- Targeted tissue analysis (supporting PK/PD modeling)
- Identification of major circulating metabolites
- Gene expression analysis
- Targeted biomarker analysis
- Immunophenotyping
The DMT 620M Wire Myograph™ system is used to conduct ex vivo vascular ring tension recording on multiple vessel types including the aorta, the pulmonary artery and the middle cerebral artery. The highly sensitive, flexible system can accommodate vessels down to 100 μm in diameter. Relaxation and contractile activity are measured using force transducers. The system:
- Allows ex vivo study of compound activity on vascular function
- Enables assessment of antagonist potency for receptor/agonist combinations in both naïve and diseased model tissues
- Assess vascular remodeling and function via pharmacologic challenge or evaluating length-tension relationships from therapeutic or prophylactic in vivo studies
Our experienced staff engage in a broad spectrum of studies, tissues, species, and disease states.
- Pathology assessment of tissues
- Board certified veterinary pathologists
- In vivo model sample analysis
- Customized model development
Get more insights into our Pathology Team
Established Pharmacology and Toxicology Models
Access a wide range of in vivo preclinical early-stage research, efficacy, pharmacology, and safety studies. Our experienced staff has the expertise to offer a wide range of study designs in pharmacology, toxicology, inflammatory bowel disease, and immunologic models. Our hands-on collaborative approach means that our scientists will work with you to learn your specific preclinical study requirements and assist you from initial study design to final reporting with dependable, reproducible results.
Histology
Pathology
Surgical Models and Medical Device Testing
Drug Metabolism and Pharmacokinetics (DMPK)
In Vivo Services