At Inotiv, you have access to specialized in vivo models to help you drive your program forward. Our goal is to provide you with preclinical (efficacy and toxicity) data to support the advancement of your biologic and small molecule from discovery to First-in-Human studies. We work with you to customize your study design to effectively reach your project’s goal. If you do not see a capability you need listed below, please contact us as we are continuously developing new models.
Our capabilities include the following:
Rodent (mouse and rat) | Pig |
Rabbit | Canine |
Guinea pig | Sheep, goats, cattle, horses |
Ferret | Non-human primates |
Our in vitro services deliver solutions that facilitate your decision-making process.
Click here for a more comprehensive list of our DMPK services
We offer a wide array of ex vivo services, providing you with the data needed to efficiently make informed decisions.
The DMT 620M Wire Myograph™ system is used to conduct ex vivo vascular ring tension recording on multiple vessel types including the aorta, the pulmonary artery and the middle cerebral artery. The highly sensitive, flexible system can accommodate vessels down to 100 μm in diameter. Relaxation and contractile activity are measured using force transducers. The system:
Our experienced staff engage in a broad spectrum of studies, tissues, species, and disease states.
Get more insights into our Pathology Team
Access a wide range of in vivo preclinical early-stage research, efficacy, pharmacology, and safety studies. Our experienced staff has the expertise to offer a wide range of study designs in pharmacology, toxicology, inflammatory bowel disease, and immunologic models. Our hands-on collaborative approach means that our scientists will work with you to learn your specific preclinical study requirements and assist you from initial study design to final reporting with dependable, reproducible results.
Monoarticular inflammation/arthritis
Myocardial infarction
Hypertension-based cardia dysfunction, hypertrophy, and failure
Cardiac hypertrophy, cardiac pressure overload, and heart failure
Left Ventricular Function, Cardiac remodeling and Histological evaluation
Methods: Echocardiography (M-Mode, B-Mode & Doppler), Pressure/Volume, Invastive LV Hemodynamics (+/-dP/dT, Tau, LVEDP and LVESP)
Disease Models: Myocardial Infarction, ZSF1, SHHF, Dahl Salt Sensitive (DSS) (additional models available)
Type 1 diabetes
Type 2 diabetes
Metabolism and diet
Hepatic fibrosis
Other hepatic conditions
Collagen/Hydroxyproline content
Serum ALT/AST/ALP
Portal Vein Pressure
Histological evaluation
Models: Carbon Tetrachloride (CCl4) and Bile Duct Ligation (BDL)
Pulmonary fibrosis
Pulmonary arterial hypertension
Acute lung injury
Airway hyper-responsiveness (AHR)/asthma
Right Ventricular Systolic Pressure/Pulmonary Arterial Pressure
Heart and Lung Weight
Myocardial, Pulmonary Artery and Lung Histology
Disease Models: Monocrotaline PAH
Acute kidney injury and failure (AKI/ARG)
Nephrotoxicity
Chronic kidney disease and renal insufficiency
Autoimmune kidney injury
Diabetic nephropathy
Proteinuria, albuminuria, GFR, Creatinine Clearance, histological evaluation
Plasma/Urine Biomarkers of damage
Chronic blood pressure monitoring using radio telemetry
Disease Models:: 5/6 Nephrectomy, Renal Ischemia/Reperfusion, Dahl Salt Sensitive (DSS), Streptozotocin (STZ), ZSF1, Unilateral Urethral Obstruction (UUO), Puromycin Aminonucleoside (PAN), Uninephrectomized (additional models available)
Non-GLP discovery toxicology
Regulated IND/CTA enabling
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