Developmental and Reproductive Toxicology

Developmental and Reproductive Toxicology (DART)

We offer a broad scope and wide range of DART services:

Fertility (male and/or female)
Embryo-fetal development/prenatal developmental toxicity study
Prenatal and postnatal development, including maternal function
Combined 28-day/reproduction screening
One- and two-generation reproduction study
EOGRTS

Developmental Neurotoxicity

Scope and range of services:

Studies
- OECD 426: Developmental neurotoxicity study
- EPA OPPTS 870.6300: Developmental neurotoxicity study
Evaluations
- Clinical observations and bodyweight
- Neuropathology (immersion or perfusion fixation)
- Sexual maturation
- Other developmental landmarks
- Behavioral ontogeny
- Motor activity
- Motor and sensory function (auditory startle)
- Learning and memory

Juvenile Animal Studies (JAS)

Scope and range of services:

Customized study designs
- Species selection and age for intended patient populations
- Consideration of timing of dosing, exposure, monitoring, pharmacological/toxicological differences
Evaluations
- Routine and target organ toxicological endpoints
- Nervous system
- Reproductive systems
- Skeletal system (growth)
- Neurobehavioral

Inotiv has built an internationally recognized DART and JAS study team through close collaboration with industry-leading experts.

In Vivo Services In Vivo Services From discovery to regulatory-enabling safety assessments in advanced developmental and reproductive toxicology (DART), we have the in vivo services and associated bioanalysis capabilities you need to find answers.

Drug Metabolism and Pharmacokinetics (DMPK) Drug Metabolism and Pharmacokinetics (DMPK) Whatever you need, from method development to metabolite ID, our phase-appropriate bioanalytical services help you analyze, answer, and advance.

Histology Histology Our industry-leading histology laboratories support your discovery and nonclinical development projects with a wide range of services. From tissue processing to digital analysis, our team delivers the quality you expect.

Pathology Pathology Access world-class anatomical, clinical, and medical device pathology services, from routine histochemistry, IHC, IF, and ISH to stereology.

Consulting Consulting

Our experts deliver the insights you deserve to get the answers you need, whether in DMPK data analysis, biomarker analysis, or bioequivalence studies.

Developmental and Reproductive Toxicology (DART)

Developmental Neurotoxicity

Juvenile Animal Studies (JAS)

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