In the scientific community, his name and animal models become synonymous with high-quality laboratory animals. (Bldg. 202 in Cumberland, Indiana pictured)
Started in Cambridgeshire, England, the organization is originally focused on nutrition, veterinary, and biochemical research.
Hal, Howard Harlan's son, assumes responsibility for operations, overseeing approximately ten employees. The following year, Harlan becomes incorporated as Harlan Industries.
Purdue University chemistry professor, Peter Kissinger, launches Bioanalytical Systems, Inc. (BASi), headquartered in West Lafayette, Indiana, as a resource for research labs.
Biotrol provided entry into the immunological services sector. Today, this is recognized as Envigo Bioproducts. The same year, Spartan Research Animals in Haslett, Michigan was acquired.Learn more
Based in Madison, Wisconsin, GIBCO included the following operations:
+ The former Sprague Dawley Company
+ The former A.R. Schmidt Company
+ Teklad Standard Diets
+ Teklad Custom Diets
+ Teklad Trucking
The name Teklad was derived from the previous owner, Thomas E. Kanickus, called TEK Lab Animal Diet. We changed it to TEKLAD to maintain the name recognition.
After Harlan Industries acquired GIBCO Animal Research Laboratories, it was renamed to reflect its acquisition of the former Sprague Dawley Company. This same year, M.A. Laboratory Animals of Walkersville, Maryland was purchased from the Whittaker Corporation in Whittier, California.Sprague Dawley
TIMCO Breeding Laboratories in Houston, Texas was acquired from the Texas Medical Center.
Engle Laboratory Animals in Farmersburg, Indiana and Laboratory Supply Company, Inc. of Indianapolis, Indiana were acquired.
Harlan Bioproducts for Science, Inc. manufactured custom immunological and biological products and research services.
With the purchase of OLAC Limited of Oxfordshire, England, Harlan becomes an international corporation to supply models in countries including, but not limited to, the United Kingdom, France, Germany, Italy, the Netherlands, and Israel.
Expanded into Europe with Oxford Laboratory Animal Center (OLAC) acquisition. Located in UK as Harlan Olac Limited.
Serotec was started by one of the founders of OLAC, Ed Bernard. This partial acquisition further expanded Harlan's immunological service offerings to include catalog antibodies.Custom antibody production
Based in Prattville, Alabama, Southern Animal Farms was purchased to support government institutions and universities in the Southeast United States. The Holtzman Company in Madison, Wisconsin, producer of the Holtzman albino rat, was also acquired.
The Central Institute for Breeding of Laboratory Animals (CPB) in the Netherlands was acquired to expand operations in continental Europe. Additionally, Harlan Sprague Dawley, Inc. expanded into the Netherlands. Large animals were also added to the range of stocks and strains.
Based in Altamont, New York, Blue Spruce Farms was known for producing the Long Evans outbred rat.
In Europe, Porcellus Animal Breeding Limited in Heathfield, England and Riom Laboratories-CERM in Riom France were acquired by Harlan Olac Ltd. Porcellus also provided Harlan with a supply of guinea pigs throughout the UK and Europe. With these acquisitions, we also introduced rabbit production in the UK and a second canine colony in France.
Premier Laboratory Diets in Bartonville, Illinois was purchased. Premier was the manufacturer of the well-known Wayne Diets. Twin City Testing, Kansas City Southwestern, Empire Soils, and Applied Biosciences International were also acquired.
A new maximum barrier laboratory animal facility was constructed and opened in Houston, Texas.
The organization was based in Dublin, Virginia.
Harlan continues building an international presence with operations established in Germany, Italy, and Israel. In 1993, we entered a lease agreement with the Weizmann Institute and with the Hebrew University with two RMS facilities. Winkelmann Versuchstierzucht GmbH of Germany was also acquired in 1993.
Significant stock and strain expansion was accomplished through acquisitions from the Hannover Institute in Hannover, Germany and the TNO-REPGO Institute in Rijswijk, the Netherlands. The result was Harlan's inventory of research models increased to more than 240 stocks and strains including mice, rats, and hamsters.Research models
Harlan also acquired Interfauna Group with facilities in UK, Germany, and Spain.
This allowed us to sell antibodies and other immunological products in Europe/globally. The business was moved to Hillcrest, which still operates under the Bioproducts banner. The following year, Harlan Bioservice for Science was formed in Walsrode, Germany.Biological products and services
BASi expands its service offerings with acquisition of Toxic Pathology Services (TPS) Inc., a contract research laboratory in Evansville, Indiana. BASi expands its services to provide regulated nonclinical services for pharmaceutical and biotechnology companies.
This expanded contract research services for the pharmaceutical, chemical, and agrochemical industries in Europe and Asia.
Acquired RCC Ltd., a large contract research organization based in Switzerland. RCC has since expanded to India, Spain, and Germany.
Acquired by Genstar Capital of San Francisco, California, Harlan Sprague Dawley, Inc. was purchased as a company in a growing, vital industry with continued growth opportunity.
The acquisition of Safepharm Laboratories in Shardlow, United Kingdom, allowed the expansion of contract research services into the chemical industries.
The company united as Harlan Laboratories, Inc., with all legal entities initiating a name change to become one company with one vision to help our customers do research better.
HLS provided preclinical and nonclinical biological safety evaluation research, eventually becoming the third largest non-clinical CRO in the world.
Genetics 2010 186(2):451-2
Nat Biotechnol 2011 29(1):64-7
Nat Methods 2013 10(7):638-4
Harlan Laboratories and Huntingdon Life Sciences merge to create the Envigo brand and name.
BASi and Seventh Wave combine operations to provide broader solutions and greater scientific expertise to their clients.
Envigo's acquisition of Horizon's (formerly SAGE Labs, Inc.) research models business unit broadened our product and service offerings to include custom model generation and genetically engineered models and services.Explore GEMS
BASi/Seventh Wave acquire the Smithers Avanza Toxicology Services business unit, a contract research organization (CRO) located in Gaithersburg, Maryland. The acquisition includes a GLP laboratory specializing in general toxicology, vaccine safety, and developmental and reproductive toxicology (DART) studies.
BASi rebrands to become Inotiv. The company retains its products business under the name BASi Research Products.
Inotiv acquires Ft. Collins, Colorado-based PreClinical Research Services (“PCRS”), a premier provider of surgical and medical device contract research services.
Inotiv completes the acquisition of HistoTox Labs, Inc. and the acquisition by merger of Boulder, Colorado-based Bolder BioPATH, Inc. These strategic acquisitions expand Inotiv’s nonclinical pharmacology and histopathology services and augment and extend the effective range of services from early discovery through preclinical development.
Inotiv acquires key genetic toxicology assets from MilliporeSigma’s BioReliance® portfolio, including standard operating procedures, stock cultures, historic control data, and client list.
Inotiv acquires Gateway Pharmacology Laboratories LLC, which increases Inotiv’s drug metabolism and pharmacokinetics (DMPK) technology and capability, as well as in vitro pharmacology and toxicology studies.
Inotiv acquires Envigo RMS Holding Corp. (Envigo), a leading global provider of research models and services.Learn more
Inotiv acquires Plato BioPharma, Inc. (“PBI”), a Colorado-based, in vivo pharmacology research and drug discovery company specializing in cardiovascular, renal, pulmonary, and hepatic therapeutic areas.