At Inotiv, you have access to specialized in vivo models to help you drive your program forward. Our goal is to provide you with preclinical (efficacy and toxicity) data to support the advancement of your biologic and small molecule from discovery to First-in-Human. We work with you to customize your study design to effectively reach your project’s goal. If you do not see a capability you need listed below, please contact us as we are continuously developing new models.

Our capabilities include the following:

  • In vitro services
  • Ex vivo analysis
  • Pathology services
  • In vivo research of specific toxicology, pharmacokinetic, and pharmacological models
  • Established pharmacology models
  • PK/TK modeling and simulation

Rodent (mouse and rat)Pig
RabbitDog
Guinea pigSheep, goats, cattle, horses
FerretNon-human primates

Our in vitro services deliver solutions that facilitate your decision-making process.

  • Primary cell lines (neurons, astrocytes, oligodendrocytes)
  • Established cell lines and novel modalities (osteoblasts, HEK, Hela, etc.)
  • Models of aging, neurodegeneration, injury, stroke, mitochondrial health and more
  • Customized model development
  • Metabolic stability/permeability assessment (including drug transporter assessment, permeability)
  • Protein binding/tissue binding
  • Mass spectrometry (LC-MS/MS) based analysis

Click here for a more comprehensive list of our DMPK services

We offer a wide array of ex vivo services, providing you with the data needed to efficiently make informed decisions.

  • Multiplexing offers an extensive list of analytes and can tailor any Luminex® profile to meet your needs
  • ELISA analysis
  • Fluorescent activated cell sorting (FACS)
  • Blood, plasma, serum analysis
    • Pharmacokinetic (PK) modeling
    • Stability
  • Targeted tissue analysis (supporting PK/PD modeling)
  • Identification of major circulating metabolites
  • Gene expression analysis
  • Targeted biomarker analysis
  • Immunophenotyping

The DMT 620M Wire Myograph™ system is used to conduct ex vivo vascular ring tension recording on multiple vessel types including the aorta, the pulmonary artery and the middle cerebral artery.  The highly sensitive, flexible system can accommodate vessels down to 100 μm in diameter.  Relaxation and contractile activity are measured using force transducers. The system:

  • Allows ex vivo study of compound activity on vascular function
  • Enables assessment of antagonist potency for receptor/agonist combinations in both naïve and diseased model tissues
  • Assess vascular remodeling and function via pharmacologic challenge or evaluating length-tension relationships from therapeutic or prophylactic in vivo studies

Our experienced staff engage in a broad spectrum of studies, tissues, species, and disease states.

Pathology
  • Pathology assessment of tissues
  • Board certified veterinary pathologists
  • In vivo model sample analysis
  • Customized model development

Get more insights into our Pathology Team

Established Pharmacology and Toxicology Models

Access a wide range of in vivo preclinical early-stage research, efficacy, pharmacology, and safety studies. Our experienced staff has the expertise to offer a wide range of study designs in pharmacology, toxicology, inflammatory bowel disease, and immunologic models. Our hands-on collaborative approach means that our scientists will work with you to learn your specific preclinical study requirements and assist you from initial study design to final reporting with dependable, reproducible results.

To request a quote click here.

Scleroderma

Lupus

Rheumatoid arthritis

Monoarticular inflammation/arthritis

Ulcerative colitis

Crohn’s disease

Irritable bowel syndrome

Surgically induced/injury

Naturally occurring

Glioblastoma

Epilepsy

Addiction

Cognition

Neuroinflammation

Developmental milestones/functional observation battery

Anxiety disorders

Depression

Autism spectrum disorder

Parkinson’s disease

Alzheimer’s disease

Myocardial infarction

Hypertension-based cardia dysfunction, hypertrophy, and failure

Cardiac hypertrophy, cardiac pressure overload, and heart failure

Type 1 diabetes

Type 2 diabetes

Metabolism and diet

Hepatic fibrosis

Other hepatic conditions

Pulmonary fibrosis

Pulmonary arterial hypertension

Acute lung injury

Airway hyper-responsiveness (AHR)/asthma

Acute kidney injury and failure (AKI/ARG)

Nephrotoxicity

Chronic kidney disease and renal insufficiency

Autoimmune kidney injury

Diabetic nephropathy

Osteoarthritis

Inflammatory

Neuropathic

Bone tumor

Anemia

Psoriasis

Dermatitis

Delayed type hyper-sensitivity

Anaphylaxis

Peritonitis

Acute edema

Pancreatitis

Non-GLP discovery toxicology

Regulated IND/CTA enabling

Standard pharmacokinetic studies

Pharmacokinetic, pharmacodynamic and metabolic sample collection

Standard routes of administration: SC, PO, IP, IV, IA, IR, ID, ad libitum