Bolder BioPATH, Inc., an Inotiv company, is a contract pharmacology and pathology company specializing in in vivo models of Rheumatoid Arthritis, Osteoarthritis, and Inflammatory Bowel Disease as well as other autoimmune and inflammation models. Our goals are to provide preclinical (efficacy and toxicity) data to support advancing proteins and small molecules to IND/NDA stage.
“At Bolder BioPATH, our mission has been to always deliver exceptional service and provide clients with the highest quality data to help them move quickly toward key decisions.”
- Alison Bendele, founder and President of Bolder BioPATH
|Rodent (mouse and rat)||Pig|
|Guinea pig||Sheep, goats, cattle, horses|
Our in vitro services deliver solutions that facilitate your decision-making process.
We offer a wide array of ex vivo services, providing you with the data needed to efficiently make informed decisions.
The DMT 620M Wire Myograph™ system is used to conduct ex vivo vascular ring tension recording on multiple vessel types including the aorta, the pulmonary artery and the middle cerebral artery. The highly sensitive, flexible system can accommodate vessels down to 100 μm in diameter. Relaxation and contractile activity are measured using force transducers. The system:
Our experienced staff engage in a broad spectrum of studies, tissues, species, and disease states.
Get more insights into our Pathology Team
Access a wide range of in vivo preclinical early-stage research, efficacy, pharmacology, and safety studies. Our experienced staff has the expertise to offer a wide range of study designs in pharmacology, toxicology, inflammatory bowel disease, and immunologic models. Our hands-on collaborative approach means that our scientists will work with you to learn your specific preclinical study requirements and assist you from initial study design to final reporting with dependable, reproducible results.
Left Ventricular Function, Cardiac remodeling and Histological evaluation
Methods: Echocardiography (M-Mode, B-Mode & Doppler), Pressure/Volume, Invastive LV Hemodynamics (+/-dP/dT, Tau, LVEDP and LVESP)
Disease Models: Myocardial Infarction, ZSF1, SHHF, Dahl Salt Sensitive (DSS) (additional models available)
Acute kidney injury and failure (AKI/ARG)
Chronic kidney disease and renal insufficiency
Autoimmune kidney injury
Proteinuria, albuminuria, GFR, Creatinine Clearance, histological evaluation
Plasma/Urine Biomarkers of damage
Chronic blood pressure monitoring using radio telemetry
Disease Models:: 5/6 Nephrectomy, Renal Ischemia/Reperfusion, Dahl Salt Sensitive (DSS), Streptozotocin (STZ), ZSF1, Unilateral Urethral Obstruction (UUO), Puromycin Aminonucleoside (PAN), Uninephrectomized (additional models available)
Delayed type hyper-sensitivity
Non-GLP discovery toxicology
Regulated IND/CTA enabling
Left Ventricular Function – +/-dP/dt, Tau, LVEDP and LVESP
Standard pharmacokinetic studies
Pharmacokinetic, pharmacodynamic and metabolic sample collection
Standard routes of administration: SC, PO, IP, IV, IA, IR, ID, ad libitum