Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony
This model contains an 11 bp bi-allelic deletion within exon 1 of the Slc22a1 solute carrier family 22 (organic cation transporter), member 1, encoding for the basolateral hepatocyte uptake transporter OCT1.
Oct1 is involved in disposition and excretion through its role in xenobiotic uptake in the basolateral membrane of the liver. Polymorphisms within the gene also have clinical relevance - making this a useful model for studying drug-drug interations, toxicity and metabolism in the liver.Oct1 was cryopreserved at the 12th generation. For more information on cryorecovery, please follow the link below.