Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony
Generated in conjunction with Autism Speaks, this knockout rat model contains a 176 kb deletion in the RNA binding protein, fox-1 homolog (Rbfox1) gene. Rbfox1 has been associated with the autism spectrum disorders and affects the expression of other autism-linked genes.
The Rbfox1 Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.