Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
- Homozygous knockout rats exhibit complete loss of p75NTR protein
- p75NTR knockout rats show hyposensitivity to thermal pain via hot plate assay
- p75NTR knockout rats show increased reactivity to touch in a functional observational battery (Irwin)
- Background strain: Sprague Dawley
Availability: Cryopreserved as heterozygous embryos
This model contains a biallelic deletion of the Ngfr gene, encoding for the p75 neurotrophin receptor (p75NTR). Along with TrkA, p75NTR is a receptor for the nerve growth receptor and is important in nociception. The p75NTR knockout rat is useful for pain research.
NGF dysfunction has been linked to neuropathic and osteoarthritic pain along with hyperalgesia. Inhibition of NGF, including inhibition of the p75NTR, is being pursued as a potential analgesic.
gem~gem rat~gem rats~knockout rats~knockout rat~p75NTR rat~p75NTR knockout rats~p75NTR knockout rat~p75NTR~HsdSage:SD-Ngfrtm1Sage~Cryopreserved~p75 neurotrophin receptor~p75~Nerve Growth Factor Receptor~TNFRSF16~Tumor Necrosis Factor Receptor Superfamily Member 16~Low Affinity Neurotrophin Receptor P75NTR~Low-Affinity Nerve Growth Factor Receptor~TNFR Superfamily, Member 16~NGF Receptor~Gp80-LNGFR~P75 ICD~P75NTR~CD271~Nerve Growth Factor Receptor (TNFR Superfamily, Member 16)~Low Affinity Nerve Growth Factor Receptor~CD271 Antige~P75(NTR)~NGFR
Origin: The p75NTR KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.