Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony
This model contains a biallelic deletion of the Ngfr gene, encoding for the p75 neurotrophin receptor (p75NTR). Along with TrkA, p75NTR is a receptor for the nerve growth receptor and is important in nociception. The p75NTR knockout rat is useful for pain research.
NGF dysfunction has been linked to neuropathic and osteoarthritic pain along with hyperalgesia. Inhibition of NGF, including inhibition of the p75NTR, is being pursued as a potential analgesic.