Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony
Generated in partnership with Autism Speaks, this model possesses a deletion in exon 8 of MET receptor tyrosine kinase (MET). Mutations in MET have been associated with the autism spectrum disorders in human patients, and this model is useful for the study of autism.
Homozygous knockout of MET is embryonic lethal.
The Met Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.