Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
- Background strain: Sprague Dawley
- Hemi males are compromised at 6 weeks of age
- Knockout rats exhibit complete loss of target protein as demonstrated by Western blot
- Mutations in methyl-CpG-binding protein (MeCP2) result in Rett syndrome, a leading cause of intellectual disabilities in girls
Availability: Cryopreserved as heterozygous embryos (female only)
Zygosity: Heterozygous (females) as live colony
This model contains a deletion of the methyl-CpG-binding protein (MeCP2)and is useful for the study of Rett syndrome. The gene is X-Linked. Mutations in MeCP2 have been linked to the development of Rett syndrome, a leading cause of intellectual disabilities in girls.
Origin: The MeCP2 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.