Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony
Generated in conjunction with Autism Speaks, this knockout rat model possesses a 13 bp deletion in the chromodomain helicase DNA binding protein encoded by the CHD8 gene and is a chromatin regulator enzyme that is essential during fetal development. CHD8 has been associated with autism spectrum disorders.
The CHD8 Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.