Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous as live colony
This model contains a deletion of the 1c subunit of the L-type voltage-gated calcium channel CACNA1C.
Cav1.2 is an L-type voltage-gated calcium channel encoded by the Cacna1c gene. Mutations in Cav1.2 result have been associated with schizophrenia, bipolar disorder, and most notably Timothy syndrome. Timothy syndrome is associated with long QT syndrome, heart arrhythmias, neurological impairment, and autism.
The Cacna1c Knockout Rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.