- Background strain: Sprague Dawley
- Biallelic 588 bp deletion within Abcg2 gene
- Homozygous knockouts display total loss of protein via Western blot
- Increased oral bioavailability of BCRP-specific substrates
Availability: Live colony
Zygosity genotype: Homozygous
Bcrp plays a protective role in neurotoxicity by limiting the efflux of xenobiotics into the brain. Homozygous null rats demonstrate increased exposure in the brain and plasma when dosed with Bcrp-specific substrates.
Loss of function of Bcrp leads to improper transport of drugs across epithelial cells and increased bioavailability of Bcrp substrates. This model is useful for studying metabolism of xenobiotic compounds, tissue distribution, DMPK, efficacy, formulation, and blood brain barrier efflux.
gem~gem rat~gem rats~knockout rats~knockout rat~Bcrp knockout rats~Bcrp~Bcrp knockout~HsdSage:SD-Abcg2tm1Sage~351~ATP~ATP Binding Cassette Subfamily G Member 2 (Junior Blood Group)~Binding Cassette~ABCP~BCRP~MXR~ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (Junior Blood Group)~Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2~Placenta-Specific ATP-Binding Cassette Transporter~Mitoxantrone Resistance-Associated Protein~Breast Cancer Resistance Protein~Urate Exporter~EST157481~CDw338~BCRP1~CD338~Multi Drug Resistance Efflux Transport ATP-Binding Cassette Sub-Family G (WHITE) Member~ATP-Binding Cassette, Sub-Family G (WHITE), Member~ATP-Binding Cassette Sub-Family G Member~ATP-Binding Cassette Transporter G2~Placenta Specific MDR Protein~ABC Transporter~CD338 Antigen~EC 22.214.171.124~UAQTL1~ABC15~GOUT1~MXR-1~ABCG2~BMDP~MXR1~MRX
Origin: The Bcrp KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.