Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of 7 weeks old can be produced within 20-22 weeks.
- Background strain: Long Evans Hooded
Availability: Cryopreserved as heterozygous embryos
Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Lrrk1 gene, encoding for the leucine-rich repeat kinase 1. This model is useful in understanding Lrrk1 biology.
gem~gem rat~gem rats~knockout rats~knockout rat~Lrrk1 knockout rats~Lrrk1 knockout rat~Lrrk1~Lrrk1 rat~HsdSage:LE-Lrrk1tm1Sage~Cryopreserved~leucine-rich repeat kinase 1~Leucine~Leucine Rich Repeat Kinase 1~Leucine-Rich Repeat Serine/Threonine-Protein Kinase 1~KIAA1790~RIPK6~Roco1~EC 184.108.40.206~FLJ23119
Origin: The Lrrk1 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by Inotiv in 2021.