Teklad diets provides a range of research diet options, including diet containing doxycycline for your Tet-regulated systems. Commonly requested Teklad Diet TD.01306 containing 625mg/kg of doxycycline hyclate added to our base rodent chow 2018 is stocked and available for shipping within 2 days for non-irradiated diet or 2 weeks for irradiated diet. Highly customizable, our nutritionists will work with you to tailor the base diet, doxycycline concentration, and food coloring to meet your specific requirements. If the options below do not meet your needs, contact a nutritionist to discuss a custom solution.

Browse our curated list of doxycycline references for additional information.

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Watch our Teklad Tek Talk on Doxycycline Diets featuring Dr. Barb Mickelson.

Formula examples with Teklad global 2018 base diet

Doxycycline hyclate1
(mg/kg diet)
Natural color Alternatives with food coloring
46 TD.10483 TD.180327 Red
TD.120240 Blue
100 TD.04233 TD.130840 Blue
200 TD.00502 TD.180625 Red
TD.150431 Blue
TD.04104 Green
625 TD.01306
TD.08541 Red
TD.120769 Blue
TD.09628 Green
1000 TD.05298 TD.06294 Red
TD.120658 Blue
2000 TD.05512 TD.140011 Red
TD.09633 Green
6000 TD.01533

1 Doxycycline hyclate is ~87% doxycycline
2 TD.01306 typically ships within 2 days non-irradiated or 2 weeks with irradiation

Considerations when choosing a base diet

  • Teklad Global Rodent Diets® like 2018 do not contain alfalfa and are thus ideal if your work requires an alfalfa-free diet for fluorescent imaging, If further imaging clarity is needed, we can make purified diets with doxycycline.
  • Teklad global 2018 (base diet in examples above) contains a moderate amount of soybean meal, a source of phytoestrogens. The table below includes several options of minimal phytoestrogen diets with the most common doxycycline concentration of 625 mg/kg diet. For different doxycycline concentrations or base diets, contact our expert nutritionists.

Examples of minimal phytoestrogen global rodent diets with doxycycline hyclate1 at 625 mg/kg diet

Base diet Natural color Alternatives with food coloring
2014 TD.00426 TD.07382 Red
TD.07573 Yellow
2016 TD.02503 TD.140263 Blue
TD.170364v Red
2019 TD.09651 TD.09761 Green
2020 TD.110720 TD.130141 Red

1 Doxycycline hyclate is ~87% doxycycline

Advantages of diet delivery of doxycycline

  • Typically the same doxycycline concentration can be utilized in diet as in water. Lower concentrations of doxycycline may be adequate with 625 mg/kg diet being the most common concentration.
  • Diet containing doxycycline is very stable for at least 6 months (Redelsperger, et. al. 2016), whereas using a water vehicle will require weekly changes.
  • Administering the compound through diet instead of water could also decrease the risk of dehydration and eliminate the need to add sucrose (Cawthorne et al. 2007).

Key planning information

  • Minimum order quantity is 3 kg, sufficient for feeding ~20 mice for one month.
  • Cold storage (refrigerator or freezer) is the best practice for doxycycline-containing diet that is not irradiated. Irradiated diet can be stored cool and dry.
  • While the default recommendation for shelf life is six months, doxycycline is stable longer (Redesperger, et. al. 2016). We recommend that use up to nine months is reasonable based on overall doxycycline stability in the diet along with nutritional adequacy of the base diet. Note that shelf life policies of a given institution may take precedence over this assessment.
  • Lead time for shipment is approximately 2 weeks for non-irradiated and 4 weeks for irradiated diet.
  • TD.01306 ships within 2 days for non-irradiated or 2 weeks for irradiated diet.
  • Irradiation (20 - 50 kGy) is optional, and must be requested at time of order.

Safe handling of doxycycline diets

  • Doxycycline is a tetracycline class antibiotic.
  • A usual dose for therapeutic effects in humans is 100-200 mg/day.
  • Doxycycline diets for rodents typically contain ~2 mg/pellet.
  • Accidental doxycycline exposure can be minimized by using typical lab precautions such as lab coat, gloves, and mask when handling the diet.
  • Your chemical safety department should be contacted for additional institution specific guidelines for handling and disposal of doxycycline containing diets.

Browse our curated list of doxycycline references for additional information.

Contact our expert nutritionists to discuss your specific needs or custom formulation.

Browse our curated list of recent doxycycline references for additional information.

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