¹ Doxycycline hyclate is ~87% doxycycline
² TD.01306 typically ships within 2 days non-irradiated or 2 weeks with irradiation

Considerations when choosing a base diet

• Teklad Global Rodent Diets^® like 2018 do not contain alfalfa and are thus ideal if your work requires an alfalfa-free diet for fluorescent imaging, If further imaging clarity is needed, we can make purified diets with doxycycline.
• Teklad global 2018 (base diet in examples above) contains a moderate amount of soybean meal, a source of phytoestrogens. The table below includes several options of minimal phytoestrogen diets with the most common doxycycline concentration of 625 mg/kg diet. For other concentrations contact us. For additional phytoestrogen information, see our list of phytoestrogen references.

¹ Doxycycline hyclate is ~87% doxycycline

Advantages of diet delivery of doxycycline

• Typically the same doxycycline concentration can be used in diet as in water. Lower concentrations of doxycycline may be adequate with 625 mg/kg diet being the most common concentration.
• Diet offers protection from light. Water may have to be given in dark-colored or foil-wrapped bottles
• Diet is typically changed once per week. Water may need to be changed every few days
• Diet delivery may also reduce risk of dehydration and preclude the need to give with sucrose (Cawthorne et. al. 2007)

Key planning information

• Minimum order quantity is 3 kg, sufficient for feeding ~20 mice for one month
• Store diet refrigerated and plan to use within six months
• Typical lead time is two weeks (four weeks if irradiated)
• TD.01306 typically ships within 2 days non-irradiated or 2 weeks with irradiation
• Irradiation (20 - 50 kGy) is optional, and must be requested at time of order

Safe handling of doxycycline diets

• Doxycycline is a tetracycline class antibiotic.
• Usual dose for therapeutic effects in humans is 100-200 mg/day.
• Doxycycline diets for rodents typically contain ~2 mg/pellet.
• Accidental doxycycline exposure can be minimized by using typical lab precautions of lab coat, gloves, and mask when handling the diet.
• Your chemical safety department should be contacted for additional institution specific guidelines for handling and disposal of doxycycline containing diets.

See our list of doxycycline references for additional information.

Contact us with your specific needs, and we can recommend an existing product code or create a new formulation.