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Aging

Crowley EK, Grabrucker S, Long-Smith CM, Stack A, O'Gorman DM, Nolan YM., A Reduction in Behavioral Pattern Separation Is Attenuated by Dietary Supplementation with a Magnesium-Rich Marine Mineral Blend in Middle-Aged Rats, J Med Food. 2022 Sep;25(9):924-929. doi: 10.1089/jmf.2020.0213. Epub 2021 Jun 29.
Yu X, Nguyen P, Burns NC, Heaps CL, Stallone JN, Sohrabji F, Han G., Activation of G protein-coupled estrogen receptor fine-tunes age-related decreased vascular activities in the aortae of female and male rats, Steroids. 2022 Jul;183:108997. doi: 10.1016/j.steroids.2022.108997. Epub 2022 Mar 18.
Malmo, V., Kelly, A., Garten, K. S., Stolen, T., Rolim, N. P. L., Wisloff, U., . . . Loennechen, J. P. (2018)., Aerobic interval training prevents age-dependent vulnerability to atrial fibrillation in rodents, Frontiers in Physiology, 9, 206. doi:10.3389/fphys.2018.00206 [doi]
Green TRF, Murphy SM, Ortiz JB, Rowe RK., Age-At-Injury Influences the Glial Response to Traumatic Brain Injury in the Cortex of Male Juvenile Rats, Front Neurol. 2022 Jan 17;12:804139. doi: 10.3389/fneur.2021.804139. eCollection 2021.
de Oliveira AA, Mendoza VO, Priviero F, Webb RC, Nunes KP., Age-Related Decline in Vascular Responses to Phenylephrine Is Associated with Reduced Levels of HSP70, Biomolecules. 2022 Aug 16;12(8):1125. doi: 10.3390/biom12081125.
Xue Y, Kossar AP, Abramov A, Frasca A, Sun M, Zyablitskaya M, Paik D, Kalfa D, Della Barbera M, Thiene G, Kozaki S, Kawashima T, Gorman JH, Gorman RC, Gillespie MJ, Carreon CK, Sanders SP, Levy RJ, Ferrari G., Age-related enhanced degeneration of bioprosthetic valves due to leaflet calcification, tissue crosslinking, and structural changes., Cardiovasc Res. 2023 Mar 17;119(1):302-315. doi: 10.1093/cvr/cvac002.
Shavlakadze T, Xiong K, Mishra S, McEwen C, Gadi A, Wakai M, Salmon H, Stec MJ, Negron N, Ni M, Wei Y, Atwal GS, Bai Y, Glass DJ., Age-related gene expression signatures from limb skeletal muscles and the diaphragm in mice and rats reveal common and species-specific changes., Skelet Muscle. 2023 Jul 12;13(1):11. doi: 10.1186/s13395-023-00321-3.
Pushkar, Y., Robison, G., Sullivan, B., Fu, S. X., Kohne, M., Jiang, W., . . . Zheng, W. (2013)., Aging results in copper accumulations in glial fibrillary acidic protein-positive cells in the subventricular zone., Aging Cell, 12(5), 823-832. doi:10.1111/acel.12112 [doi]
Ho AM, Peyton MP, Scaletty SJ, Trapp S, Schreiber A, Madden BJ, Choi DS, Matthews DB., Chronic Intermittent Ethanol Exposure Alters Behavioral Flexibility in Aged Rats Compared to Adult Rats and Modifies Protein and Protein Pathways Related to Alzheimer's Disease, ACS Omega. 2022 Dec 7;7(50):46260-46276. doi: 10.1021/acsomega.2c04528. eCollection 2022 Dec 20.
Lukefahr, A. L., Frye, J. B., Wright, L. E., Marion, S. L., Hoyer, P. B., & Funk, J. L. (2012), Decreased bone mineral density in rats rendered follicle-deplete by an ovotoxic chemical correlates with changes in follicle-stimulating hormone and inhibin A., Calcified Tissue International, 90(3), 239-249. doi:10.1007/s00223-011-9565-2 [doi]
Russ DW, Dimova K, Morris E, Pacheco M, Garvey SM, Scordilis SP., Dietary fish oil supplement induces age-specific contractile and proteomic responses in muscles of male rats, Lipids Health Dis. 2020 Jul 9;19(1):165. doi: 10.1186/s12944-020-01333-4.
Laast, V. A., Larsen, T., Allison, N., Hoenerhoff, M. J., & Boorman, G. A. (2014), Distinguishing cystic degeneration from other aging lesions in the adrenal cortex of sprague-dawley rats., Toxicologic Pathology, 42(5), 823-829. doi:10.1177/0192623313502258 [doi]
Thunhorst, R. L., Beltz, T. G., & Johnson, A. K. (2013)., Effects of aging on mineralocorticoid-induced salt appetite in rats, American Journal of Physiology.Regulatory, Integrative and Comparative Physiology, 305(12), R1498-505. doi:10.1152/ajpregu.00349.2013 [doi]
Owusu, B. Y., Stapley, R., Honavar, J., & Patel, R. P. (2013)., Effects of erythrocyte aging on nitric oxide and nitrite metabolism, Antioxidants & Redox Signaling, 19(11), 1198-1208. doi:10.1089/ars.2012.4884 [doi]
Warden, S. J., Galley, M. R., Hurd, A. L., Wallace, J. M., Gallant, M. A., Richard, J. S., & George, L. A. (2013), Elevated mechanical loading when young provides lifelong benefits to cortical bone properties in female rats independent of a surgically induced menopause., Endocrinology, 154(9), 3178-3187. doi:10.1210/en.2013-1227 [doi]
Geissler, S., Textor, M., Schmidt-Bleek, K., Klein, O., Thiele, M., Ellinghaus, A., . . . Strube, P. (2013)., In serum veritas-in serum sanitas? cell non-autonomous aging compromises differentiation and survival of mesenchymal stromal cells via the oxidative stress pathway, Cell Death & Disease, 4, e970. doi:10.1038/cddis.2013.501 [doi]
Witty, C. F., Foster, T. C., Semple-Rowland, S. L., & Daniel, J. M. (2012)., Increasing hippocampal estrogen receptor alpha levels via viral vectors increases MAP kinase activation and enhances memory in aging rats in the absence of ovarian estrogens., PloS One, 7(12), e51385. doi:10.1371/journal.pone.0051385 [doi]
Marsland P, Trapp S, Vore A, Lutzke A, Varlinskaya EI, Deak T., Intermittent Exposure to a Single Bottle of Ethanol Modulates Stress Sensitivity: Impact of Age at Exposure Initiation., Cells. 2023 Aug 3;12(15). pii: 1991. doi: 10.3390/cells12151991.
Stouffer, E. M., & Heisey, J. L. (2013), Latent learning of spatial information is impaired in middle-aged rats., Developmental Psychobiology, 55(3), 309-315. doi:10.1002/dev.21021 [doi]
Daniel, J. M., Witty, C. F., & Rodgers, S. P. (2015)., Long-term consequences of estrogens administered in midlife on female cognitive aging., Hormones and Behavior, doi:S0018-506X(15)00062-8 [pii]
Mackert GA, Schulte M, Hirche C, Kotsougiani D, Vogelpohl J, Hoener B, Fiebig T, Kirschner S, Brockmann MA, Lehnhardt M, Kneser U, Harhaus L., Low-energy extracorporeal shockwave therapy (ESWT) improves metaphyseal fracture healing in an osteoporotic rat model, PLoS One. 2017 Dec 12;12(12):e0189356. doi: 10.1371/journal.pone.0189356. eCollection 2017.
Frye, J. B., Lukefahr, A. L., Wright, L. E., Marion, S. L., Hoyer, P. B., & Funk, J. L. (2012)., Modeling perimenopause in sprague-dawley rats by chemical manipulation of the transition to ovarian failure., Comparative Medicine, 62(3), 193-202.
Barha, C. K., Lieblich, S. E., Chow, C., & Galea, L. A. (2015)., Multiparity-induced enhancement of hippocampal neurogenesis and spatial memory depends on ovarian hormone status in middle age., Neurobiology of Aging, 36(8), 2391-2405. doi:10.1016/j.neurobiolaging.2015.04.007 [doi]
Kim C, Bae HM, Baik I., Potential Antiaging and Hepatoprotective Effects of Acanthopanax senticosus Extracts in Adult Rat Models., Rejuvenation Res. 2023 Apr;26(2):51-56. doi: 10.1089/rej.2022.0051. Epub 2023 Jan 20.
Sampath D, Branyan TE, Markowsky KG, Gunda R, Samiya N, Obenaus A, Sohrabji F., Sex differences in cognitive impairment after focal ischemia in middle-aged rats and the effect of iv miR-20a-3p treatment., Neurobiol Aging. 2023 Sep;129:168-177. doi: 10.1016/j.neurobiolaging.2023.05.001. Epub 2023 May 5.
Ferreira, J. A., Foley, A. M., & Brown, M. (2012)., Sex hormones differentially influence voluntary running activity, food intake and body weight in aging female and male rats., European Journal of Applied Physiology, 112(8), 3007-3018. doi:10.1007/s00421-011-2271-y [doi]
Shavlakadze, T., Zhu, J., Wang, S., Zhou, W., Morin, B., Egerman, M. A., . . . Glass, D. J. (2018)., Short-term low-dose mTORC1 inhibition in aged rats counter-regulates age-related gene changes and blocks age-related kidney pathology., The Journals of Gerontology.Series A, Biological Sciences and Medical Sciences, 73(7), 845-852. doi:10.1093/gerona/glx249 [doi]
Uliana DL, Gomes FV, Grace AA., Stress impacts corticoamygdalar connectivity in an age-dependent manner, Neuropsychopharmacology. 2020 Oct 23. doi: 10.1038/s41386-020-00886-3. Online ahead of print.

Cardiovascular

Murninkas M, Gillis R, Lee DI, Elyagon S, Bhandarkar NS, Levi O, Polak R, Klapper-Goldstein H, Mulla W, Etzion Y., A new implantable tool for repeated assessment of supraventricular electrophysiology and atrial fibrillation susceptibility in freely moving rats, Am J Physiol Heart Circ Physiol. 2020 Dec 18. doi: 10.1152/ajpheart.00676.2020. Online ahead of print.
George J, Rappaport M, Shimoni S, Goland S, Voldarsky I, Fabricant Y, Edri O, Cuciuc V, Lifshitz S, Tshori S, Fassler M., A novel monoclonal antibody targeting aggregated transthyretin facilitates its removal and functional recovery in an experimental model, Eur Heart J. 2020 Mar 21;41(12):1260-1270. doi: 10.1093/eurheartj/ehz695.
Gohar EY, De Miguel C, Obi IE, Daugherty EM, Hyndman KA, Becker BK, Jin C, Sedaka R, Johnston JG, Liu P, Speed JS, Mitchell T, Kriegel AJ, Pollock JS, Pollock DM., Acclimation to a High-Salt Diet Is Sex Dependent, J Am Heart Assoc. 2022 Mar;11(5):e020450. doi: 10.1161/JAHA.120.020450. Epub 2022 Feb 22.
Sharifi Kia D, Benza E, Bachman TN, Tushak C, Kim K, Simon MA., Angiotensin Receptor-Neprilysin Inhibition Attenuates Right Ventricular Remodeling in Pulmonary Hypertension, J Am Heart Assoc. 2020 Jul 7;9(13):e015708. doi: 10.1161/JAHA.119.015708. Epub 2020 Jun 18.
Rahimi O, Melo AC, Westwood B, Grier RDM, Tallant EA, Gallagher PE., Angiotensin-(1-7) reduces doxorubicin-induced aortic arch dysfunction in male and female juvenile Sprague Dawley rats through pleiotropic mechanisms, Peptides. 2022 Jun;152:170784. doi: 10.1016/j.peptides.2022.170784. Epub 2022 Mar 12.
Almutlaq RN, Newell-Fugate AE, Evans LC, Fatima H, Gohar EY., Aromatase inhibition increases blood pressure and markers of renal injury in female rats, Am J Physiol Renal Physiol. 2022 Sep 1;323(3):F349-F360. doi: 10.1152/ajprenal.00055.2022. Epub 2022 Jul 28.
Nural-Guvener, H. F., Mutlu, N., & Gaballa, M. A. (2013)., BACE1 levels are elevated in congestive heart failure, Neuroscience Letters, 532, 7-11. doi:10.1016/j.neulet.2012.10.051 [doi]
Yu, H., Shao, H., Yan, J., Tsoukias, N. M., & Zhou, M. S. (2012)., Bone marrow transplantation improves endothelial function in hypertensive dahl salt-sensitive rats. Journal, Journal of the American Society of Hypertension : JASH, 6(5), 331-337. doi:10.1016/j.jash.2012.08.003 [doi]
Nguyen ITN, Wiggenhauser LM, Bulthuis M, Hillebrands JL, Feelisch M, Verhaar MC, van Goor H, Joles JA., Cardiac Protection by Oral Sodium Thiosulfate in a Rat Model of L-NNA-Induced Heart Disease, Front Pharmacol. 2021 Apr 15;12:650968. doi: 10.3389/fphar.2021.650968. eCollection 2021.
Stover, K. R., & Cleary, J. D. (2015)., Cardiac response to centrally administered echinocandin antifungals., The Journal of Pharmacy and Pharmacology, 67(9), 1279-1283. doi:10.1111/jphp.12429 [doi]
Micucci M, Budriesi R, Aldini R, Fato R, Bergamini C, Vivarelli F, Canistro D, Bolchi C, Chiarini A, Rizzardi N, Pallavicini M, Frosini M, Angeletti A., Castanea sativa Mill. bark extract cardiovascular effects in a rat model of high-fat diet, Phytother Res. 2020 Dec 8. doi: 10.1002/ptr.6967. Online ahead of print.
Wang Z, Cui M, Shah AM, Tan W, Liu N, Bassel-Duby R, Olson EN., Cell-Type-Specific Gene Regulatory Networks Underlying Murine Neonatal Heart Regeneration at Single-Cell Resolution, Cell Rep. 2020 Dec 8;33(10):108472. doi: 10.1016/j.celrep.2020.108472.
Hooper, J. S., Hadley, S. H., Morris, K. F., Breslin, J. W., Dean, J. B., & Taylor-Clark, T. E. (2016)., Characterization of cardiovascular reflexes evoked by airway stimulation with allylisothiocyanate, capsaicin, and ATP in sprague-dawley rats., Journal of Applied Physiology (Bethesda, Md.: 1985), 120(6), 580-591. doi:10.1152/japplphysiol.00944.2015 [doi]
Hoyt, R. E., Speakman, R. O., Brown, D. R., Cassis, L. A., Silcox, D. L., Anigbogu, C. N., & Randall, D. C. (2013)., Chronic angiotensin-II treatment potentiates HR slowing in sprague-dawley rat during acute behavioral stress. Autonomic Neuroscience, Basic & Clinical, 174(1-2), 42-46. doi:10.1016/j.autneu.2012.12.004 [doi]
da Silva AA, Pinkerton MA, Spradley FT, Palei AC, Hall JE, do Carmo JM., Chronic CNS-mediated cardiometabolic actions of leptin: potential role of sex differences, Am J Physiol Regul Integr Comp Physiol. 2020 Nov 18. doi: 10.1152/ajpregu.00027.2020. Online ahead of print.
Wong EM, Tablin F, Schelegle ES., Comparison of nonparametric and parametric methods for time-frequency heart rate variability analysis in a rodent model of cardiovascular disease, PLoS One. 2020 Nov 9;15(11):e0242147. doi: 10.1371/journal.pone.0242147. eCollection 2020.
Ye, S., Weng, Y., Sun, S., Chen, W., Wu, X., Li, Z., . . . Tang, W. (2012)., Comparison of the durations of mild therapeutic hypothermia on outcome after cardiopulmonary resuscitation in the rat., Circulation, 125(1), 123-129. doi:10.1161/CIRCULATIONAHA.111.062257 [doi]
Dedkov, E. I., Oak, K., Christensen, L. P., & Tomanek, R. J. (2014)., Coronary vessels and cardiac myocytes of middle-aged rats demonstrate regional sex-specific adaptation in response to postmyocardial infarction remodeling., Biology of Sex Differences, 5(1), 1-6410-5-1. doi:10.1186/2042-6410-5-1 [doi]
Getsy PM, Young AP, Grossfield A, Seckler JM, Wilson CG, Gaston B, Bates JN, Lewis SJ., D-cysteine ethyl ester and D-cystine dimethyl ester reverse the deleterious effects of morphine on arterial blood-gas chemistry and Alveolar-arterial gradient in anesthetized rats, Respir Physiol Neurobiol. 2022 Aug;302:103912. doi: 10.1016/j.resp.2022.103912. Epub 2022 Apr 18.
Xia P, Chen J, Liu Y, Fletcher M, Jensen BC, Cheng Z., Doxorubicin induces cardiomyocyte apoptosis and atrophy through cyclin-dependent kinase 2-mediated activation of forkhead box O1, J Biol Chem. 2020 Mar 27;295(13):4265-4276. doi: 10.1074/jbc.RA119.011571. Epub 2020 Feb 19.
Cui M, Wang Z, Chen K, Shah AM, Tan W, Duan L, Sanchez-Ortiz E, Li H, Xu L, Liu N, Bassel-Duby R, Olson EN., Dynamic Transcriptional Responses to Injury of Regenerative and Non-regenerative Cardiomyocytes Revealed by Single-Nucleus RNA Sequencing, Dev Cell. 2020 Apr 6;53(1):102-116.e8. doi: 10.1016/j.devcel.2020.02.019. Epub 2020 Mar 26.
Terashvili MN, Kozak KN, Gebremedhin D, Allen LA, Gifford AL, Allen KP, Thulin JD, Lombard JH., Effect of Nearby Construction Activity on Endothelial Function, Sensitivity to Nitric Oxide, and Potassium Channel Activity in the Middle Cerebral Arteries of Rats, J Am Assoc Lab Anim Sci. 2020 May 13;59(4):411-22. doi: 10.30802/AALAS-JAALAS-19-000116. Online ahead of print.
Gibson, N. M., Quinn, C. J., Pfannenstiel, K. B., Hydock, D. S., & Hayward, R. (2014), Effects of age on multidrug resistance protein expression and doxorubicin accumulation in cardiac and skeletal muscle., Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 44(5), 472-479. doi:10.3109/00498254.2013.846489 [doi]
Cho JS, Han YS, Jensen C, Sieck G., Effects of arginase inhibition on myocardial Ca(2+) and contractile responses, Physiol Rep. 2022 Jul;10(14):e15396. doi: 10.14814/phy2.15396.
Yurista SR, SilljĂŠ HHW, van Goor H, Hillebrands JL, Heerspink HJL, de Menezes Montenegro L, Oberdorf-Maass SU, de Boer RA, Westenbrink BD., Effects of Sodium-Glucose Co-transporter 2 Inhibition with Empaglifozin on Renal Structure and Function in Non-diabetic Rats with Left Ventricular Dysfunction After Myocardial Infarction, Cardiovasc Drugs Ther. 2020 Jun;34(3):311-321. doi: 10.1007/s10557-020-06954-6.
Bhatia, P. M., Chamberlain, R., Luo, X., Hartley, E. W., & Divani, A. A. (2012)., Elevated blood pressure causes larger hematoma in a rat model of intracerebral hemorrhage, Translational Stroke Research, 3(4), 428-434. doi:10.1007/s12975-012-0199-0 [doi]
Morin EE, Salbato S, Walker BR, Naik JS., Endothelial cell membrane cholesterol content regulates the contribution of TRPV4 channels in ACh-induced vasodilation in rat gracilis arteries, Microcirculation. 2022 Jul;29(4-5):e12774. doi: 10.1111/micc.12774. Epub 2022 Jun 21.
El-Nachef D, Bugg D, Beussman KM, Steczina S, Martinson AM, Murry CE, Sniadecki NJ, Davis J., Engrafted Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Undergo Clonal Expansion In Vivo, Circulation. 2021 Apr 20;143(16):1635-1638. doi: 10.1161/CIRCULATIONAHA.119.044974. Epub 2021 Apr 19.
Buniam, Jariya; Chukijrungroat, Natsasi; Khamphaya, Tanaporn; Weerachayaphorn, Jittima; Saengsirisuwan, Vitoon;, Estrogen and voluntary exercise attenuate cardiometabolic syndrome and hepatic steatosis in ovariectomized rats fed a high-fat high-fructose diet. American journal of physiology., Endocrinology and metabolism Vol.316, 2019
Bradley, J. M., Cryar, K. A., El Hajj, M. C., El Hajj, E. C., & Gardner, J. D. (2013)., Exposure to diesel exhaust particulates induces cardiac dysfunction and remodeling., Journal of Applied Physiology (Bethesda, Md.: 1985), 115(7), 1099-1106. doi:10.1152/japplphysiol.00343.2013 [doi]
Bradshaw JL, Cushen SC, Ricci CA, Tucker SM, Gardner JJ, Little JT, Osikoya O, Goulopoulou S., Exposure to unmethylated CpG oligonucleotides disrupts blood pressure circadian rhythms and placental clock gene network in pregnant rats., Am J Physiol Heart Circ Physiol. 2023 Aug 1;325(2):H323-H337. doi: 10.1152/ajpheart.00154.2023. Epub 2023 Jun 23.
Steagall, R. J., Daniels, C. R., Dalal, S., Joyner, W. L., Singh, M., & Singh, K. (2014)., Extracellular ubiquitin increases expression of angiogenic molecules and stimulates angiogenesis in cardiac microvascular endothelial cells., Microcirculation (New York, N.Y.: 1994), 21(4), 324-332. doi:10.1111/micc.12109 [doi]
Yurista SR, Silljé HHW, Nijholt KT, Dokter MM, van Veldhuisen DJ, de Boer RA, Westenbrink BD., Factor Xa Inhibition with Apixaban Does Not Influence Cardiac Remodelling in Rats with Heart Failure After Myocardial Infarction, Cardiovasc Drugs Ther. 2021 Oct;35(5):953-963. doi: 10.1007/s10557-020-06999-7.
Belanger KM, Crislip GR, Gillis EE, Abdelbary M, Musall JB, Mohamed R, Baban B, Elmarakby A, Brands MW, Sullivan JC., Greater T Regulatory Cells in Females Attenuate DOCA-Salt-Induced Increases in Blood Pressure Versus Males, Hypertension. 2020 Jun;75(6):1615-1623. doi: 10.1161/HYPERTENSIONAHA.119.14089. Epub 2020 Apr 27.
Garcia-Prieto, C. F., Hernandez-Nuno, F., Rio, D. D., Ruiz-Hurtado, G., Aranguez, I., Ruiz-Gayo, M., . . . Fernandez-Alfonso, M. S. (2015)., High-fat diet induces endothelial dysfunction through a down-regulation of the endothelial AMPK-PI3K-akt-eNOS pathway., Molecular Nutrition & Food Research, 59(3), 520-532. doi:10.1002/mnfr.201400539 [doi]
Harmon, A., Cornelius, D., Amaral, L., Paige, A., Herse, F., Ibrahim, T., . . . LaMarca, B. (2015)., IL-10 supplementation increases tregs and decreases hypertension in the RUPP rat model of preeclampsia., Hypertension in Pregnancy, 34(3), 291-306. doi:10.3109/10641955.2015.1032054 [doi]
Carmichael, C. Y., Carmichael, A. C., Kuwabara, J. T., Cunningham, J. T., & Wainford, R. D. (2016), Impaired sodium-evoked paraventricular nucleus neuronal activation and blood pressure regulation in conscious sprague-dawley rats lacking central Galphai2 proteins, Acta Physiologica (Oxford, England), 216(3), 314-329. doi:10.1111/apha.12610 [doi]
Seymour, A. M., Giles, L., Ball, V., Miller, J. J., Clarke, K., Carr, C. A., & Tyler, D. J. (2015)., In vivo assessment of cardiac metabolism and function in the abdominal aortic banding model of compensated cardiac hypertrophy, Cardiovascular Research, 106(2), 249-260. doi:10.1093/cvr/cvv101 [doi]
Ocak U, Eser Ocak P, Huang L, Xu W, Zuo Y, Li P, Gamdzyk M, Zuo G, Mo J, Zhang G, Zhang JH., Inhibition of mast cell tryptase attenuates neuroinflammation via PAR-2/p38/NFÎşB pathway following asphyxial cardiac arrest in rats, J Neuroinflammation. 2020 May 4;17(1):144. doi: 10.1186/s12974-020-01808-2.
Yurista SR, Matsuura TR, Silljé HHW, Nijholt KT, McDaid KS, Shewale SV, Leone TC, Newman JC, Verdin E, van Veldhuisen DJ, de Boer RA, Kelly DP, Westenbrink BD., Ketone Ester Treatment Improves Cardiac Function and Reduces Pathologic Remodeling in Preclinical Models of Heart Failure, Circ Heart Fail. 2020 Dec 28:CIRCHEARTFAILURE120007684. doi: 10.1161/CIRCHEARTFAILURE.120.007684. Online ahead of print.
Salman IM, Ameer OZ, McMurray S, Giarola AS, Sridhar A, Lewis SJ, Hsieh YH., Laterality Influences Central Integration of Baroreceptor Afferent Input in Male and Female Sprague Dawley Rats, Front Physiol. 2020 May 27;11:499. doi: 10.3389/fphys.2020.00499. eCollection 2020.
Yang, Y., Wu, Z., Meininger, C. J., & Wu, G. (2015), L-leucine and NO-mediated cardiovascular function., Amino Acids, 47(3), 435-447. doi:10.1007/s00726-014-1904-y [doi]
Torres Fernandez, E. D., Adams, K. V., Syed, M., Maranon, R. O., Romero, D. G., & Yanes Cardozo, L. L. (2018)., Long-lasting androgen-induced cardiometabolic effects in polycystic ovary syndrome., Journal of the Endocrine Society, 2(8), 949-964. doi:10.1210/js.2018-00131 [doi]
Patel, J. R., Pleitner, J. M., Moss, R. L., & Greaser, M. L. (2012)., Magnitude of length-dependent changes in contractile properties varies with titin isoform in rat ventricles., American Journal of Physiology.Heart and Circulatory Physiology, 302(3), H697-708. doi:10.1152/ajpheart.00800.2011 [doi]
Shafiei-Irannejad V, Abbaszadeh S, Janssen PML, Soraya H., Memantine and its benefits for cancer, cardiovascular and neurological disorders, Eur J Pharmacol. 2021 Nov 5;910:174455. doi: 10.1016/j.ejphar.2021.174455. Epub 2021 Aug 27.
Messmer SJ, Fraser JF, Pennypacker KR, Roberts JM., Method of intra-arterial drug administration in a rat: Sex based optimization of infusion rate, J Neurosci Methods. 2021 Jun 1;357:109178. doi: 10.1016/j.jneumeth.2021.109178. Epub 2021 Apr 2.
Fujioka, H., Tandler, B., & Hoppel, C. L. (2012)., Mitochondrial division in rat cardiomyocytes: An electron microscope study., Anatomical Record (Hoboken, N.J.: 2007), 295(9), 1455-1461. doi:10.1002/ar.22523 [doi]
Chinyere IR, Hutchinson M, Moukabary T, Koevary JW, Juneman E, Goldman S, Lancaster JJ., Modulating the Infarcted Ventricle's Refractoriness with an Epicardial Biomaterial, J Investig Med. 2021 Feb;69(2):364-370. doi: 10.1136/jim-2020-001486. Epub 2020 Oct 28.
Interdonato L, Impellizzeri D, D'Amico R, Cordaro M, Siracusa R, D'Agostino M, Genovese T, Gugliandolo E, Crupi R, Fusco R, Cuzzocrea S, Di Paola R., Modulation of TLR4/NFκB Pathways in Autoimmune Myocarditis, Antioxidants (Basel). 2023 Jul 27;12(8). pii: 1507. doi: 10.3390/antiox12081507.
Frame AA, Nist KM, Kim K, Kuwabara JT, Wainford RD., Natriuresis During an Acute Intravenous Sodium Chloride Infusion in Conscious Sprague Dawley Rats Is Mediated by a Blood Pressure-Independent α(1)-Adrenoceptor-Mediated Mechanism, Front Physiol. 2022 Jan 17;12:784957. doi: 10.3389/fphys.2021.784957. eCollection 2021.
He F, Zheng G, Hu J, Ge W, Ji X, Bradley JL, Peberdy MA, Ornato JP, Tang W., Necrosulfonamide improves post-resuscitation myocardial dysfunction via inhibiting pyroptosis and necroptosis in a rat model of cardiac arrest, Eur J Pharmacol. 2022 Jul 5;926:175037. doi: 10.1016/j.ejphar.2022.175037. Epub 2022 May 16.
Chojnacki MR, Thorndike EB, Partilla JS, Rice KC, Schindler CW, Baumann MH., Neurochemical and Cardiovascular Effects of 4-Chloro Ring-Substituted Synthetic Cathinones in Rats., J Pharmacol Exp Ther. 2023 Jun;385(3):162-170. doi: 10.1124/jpet.122.001478. Epub 2023 Jan 20.
Walsh, K. R., Kuwabara, J. T., Shim, J. W., & Wainford, R. D. (2016)., Norepinephrine-evoked salt-sensitive hypertension requires impaired renal sodium chloride cotransporter activity in sprague-dawley rats, American Journal of Physiology.Regulatory, Integrative and Comparative Physiology, 310(2), R115-24. doi:10.1152/ajpregu.00514.2014 [doi]
Das S, Komnenov D, Newhouse L, Rishi AK, Rossi NF., Paraventricular Nucleus V(1a) Receptor Knockdown Blunts Neurocardiovascular Responses to Acute Stress in Male Rats after Chronic Mild Unpredictable Stress, Physiol Behav. 2022 Sep 1;253:113867. doi: 10.1016/j.physbeh.2022.113867. Epub 2022 Jun 2.
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Manole MD, Hook MJA, Nicholas MA, Nelson BP, Liu AC, Stezoski QC, Rowley AP, Cheng JP, Alexander H, Moschonas EH, Bondi CO, Kline AE., Preclinical neurorehabilitation with environmental enrichment confers cognitive and histological benefits in a model of pediatric asphyxial cardiac arrest, Exp Neurol. 2021 Jan;335:113522. doi: 10.1016/j.expneurol.2020.113522. Epub 2020 Nov 2.
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Xia P, Chen J, Sapkota Y, Scott EN, Liu Y, Hudson MM, Rassekh SR, Carleton BC, Ross CJD, Chow EJ, Cheng Z., RBL2 Regulates Cardiac Sensitivity to Anthracycline Chemotherapy., JACC CardioOncol. 2023 Mar 28;5(3):360-373. doi: 10.1016/j.jaccao.2022.10.017. eCollection 2023 Jun.
Cruz, M. V., Luker, J. N., Carney, B. C., Brummel-Ziedins, K. E., Bravo, M. C., Orfeo, T., . . . Shupp, J. W. (2017)., Reference ranges for rotational thromboelastometry in male sprague dawley rats, Thrombosis Journal, 15, 31-017-0154-0. eCollection 2017. doi:10.1186/s12959-017-0154-0 [doi]
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Yu Y, Wei SG, Weiss RM, Felder RB., Silencing Epidermal Growth Factor Receptor in Hypothalamic Paraventricular Nucleus Reduces Extracellular Signal-regulated Kinase 1 and 2 Signaling and Sympathetic Excitation in Heart Failure Rats, Neuroscience. 2021 May 21;463:227-237. doi: 10.1016/j.neuroscience.2021.01.025. Epub 2021 Feb 2.
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Alexander ED, Aldridge JL, Burleson TS, Frasier CR., Teriflunomide treatment exacerbates cardiac ischemia reperfusion injury in isolated rat hearts, Cardiovasc Drugs Ther. 2022 Apr 30:1-6. doi: 10.1007/s10557-022-07341-z. Online ahead of print.
Alexander ED, Aldridge JL, Burleson TS, Frasier CR., Teriflunomide treatment exacerbates cardiac ischemia reperfusion injury in isolated rat hearts., Cardiovasc Drugs Ther. 2023 Oct;37(5):1021-1026. doi: 10.1007/s10557-022-07341-z. Epub 2022 Apr 30.
Silva AFR, Silva-Reis R, Ferreira R, Oliveira PA, Faustino-Rocha AI, Pinto ML, Coimbra MA, Silva AMS, Cardoso SM., The Impact of Resveratrol-Enriched Bread on Cardiac Remodeling in a Preclinical Model of Diabetes., Antioxidants (Basel). 2023 May 9;12(5). pii: 1066. doi: 10.3390/antiox12051066.
Villegas-Esguevillas M, Cho S, Vera-Zambrano A, Kwon JW, Barreira B, Telli G, Navarro-Dorado J, Morales-Cano D, de Olaiz B, Moreno L, Greenwood I, Pérez-Vizcaíno F, Kim SJ, Climent B, Cogolludo A., The novel K(V)7 channel activator URO-K10 exerts enhanced pulmonary vascular effects independent of the KCNE4 regulatory subunit., Biomed Pharmacother. 2023 Aug;164:114952. doi: 10.1016/j.biopha.2023.114952. Epub 2023 Jun 7.
Geraghty JR, Saini NS, Deshpande A, Cheng T, Nazir N, Testai FD., The Role of Serum Monocytes and Tissue Macrophages in Driving Left Ventricular Systolic Dysfunction and Cardiac Inflammation Following Subarachnoid Hemorrhage., Neurocrit Care. 2023 Dec 7. doi: 10.1007/s12028-023-01891-2. [Epub ahead of print]
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COVID-19

Moutal A, Martin LF, Boinon L, Gomez K, Ran D, Zhou Y, Stratton HJ, Cai S, Luo S, Gonzalez KB, Perez-Miller S, Patwardhan A, Ibrahim MM, Khanna R., SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia, Pain. 2020 Oct 1. doi: 10.1097/j.pain.0000000000002097. Online ahead of print.

Diabetes induced obesity

Aranaz P , Zabala M , Romo-Hualde A , Navarro-Herrera D , LĂłpez-Yoldi M , Vizmanos JL , MartĂ­nez JA , Milagro FI , GonzĂĄlez-Navarro CJ ., A combination of borage seed oil and quercetin reduces fat accumulation and improves insulin sensitivity in obese rats, Food Funct. 2020 May 1;11(5):4512-4524. doi: 10.1039/d0fo00504e. Epub 2020 May 11.
Daniels SJ, Leeming DJ, Detlefsen S, Bruun MF, Hjuler ST, Henriksen K, Hein P, Krag A, Karsdal MA, Nielsen MJ, Brockbank S, Cruwys S., Addition of trans fat and alcohol has divergent effects on atherogenic diet-induced liver injury in rodent models of steatohepatitis, Am J Physiol Gastrointest Liver Physiol. 2020 Mar 1;318(3):G410-G418. doi: 10.1152/ajpgi.00066.2019. Epub 2020 Jan 6.
Derman RC, Ferrario CR., Affective Pavlovian motivation is enhanced in obesity susceptible populations: Implications for incentive motivation in obesity, Behav Brain Res. 2020 Feb 17;380:112318. doi: 10.1016/j.bbr.2019.112318. Epub 2019 Nov 21.
McDevitt E, Henein L, Crawford A, Kondakala S, Young D, Meek E, Howell GE 3rd., Alterations of Systemic and Hepatic Metabolic Function Following Exposure to Trans-nonachlor in Low and High Fat Diet Fed Male Sprague Dawley Rats., Int J Toxicol. 2023 Sep-Oct;42(5):407-419. doi: 10.1177/10915818231170527. Epub 2023 Apr 26.
Ansari P, Flatt PR, Harriott P, Abdel-Wahab YHA., Anti-hyperglycaemic and insulin releasing effects of Camellia sinensis leaves and isolation and characterization of active compounds, Br J Nutr. 2020 Dec 17:1-35. doi: 10.1017/S0007114520005085. Online ahead of print.
Kamat V, Radtke JR, Hu Q, Wang W, Sweet IR, Hampe CS., Autoantibodies directed against glutamate decarboxylase interfere with glucose-stimulated insulin secretion in dispersed rat islets, Int J Exp Pathol. 2022 Aug;103(4):140-148. doi: 10.1111/iep.12437. Epub 2022 Mar 4.
Roglans N, Fauste E, Bentanachs R, Velázquez AM, Pérez-Armas M, Donis C, Panadero MI, Alegret M, Otero P, Bocos C, Laguna JC., Bempedoic Acid Restores Liver H(2)S Production in a Female Sprague-Dawley Rat Dietary Model of Non-Alcoholic Fatty Liver, Int J Mol Sci. 2022 Dec 28;24(1):473. doi: 10.3390/ijms24010473.
Méndez, L., Muñoz, S., Barros, L., Miralles-Pérez, B., Romeu, M., Ramos-Romero, S., Torres, J. L., & Medina, I., Combined Intake of Fish Oil and D-Fagomine Prevents High-Fat High-Sucrose Diet-Induced Prediabetes by Modulating Lipotoxicity and Protein Carbonylation in the Kidney., Antioxidants (Basel). 2023 Mar 19;12(3). pii: 751. doi: 10.3390/antiox12030751.
Niepoetter P, Butts-Wilmsmeyer C, Kaviani S, Viernow C, Ruholl H, Gopalan C., Correlation between ketones and mental fatigue in high fat-induced obese and non-obese rats, Physiol Rep. 2021 Jul;9(13):e14930. doi: 10.14814/phy2.14930.
Noli B, Brancia C, Corda G, Ferri GL, Cocco C., Dynamic of TLQP-peptides upon fasting, Tissue Cell. 2020 Aug;65:101368. doi: 10.1016/j.tice.2020.101368. Epub 2020 Apr 15.
Ansari P, Hannon-Fletcher MP, Flatt P, Abdel-Wahab YHA., Effects of 22 traditional anti-diabetic medicinal plants on DPP-IV enzyme activity and glucose homeostasis in high-fat fed obese diabetic rats, Biosci Rep. 2021 Jan 8:BSR20203824. doi: 10.1042/BSR20203824. Online ahead of print.
Wu L, Wang M, Maher S, Fu P, Cai D, Wang B, Gupta S, Hijaz A, Daneshgari F, Liu G., Effects of different diets used to induce obesity/metabolic syndrome on bladder function in rats., Am J Physiol Regul Integr Comp Physiol. 2023 Jan 1;324(1):R70-R81. doi: 10.1152/ajpregu.00218.2022. Epub 2022 Nov 14.
Hoffman EG, D'Souza NC, Aiken J, Atherley S, Liggins R, Riddell MC., Effects of somatostatin receptor type 2 antagonism during insulin-induced hypoglycaemia in male rats with prediabetes., Diabetes Obes Metab. 2023 Jun;25(6):1547-1556. doi: 10.1111/dom.15002. Epub 2023 Mar 6.
Ansari P, Flatt PR, Harriott P, Abdel-Wahab YHA., Evaluation of the Antidiabetic and Insulin Releasing Effects of A. squamosa, Including Isolation and Characterization of Active Phytochemicals, Plants (Basel). 2020 Oct 12;9(10):1348. doi: 10.3390/plants9101348.
Richardson JR, O'Dell LE, Nazarian A., Examination of nicotine and saccharin reward in the Goto-Kakizaki diabetic rat model, Neurosci Lett. 2020 Mar 16;721:134825. doi: 10.1016/j.neulet.2020.134825. Epub 2020 Feb 6.
Dasilva G, Lois S, Méndez L, Miralles-Pérez B, Romeu M, Ramos-Romero S, Torres JL, Medina I., Fish Oil Improves Pathway-Oriented Profiling of Lipid Mediators for Maintaining Metabolic Homeostasis in Adipose Tissue of Prediabetic Rats, Front Immunol. 2021 Apr 21;12:608875. doi: 10.3389/fimmu.2021.608875. eCollection 2021.
Volcko KL, Carroll QE, Brakey DJ, Daniels D., High-fat diet alters fluid intake without reducing sensitivity to glucagon-like peptide-1 receptor agonist effects, Physiol Behav. 2020 Jul 1;221:112910. doi: 10.1016/j.physbeh.2020.112910. Epub 2020 Apr 10.
Bier A, Shapira E, Khasbab R, Sharabi Y, Grossman E, Leibowitz A., High-Fructose Diet Increases Renal ChREBPβ Expression, Leading to Intrarenal Fat Accumulation in a Rat Model with Metabolic Syndrome, Biology (Basel). 2022 Apr 18;11(4):618. doi: 10.3390/biology11040618.
Ayyappan P, Larsen TD, Gandy TCT, Louwagie EJ, Baack ML., Impact of Prenatal Exposure to Maternal Diabetes and High-Fat Diet on Postnatal Myocardial Ketone Body Metabolism in Rats., Int J Mol Sci. 2023 Feb 12;24(4). pii: 3684. doi: 10.3390/ijms24043684.
Melander SA, Katri A, Karsdal MA, Henriksen K., Improved metabolic efficacy of a dual amylin and calcitonin receptor agonist when combined with semaglutide or empagliflozin., Eur J Pharmacol. 2023 Jan 5;938:175397. doi: 10.1016/j.ejphar.2022.175397. Epub 2022 Nov 19.
Ansari P, Islam SS, Akther S, Khan JT, Shihab JA, Abdel-Wahab YHA., Insulin secretory actions of ethanolic extract of Acacia arabica bark in high fat-fed diet-induced obese Type 2 diabetic rats., Biosci Rep. 2023 May 31;43(5). pii: BSR20230329. doi: 10.1042/BSR20230329.
Niepoetter P, Butts-Wilmsmeyer C, Gopalan C., Intermittent fasting and mental and physical fatigue in obese and non-obese rats, PLoS One. 2022 Nov 2;17(11):e0275684. doi: 10.1371/journal.pone.0275684. eCollection 2022.
Jobgen WS, Lee MJ, Fried SK, Wu G., l-Arginine supplementation regulates energy-substrate metabolism in skeletal muscle and adipose tissue of diet-induced obese rats, Exp Biol Med (Maywood). 2022 Dec 21:15353702221139207. doi: 10.1177/15353702221139207. Online ahead of print.
Han L, Bittner S, Dong D, Cortez Y, Bittner A, Chan J, Umar M, Shen WJ, Peterson RG, Kraemer FB, Azhar S., Molecular changes in hepatic metabolism in ZDSD rats-A new polygenic rodent model of obesity, metabolic syndrome, and diabetes, Biochim Biophys Acta Mol Basis Dis. 2020 May 1;1866(5):165688. doi: 10.1016/j.bbadis.2020.165688. Epub 2020 Jan 24.
Ganugula R, Nuthalapati NK, Dwivedi S, Zou D, Arora M, Friend R, Sheikh-Hamad D, Basu R, Kumar MNVR., Nanocurcumin combined with insulin alleviates diabetic kidney disease through P38/P53 signaling axis., J Control Release. 2023 Jan;353:621-633. doi: 10.1016/j.jconrel.2022.12.012. Epub 2022 Dec 14.
Pathak R, Kumar A, Palfrey HA, Stone KP, Raju NR, Gettys TW, Murthy SN., Prolonged effects of DPP-4 inhibitors on steato-hepatitic changes in Sprague-Dawley rats fed a high-cholesterol diet, Inflamm Res. 2022 Jun;71(5-6):711-722. doi: 10.1007/s00011-022-01572-4. Epub 2022 May 16.
Yang TY, Gardner JC, Gao Z, Pan YX, Liang NC., Role of glucocorticoid signaling in exercise-associated changes in high-fat diet preference in rats, Am J Physiol Regul Integr Comp Physiol. 2020 Mar 1;318(3):R515-R528. doi: 10.1152/ajpregu.00288.2019. Epub 2020 Jan 15.
Yang TY, Gao Z, Liang NC., Sex-Dependent Wheel Running Effects on High Fat Diet Preference, Metabolic Outcomes, and Performance on the Barnes Maze in Rats, Nutrients. 2020 Sep 5;12(9):2721. doi: 10.3390/nu12092721.
Silva-Reis R, Faustino-Rocha AI, Silva J, Valada A, Azevedo T, Anjos L, Gonçalves L, Pinto ML, Ferreira R, Silva AMS, Cardoso SM, Oliveira PA., Studying and Analyzing Humane Endpoints in the Fructose-Fed and Streptozotocin-Injected Rat Model of Diabetes., Animals (Basel). 2023 Apr 18;13(8). pii: 1397. doi: 10.3390/ani13081397.
Yun H, Dumbell R, Hanna K, Bowen J, McLean SL, Kantamneni S, Pors K, Wu QF, Helfer G., The Chemerin-CMKLR1 Axis is Functionally important for Central Regulation of Energy Homeostasis, Front Physiol. 2022 May 30;13:897105. doi: 10.3389/fphys.2022.897105. eCollection 2022.
Larsen AT, Gydesen S, Sonne N, Karsdal MA, Henriksen K., The dual amylin and calcitonin receptor agonist KBP-089 and the GLP-1 receptor agonist liraglutide act complimentarily on body weight reduction and metabolic profile, BMC Endocr Disord. 2021 Jan 7;21(1):10. doi: 10.1186/s12902-020-00678-2.
Sonne N, Larsen AT, Andreassen KV, Karsdal MA, Henriksen K., The Dual Amylin and Calcitonin Receptor Agonist, KBP-066, Induces an Equally Potent Weight Loss Across a Broad Dose Range While Higher Doses May Further Improve Insulin Action, J Pharmacol Exp Ther. 2020 Apr;373(1):92-102. doi: 10.1124/jpet.119.263723. Epub 2020 Jan 28.
Sonne N, Larsen AT, Karsdal MA, Henriksen K., The Impact of Exposure Profile on the Efficacy of Dual Amylin and Calcitonin Receptor Agonist Therapy, Biomedicines. 2022 Sep 22;10(10):2365. doi: 10.3390/biomedicines10102365.
Saande CJ, Bries AE, Pritchard SK, Nass CA, Reed CH, Rowling MJ, Schalinske KL., Whole Egg Consumption Decreases Cumulative Weight Gain in Diet-Induced Obese Rats, J Nutr. 2020 Jul 1;150(7):1818-1823. doi: 10.1093/jn/nxaa114.

Diet induced obesity

Hsu, T. M., Noble, E. E., Liu, C. M., Cortella, A. M., Konanur, V. R., Suarez, A. N., . . . Kanoski, S. E. (2018), A hippocampus to prefrontal cortex neural pathway inhibits food motivation through glucagon-like peptide-1 signaling, Molecular Psychiatry, 23(7), 1555-1565. doi:10.1038/mp.2017.91 [doi]
Davidson, E. P., Coppey, L. J., Kardon, R. H., & Yorek, M. A. (2014)., Differences and similarities in development of corneal nerve damage and peripheral neuropathy and in diet-induced obesity and type 2 diabetic rats., Investigative Ophthalmology & Visual Science, 55(3), 1222-1230. doi:10.1167/iovs.13-13794 [doi]
Apolzan, J. W., & Harris, R. B. (2012)., Differential effects of chow and purified diet on the consumption of sucrose solution and lard and the development of obesity., Physiology & Behavior, 105(2), 325-331. doi:10.1016/j.physbeh.2011.08.023 [doi]
Wu, M. J., & Chang, C. J. (2016), High fat diet-induced breast cancer model in rat., Bio-Protocol, 6(13), 10.21769/BioProtoc.1852. doi:e1852 [pii]
Song, M., Schuschke, D. A., Zhou, Z., Chen, T., Pierce, W. M.,Jr, Wang, R., . . . McClain, C. J. (2012), High fructose feeding induces copper deficiency in sprague-dawley rats: A novel mechanism for obesity related fatty liver, Journal of Hepatology, 56(2), 433-440. doi:10.1016/j.jhep.2011.05.030 [doi]
Song, Z., Xie, W., Chen, S., Strong, J. A., Print, M. S., Wang, J. I., . . . Zhang, J. M. (2017)., High-fat diet increases pain behaviors in rats with or without obesity., Scientific Reports, 7(1), 10350-017-10458-z. doi:10.1038/s41598-017-10458-z [doi]
Stengel, A., Goebel-Stengel, M., Wang, L., Hu, E., Karasawa, H., Pisegna, J. R., & Tache, Y. (2013)., High-protein diet selectively reduces fat mass and improves glucose tolerance in western-type diet-induced obese rats., American Journal of Physiology.Regulatory, Integrative and Comparative Physiology, 305(6), R582-91. doi:10.1152/ajpregu.00598.2012 [doi]
Lee, S. J., Sanchez-Watts, G., Krieger, J. P., Pignalosa, A., Norell, P. N., Cortella, A., . . . Watts, A. G. (2018), Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity., Molecular Metabolism, 11, 33-46. doi:S2212-8778(18)30143-1 [pii]
Vivarelli, F., Canistro, D., Sapone, A., De Nicola, G. R., Babot Marquillas, C., Iori, R., . . . Paolini, M. (2016)., Raphanus sativus cv. sango sprout juice decreases diet-induced obesity in sprague dawley rats and ameliorates related disorders., PloS One, 11(3), e0150913. doi:10.1371/journal.pone.0150913 [doi]
Northcott, C. A., Fink, G. D., Garver, H., Haywood, J. R., Laimon-Thomson, E. L., McClain, J. L., . . . Dorrance, A. M. (2012)., The development of hypertension and hyperaldosteronism in a rodent model of life-long obesity, Endocrinology, 153(4), 1764-1773. doi:10.1210/en.2011-1176 [doi]
Davidson, T. L., Monnot, A., Neal, A. U., Martin, A. A., Horton, J. J., & Zheng, W. (2012), The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood-brain barrier integrity differ for diet-induced obese and diet-resistant rats, Physiology & Behavior, 107(1), 26-33. doi:10.1016/j.physbeh.2012.05.015 [doi]

General studies

Boero G, Tyler RE, Todd CA, O'Buckley TK, Balan I, Besheer J, Morrow AL., (3?,5?)3-hydroxypregnan-20-one (3?,5?-THP) regulation of hypothalamic and extrahypothalamic corticotropin releasing factor (CRF): Sexual dimorphism and brain region specificity in Sprague Dawley rats, Neuropharmacology. 2021 Mar 15;186:108463. doi: 10.1016/j.neuropharm.2021.108463. Epub 2021 Jan 16.
Bilder A, Rachmiel A, Ginini JG, Capucha T, Ohayon C, Weitman E, Emodi O., A Comparative Study of Mucosal Wound Healing after Excision with a Scalpel, Diode Laser, or CO(2) Laser., Plast Reconstr Surg Glob Open. 2023 Aug 4;11(8):e5150. doi: 10.1097/GOX.0000000000005150. eCollection 2023 Aug.
Taki, F. A., Abdel-Rahman, A. A., & Zhang, B. (2014)., A comprehensive approach to identify reliable reference gene candidates to investigate the link between alcoholism and endocrinology in sprague-dawley rats, PloS One, 9(5), e94311. doi:10.1371/journal.pone.0094311 [doi]
Stouffer, E. M., Warninger, E. E., & Michener, P. N. (2015)., A high-fat diet impairs learning that is dependent on the dorsal hippocampus but spares other forms of learning., Hippocampus, doi:10.1002/hipo.22476 [doi]
Edwards J, Kowal M, VanDreel A, Lamar P, Prozialeck W., A Method for the Evaluation of Site-Specific Nephrotoxic Injury in the Intact Rat Kidney, Toxics. 2020 Jan 20;8(1):4. doi: 10.3390/toxics8010004.
Martínez-Rivera FJ, Pérez-Torres J, Velázquez-Díaz CD, Sánchez-Navarro MJ, Huertas-Pérez CI, Diehl MM, Phillips ML, Haber SN, Quirk GJ., A Novel Insular/Orbital-Prelimbic Circuit That Prevents Persistent Avoidance in a Rodent Model of Compulsive Behavior., Biol Psychiatry. 2023 Jun 1;93(11):1000-1009. doi: 10.1016/j.biopsych.2022.02.008. Epub 2022 Feb 19.
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Hanania T, Manfredi P, Inturrisi C, Vitolo OV., The N-methyl-D-aspartate receptor antagonist d-methadone acutely improves depressive-like behavior in the forced swim test performance of rats, Exp Clin Psychopharmacol. 2020 Apr;28(2):196-201. doi: 10.1037/pha0000310. Epub 2019 Aug 1.
Walker, J. J., Spiga, F., Waite, E., Zhao, Z., Kershaw, Y., Terry, J. R., & Lightman, S. L. (2012)., The origin of glucocorticoid hormone oscillations., PLoS Biology, 10(6), e1001341. doi:10.1371/journal.pbio.1001341 [doi]
Loai S, Szulc DA, Cheng HM., Three-Dimensional Bioprinted MR-Trackable Regenerative Scaffold for Postimplantation Monitoring on T1-Weighted MRI, J Magn Reson Imaging. 2022 Aug;56(2):570-578. doi: 10.1002/jmri.28057. Epub 2022 Jan 7.
Birnie MT, Eapen AV, Kershaw YM, Lodge D, Collingridge GL, Conway-Campbell BL, Lightman SL., Time of day influences stress hormone response to ketamine, J Neuroendocrinol. 2022 Oct;34(10):e13194. doi: 10.1111/jne.13194. Epub 2022 Sep 2.
Brown KT, Levis SC, O'Neill CE, Levy C, Rice KC, Watkins LR, Bachtell RK., Toll-like receptor 4 antagonists reduce cocaine-primed reinstatement of drug seeking., Psychopharmacology (Berl). 2023 Jul;240(7):1587-1600. doi: 10.1007/s00213-023-06392-w. Epub 2023 Jun 7.
Woodward, N. C., Levine, M. C., Haghani, A., Shirmohammadi, F., Saffari, A., Sioutas, C., . . . Finch, C. E. (2017)., Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo., Journal of Neuroinflammation, 14(1), 84-017-0858-x. doi:10.1186/s12974-017-0858-x [doi]
Ying, W. Z., Aaron, K. J., & Sanders, P. W. (2013)., Transforming growth factor-beta regulates endothelial function during high salt intake in rats., Hypertension, 62(5), 951-956. doi:10.1161/HYPERTENSIONAHA.113.01835 [doi]
Janssen K, Deng K, Majerus SJA, Lin DL, Hanzlicek B, Butler RS, van der Vaart CH, Damaser MS., Transurethral versus suprapubic catheterization to test urethral function in rats, Sci Rep. 2021 Jul 13;11(1):14369. doi: 10.1038/s41598-021-93772-x.
Toti A, Micheli L, Lucarini E, Ferrara V, Ciampi C, Margiotta F, Failli P, Gomiero C, Pallecchi M, Bartolucci G, Ghelardini C, Di Cesare Mannelli L., Ultramicronized N-Palmitoylethanolamine Regulates Mast Cell-Astrocyte Crosstalk: A New Potential Mechanism Underlying the Inhibition of Morphine Tolerance., Biomolecules. 2023 Jan 25;13(2). pii: 233. doi: 10.3390/biom13020233.
Vivarelli F, Canistro D, Cirillo S, Elias RJ, Granata S, Mussoni M, Burattini S, Falcieri E, Turrini E, Fimognari C, Buschini A, Lazzaretti M, Beghi S, Girotti S, Sangiorgi S, Bolelli L, Ghini S, Ferri EN, Fagiolino I, Franchi P, Lucarini M, Mercatante D, Rodriguez-Estrada MT, Lorenzini A, Marchionni S, Gabriele M, Longo V, Paolini M., Unburned Tobacco Cigarette Smoke Alters Rat Ultrastructural Lung Airways and DNA, Nicotine Tob Res. 2021 Nov 5;23(12):2127-2134. doi: 10.1093/ntr/ntab108.
Moran AE, Huynh YW, Finkner AP, Selleck C, Thompson A, Barrett ST, Bevins RA., Understanding the stimulus effects of nicotine and bupropion in a drug-drug discriminated goal-tracking task, Psychopharmacology (Berl). 2022 Mar;239(3):819-830. doi: 10.1007/s00213-022-06072-1. Epub 2022 Feb 9.
Hu, H., Huang, N., Yi, P., Hui, Y. H., Dally, R. D., Ehlhardt, W. J., & Kulanthaivel, P. (2015), Utilizing F NMR to investigate drug disposition early in drug discovery, Xenobiotica; the Fate of Foreign Compounds in Biological Systems, , 1-11. doi:10.3109/00498254.2015.1040866 [doi]
Tsuda MC, Mahdi S, Namchuk A, Wu TJ, Lucki I., Vendor differences in anxiety-like behaviors in female and male Sprague Dawley rats, Physiol Behav. 2020 Dec 1;227:113131. doi: 10.1016/j.physbeh.2020.113131. Epub 2020 Aug 10.
Huang S, Ghasem Ardabili N, Davidson TL, Riley AL., Western diet consumption does not impact the rewarding and aversive effects of morphine in male Sprague-Dawley rats., Physiol Behav. 2023 Oct 15;270:114317. doi: 10.1016/j.physbeh.2023.114317. Epub 2023 Aug 3.

Immunology

Ogura S, Baldeosingh R, Bhutto IA, Kambhampati SP, Scott McLeod D, Edwards MM, Rais R, Schubert W, Lutty GA., A role for mast cells in geographic atrophy, FASEB J. 2020 Aug;34(8):10117-10131. doi: 10.1096/fj.202000807R. Epub 2020 Jun 11.
Tobin MK, Stephen TKL, Lopez KL, Pergande MR, Bartholomew AM, Cologna SM, Lazarov O., Activated Mesenchymal Stem Cells Induce Recovery Following Stroke Via Regulation of Inflammation and Oligodendrogenesis, J Am Heart Assoc. 2020 Apr 7;9(7):e013583. doi: 10.1161/JAHA.119.013583. Epub 2020 Mar 24.
Kimmerling KA, Gomoll AH, Farr J, Mowry KC., Amniotic Suspension Allograft Modulates Inflammation in a Rat Pain Model of Osteoarthritis, J Orthop Res. 2020 May;38(5):1141-1149. doi: 10.1002/jor.24559. Epub 2019 Dec 19.
Meyer DW, Bou LB, Shum S, Jonas M, Anderson ME, Hamilton JZ, Hunter JH, Wo SW, Wong AO, Okeley NM, Lyon RP., An in Vitro Assay Using Cultured Kupffer Cells Can Predict the Impact of Drug Conjugation on in Vivo Antibody Pharmacokinetics, Mol Pharm. 2020 Mar 2;17(3):802-809. doi: 10.1021/acs.molpharmaceut.9b00991. Epub 2020 Feb 5.
Ilari S, Giancotti LA, Lauro F, Dagostino C, Gliozzi M, Malafoglia V, Sansone L, Palma E, Tafani M, Russo MA, Tomino C, Fini M, Salvemini D, Mollace V, Muscoli C., Antioxidant modulation of sirtuin 3 during acute inflammatory pain: The ROS control, Pharmacol Res. 2020 Jul;157:104851. doi: 10.1016/j.phrs.2020.104851. Epub 2020 May 11.
Cordaro M, Siracusa R, Fusco R, D'Amico R, Peritore AF, Gugliandolo E, Genovese T, Scuto M, Crupi R, Mandalari G, Cuzzocrea S, Di Paola R, Impellizzeri D., Cashew (Anacardium occidentale L.) Nuts Counteract Oxidative Stress and Inflammation in an Acute Experimental Model of Carrageenan-Induced Paw Edema, Antioxidants (Basel). 2020 Jul 24;9(8):660. doi: 10.3390/antiox9080660.
Smith TA, Ghergherehchi CL, Tucker HO, Bittner GD., Coding transcriptome analyses reveal altered functions underlying immunotolerance of PEG-fused rat sciatic nerve allografts, J Neuroinflammation. 2020 Oct 2;17(1):287. doi: 10.1186/s12974-020-01953-8.
Loupy KM, Cler KE, Marquart BM, Yifru TW, D'Angelo HM, Arnold MR, Elsayed AI, Gebert MJ, Fierer N, Fonken LK, Frank MG, Zambrano CA, Maier SF, Lowry CA., Comparing the effects of two different strains of mycobacteria, Mycobacterium vaccae NCTC 11659 and M. vaccae ATCC 15483, on stress-resilient behaviors and lipid-immune signaling in rats, Brain Behav Immun. 2021 Jan;91:212-229. doi: 10.1016/j.bbi.2020.09.030. Epub 2020 Oct 1.
Smith ZZ, Kubiak RA, Arnold MR, Loupy KM, Taylor JA, Crist TG, Bernier AE, D'Angelo HM, Heinze JD, Lowry CA, Barth DS., Effects of immunization with heat-killed Mycobacterium vaccae on autism spectrum disorder-like behavior and epileptogenesis in a rat model of comorbid autism and epilepsy, Brain Behav Immun. 2020 Aug;88:763-780. doi: 10.1016/j.bbi.2020.05.034. Epub 2020 May 19.
Hakami Z, Hand AR., Expression of aquaporin 5 during murine palatine glands development: a light and electron microscopic immunocytochemical study, Eur J Oral Sci. 2020 Oct;128(5):379-385. doi: 10.1111/eos.12734. Epub 2020 Aug 19.
Ezeomah C, Cunningham KA, Stutz SJ, Fox RG, Bukreyeva N, Dineley KT, Paessler S, Cisneros IE., Fentanyl self-administration impacts brain immune responses in male Sprague-Dawley rats, Brain Behav Immun. 2020 Jul;87:725-738. doi: 10.1016/j.bbi.2020.03.003. Epub 2020 Mar 9.
Belanger KM, Crislip GR, Gillis EE, Abdelbary M, Musall JB, Mohamed R, Baban B, Elmarakby A, Brands MW, Sullivan JC., Greater T Regulatory Cells in Females Attenuate DOCA-Salt-Induced Increases in Blood Pressure Versus Males, Hypertension. 2020 Jun;75(6):1615-1623. doi: 10.1161/HYPERTENSIONAHA.119.14089. Epub 2020 Apr 27.
Metzger CE, Anand Narayanan S, Phan PH, Bloomfield SA., Hindlimb unloading causes regional loading-dependent changes in osteocyte inflammatory cytokines that are modulated by exogenous irisin treatment, NPJ Microgravity. 2020 Oct 7;6:28. doi: 10.1038/s41526-020-00118-4. eCollection 2020.
Ramirez LA, Gillis EE, Musall JB, Mohamed R, Snyder E, El-Marakby A, Sullivan JC., Hypertensive female Sprague-Dawley rats require an intact nitric oxide synthase system for compensatory increases in renal regulatory T cells, Am J Physiol Renal Physiol. 2020 Aug 1;319(2):F192-F201. doi: 10.1152/ajprenal.00228.2020. Epub 2020 Jun 29.
Morales W, Triantafyllou K, Parodi G, Weitsman S, Park SC, Rezaie A, Pichetshote N, Lin E, Pimentel M., Immunization with cytolethal distending toxin B produces autoantibodies to vinculin and small bowel bacterial changes in a rat model of postinfectious irritable bowel syndrome, Neurogastroenterol Motil. 2020 Oct;32(10):e13875. doi: 10.1111/nmo.13875. Epub 2020 May 21.
Cornelius DC, Travis OK, Tramel RW, Borges-Rodriguez M, Baik CH, Greer M, Giachelli CA, Tardo GA, Williams JM., NLRP3 inflammasome inhibition attenuates sepsis-induced platelet activation and prevents multi-organ injury in cecal-ligation puncture, PLoS One. 2020 Jun 17;15(6):e0234039. doi: 10.1371/journal.pone.0234039. eCollection 2020.
Litvin DG, Denstaedt SJ, Borkowski LF, Nichols NL, Dick TE, Smith CB, Jacono FJ., Peripheral-to-central immune communication at the area postrema glial-barrier following bleomycin-induced sterile lung injury in adult rats, Brain Behav Immun. 2020 Jul;87:610-633. doi: 10.1016/j.bbi.2020.02.006. Epub 2020 Feb 22.
Smith TA, Ghergherehchi CL, Mikesh M, Shores JT, Tucker HO, Bittner GD., Polyethylene glycol-fusion repair of sciatic allografts in female rats achieves immunotolerance via attenuated innate and adaptive responses, J Neurosci Res. 2020 Dec;98(12):2468-2495. doi: 10.1002/jnr.24720. Epub 2020 Sep 15.
Munshi S, Loh MK, Ferrara N, DeJoseph MR, Ritger A, Padival M, Record MJ, Urban JH, Rosenkranz JA., Repeated stress induces a pro-inflammatory state, increases amygdala neuronal and microglial activation, and causes anxiety in adult male rats, Brain Behav Immun. 2020 Feb;84:180-199. doi: 10.1016/j.bbi.2019.11.023. Epub 2019 Nov 27.
Worth AA, Shoop R, Tye K, Feetham CH, D'Agostino G, Dodd GT, Reimann F, Gribble FM, Beebe EC, Dunbar JD, Alexander-Chacko JT, Sindelar DK, Coskun T, Emmerson PJ, Luckman SM., The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling, Elife. 2020 Jul 29;9:e55164. doi: 10.7554/eLife.55164.
Waldron RT, Chen Y, Pham H, Go A, Su HY, Hu C, Wen L, Husain SZ, Sugar CA, Roos J, Ramos S, Lugea A, Dunn M, Stauderman K, Pandol SJ., The Orai Ca(2+) channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis, J Physiol. 2019 Jun;597(12):3085-3105. doi: 10.1113/JP277856. Epub 2019 May 22.
Ellison TJ, Talbott GC, Henderson DR., VaxiPatch™, a novel vaccination system comprised of subunit antigens, adjuvants and microneedle skin delivery: An application to influenza B/Colorado/06/2017, Vaccine. 2020 Oct 7;38(43):6839-6848. doi: 10.1016/j.vaccine.2020.07.040. Epub 2020 Jul 31.

Infectious disease

Moutal A, Martin LF, Boinon L, Gomez K, Ran D, Zhou Y, Stratton HJ, Cai S, Luo S, Gonzalez KB, Perez-Miller S, Patwardhan A, Ibrahim MM, Khanna R., SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia, Pain. 2020 Oct 1. doi: 10.1097/j.pain.0000000000002097. Online ahead of print.
Zhao M, Zhang F, Zarnowski R, Barns K, Jones R, Fossen J, Sanchez H, Rajski SR, Audhya A, Bugni TS, Andes DR., Turbinmicin inhibits Candida biofilm growth by disrupting fungal vesicle-mediated trafficking, J Clin Invest. 2021 Mar 1;131(5):e145123. doi: 10.1172/JCI145123.

Metabolism

Cladis DP, Simpson AMR, Cooper KJ, Nakatsu CH, Ferruzzi MG, Weaver CM., Blueberry polyphenols alter gut microbiota & phenolic metabolism in rats., Food Funct. 2021 Mar 21;12(6):2442-2456. doi: 10.1039/d0fo03457f. Epub 2021 Feb 25.

Neurology

Boero G, Tyler RE, O'Buckley TK, Balan I, Besheer J, Morrow AL., (3α,5α)3-Hydroxypregnan-20-one (3α,5α-THP) Regulation of the HPA Axis in the Context of Different Stressors and Sex, Biomolecules. 2022 Aug 18;12(8):1134. doi: 10.3390/biom12081134.
Lacagnina MJ, Li J, Lorca S, Rice KC, Sullivan K, O'Callaghan JP, Grace PM., A role for neuroimmune signaling in a rat model of Gulf War Illness-related pain, Brain Behav Immun. 2021 Jan;91:418-428. doi: 10.1016/j.bbi.2020.10.022. Epub 2020 Oct 27.
Carney AE, Clarke C, Pratt WE., Administration of neuropeptide Y into the rat nucleus accumbens shell, but not core, attenuates the motivational impairment from systemic dopamine receptor antagonism by α-flupenthixol., Neurosci Lett. 2023 Feb 16;797:137069. doi: 10.1016/j.neulet.2023.137069. Epub 2023 Jan 11.
Carney AE, Clarke C, Pratt WE., Administration of neuropeptide Y into the rat nucleus accumbens shell, but not core, attenuates the motivational impairment from systemic dopamine receptor antagonism by α-flupenthixol, Neurosci Lett. 2023 Jan 11;797:137069. doi: 10.1016/j.neulet.2023.137069. Online ahead of print.
Wang T, Chen S, Mao Z, Shang Y, Brinton RD., Allopregnanolone pleiotropic action in neurons and astrocytes: calcium signaling as a unifying mechanism., Front Endocrinol (Lausanne). 2023 Dec 22;14:1286931. doi: 10.3389/fendo.2023.1286931. eCollection 2023.
Shao LR, Janicot R, Stafstrom CE., Antiseizure effect of 2-deoxyglucose is not dependent on the presynaptic vacuole ATP pump or the somatic ATP-sensitive K(+) channel., J Neurophysiol. 2023 Jun 1;129(6):1423-1433. doi: 10.1152/jn.00124.2023. Epub 2023 May 24.
Nalamolu KR, Challa SR, Fornal CA, Grudzien NA, Jorgenson LC, Choudry MM, Smith NJ, Palmer CJ, Pinson DM, Klopfenstein JD, Veeravalli KK., Attenuation of the Induction of TLRs 2 and 4 Mitigates Inflammation and Promotes Neurological Recovery After Focal Cerebral Ischemia, Transl Stroke Res. 2021 Oct;12(5):923-936. doi: 10.1007/s12975-020-00884-z. Epub 2021 Jan 11.
Lillyman DJ, Lee FS, Barnett EC, Miller TJ, Alvaro ML, Drvol HC, Wachs RA., Axial hypersensitivity is associated with aberrant nerve sprouting in a novel model of disc degeneration in female Sprague Dawley rats, JOR Spine. 2022 Jul 14;5(3):e1212. doi: 10.1002/jsp2.1212. eCollection 2022 Sep.
Shakil S, Masjoan Juncos JX, Mariappan N, Zafar I, Amudhan A, Amudhan A, Aishah D, Siddiqui S, Manzoor S, Santana CM, Rumbeiha WK, Salim S, Ahmad A, Ahmad S., Behavioral and Neuronal Effects of Inhaled Bromine Gas: Oxidative Brain Stem Damage, Int J Mol Sci. 2021 Jun 12;22(12):6316. doi: 10.3390/ijms22126316.
Kim HK, Bae J, Lee SH, Hwang SH, Kim MS, Kim MJ, Jun S, Cervantes CL, Jung YS, Back S, Lee H, Lee SE, Dougherty PM, Lee SW, Park JI, Abdi S., Blockers of Wnt3a, Wnt10a, or ?-Catenin Prevent Chemotherapy-Induced Neuropathic Pain In Vivo, Neurotherapeutics. 2021 Jan;18(1):601-614. doi: 10.1007/s13311-020-00956-w. Epub 2020 Oct 30.
Frank D, Gruenbaum BF, Shelef I, Zvenigorodsky V, Severynovska O, Fleidervish I, Knyazer B, Frenkel A, Zlotnik A, Kofman O, Boyko M., Blood glutamate scavenging as a novel glutamate-based therapeutic approach for post-traumatic brain injury anxiety and social impairment., Transl Psychiatry. 2023 Feb 4;13(1):41. doi: 10.1038/s41398-023-02329-1.
Budrow C, Elder K, Coyle M, Centner A, Lipari N, Cohen S, Glinski J, Kinzonzi N, Wheelis E, McManus G, Manfredsson F, Bishop C., Broad Serotonergic Actions of Vortioxetine as a Promising Avenue for the Treatment of L-DOPA-Induced Dyskinesia., Cells. 2023 Mar 8;12(6). pii: 837. doi: 10.3390/cells12060837.
Gwak YS, Chen G, Abdi S, Kim HK., Calcium-independent phospholipase A2 inhibitor produces an analgesic effect in a rat model of neuropathic pain by reducing central sensitization in the dorsal horn, Neurol Res. 2021 Aug;43(8):683-692. doi: 10.1080/01616412.2021.1915079. Epub 2021 Apr 18.
Kalvala AK, Bagde A, Arthur P, Kulkarni T, Bhattacharya S, Surapaneni S, Patel NK, Nimma R, Gebeyehu A, Kommineni N, Meckes DG Jr, Sun L, Banjara B, Mosley-Kellum K, Dinh TC, Singh M., Cannabidiol-Loaded Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Paclitaxel-Induced Peripheral Neuropathy., Pharmaceutics. 2023 Feb 7;15(2). pii: 554. doi: 10.3390/pharmaceutics15020554. Erratum in: Pharmaceutics. 2023 Aug 25;15(9):.
Li AJ, Wang Q, Rogers RC, Herman G, Ritter RC, Ritter S., Chemogenetic activation of ventral medullary astrocytes enhances feeding and corticosterone release in response to mild glucoprivation., Am J Physiol Regul Integr Comp Physiol. 2023 Sep 1;325(3):R229-R237. doi: 10.1152/ajpregu.00079.2023. Epub 2023 Jul 10.
Malone IG, Kelly MN, Nosacka RL, Nash MA, Yue S, Xue W, Otto KJ, Dale EA., Closed-Loop, Cervical, Epidural Stimulation Elicits Respiratory Neuroplasticity after Spinal Cord Injury in Freely Behaving Rats, eNeuro. 2022 Feb 9;9(1):ENEURO.0426-21.2021. doi: 10.1523/ENEURO.0426-21.2021. Print 2022 Jan-Feb.
Corbett CM, Miller END, Wannen EE, Rood BD, Chandler DJ, Loweth JA., Cocaine Exposure Increases Excitatory Synaptic Transmission and Intrinsic Excitability in the Basolateral Amygdala in Male and Female Rats and across the Estrous Cycle., Neuroendocrinology. 2023;113(11):1127-1139. doi: 10.1159/000531351. Epub 2023 Jun 2.
Gu Q, Sarkar S, Raymick B, Kanungo J., Combining tissue clearing and Fluoro-Jade C labeling for neurotoxicity assessments., Exp Biol Med (Maywood). 2023 Apr;248(7):605-611. doi: 10.1177/15353702231165009. Epub 2023 May 19.
Robinson HL, Nicholson KL, Shelton KL, Hamilton PJ, Banks ML., Comparison of three DREADD agonists acting on Gq-DREADDs in the ventral tegmental area to alter locomotor activity in tyrosine hydroxylase:Cre male and female rats., Behav Brain Res. 2023 Oct 18;455:114674. doi: 10.1016/j.bbr.2023.114674. Epub 2023 Sep 16.
Pace SA, Lukinic E, Wallace T, McCartney C, Myers B., Cortical-brainstem circuitry attenuates physiological stress reactivity., bioRxiv. 2023 Sep 1. pii: 2023.07.19.549781. doi: 10.1101/2023.07.19.549781.
Mondello JE, Gano A, Vore AS, Deak T., Cues associated with repeated ethanol exposure facilitate the corticosterone response to ethanol and immunological challenges in adult male Sprague Dawley rats: implications for neuroimmune regulation., Am J Drug Alcohol Abuse. 2023 May 4;49(3):359-369. doi: 10.1080/00952990.2023.2169831. Epub 2023 Mar 2.
Rusheen AE, Rojas-Cabrera J, Goyal A, Shin H, Yuen J, Jang DP, Bennet KE, Blaha CD, Lee KH, Oh Y., Deep brain stimulation alleviates tics in Tourette syndrome via striatal dopamine transmission., Brain. 2023 Oct 3;146(10):4174-4190. doi: 10.1093/brain/awad142.
Ferrara NC, Trask S, Avonts B, Loh MK, Padival M, Rosenkranz JA., Developmental Shifts in Amygdala Activity during a High Social Drive State, J Neurosci. 2021 Nov 10;41(45):9308-9325. doi: 10.1523/JNEUROSCI.1414-21.2021. Epub 2021 Oct 5.
Scott MC, Haase CM, Olson SD, Cox CS Jr., Dexmedetomidine Alters the Inflammatory Profile of Rat Microglia In Vitro, Neurocrit Care. 2022 Nov 23. doi: 10.1007/s12028-022-01638-5. Online ahead of print.
Scott MC, Haase CM, Olson SD, Cox CS Jr., Dexmedetomidine Alters the Inflammatory Profile of Rat Microglia In Vitro., Neurocrit Care. 2023 Jun;38(3):688-697. doi: 10.1007/s12028-022-01638-5. Epub 2022 Nov 23.
Ummear Raza M, Gautam D, Rorie D, Sivarao DV., Differential Effects of Clozapine and Haloperidol on the 40 Hz Auditory Steady State Response-mediated Phase Resetting in the Prefrontal Cortex of the Female Sprague Dawley Rat., Schizophr Bull. 2023 May 3;49(3):581-591. doi: 10.1093/schbul/sbac203.
Jawaid S, Herring AI, Getsy PM, Lewis SJ, Watanabe M, Kolesova H., Differential immunostaining patterns of transient receptor potential (TRP) ion channels in the rat nodose ganglion, J Anat. 2022 Aug;241(2):230-244. doi: 10.1111/joa.13656. Epub 2022 Apr 9.
Nim, S., O'Hara, D. M., Corbi-Verge, C., Perez-Riba, A., Fujisawa, K., Kapadia, M., Chau, H., Albanese, F., Pawar, G., De Snoo, M. L., Ngana, S. G., Kim, J., El-Agnaf, O. M. A., Rennella, E., Kay, L. E., Kalia, S. K., Kalia, L. V., & Kim, P. M., Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson's disease, Nature communications, 14(1), 2150. https://doi.org/10.1038/s41467-023-37464-2
Dela Peńa I, Shen G, Shi WX., Droxidopa alters dopamine neuron and prefrontal cortex activity and improves attention-deficit/hyperactivity disorder-like behaviors in rats, Eur J Pharmacol. 2021 Feb 5;892:173826. doi: 10.1016/j.ejphar.2020.173826. Epub 2020 Dec 19.
Walter LA, Blake LP, Gallot YS, Arends CJ, Sozio RS, Onifer SM, Bohnert KR., Effect of Denervation on XBP1 in Skeletal Muscle and the Neuromuscular Junction, Int J Mol Sci. 2021 Dec 24;23(1):169. doi: 10.3390/ijms23010169.
Cedeño, D. L., Kelley, C. A., & Vallejo, R., Effect of stimulation intensity of a differential target multiplexed SCS program in an animal model of neuropathic pain., Pain Pract. 2023 Jul;23(6):639-646. doi: 10.1111/papr.13235. Epub 2023 Apr 17.
Vazquez-Sanroman DB, Arlington Wilson G, Bardo MT., Effects of Social Isolation on Perineuronal Nets in the Amygdala Following a Reward Omission Task in Female Rats, Mol Neurobiol. 2021 Jan;58(1):348-361. doi: 10.1007/s12035-020-02125-8. Epub 2020 Sep 17.
Zhang M, Spencer HF, Berman RY, Radford KD, Choi KH., Effects of subanesthetic intravenous ketamine infusion on neuroplasticity-related proteins in male and female Sprague-Dawley rats, IBRO Neurosci Rep. 2021 Jul 3;11:42-51. doi: 10.1016/j.ibneur.2021.06.005. eCollection 2021 Dec.
Moschonas EH, Ranellone TS, Vozzella VJ, Rennerfeldt PL, Bondi CO, Annas EM, Bittner RA, Tamura DM, Reddy RI, Eleti RR, Cheng JP, Jarvis JM, Fink EL, Kline AE., Efficacy of a music-based intervention in a preclinical model of traumatic brain injury: An initial foray into a novel and non-pharmacological rehabilitative therapy., Exp Neurol. 2023 Nov;369:114544. doi: 10.1016/j.expneurol.2023.114544. Epub 2023 Sep 17.
Dore K, Malinow R., Elevated PSD-95 Blocks Ion-flux Independent LTD: A Potential New Role for PSD-95 in Synaptic Plasticity, Neuroscience. 2021 Feb 21;456:43-49. doi: 10.1016/j.neuroscience.2020.02.020. Epub 2020 Feb 28.
Hoogland G, Raijmakers M, Clynen E, Brône B, Rigo JM, Swijsen A., Experimental early-life febrile seizures cause a sustained increase in excitatory neurotransmission in newborn dentate granule cells, Brain Behav. 2022 Mar;12(3):e2505. doi: 10.1002/brb3.2505. Epub 2022 Feb 22.
Hess EM, Kassel SN, Simandl G, Raddatz N, Maunze B, Hurley MM, Grzybowski M, Klotz J, Geurts A, Liu QS, Choi S, Twining RC, Baker DA., Genetic Disruption of System xc-Mediated Glutamate Release from Astrocytes Increases Negative-Outcome Behaviors While Preserving Basic Brain Function in Rat., J Neurosci. 2023 Mar 29;43(13):2349-2361. doi: 10.1523/JNEUROSCI.1525-22.2023. Epub 2023 Feb 14.
Yang J, Betterton RD, Williams EI, Stanton JA, Reddell ES, Ogbonnaya CE, Dorn E, Davis TP, Lochhead JJ, Ronaldson PT., High-Dose Acetaminophen Alters the Integrity of the Blood-Brain Barrier and Leads to Increased CNS Uptake of Codeine in Rats, Pharmaceutics. 2022 Apr 27;14(5):949. doi: 10.3390/pharmaceutics14050949.
Lehtonen SM, Waselius T, Penttonen M, Nokia MS., Hippocampal responses to electrical stimulation of the major input pathways are modulated by dentate spikes, Hippocampus. 2022 Nov;32(11-12):808-817. doi: 10.1002/hipo.23470. Epub 2022 Sep 16.
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Neuroscience

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Oncology

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Ibrahim R, Brix A, Malarkey DE, Nyska A, Asif M, Ramot Y., Chemical-Induced Oral Squamous Cell Neoplasms in Rodents: An Overview of NTP 2-Year Cancer Studies, Toxicol Pathol. 2021 Jul;49(5):1062-1076. doi: 10.1177/0192623321989956. Epub 2021 Feb 12.
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De La Chapa JJ, Singha PK, Self KK, Sallaway ML, McHardy SF, Hart MJ, McGuff HS, Valdez MC, Ruiz F 2nd, Polusani SR, Gonzales CB, The novel capsazepine analog, CIDD-99, significantly inhibits oral squamous cell carcinoma in vivo through a TRPV1-independent induction of ER stress, mitochondrial dysfunction, and apoptosis., J Oral Pathol Med. 2019 May;48(5):389-399.
Forsgård, Richard A; Marrachelli, Vannina G; Lindén, Jere; Frias, Rafael; Collado, Maria Carmen; Korpela, Riitta; Monleon, Daniel; Spillmann, Thomas; Österlund, Pia, Two-Week Aflibercept or Erlotinib Administration Does Not Induce Changes in Intestinal Morphology in Male Sprague-Dawley Rats But Aflibercept Affects Serum and Urine Metabolic Profiles., Translational oncology Vol.12, 2019
Sharp AM, Lertphinyowong S, Yee SS, Paredes D, Gelfond J, Johnson-Pais TL, Leach RJ, Liss M, Risinger AL, Sullivan AC, Thompson IM, Morilak DA., Vortioxetine reverses medial prefrontal cortex-mediated cognitive deficits in male rats induced by castration as a model of androgen deprivation therapy for prostate cancer, Psychopharmacology (Berl). 2019 Nov;236(11):3183-3195. doi: 10.1007/s00213-019-05274-4. Epub 2019 May 28.

Preclinical (PK/PD)

Katyayan KK, Hui YH., An evaluation of metabolite profiling of six drugs using dried blood spot, Xenobiotica. 2019 Dec;49(12):1458-1469. doi: 10.1080/00498254.2019.1572938. Epub 2019 Feb 18.
Sharma PK, Kushwaha A, Repka MA, Murthy SN, Formulation development and pharmacokinetic investigation of self-assembled hybrid niosomes for oral delivery of 17-Hydroxyprogesterone caproate, Journal of Drug Delivery Science and Technology Volume 61, February 2021, 102215
Rioux N, Smith S, Korpal M, O'Shea M, Prajapati S, Zheng GZ, Warmuth M, Smith PG., Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERÎą covalent antagonist (SERCA), Cancer Chemother Pharmacol. 2019 Jan;83(1):151-160. doi: 10.1007/s00280-018-3716-3. Epub 2018 Nov 1.
Grecco GG, Kisor DF, Sprague JE., Pharmacokinetic data of synthetic cathinones in female Sprague-Dawley rats, Data Brief. 2018 Oct 25;21:1045-1050. doi: 10.1016/j.dib.2018.10.073. eCollection 2018 Dec.
Berthold EC, Kamble SH, Raju KS, King TI, Popa R, Sharma A, León F, Avery BA, McMahon LR, McCurdy CR., Preclinical pharmacokinetic study of speciociliatine, a kratom alkaloid, in rats using an UPLC-MS/MS method., J Pharm Biomed Anal. 2021 Feb 5;194:113778. doi: 10.1016/j.jpba.2020.113778. Epub 2020 Nov 21.
Sarkar M, Grossman RG, Toups EG, Chow DS., Rational design and development of a stable liquid formulation of riluzole and its pharmacokinetic evaluation after oral and IV administrations in rats, Eur J Pharm Sci. 2018 Dec 1;125:1-10. doi: 10.1016/j.ejps.2018.09.004. Epub 2018 Sep 8.
Ahmed F, Rahman Md, Thompson R, Bereiter DA., Role of Connexin 43 in an Inflammatory Model for TMJ Hyperalgesia, Front. Pain Res., 03 August 2021.
Crowley ML, Restrepo LF, Gamez-Jimenez LR, Patel A, Braun T, Pallares VLC, Ho NP, Reeves ME, McCurdy CR, McMahon LR, Hiranita T., The use of hypercapnic conditions to assess opioid-induced respiratory depression in rats., J Pharmacol Toxicol Methods. 2021 Sep-Oct;111:107101. doi: 10.1016/j.vascn.2021.107101. Epub 2021 Jul 7.

Reproductive

Lovelock DF, Deak T., Acute stress imposed during adolescence has minimal effects on hypothalamic-pituitary-adrenal (HPA) axis sensitivity in adulthood in female Sprague Dawley rats, Physiol Behav. 2020 Jan 1;213:112707. doi: 10.1016/j.physbeh.2019.112707. Epub 2019 Oct 18.
Dungar BM, Schupbach CD, Jacobson JR, Kopf PG., Adrenal Corticosteroid Perturbation by the Endocrine Disruptor BDE-47 in a Human Adrenocortical Cell Line and Male Rats, Endocrinology. 2021 Nov 1;162(11):bqab160. doi: 10.1210/endocr/bqab160.
Deepika Kubsad, Eric E Nilsson, Stephanie E King, Ingrid Sadler-Riggleman, Daniel Beck, Michael K Skinner, Assessment of Glyphosate Induced Epigenetic Transgenerational Inheritance of Pathologies and Sperm Epimutations: Generational Toxicology, Sci Rep. 2019 Apr 23;9(1):6372. doi: 10.1038/s41598-019-42860-0.
Deer E, Reeve KE, Amaral L, Vaka VR, Franks M, Campbell N, Fitzgerald S, Herrock O, Ibrahim T, Cornelius D, LaMarca B., CD4+ T cells cause renal and placental mitochondrial oxidative stress as mechanisms of hypertension in response to placental ischemia, Am J Physiol Renal Physiol. 2021 Jan 1;320(1):F47-F54. doi: 10.1152/ajprenal.00398.2020. Epub 2020 Nov 16.
Palei, A. C., Spradley, F. T., & Granger, J. P. (2015)., Chronic hyperleptinemia results in the development of hypertension in pregnant rats. American, American Journal of Physiology.Regulatory, Integrative and Comparative Physiology, 308(10), R855-61. doi:10.1152/ajpregu.00286.2014 [doi]
Corbett CM, Miller END, Wannen EE, Rood BD, Chandler DJ, Loweth JA., Cocaine Exposure Increases Excitatory Synaptic Transmission and Intrinsic Excitability in the Basolateral Amygdala in Male and Female Rats and across the Estrous Cycle., Neuroendocrinology. 2023;113(11):1127-1139. doi: 10.1159/000531351. Epub 2023 Jun 2.
Nakamura N, Sloper DT., Comparison of germ cell differentiation of rat testis fragments cultured in knockout serum replacement versus Albumax™ I, Birth Defects Res. 2021 Mar;113(4):359-370. doi: 10.1002/bdr2.1859. Epub 2020 Dec 21.
Diaz JC, Dunaway K, Zuniga C, Sheil E, Sadeghian K, Auger AP, Baldo BA., Delayed estrogen actions diminish food consumption without changing food approach, motor activity, or hypothalamic activation elicited by corticostriatal µ-opioid signaling., Neuropsychopharmacology. 2023 Dec;48(13):1952-1962. doi: 10.1038/s41386-023-01711-3. Epub 2023 Aug 28.
Ding, Lina; Shunkwiler, Lauren B; Harper, Nicholas W; Zhao, Yang; Hinohara, Kunihiko; Huh, Sung Jin; Ekram, Muhammad B; Guz, Jan; Kern, Michael J; Awgulewitsch, Alexander; Shull, James D; Smits, Bart M G; Polyak, Kornelia, Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment, PLoS genetics Vol.15, 2019
Ben Maamar, Millissia; Nilsson, Eric; Sadler-Riggleman, Ingrid; Beck, Daniel; McCarrey, John R; Skinner, Michael K;, Developmental origins of transgenerational sperm DNA methylation epimutations following ancestral DDT exposure., Developmental biology Vol.445, 2019
Zakerkish F, Soriano MJ, Novella-Mestre E, Brännström M, Díaz-García C., Differential effects of the immunosuppressive calcineurin inhibitors cyclosporine-A and tacrolimus on ovulation in a murine model, Hum Reprod Open. 2021 May 11;2021(2):hoab012. doi: 10.1093/hropen/hoab012. eCollection 2021.
Walker, D. M., Kermath, B. A., Woller, M. J., & Gore, A. C. (2013)., Disruption of reproductive aging in female and male rats by gestational exposure to estrogenic endocrine disruptors., Endocrinology, 154(6), 2129-2143. doi:10.1210/en.2012-2123 [doi]
Nakamura N, Pence LM, Cao Z, Beger RD., Distinct lipid signatures are identified in the plasma of rats with chronic inflammation induced by estradiol benzoate and sex hormones, Metabolomics. 2020 Sep 7;16(9):95. doi: 10.1007/s11306-020-01715-w.
Kulkarni, K. H., Yang, Z., Niu, T., & Hu, M. (2012), Effects of estrogen and estrus cycle on pharmacokinetics, absorption, and disposition of genistein in female sprague-dawley rats., Journal of Agricultural and Food Chemistry, 60(32), 7949-7956. doi:10.1021/jf204755g [doi]
Klukovich, Rachel; Nilsson, Eric; Sadler-Riggleman, Ingrid; Beck, Daniel; Xie, Yeming; Yan, Wei; Skinner, Michael K;, Environmental Toxicant Induced Epigenetic Transgenerational Inheritance of Prostate Pathology and Stromal-Epithelial Cell Epigenome and Transcriptome Alterations: Ancestral Origins of Prostate Disease., Scientific reports Vol.9, 2019
Ben Maamar, Millissia; King, Stephanie E; Nilsson, Eric; Beck, Daniel; Skinner, Michael K;, Epigenetic transgenerational inheritance of parent-of-origin allelic transmission of outcross pathology and sperm epimutations., Developmental biology Vol.108, 2019
Sadler-Riggleman, Ingrid; Klukovich, Rachel; Nilsson, Eric; Beck, Daniel; Xie, Yeming; Yan, Wei; Skinner, Michael K, Epigenetic transgenerational inheritance of testis pathology and Sertoli cell epimutations: generational origins of male infertility., Environmental epigenetics Vol.5, 2019
Hilz EN, Agee LA, Jun D, Monfils MH, Lee HJ., Estrous cycle state-dependent renewal of appetitive behavior recruits unique patterns of Arc mRNA in female rats., Front Behav Neurosci. 2023 Jul 13;17:1210631. doi: 10.3389/fnbeh.2023.1210631. eCollection 2023.
Frawley RP, Witt KL, Cunny H, Germolec DR, Jackson-Humbles D, Malarkey D, Shockley KR, Stout M, Travlos G, Buccellato M, Fallacara D, Harris S, Kissling GE, Manheng W, Surh II, White K Jr, Auerbach SS., Evaluation of 2-methoxy-4-nitroaniline (MNA) in hypersensitivity, 14-day subacute, reproductive, and genotoxicity studies, Toxicology. 2020 Aug;441:152474. doi: 10.1016/j.tox.2020.152474. Epub 2020 May 5.
Iqbal, K., Pierce, S., Kozai, K. et al., Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway in a Rat Model of Dioxin Exposure, Environmental Health Perspectives 129:11 CID: 117001
Gohar EY, Daugherty EM, Aceves JO, Sedaka R, Obi IE, Allan JM, Soliman RH, Jin C, De Miguel C, Lindsey SH, Pollock JS, Pollock DM., Evidence for G-Protein-Coupled Estrogen Receptor as a Pronatriuretic Factor, J Am Heart Assoc. 2020 May 18;9(10):e015110. doi: 10.1161/JAHA.119.015110. Epub 2020 May 10.
Foster ML, Mahapatra D, Maronpot RR, Nishino M, Chiba S, Koyanagi M, Burleson F, Hayashi SM., Extended one-generation reproductive toxicity study evaluating gardenia blue in Sprague Dawley rats., Regul Toxicol Pharmacol. 2023 Oct;144:105472. doi: 10.1016/j.yrtph.2023.105472. Epub 2023 Aug 21.
Tanner MK, Hohorst AA, Mellert SM, Loetz EC, Baratta MV, Greenwood BN., Female rats are more responsive than are males to the protective effects of voluntary physical activity against the behavioral consequences of inescapable stress., Stress. 2023 Nov;26(1):2245492. doi: 10.1080/10253890.2023.2245492.
Gohar EY, Pollock DM., Functional Interaction of Endothelin Receptors in Mediating Natriuresis Evoked by G Protein-Coupled Estrogen Receptor 1, J Pharmacol Exp Ther. 2021 Jan;376(1):98-105. doi: 10.1124/jpet.120.000322. Epub 2020 Oct 30.
Gohar EY, Pollock DM., Functional Interaction of Endothelin Receptors in Mediating Natriuresis Evoked by G Protein-Coupled Estrogen Receptor 1, J Pharmacol Exp Ther. 2021 Jan;376(1):98-105. doi: 10.1124/jpet.120.000322. Epub 2020 Oct 30.
Gray LE, Lambright CS, Conley JM, Evans N, Furr JR, Hannas BR, Wilson VS, Sampson H, Foster PMD., Genomic and Hormonal Biomarkers of Phthalate-Induced Male Rat Reproductive Developmental Toxicity Part II: A Targeted RT-qPCR Array Approach That Defines a Unique Adverse Outcome Pathway, Toxicol Sci. 2021 Aug 3;182(2):195-214. doi: 10.1093/toxsci/kfab053.
Gao, H., Yallampalli, U., & Yallampalli, C. (2012)., Gestational protein restriction reduces expression of Hsd17b2 in rat placental labyrinth., Biology of Reproduction, 87(3), 68. doi:biolreprod.112.100479 [pii]
Hanson AE, Perusquia M, Stallone JN., Hypogonadal hypertension in male Sprague-Dawley rats is renin-angiotensin system-dependent: role of endogenous androgens, Biol Sex Differ. 2020 Aug 26;11(1):48. doi: 10.1186/s13293-020-00324-5.
Pruett JE, Torres Fernandez ED, Everman SJ, Vinson RM, Davenport K, Logan MK, Ye SA, Romero DG, Yanes Cardozo LL., Impact of SGLT-2 Inhibition on Cardiometabolic Abnormalities in a Rat Model of Polycystic Ovary Syndrome, Int J Mol Sci. 2021 Mar 4;22(5):2576. doi: 10.3390/ijms22052576.
Beverly, Brandiese E J; Furr, Johnathan R; Lambright, Christy S; Wilson, Vickie S; McIntyre, Barry S; Foster, Paul M D; Travlos, Greg; Earl Gray, L;, In utero exposure to simvastatin reduces postnatal survival and permanently alters reproductive tract development in the Crl:CD(SD) male rat., Toxicology and applied pharmacology Vol.365, 2019
Gordon, E. E., Reinking, B. E., Hu, S., Yao, J., Kua, K. L., Younes, A. K., . . . Norris, A. W. (2015), Maternal hyperglycemia directly and rapidly induces cardiac septal overgrowth in fetal rats., Journal of Diabetes Research, 2015, 479565. doi:10.1155/2015/479565 [doi]
Gao, H., Yallampalli, U., & Yallampalli, C. (2012), Maternal protein restriction reduces expression of angiotensin I-converting enzyme 2 in rat placental labyrinth zone in late pregnancy., Biology of Reproduction, 86(2), 31. doi:10.1095/biolreprod.111.094607 [doi]
Jain A, Woolley CS., Mechanisms That Underlie Expression of Estradiol-Induced Excitatory Synaptic Potentiation in the Hippocampus Differ between Males and Females., J Neurosci. 2023 Feb 22;43(8):1298-1309. doi: 10.1523/JNEUROSCI.2080-19.2023. Epub 2023 Jan 17.
Behl M, Willson CJ, Cunny H, Foster PMD, McIntyre B, Shackelford C, Shockley KR, McBride S, Turner K, Waidyanatha S, Blystone CR., Multigenerational reproductive assessment of 4-methylimidazole administered in the diet to Hsd:Sprague Dawley SD rats, Reprod Toxicol. 2020 Dec;98:13-28. doi: 10.1016/j.reprotox.2020.03.005. Epub 2020 Mar 27.
Mohr, M. A., Garcia, F. L., DonCarlos, L. L., & Sisk, C. L. (2016)., Neurons and glial cells are added to the female rat anteroventral periventricular nucleus during puberty, Endocrinology, 157(6), 2393-2402. doi:10.1210/en.2015-2012 [doi]
Tassinari, R., Cubadda, F., Moracci, G., Aureli, F., D'Amato, M., Valeri, M., . . . Maranghi, F. (2014)., Oral, short-term exposure to titanium dioxide nanoparticles in sprague-dawley rat: Focus on reproductive and endocrine systems and spleen, Nanotoxicology, 8(6), 654-662. doi:10.3109/17435390.2013.822114 [doi]
Occhiuto C, Santoro G, Tranchida PQ, Bono G, Occhiuto F., Pharmacological Effects of the Lipidosterolic Extract from Kigelia africana Fruits in Experimental Benign Prostatic Hyperplasia Induced by Testosterone in Sprague Dawley Rats., J Exp Pharmacol. 2023 Feb 5;15:41-50. doi: 10.2147/JEP.S383699. eCollection 2023.
Mishra JS, Kumar S., Placental Fatty Acid Metabolism and Transport in a Rat Model of Gestational Diabetes Mellitus., J Womens Health Dev. 2023;6(2):56-67. doi: 10.26502/fjwhd.2644-288400108. Epub 2023 May 4.
Watson ATD, Sutherland VL, Cunny H, Miller-Pinsler L, Furr J, Hebert C, Collins B, Waidyanatha S, Smith L, Vinke T, Aillon K, Xie G, Shockley KR, McIntyre BS., Postnatal Effects of Gestational and Lactational Gavage Exposure to Boric Acid in the Developing Sprague Dawley Rat, Toxicol Sci. 2020 Jul 1;176(1):65-73. doi: 10.1093/toxsci/kfaa061.
Shawky NM, Patil CN, Dalmasso C, Maranon RO, Romero DG, Drummond H, Reckelhoff JF., Pregnancy Protects Hyperandrogenemic Female Rats From Postmenopausal Hypertension, Hypertension. 2020 Sep;76(3):943-952. doi: 10.1161/HYPERTENSIONAHA.120.15504. Epub 2020 Aug 3.
Sathishkumar, K., Elkins, R., Yallampalli, U., & Yallampalli, C. (2012), Protein restriction during pregnancy induces hypertension in adult female rat offspring--influence of oestradiol, The British Journal of Nutrition, 107(5), 665-673. doi:10.1017/S0007114511003448 [doi]
Gohar EY, Kasztan M, Zhang S, Inscho EW, Pollock DM., Role for ovarian hormones in purinoceptor-dependent natriuresis, Biol Sex Differ. 2020 Sep 14;11(1):52. doi: 10.1186/s13293-020-00329-0.
Liu CM, Davis EA, Suarez AN, Wood RI, Noble EE, Kanoski SE., Sex Differences and Estrous Influences on Oxytocin Control of Food Intake, Neuroscience. 2020 Nov 1;447:63-73. doi: 10.1016/j.neuroscience.2019.10.020. Epub 2019 Nov 15.
Ben Musa R, Cornelius-Green J, Hasser EM, Cummings KJ., The effect of orexin on the hypoxic ventilatory response of female rats is greatest in the active phase during diestrus., J Appl Physiol (1985). 2023 Mar 1;134(3):638-648. doi: 10.1152/japplphysiol.00661.2022. Epub 2023 Jan 19.
Heath, J. C., Abdelmageed, Y., Braden, T. D., & Goyal, H. O. (2012)., The effects of chronic ingestion of mercuric chloride on fertility and testosterone levels in male sprague dawley rats., Journal of Biomedicine & Biotechnology, 2012, 815186. doi:10.1155/2012/815186 [doi]
Heath, J. C., Abdelmageed, Y., Braden, T. D., Nichols, A. C., & Steffy, D. A. (2009)., The effects of chronic mercuric chloride ingestion in female sprague-dawley rats on fertility and reproduction., Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association, 47(7), 1600-1605. doi:10.1016/j.fct.2009.04.007 [doi]
Katri A, Reker D, Karsdal MA, Bay-Jensen AC, Henriksen K., Treatment with a dual amylin and calcitonin receptor agonist improves metabolic health in an old, obese, and ovariectomized rat model, Menopause. 2021 Jan 4;28(4):423-430. doi: 10.1097/GME.0000000000001722.
Spradley FT, Ge Y, Granger JP, Chade AR., Utero-placental vascular remodeling during late gestation in Sprague-Dawley rats, Pregnancy Hypertens. 2020 Apr;20:36-43. doi: 10.1016/j.preghy.2020.02.007. Epub 2020 Mar 3.

Surgical

Hay M, Polt R, Heien ML, Vanderah TW, Largent-Milnes TM, Rodgers K, Falk T, Bartlett MJ, Doyle KP, Konhilas JP., A Novel Angiotensin-(1-7) Glycosylated Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Inflammation-Related Memory Dysfunction, J Pharmacol Exp Ther. 2019 Apr;369(1):9-25. doi: 10.1124/jpet.118.254854. Epub 2019 Feb 1.
Sharma PK, Avula B, Panda A, Wang YH, Khan IA, Murthy SN., A sensitive bioanalytical method for quantitative determination of resiniferatoxin in rat plasma using ultra-high performance liquid chromatography coupled to tandem mass spectrometry and its application in pharmacokinetic study, J Pharm Biomed Anal. 2019 Feb 20;165:284-291. doi: 10.1016/j.jpba.2018.12.024. Epub 2018 Dec 14.
Wright DM, Small KM, Nag S, Mokha SS., Activation of Membrane Estrogen Receptors Attenuates NOP-Mediated Tactile Antihypersensitivity in a Rodent Model of Neuropathic Pain, Brain Sci. 2019 Jun 21;9(6):147. doi: 10.3390/brainsci9060147.
Katyayan KK, Hui YH., An evaluation of metabolite profiling of six drugs using dried blood spot, Xenobiotica. 2019 Dec;49(12):1458-1469. doi: 10.1080/00498254.2019.1572938. Epub 2019 Feb 18.
Liu C, Cui Z, Yan Y, Wu NL, Li L, Ying Q, Peng L., An optimized proliferation system of embryonic stem cells for generating the rat model with large fragment modification., Biochem Biophys Res Commun. 2021 Sep 24;571:8-13. doi: 10.1016/j.bbrc.2021.07.053. Epub 2021 Jul 20.
Cladis DP, Simpson AMR, Cooper KJ, Nakatsu CH, Ferruzzi MG, Weaver CM., Blueberry polyphenols alter gut microbiota & phenolic metabolism in rats., Food Funct. 2021 Mar 21;12(6):2442-2456. doi: 10.1039/d0fo03457f. Epub 2021 Feb 25.
Shao XM, Liu S, Lee ES, Fung D, Pei H, Liang J, Mudgway R, Zhang J, Feldman JL, Zhu Y, Louie S, Xie XS., Chronic intermittent nicotine delivery via lung alveolar region-targeted aerosol technology produces circadian pharmacokinetics in rats resembling human smokers, J Appl Physiol (1985). 2018 Nov 1;125(5):1555-1562. doi: 10.1152/japplphysiol.00357.2018. Epub 2018 Sep 20.
Benmansour, S., Arroyo, L. D., & Frazer, A. (2016)., Comparison of the antidepressant-like effects of estradiol and that of selective serotonin reuptake inhibitors in middle-aged ovariectomized rats., Frontiers in Aging Neuroscience, 8, 311. doi:10.3389/fnagi.2016.00311 [doi]
Sanna F, Bratzu J, Piludu MA, Corda MG, Melis MR, Giorgi O, Argiolas A., Dopamine, Noradrenaline and Differences in Sexual Behavior between Roman High and Low Avoidance Male Rats: A Microdialysis Study in the Medial Prefrontal Cortex, Front Behav Neurosci. 2017 Jun 7;11:108. doi: 10.3389/fnbeh.2017.00108. eCollection 2017.
Ikeda K, Osuru HP, Thiele RH, Dual One-Way Study of Sepsis Survivability Study in Rats Exposed to Cecal Ligation and Puncture with Propofol or Isoflurane, Preprint from Research Square, 18 Nov 2021 DOI: 10.21203/rs.3.rs-1072022/v1 PPR: PPR421944 
Huijgens PT, Snoeren EMS, Meisel RL, Mermelstein PG., Effects of gonadectomy and dihydrotestosterone on neuronal plasticity in motivation and reward related brain regions in the male rat, J Neuroendocrinol. 2021 Jan;33(1):e12918. doi: 10.1111/jne.12918. Epub 2020 Dec 19.
Radford KD, Park TY, Jaiswal S, Pan H, Knutsen A, Zhang M, Driscoll M, Osborne-Smith LA, Dardzinski BJ, Choi KH., Enhanced fear memories and brain glucose metabolism (18F-FDG-PET) following sub-anesthetic intravenous ketamine infusion in Sprague-Dawley rats, Transl Psychiatry. 2018 Nov 30;8(1):263. doi: 10.1038/s41398-018-0310-8.
Martinez LA, Gross KS, Himmler BT, Emmitt NL, Peterson BM, Zlebnik NE, Foster Olive M, Carroll ME, Meisel RL, Mermelstein PG., Estradiol Facilitation of Cocaine Self-Administration in Female Rats Requires Activation of mGluR5, eNeuro. 2016 Oct 25;3(5):ENEURO.0140-16.2016. doi: 10.1523/ENEURO.0140-16.2016. eCollection 2016 Sep-Oct.
Robinson DL Jr, Nag S, Mokha SS., Estrogen facilitates and the kappa and mu opioid receptors mediate antinociception produced by intrathecal (-)-pentazocine in female rats, Behav Brain Res. 2016 Oct 1;312:163-8. doi: 10.1016/j.bbr.2016.06.019. Epub 2016 Jun 14.
Garcia J, Mankin P, Gnanamony M, de Alarcon PA., Evaluation of angiogenic signaling molecules associated with reactive thrombocytosis in an iron-deficient rat model, Pediatr Res. 2021 Aug;90(2):341-346. doi: 10.1038/s41390-020-01318-0. Epub 2021 Jan 19.
Dantzler HA, Kline DD., Exaggerated potassium current reduction by oxytocin in visceral sensory neurons following chronic intermittent hypoxia, Auton Neurosci. 2020 Dec;229:102735. doi: 10.1016/j.autneu.2020.102735. Epub 2020 Sep 28.
Leber A, Hontecillas R, Zoccoli-Rodriguez V, Ehrich M, Chauhan J, Bassaganya-Riera J., Exploratory studies with NX-13: oral toxicity and pharmacokinetics in rodents of an orally active, gut-restricted first-in-class therapeutic for IBD that targets NLRX1, Drug Chem Toxicol. 2019 Oct 25:1-6. doi: 10.1080/01480545.2019.1679828. Online ahead of print.
Kao HW, Lin YY, Gwathney WJ, Hong K., Formulation and evaluation of multilamellar vesicles ropivacaine in pain management, Int J Nanomedicine. 2019 Sep 27;14:7891-7901. doi: 10.2147/IJN.S215952. eCollection 2019.
Sharma PK, Kushwaha A, Repka MA, Murthy SN, Formulation development and pharmacokinetic investigation of self-assembled hybrid niosomes for oral delivery of 17-Hydroxyprogesterone caproate, Journal of Drug Delivery Science and Technology Volume 61, February 2021, 102215
Bakewell SJ, Carie A, Costich TL, Sethuraman J, Semple JE, Sullivan B, Martinez GV, Dominguez-Viqueira W, Sill KN., Imaging the delivery of drug-loaded, iron-stabilized micelles, Nanomedicine. 2017 May;13(4):1353-1362. doi: 10.1016/j.nano.2017.01.009. Epub 2017 Jan 20.
Cladis DP, Debelo H, Lachcik PJ, Ferruzzi MG, Weaver CM., Increasing Doses of Blueberry Polyphenols Alters Colonic Metabolism and Calcium Absorption in Ovariectomized Rats, Mol Nutr Food Res. 2020 Jun;64(12):e2000031. doi: 10.1002/mnfr.202000031. Epub 2020 May 27.
Roberts SM, Rohr AC, Mikheev VB, Munson J, Sabo-Attwood T., Influence of airborne particulates on respiratory tract deposition of inhaled toluene and naphthalene in the rat, Inhal Toxicol. 2018 Jan;30(1):19-28. doi: 10.1080/08958378.2018.1438539. Epub 2018 Feb 21.
Mackert GA, Schulte M, Hirche C, Kotsougiani D, Vogelpohl J, Hoener B, Fiebig T, Kirschner S, Brockmann MA, Lehnhardt M, Kneser U, Harhaus L., Low-energy extracorporeal shockwave therapy (ESWT) improves metaphyseal fracture healing in an osteoporotic rat model, PLoS One. 2017 Dec 12;12(12):e0189356. doi: 10.1371/journal.pone.0189356. eCollection 2017.
Gross KS, Moore KM, Meisel RL, Mermelstein PG., mGluR5 Mediates Dihydrotestosterone-Induced Nucleus Accumbens Structural Plasticity, but Not Conditioned Reward, Front Neurosci. 2018 Nov 20;12:855. doi: 10.3389/fnins.2018.00855. eCollection 2018.
Liu J, Kim EK, Ni A, Kim YR, Zheng F, Lee BS, Kim DG., Multiscale characterization of ovariectomized rat femur, J Biomech. 2021 Jun 9;122:110462. doi: 10.1016/j.jbiomech.2021.110462. Epub 2021 Apr 18.
Rioux N, Smith S, Korpal M, O'Shea M, Prajapati S, Zheng GZ, Warmuth M, Smith PG., Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERÎą covalent antagonist (SERCA), Cancer Chemother Pharmacol. 2019 Jan;83(1):151-160. doi: 10.1007/s00280-018-3716-3. Epub 2018 Nov 1.
Ji Y, Hu B, Klontz C, Li J, Dessem D, Dorsey SG, Traub RJ., Peripheral mechanisms contribute to comorbid visceral hypersensitivity induced by preexisting orofacial pain and stress in female rats, Neurogastroenterol Motil. 2020 Jul;32(7):e13833. doi: 10.1111/nmo.13833. Epub 2020 Mar 10.
Grecco GG, Kisor DF, Sprague JE., Pharmacokinetic data of synthetic cathinones in female Sprague-Dawley rats, Data Brief. 2018 Oct 25;21:1045-1050. doi: 10.1016/j.dib.2018.10.073. eCollection 2018 Dec.
Waidyanatha S, Mutlu E, Gibbs S, Pierfelice J, Smith JP, Burback B, Blystone CT., Phenolic benzotriazoles: a class comparison of toxicokinetics of ultraviolet-light absorbers in male rats., Xenobiotica. 2021 Jul;51(7):831-841. doi: 10.1080/00498254.2021.1927239. Epub 2021 May 24.
Vigiola Cruz M, Carney BC, Luker JN, Monger KW, Vazquez JS, Moffatt LT, Johnson LS, Shupp JW., Plasma Ameliorates Endothelial Dysfunction in Burn Injury, J Surg Res. 2019 Jan;233:459-466. doi: 10.1016/j.jss.2018.08.027. Epub 2018 Sep 22.
Berthold EC, Kamble SH, Raju KS, King TI, Popa R, Sharma A, León F, Avery BA, McMahon LR, McCurdy CR., Preclinical pharmacokinetic study of speciociliatine, a kratom alkaloid, in rats using an UPLC-MS/MS method., J Pharm Biomed Anal. 2021 Feb 5;194:113778. doi: 10.1016/j.jpba.2020.113778. Epub 2020 Nov 21.
Sarkar M, Grossman RG, Toups EG, Chow DS., Rational design and development of a stable liquid formulation of riluzole and its pharmacokinetic evaluation after oral and IV administrations in rats, Eur J Pharm Sci. 2018 Dec 1;125:1-10. doi: 10.1016/j.ejps.2018.09.004. Epub 2018 Sep 8.
Ahmed F, Rahman Md, Thompson R, Bereiter DA., Role of Connexin 43 in an Inflammatory Model for TMJ Hyperalgesia, Front. Pain Res., 03 August 2021.
Hill K, Walker SN, Salminen A, Chung HL, Li X, Ezzat B, Miller JJ, DesOrmeaux JS, Zhang J, Hayden A, Burgin T, Piraino L, May MN, Gaborski TR, Roussie JA, Taylor J, DiVincenti L Jr, Shestopalov AA, McGrath JL, Johnson DG., Second Generation Nanoporous Silicon Nitride Membranes for High Toxin Clearance and Small Format Hemodialysis, Adv Healthc Mater. 2020 Feb;9(4):e1900750. doi: 10.1002/adhm.201900750. Epub 2020 Jan 15.
Cao J, Ng M, Felmlee MA., Sex Hormones Regulate Rat Hepatic Monocarboxylate Transporter Expression and Membrane Trafficking, J Pharm Pharm Sci. 2017;20(1):435-444. doi: 10.18433/J3CH29.
Waldron RT, Chen Y, Pham H, Go A, Su HY, Hu C, Wen L, Husain SZ, Sugar CA, Roos J, Ramos S, Lugea A, Dunn M, Stauderman K, Pandol SJ., The Orai Ca(2+) channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis, J Physiol. 2019 Jun;597(12):3085-3105. doi: 10.1113/JP277856. Epub 2019 May 22.
Crowley ML, Restrepo LF, Gamez-Jimenez LR, Patel A, Braun T, Pallares VLC, Ho NP, Reeves ME, McCurdy CR, McMahon LR, Hiranita T., The use of hypercapnic conditions to assess opioid-induced respiratory depression in rats., J Pharmacol Toxicol Methods. 2021 Sep-Oct;111:107101. doi: 10.1016/j.vascn.2021.107101. Epub 2021 Jul 7.
Zhao M, Zhang F, Zarnowski R, Barns K, Jones R, Fossen J, Sanchez H, Rajski SR, Audhya A, Bugni TS, Andes DR., Turbinmicin inhibits Candida biofilm growth by disrupting fungal vesicle-mediated trafficking, J Clin Invest. 2021 Mar 1;131(5):e145123. doi: 10.1172/JCI145123.
Sharp AM, Lertphinyowong S, Yee SS, Paredes D, Gelfond J, Johnson-Pais TL, Leach RJ, Liss M, Risinger AL, Sullivan AC, Thompson IM, Morilak DA., Vortioxetine reverses medial prefrontal cortex-mediated cognitive deficits in male rats induced by castration as a model of androgen deprivation therapy for prostate cancer, Psychopharmacology (Berl). 2019 Nov;236(11):3183-3195. doi: 10.1007/s00213-019-05274-4. Epub 2019 May 28.

Teratology

Li Y, Wei L, Meinsohn MC, Suliman R, Chauvin M, Berstler J, Hartland K, Jensen MM, Sicher NA, Nagykery N, Donahoe PK, Pepin D., A screen of repurposed drugs identifies AMHR2/MISR2 agonists as potential contraceptives, Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2122512119. doi: 10.1073/pnas.2122512119. Epub 2022 Apr 5.
Itzhak I, Cohen S, Fishman S, Fishman P., A3 adenosine receptor allosteric modulator CF602 reverses erectile dysfunction in a diabetic rat model, Andrologia. 2022 Oct;54(9):e14498. doi: 10.1111/and.14498. Epub 2022 Jun 22.
Turano, A., Lawrence, J. H., & Schwarz, J. M. (2017), Activation of neonatal microglia can be influenced by other neural cells, Neuroscience Letters, 657, 32-37. doi:S0304-3940(17)30624-9 [pii]
Waidyanatha S, Collins BJ, Cunny H, Aillon K, Riordan F, Turner K, McBride S, Betz L, Sutherland V., An investigation of systemic exposure to bisphenol AF during critical periods of development in the rat, Toxicol Appl Pharmacol. 2021 Jan 15;411:115369. doi: 10.1016/j.taap.2020.115369. Epub 2020 Dec 15.
Campbell N, Strong L, Fang X, Border JJ, Herrock O, Turner T, Deer E, Amaral L, Dechend R, Roman RJ, LaMarca B., AT1-AA Infusion during Pregnancy Impairs CBF Autoregulation Postpartum., Int J Cerebrovasc Dis Stroke. 2023;6(1). pii: 154. doi: 10.29011/2688-8734.100154. Epub 2023 Jul 17.
Vaka VR, Cunningham MW, Deer E, Franks M, Ibrahim T, Amaral LM, Usry N, Cornelius DC, Dechend R, Wallukat G, LaMarca BD., Blockade of endogenous angiotensin II type I receptor agonistic autoantibody activity improves mitochondrial reactive oxygen species and hypertension in a rat model of preeclampsia, Am J Physiol Regul Integr Comp Physiol. 2020 Feb 1;318(2):R256-R262. doi: 10.1152/ajpregu.00179.2019. Epub 2019 Nov 13.
Deer E, Reeve KE, Amaral L, Vaka VR, Franks M, Campbell N, Fitzgerald S, Herrock O, Ibrahim T, Cornelius D, LaMarca B., CD4+ T cells cause renal and placental mitochondrial oxidative stress as mechanisms of hypertension in response to placental ischemia, Am J Physiol Renal Physiol. 2021 Jan 1;320(1):F47-F54. doi: 10.1152/ajprenal.00398.2020. Epub 2020 Nov 16.
Kuna M, Dhakal P, Iqbal K, Dominguez EM, Kent LN, Muto M, Moreno-Irusta A, Kozai K, Varberg KM, Okae H, Arima T, Sucov HM, Soares MJ., CITED2 is a conserved regulator of the uterine-placental interface, Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2213622120. doi: 10.1073/pnas.2213622120. Epub 2023 Jan 10.
Kuna M, Dhakal P, Iqbal K, Dominguez EM, Kent LN, Muto M, Moreno-Irusta A, Kozai K, Varberg KM, Okae H, Arima T, Sucov HM, Soares MJ., CITED2 is a conserved regulator of the uterine-placental interface., Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2213622120. doi: 10.1073/pnas.2213622120. Epub 2023 Jan 10.
Oppong-Gyebi A, Metzger D, Vann PH, Yockey RA, Sumien N, Schreihofer DA., Dietary genistein and 17β-estradiol implants differentially influence locomotor and cognitive functions following transient focal ischemia in middle-aged ovariectomized rats at different lengths of estrogen deprivation, Horm Behav. 2022 Aug;144:105201. doi: 10.1016/j.yhbeh.2022.105201. Epub 2022 May 30.
Gosemann, J. H., Friedmacher, F., Fujiwara, N., Alvarez, L. A., Corcionivoschi, N., & Puri, P. (2013)., Disruption of the bone morphogenetic protein receptor 2 pathway in nitrofen-induced congenital diaphragmatic hernia., Birth Defects Research.Part B, Developmental and Reproductive Toxicology, 98(4), 304-309. doi:10.1002/bdrb.21065 [doi]
Sadowski, R. N., Wise, L. M., Park, P. Y., Schantz, S. L., & Juraska, J. M. (2014)., Early exposure to bisphenol A alters neuron and glia number in the rat prefrontal cortex of adult males, but not females., Neuroscience, 279, 122-131. doi:10.1016/j.neuroscience.2014.08.038 [doi]
Nakamura, N., Inselman, A. L., White, G. A., Chang, C. W., Trbojevich, R. A., Sephr, E., . . . Hansen, D. K. (2015)., Effects of maternal and lactational exposure to 2-hydroxy-4-methoxybenzone on development and reproductive organs in male and female rat offspring., Birth Defects Research.Part B, Developmental and Reproductive Toxicology, 104(1), 35-51. doi:10.1002/bdrb.21137 [doi]
Krishnan, K., Mittal, N., Thompson, L. M., Rodriguez-Santiago, M., Duvauchelle, C. L., Crews, D., & Gore, A. C. (2018), Effects of the endocrine-disrupting chemicals, vinclozolin and polychlorinated biphenyls, on physiological and sociosexual phenotypes in F2 generation sprague-dawley rats, Environmental Health Perspectives, 126(9), 97005. doi:10.1289/EHP3550 [doi]
Mowery, T. M., Wilson, S. M., Kostylev, P. V., Dina, B., Buchholz, J. B., Prieto, A. L., & Garraghty, P. E. (2015), Embryological exposure to valproic acid disrupts morphology of the deep cerebellar nuclei in a sexually dimorphic way., International Journal of Developmental Neuroscience : The Official Journal of the International Society for Developmental Neuroscience, 40, 15-23. doi:10.1016/j.ijdevneu.2014.10.003 [doi]
Maeda KJ, McClung DM, Showmaker KC, Warrington JP, Ryan MJ, Garrett MR, Sasser JM., Endothelial cell disruption drives increased blood-brain barrier permeability and cerebral edema in the Dahl SS/jr rat model of superimposed preeclampsia, Am J Physiol Heart Circ Physiol. 2021 Feb 1;320(2):H535-H548. doi: 10.1152/ajpheart.00383.2020. Epub 2020 Dec 4.
Chalil D, Aristizabal-Henao JJ, Chalil A, Stark KD., Evidence of multiple hepatic mechanisms to mobilize docosahexaenoic acid into dam plasma during pregnancy in chow-fed sprague dawley rats, Prostaglandins Leukot Essent Fatty Acids. 2021 Aug;171:102317. doi: 10.1016/j.plefa.2021.102317. Epub 2021 Jun 29.
Bradshaw JL, Cushen SC, Ricci CA, Tucker SM, Gardner JJ, Little JT, Osikoya O, Goulopoulou S., Exposure to unmethylated CpG oligonucleotides disrupts blood pressure circadian rhythms and placental clock gene network in pregnant rats., Am J Physiol Heart Circ Physiol. 2023 Aug 1;325(2):H323-H337. doi: 10.1152/ajpheart.00154.2023. Epub 2023 Jun 23.
Ishimwe JA, Akinleye A, Johnson AC, Garrett MR, Sasser JM., Gestational gut microbial remodeling is impaired in a rat model of preeclampsia superimposed on chronic hypertension, Physiol Genomics. 2021 Mar 1;53(3):125-136. doi: 10.1152/physiolgenomics.00121.2020. Epub 2021 Jan 25.
Gopalakrishnan K, Mishra JS, Ross JR, Abbott DH, Kumar S., Hyperandrogenism diminishes maternal-fetal fatty acid transport by increasing FABP4-mediated placental lipid accumulation†, Biol Reprod. 2022 Aug 9;107(2):514-528. doi: 10.1093/biolre/ioac059.
Baack, M. L., Wang, C., Hu, S., Segar, J. L., & Norris, A. W. (2014), Hyperglycemia induces embryopathy, even in the absence of systemic maternal diabetes: An in vivo test of the fuel mediated teratogenesis hypothesis, Reproductive Toxicology (Elmsford, N.Y.), 46, 129-136. doi:10.1016/j.reprotox.2014.03.013 [doi]
Dagher JB, Hahn-Townsend CK, Kaimal A, Mansi MA, Henriquez JE, Tran DG, Laurent CR, Bacak CJ, Buechter HE, Cambric C, Spivey J, Chuang YJ, Campbell EJ, Mandal A, Mohankumar PS, MohanKumar SMJ., Independent and combined effects of Bisphenol A and Diethylhexyl Phthalate on gestational outcomes and offspring development in Sprague-Dawley rats, Chemosphere. 2021 Jan;263:128307. doi: 10.1016/j.chemosphere.2020.128307. Epub 2020 Sep 14.
Baines KJ, Klausner MS, Patterson VS, Renaud SJ., Interleukin-15 deficient rats have reduced osteopontin at the maternal-fetal interface., Front Cell Dev Biol. 2023 Apr 20;11:1079164. doi: 10.3389/fcell.2023.1079164. eCollection 2023.
Oppong-Gyebi A, Metzger D, Doan T, Han J, Vann PH, Yockey RA, Sumien N, Schreihofer DA., Long-term hypogonadism diminishes the neuroprotective effects of dietary genistein in young adult ovariectomized rats after transient focal ischemia, J Neurosci Res. 2022 Feb;100(2):598-619. doi: 10.1002/jnr.24981. Epub 2021 Oct 28.
Yang W, Li Q, Duncan JW, Bakrania BA, Bradshaw JL, Granger JP, Rana S, Spradley FT., Luteolin-induced vasorelaxation in uterine arteries from normal pregnant rats, Pregnancy Hypertens. 2020 Oct 23;23:11-17. doi: 10.1016/j.preghy.2020.10.008. Online ahead of print.
Yang W, Li Q, Duncan JW, Bakrania BA, Bradshaw JL, Granger JP, Rana S, Spradley FT., Luteolin-induced vasorelaxation in uterine arteries from normal pregnant rats, Pregnancy Hypertens. 2021 Mar;23:11-17. doi: 10.1016/j.preghy.2020.10.008. Epub 2020 Oct 23.
Rieger MM, Wong M, Burnett LA, Sesillo FB, Baynes BB, Alperin M., Mechanisms governing protective pregnancy-induced adaptations of the pelvic floor muscles in the rat preclinical model, Am J Obstet Gynecol. 2022 May;226(5):708.e1-708.e13. doi: 10.1016/j.ajog.2021.11.1353. Epub 2021 Nov 18.
Tavanasefat H, Li F, Koyano K, Gourtani BK, Marty V, Mulpuri Y, Lee SH, Shin KH, Wong DTW, Xiao X, Spigelman I, Kim Y., Molecular consequences of fetal alcohol exposure on amniotic exosomal miRNAs with functional implications for stem cell potency and differentiation, PLoS One. 2020 Nov 16;15(11):e0242276. doi: 10.1371/journal.pone.0242276. eCollection 2020.
Wang X, Travis OK, Shields CA, Tardo GA, Giachelli C, Nutter CW, Glenn HL, Cooper OG, Davis T, Thomas R, Williams JM, Cornelius DC., NLRP3 inhibition improves maternal hypertension, inflammation, and vascular dysfunction in response to placental ischemia., Am J Physiol Regul Integr Comp Physiol. 2023 Apr 1;324(4):R556-R567. doi: 10.1152/ajpregu.00192.2022. Epub 2023 Feb 27.
Mariacarmela G, Milena E, Sveinbjorn G, Daniel H, Maurizio M., Placental protein 13 dilation of pregnant rat uterine vein is endothelium dependent and involves nitric oxide/calcium activated potassium channels signals, Placenta. 2022 Aug;126:233-238. doi: 10.1016/j.placenta.2022.07.001. Epub 2022 Jul 16.
Gokulakrishnan, G., Chang, X., Fleischmann, R., & Fiorotto, M. L. (2017)., Precocious glucocorticoid exposure reduces skeletal muscle satellite cells in the fetal rat., The Journal of Endocrinology, 232(3), 561-572. doi:10.1530/JOE-16-0372 [doi]
Bake S, Hurst DA, Miranda RC, Sohrabji F., Prenatal alcohol exposure exacerbates acute sensorimotor deficits and impedes long-term behavioral recovery from the effects of an adult-onset cerebrovascular ischemic stroke, Alcohol Clin Exp Res. 2022 Dec;46(12):2267-2279. doi: 10.1111/acer.14952. Epub 2022 Nov 24.
De La Torre KM, Lee Y, Safar A, Laws MJ, Meling DD, Thompson LM, Streifer M, Weis KE, Raetzman LT, Gore AC, Flaws JA., Prenatal and postnatal exposure to polychlorinated biphenyls alter follicle numbers, gene expression, and a proliferation marker in the rat ovary., Reprod Toxicol. 2023 Sep;120:108427. doi: 10.1016/j.reprotox.2023.108427. Epub 2023 Jul 1.
Hernandez Scudder ME, Weinberg A, Thompson L, Crews D, Gore AC., Prenatal EDCs Impair Mate and Odor Preference and Activation of the VMN in Male and Female Rats, Endocrinology. 2020 Sep 1;161(9):bqaa124. doi: 10.1210/endocr/bqaa124.
Wang R, Martin CD, Lei AL, Hausknecht KA, Turk M, Micov V, Kwarteng F, Ishiwari K, Oubraim S, Wang AL, Richards JB, Haj-Dahmane S, Shen RY., Prenatal ethanol exposure impairs sensory processing and habituation to visual stimuli, effects normalized by enrichment of postnatal environmental, Alcohol Clin Exp Res. 2022 May;46(5):891-906. doi: 10.1111/acer.14818. Epub 2022 Apr 18.
Gore AC, Moore T, Groom MJ, Thompson LM., Prenatal Exposure to an EDC Mixture, NeuroMix: Effects on Brain, Behavior, and Stress Responsiveness in Rats, Toxics. 2022 Mar 3;10(3):122. doi: 10.3390/toxics10030122.
Vorhees, C. V., Graham, D. L., Braun, A. A., Schaefer, T. L., Skelton, M. R., Richtand, N. M., & Williams, M. T. (2015)., Prenatal immune challenge in rats: Effects of polyinosinic-polycytidylic acid on spatial learning, prepulse inhibition, conditioned fear, and responses to MK-801 and amphetamine., Neurotoxicology and Teratology, 47, 54-65. doi:10.1016/j.ntt.2014.10.007 [doi]
Friedmacher, F., Fujiwara, N., Hofmann, A. D., Takahashi, H., Alvarez, L. A., Gosemann, J. H., & Puri, P. (2014)., Prenatal retinoic acid increases lipofibroblast expression in hypoplastic rat lungs with experimental congenital diaphragmatic hernia., Journal of Pediatric Surgery, 49(6), 876-81; discussion 881. doi:10.1016/j.jpedsurg.2014.01.017 [doi]
Traccis F, Serra V, Sagheddu C, Congiu M, Saba P, Giua G, Devoto P, Frau R, Cheer JF, Melis M., Prenatal THC Does Not Affect Female Mesolimbic Dopaminergic System in Preadolescent Rats, Int J Mol Sci. 2021 Feb 7;22(4):1666. doi: 10.3390/ijms22041666.
Deer E, Jones J, Cornelius DC, Comley K, Herrock O, Campbell N, Fitzgerald S, Ibrahim T, LaMarca B, Amaral LM., Progesterone Induced Blocking Factor Reduces Hypertension and Placental Mitochondrial Dysfunction in Response to sFlt-1 during Pregnancy, Cells. 2021 Oct 20;10(11):2817. doi: 10.3390/cells10112817.
Borracci, P., & Carratu, M. R. (2014)., Rat embryo exposure to all-trans retinoic acid results in long-term cognitive deficits, European Review for Medical and Pharmacological Sciences, 18(1), 28-33. doi:6446 [pii]
Witchey SK, Sutherland V, Collins B, Roberts G, Shockley KR, Vallant M, Krause J, Cunny H, Waidyanatha S, Mylchreest E, Sparrow B, Moyer R, Behl M., Reproductive and developmental toxicity following exposure to organophosphate ester flame retardants and plasticizers, triphenyl phosphate and isopropylated phenyl phosphate, in Sprague Dawley rats, Toxicol Sci. 2022 Dec 23:kfac135. doi: 10.1093/toxsci/kfac135. Online ahead of print.
Witchey SK, Sutherland V, Collins B, Roberts G, Shockley KR, Vallant M, Krause J, Cunny H, Waidyanatha S, Mylchreest E, Sparrow B, Moyer R, Behl M., Reproductive and developmental toxicity following exposure to organophosphate ester flame retardants and plasticizers, triphenyl phosphate and isopropylated phenyl phosphate, in Sprague Dawley rats, Toxicol Sci. 2022 Dec 23:kfac135. doi: 10.1093/toxsci/kfac135. Online ahead of print.
Witchey SK, Sutherland V, Collins B, Roberts G, Shockley KR, Vallant M, Krause J, Cunny H, Waidyanatha S, Mylchreest E, Sparrow B, Moyer R, Behl M., Reproductive and developmental toxicity following exposure to organophosphate ester flame retardants and plasticizers, triphenyl phosphate and isopropylated phenyl phosphate, in Sprague Dawley rats., Toxicol Sci. 2023 Feb 17;191(2):374-386. doi: 10.1093/toxsci/kfac135.
Rickman N, Mayer C, Vatolin S, Tokat C, Janampalli M, Bearer CF, MacFarlane P., Sexual dimorphic vulnerability of respiratory control in a neonatal rodent model of fetal alcohol spectrum disorder., Respir Physiol Neurobiol. 2023 May;311:104040. doi: 10.1016/j.resp.2023.104040. Epub 2023 Feb 24.
Cellai I, Filippi S, Comeglio P, Cipriani S, Maseroli E, Di Stasi V, Todisco T, Marchiani S, Tamburrino L, Villanelli F, Vezzani S, Corno C, Fambrini M, Guarnieri G, Sarchielli E, Morelli A, Rastrelli G, Maggi M, Vignozzi L., Testosterone positively regulates vagina NO-induced relaxation: an experimental study in rats, J Endocrinol Invest. 2022 Jun;45(6):1161-1172. doi: 10.1007/s40618-022-01743-4. Epub 2022 Jan 24.
Manikkam, M., Guerrero-Bosagna, C., Tracey, R., Haque, M. M., & Skinner, M. K. (2012)., Transgenerational actions of environmental compounds on reproductive disease and identification of epigenetic biomarkers of ancestral exposures., PloS One, 7(2), e31901. doi:10.1371/journal.pone.0031901 [doi]
Kermath BA, Thompson LM, Jefferson JR, Ward MHB, Gore AC., Transgenerational Effects of Prenatal Endocrine Disruption on Reproductive and Sociosexual Behaviors in Sprague Dawley Male and Female Rats, Toxics. 2022 Jan 20;10(2):47. doi: 10.3390/toxics10020047.
Spradley FT, Ge Y, Granger JP, Chade AR., Utero-placental vascular remodeling during late gestation in Sprague-Dawley rats, Pregnancy Hypertens. 2020 Apr;20:36-43. doi: 10.1016/j.preghy.2020.02.007. Epub 2020 Mar 3.

Toxicology

Roberts, G. K., Stout, M. D., Sayers, B., Fallacara, D. M., Hejtmancik, M. R., Waidyanatha, S., & Hooth, M. J. (2016)., 14-day toxicity studies of tetravalent and pentavalent vanadium compounds in harlan sprague dawley rats and B6C3F1/N mice via drinking water exposure, Toxicology Reports, 3, 531-538. doi:10.1016/j.toxrep.2016.05.001 [doi]
Knudsen GA, Chapman M, Trexler AW, Juberg CT, Birnbaum LS., 2,4,6-Tribromophenol Disposition and Kinetics in Pregnant and Nursing Sprague Dawley Rats, Toxicol Sci. 2020 Nov 1;178(1):36-43. doi: 10.1093/toxsci/kfaa133.
Trexler, Andrew W; Knudsen, Gabriel A; Nicklisch, Sascha C T; Birnbaum, Linda S; Cannon, Ronald E;, 2,4,6-Tribromophenol Exposure Decreases P-glycoprotein Transport at the Blood-Brain Barrier., Toxicological sciences : an official journal of the Society of Toxicology Vol.306, 2019
Cladis DP, Li S, Reddivari L, Cox A, Ferruzzi MG, Weaver CM., A 90 day oral toxicity study of blueberry polyphenols in ovariectomized sprague-dawley rats, Food Chem Toxicol. 2020 May;139:111254. doi: 10.1016/j.fct.2020.111254. Epub 2020 Mar 9.
Frank, S. J., Johansen, M. J., Martirosyan, K. S., Gagea, M., Van Pelt, C. S., Borne, A., . . . Madden, T. (2013), A biodistribution and toxicity study of cobalt dichloride-N-acetyl cysteine in an implantable MRI marker for prostate cancer treatment., International Journal of Radiation Oncology, Biology, Physics, 85(4), 1024-1030. doi:10.1016/j.ijrobp.2012.09.007 [doi]
Joshi, P S; Sanakkayala, N; Kirkpatrick, L; Terse, P S; Nonclinical safety assessment of PF614:, A novel TAAP prodrug of oxycodone for chronic pain indication., Regulatory toxicology and pharmacology : RTP Vol.108, 2019
Fuller JC Jr, Rathmacher JA., Acute dose toxicity evaluation of the food supplement calcium 3-hydroxy-3-methylbutyrate (HMB) in female Sprague Dawley rats, Regul Toxicol Pharmacol. 2022 Apr;130:105133. doi: 10.1016/j.yrtph.2022.105133. Epub 2022 Feb 2.
Di Cesare Mannelli, L., Tenci, B., Zanardelli, M., Failli, P., & Ghelardini, C. (2015)., alpha7 nicotinic receptor promotes the neuroprotective functions of astrocytes against oxaliplatin neurotoxicity., Neural Plasticity, 2015, 396908. doi:10.1155/2015/396908 [doi]
Maffini MV, Canatsey RD., An expanded toxicological profile of tetramethyl bisphenol F (TMBPF), a precursor for a new food-contact metal packaging coating, Food Chem Toxicol. 2020 Jan;135:110889. doi: 10.1016/j.fct.2019.110889. Epub 2019 Oct 17.
Waidyanatha S, Collins BJ, Cunny H, Aillon K, Riordan F, Turner K, McBride S, Betz L, Sutherland V., An investigation of systemic exposure to bisphenol AF during critical periods of development in the rat, Toxicol Appl Pharmacol. 2021 Jan 15;411:115369. doi: 10.1016/j.taap.2020.115369. Epub 2020 Dec 15.
Patlolla, A. K., Todorov, T. I., Tchounwou, P. B., van der Voet, G., & Centeno, J. A. (2012)., Arsenic-induced biochemical and genotoxic effects and distribution in tissues of sprague-dawley rats, Microchemical Journal, Devoted to the Application of Microtechniques in all Branches of Science, 105, 101-107. doi:10.1016/j.microc.2012.08.013 [doi]
Bastaki, Maria; Mendes, Odete R; Bauter, Mark R; Taylor, Sean V;, Assessment of FD&C Yellow No. 6 (Sunset Yellow FCF) effects on sperm count, motility and viability in the rat in a 28-day toxicity study., Regulatory toxicology and pharmacology : RTP Vol.108, 2019
Patlolla, A. K., Rondalph, J., & Tchounwou, P. B. (2017)., Biochemical and histopathological evaluation of graphene oxide in sprague-dawley rats, Austin Journal of Environmental Toxicology, 3(1) doi:1021 [pii]
Ramot, Yuval; Kronfeld, Noam; Steiner, Michal; Klaiman, Guy; Hadid, Amir; Sudak, Michal;, Biodegradability and Safety Study of LifeMesh™, a Novel Self-adhesive Mesh, in Sprague-Dawley Rats., Toxicologic pathology Vol.47, 2019
Reilly, T. P., Graziano, M. J., Janovitz, E. B., Dorr, T. E., Fairchild, C., Lee, F., . . . Tirmenstein, M. (2014)., Carcinogenicity risk assessment supports the chronic safety of dapagliflozin, an inhibitor of sodium-glucose co-transporter 2, in the treatment of type 2 diabetes mellitus, Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders, 5(1), 73-96. doi:10.1007/s13300-014-0053-3 [doi]
Blair RE, Hawkins E, Pinchbeck LR, DeLorenzo RJ, Deshpande LS., Chronic epilepsy and mossy fiber sprouting following organophosphate-induced status epilepticus in rats., J Pharmacol Exp Ther. 2023 Aug 29. pii: JPET-AR-2023-001739. doi: 10.1124/jpet.123.001739. [Epub ahead of print]
Maronpot R, Ramot Y, Nyska A, Sproul C, Moore R, Koyanagi M, Chiba S, Nishino M, Hayashi SM., Chronic toxicity and carcinogenicity study of dietary gardenia blue in Sprague Dawley rats., Food Chem Toxicol. 2023 Jun;176:113734. doi: 10.1016/j.fct.2023.113734. Epub 2023 Mar 17.
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Tumor biology

Hyppönen V, Stenroos P, Nivajärvi R, Ardenkjaer-Larsen JH, Gröhn O, Paasonen J, Kettunen MI., Metabolism of hyperpolarised [1-(13) C]pyruvate in awake and anaesthetised rat brains, NMR Biomed. 2021 Oct 21:e4635. doi: 10.1002/nbm.4635. Online ahead of print.

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