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Cardiovascular disease is the leading cause of death worldwide

Cardiac dysfunction has a wide range of causes and clinical presentations, typically with a high degree of medical complexity. Inotiv studies cardiovascular disease in an integrative manner by evaluating physiological & biomarker parameters ranging from cardiac & systemic hemodynamics, renal function and ex vivo vascular function. Together, these data provide a detailed view of the clinical potential of test compounds. Inotiv offers an array of cardiovascular disease and injury models, with many models reflecting the complex cardiovascular consequences of cardiac and renal injury.

Myocardial Infarction

ModelSpeciesTop Tier Data
Ischemia ReperfusionRat & Mouse• Infarction Index (Evan’s Blue / TTC Stain)
• Echocardiography
• cTNI
• Serum Electrolytes, Glucose,
• Cardiac Histology
• Cardiac Gene Expression
LAD LigationRat

Hypertension-Based Cardiac Dysfunction, Hypertrophy & Failure

ModelSpeciesTop Tier Data
Transaortic Banding (TAB)Rat• Blood Pressure (Direct & Indirect)
• Echocardiography
• Creatinine Clearance, GFR
• Urinary Protein, KIM1, NGAL, Osteopontin Albumin
• Serum Creatinine, Bun, Electrolytes Triglycerides, Glucose, HbA1C
• Kidney Histology (fibrosis, macrophages)
• Kidney Gene Expression
• Cardiac Histology (Fibrosis, macrophages)
• Cardiac Gene Expression
• cTnI
IsoproterenolRat & Mouse
Phenylephrine
ANGII (±L-NAME)Rat & Mouse
Myocardial Infarction (LAD Ligation))Rat

Radio-Telemetry – Continuous measurement of blood pressure, heart rate, ECG, respiration, activity and temperature in conscious, unrestrained animals for up to 6 months

Tethered Model – Continuous measurement of blood pressure with simultaneous infusion of test compound along with blood, urine and/or fecal collection for up to 10 days

Cardiac Hypertrophy, Cardiac Pressure Overload & Heart Failure

ModelSpeciesTop Tier Data
DOCA + SaltRat• Blood Pressure (Direct & Indirect)
• Echocardiography (Cardiac Hypertrophy, LV dysfunction)
• Creatinine Clearance, GFR
• Urinary Protein, KIM1, NGAL, Osteopontin Albumin
• Serum Creatinine, Bun, Electrolytes Triglycerides, Glucose, HbA1C
• Kidney Histology (fibrosis, macrophage infiltration, α-Smooth Muscle Actin expression)
• Kidney Gene Expression
• Cardiac Histology (Fibrosis, macrophage infiltration)
• Cardiac Gene Expression
Dahl Salt SensitiveRat
ANGII ± L-NAMERat
Spontaneously Hypertensive Rat (SHR)Rat
5/6 NPX + NaCl (pole resection method)Rat & Mouse
5/6 NPX (renal infarction method)Rat

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