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Inotiv’s ability to conduct biomarker analyses is a powerful complement to our in vivo disease modeling. This comprehensive service eliminates third party providers and streamlines the data delivery process. Our In Vitro Biology & Biomarker (IVBM) team members are classically trained biologists with backgrounds spanning the pharmaceutical industry and academia. Value is placed on assay validation, adherence to SOPs & best practices, throughput, multiplexing and flexibility.
Inotiv Core Biomarker & In Vitro Technologies
Immunoassay
- Solid phase capture and competitive ELISAs
- Bead based multiplex immunoassay
Biochemical
- Hydroxyproline analysis for tissue collagen content
- HPLC mouse serum creatinine (in development)
Clinical Chemistry
- Full offering blood based and urinary analytes
- STAT analysis for rapid data turn around
- Analysis of disease progression and compound efficacy
mRNA Analysis
- Luminex™ based multiplex mRNA analysis
Histology
- Tissue collagen / fibrosis quantitation by Picosirius Red and Masson’s Trichome staining
- Immunohistochemistry
Cellular Analysis & Isolation
- Flow Cytometry for leukocyte subset analysis
- PBMC, Total leucocytes, platelet and bronchoalveolar lavage cells isolations
Myograph Tension Recording
- Ex Vivo Aortic, Pulmonary Artery and Middle Cerebral Artery tension recording with pharmacology