C57BL/6 inbred mice

Related publications

Aging

Beccari, S., Valero, J., Maletic-Savatic, M., & Sierra, A. (2017)., A simulation model of neuroprogenitor proliferation dynamics predicts age-related loss of hippocampal neurogenesis but not astrogenesis., Scientific Reports, 7(1), 16528-017-16466-3. doi:10.1038/s41598-017-16466-3 [doi]

Bauernfeind, F., Niepmann, S., Knolle, P. A., & Hornung, V. (2016)., Aging-associated TNF production primes inflammasome activation and NLRP3-related metabolic disturbances., Journal of Immunology (Baltimore, Md.: 1950), 197(7), 2900-2908. doi:10.4049/jimmunol.1501336 [doi]

Panagiotou, M., Vyazovskiy, V. V., Meijer, J. H., & Deboer, T. (2017)., Differences in electroencephalographic non-rapid-eye movement sleep slow-wave characteristics between young and old mice, Scientific Reports, 7, 43656. doi:10.1038/srep43656 [doi]

Wolf, G., Lotan, A., Lifschytz, T., Ben-Ari, H., Kreisel Merzel, T., Tatarskyy, P., . . . Lerer, B. (2017)., Differentially severe cognitive effects of compromised cerebral blood flow in aged mice: Association with myelin degradation and microglia activation., Frontiers in Aging Neuroscience, 9, 191. doi:10.3389/fnagi.2017.00191 [doi]

Panagiotou, M., Papagiannopoulos, K., Rohling, J. H. T., Meijer, J. H., & Deboer, T. (2018)., How old is your brain? slow-wave activity in non-rapid-eye-movement sleep as a marker of brain rejuvenation after long-term exercise in mice., Frontiers in Aging Neuroscience, 10, 233. doi:10.3389/fnagi.2018.00233 [doi]

Nitzan, Keren; Benhamron, Sandrine; Valitsky, Michael; Kesner, Eyal E; Lichtenstein, Michal; Ben-Zvi, Ayal; Ella, Ezra; Segalstein, Yehudit; Saada, Ann; Lorberboum-Galski, Haya; Rosenmann, Hanna;, Mitochondrial Transfer Ameliorates Cognitive Deficits, Neuronal Loss, and Gliosis in Alzheimers Disease Mice, Journal of Alzheimer's disease : JAD Vol.72, 2019

Davis, H. M., Aref, M. W., Aguilar-Perez, A., Pacheco-Costa, R., Allen, K., Valdez, S., . . . Plotkin, L. I. (2018)., x43 overexpression in osteocytes prevents osteocyte apoptosis and preserves cortical bone quality in aging mice., JBMR Plus, 2(4), 206-216. doi:10.1002/jbm4.10035 [doi]

Moro F, Pischiutta F, Portet A, Needham EJ, Norton EJ, Ferdinand JR, Vegliante G, Sammali E, Pascente R, Caruso E, Micotti E, Tolomeo D, di Marco Barros R, Fraunberger E, Wang KKW, Esser MJ, Menon DK, Clatworthy MR, Zanier ER., Ageing is associated with maladaptive immune response and worse outcome after traumatic brain injury, null

Alcoholism

Lopez-Jimenez, A., Walter, N. A., Gine, E., Santos, A., Echeverry-Alzate, V., Buhler, K. M., . . . Lopez-Moreno, J. A. (2013)., A spontaneous deletion of alpha-synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: Effects on alcohol consumption., Synapse (New York, N.Y.), 67(6), 280-289. doi:10.1002/syn.21639 [doi]

Laitakari A, Tapio J, MĂ¤kelĂ¤ KA, Herzig KH, Dengler F, Gylling H, Walkinshaw G, Myllyharju J, Dimova EY, Serpi R, Koivunen P., HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD, J Mol Med (Berl). 2020 May;98(5):719-731. doi: 10.1007/s00109-020-01903-0. Epub 2020 Apr 15.

Boschen KE, Ptacek TS, Berginski ME, Simon JM, Parnell SE., Transcriptomic analyses of gastrulation-stage mouse embryos with differential susceptibility to alcohol, Dis Model Mech. 2021 Jun 1;14(6):dmm049012. doi: 10.1242/dmm.049012. Epub 2021 Jun 17.

Koskela M, Piepponen TP, Andressoo JO, Võikar V, Airavaara M., Female C57BL/6J Mice Show Alcohol-Seeking Behaviour after Withdrawal from Prolonged Alcohol Consumption in the Social Environment., Alcohol Alcohol. 2021 Apr 24. pii: agab032. doi: 10.1093/alcalc/agab032. [Epub ahead of print]

Tice AL, Laudato JA, Fadool DA, Gordon BS, Steiner JL., Acute binge alcohol alters whole body metabolism and the time-dependent expression of skeletal muscle-specific metabolic markers for multiple days in mice, null

Gil de Biedma-Elduayen L, Giménez-Gómez P, Morales-Puerto N, Vidal R, Núñez-de la Calle C, Gutiérrez-López MD, O'Shea E, Colado MI., Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61-8048 after chronic intermittent ethanol in mice, null

Pinson MR, Tseng AM, Adams A, Lehman TE, Chung K, Gutierrez J, Larin KV, Chambers C, Miranda RC; Collaborative Initiative on Fetal Alcohol Spectrum Disorders., Prenatal alcohol exposure contributes to negative pregnancy outcomes by altering fetal vascular dynamics and the placental transcriptome, null

Ghosh A, Muthuraju S, Badal S, Wooden J, Leasure JL, Roman G, Das J., Differential Expression of Presynaptic Munc13-1 and Munc13-2 in Mouse Hippocampus Following Ethanol Drinking, null

Alpha synuclein

Zaltieri, M., Grigoletto, J., Longhena, F., Navarria, L., Favero, G., Castrezzati, S., . . . Bellucci, A. (2015)., Alpha-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons., Journal of Cell Science, 128(13), 2231-2243. doi:10.1242/jcs.157867 [doi]

Liron, T., Raphael, B., Hiram-Bab, S., Bab, I. A., & Gabet, Y. (2018), Bone loss in C57BL/6J-OlaHsd mice, a substrain of C57BL/6J carrying mutated alpha-synuclein and multimerin-1 genes., . Journal of Cellular Physiology, 233(1), 371-377. doi:10.1002/jcp.25895 [doi]

Mahul-Mellier, A. L., Fauvet, B., Gysbers, A., Dikiy, I., Oueslati, A., Georgeon, S., . . . Lashuel, H. A. (2014)., c-abl phosphorylates alpha-synuclein and regulates its degradation: Implication for alpha-synuclein clearance and contribution to the pathogenesis of parkinson's disease., Human Molecular Genetics, 23(11), 2858-2879. doi:10.1093/hmg/ddt674 [doi]

Jonsson, O., Steffen, A. C., Sundquist, V. S., Janson, J., Martinsson, S., Maatta, U., & Emanuelsson, A. B. (2013)., Capillary microsampling and analysis of 4-microl blood, plasma and serum samples to determine human alpha-synuclein elimination rate in mice, Bioanalysis, 5(4), 449-462. doi:10.4155/bio.12.337 [doi]

Weihofen, Andreas; Liu, YuTing; Arndt, Joseph W; Huy, Christian; Quan, Chao; Smith, Benjamin A; Baeriswyl, Jean-Luc; Cavegn, Nicole; Senn, Luzia; Su, Lihe; Marsh, Galina; Auluck, Pavan K; Montrasio, Fabio; Nitsch, Roger M; Hirst, Warren D; Cedarbaum, Jesse M; Pepinsky, R Blake; Grimm, Jan; Weinreb, Paul H, Development of an aggregate-selective, human-derived ?-synuclein-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinsons disease models., Neurobiology of disease Vol.124, 2019

Weihofen, A., Liu, Y., Arndt, J. W., Huy, C., Quan, C., Smith, B. A., . . . Weinreb, P. H. (2018)., Development of an aggregate-selective, human-derived alpha-synuclein antibody BIIB054 that ameliorates disease phenotypes in parkinson's disease models, Neurobiology of Disease, doi:S0969-9961(18)30448-0 [pii]

Pelkonen, A., Kallunki, P., & Yavich, L. (2013), Effects of exogenous alpha-synuclein on stimulated dopamine overflow in dorsal striatum, Neuroscience Letters, 554, 141-145. doi:10.1016/j.neulet.2013.08.072 [doi]

Garcia-Reitboeck, P., Anichtchik, O., Dalley, J. W., Ninkina, N., Tofaris, G. K., Buchman, V. L., & Spillantini, M. G. (2013), Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra., Experimental Neurology, 248, 541-545. doi:10.1016/j.expneurol.2013.07.015 [doi]

Emanuele, M., Esposito, A., Camerini, S., Antonucci, F., Ferrara, S., Seghezza, S., . . . Chieregatti, E. (2016)., Exogenous alpha-synuclein alters pre- and post-synaptic activity by fragmenting lipid rafts., Ebiomedicine, 7, 191-204. doi:10.1016/j.ebiom.2016.03.038 [doi]

Chadchankar, H., Ihalainen, J., Tanila, H., & Yavich, L. (2012)., Methylphenidate modifies overflow and presynaptic compartmentalization of dopamine via an alpha-synuclein-dependent mechanism., The Journal of Pharmacology and Experimental Therapeutics, 341(2), 484-492. doi:10.1124/jpet.111.189225 [doi]

Burtscher J, Copin JC, Sandi C, Lashuel HA., Pronounced ?-Synuclein Pathology in a Seeding-Based Mouse Model Is Not Sufficient to Induce Mitochondrial Respiration Deficits in the Striatum and Amygdala, eNeuro. 2020 Aug 17;7(4):ENEURO.0110-20.2020. doi: 10.1523/ENEURO.0110-20.2020. Print 2020 Jul/Aug.

Bar, R., Boehm-Cagan, A., Luz, I., Kleper-Wall, Y., & Michaelson, D. M. (2017)., The effects of apolipoprotein E genotype, alpha-synuclein deficiency, and sex on brain synaptic and alzheimer's disease-related pathology, Alzheimer's & Dementia (Amsterdam, Netherlands), 10, 1-11. doi:10.1016/j.dadm.2017.08.003 [doi]

Fassler M, Benaim C, George J., A Single Chain Fragment Variant Binding Misfolded Alpha-Synuclein Exhibits Neuroprotective and Antigen-Specific Anti-Inflammatory Properties, null

Eteläinen TS, Kilpeläinen TP, Ignatius A, Auno S, De Lorenzo F, Uhari-Väänänen JK, Julku UH, Myöhänen TT., Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model, null

Background for induced and genetically-modified models

Massi L, Hagihara KM, Courtin J, Hinz J, Müller C, Fustiñana MS, Xu C, Karalis N, Lüthi A., Disynaptic specificity of serial information flow for conditioned fear, Sci Adv. 2023 Jan 18;9(3):eabq1637. doi: 10.1126/sciadv.abq1637. Epub 2023 Jan 18.

Ye H, Chen C, Wu H, Zheng K, Martín-Adrados B, Caparros E, Francés R, Nelson LJ, Gómez Del Moral M, Asensio I, Vaquero J, Bañares R, Ávila MA, Andrade RJ, Isabel Lucena M, Martínez-Chantar ML, Reeves HL, Masson S, Blumberg RS, Gracia-Sancho J, Nevzorova YA, Martínez-Naves E, Cubero FJ., Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy, Cell Death Dis. 2022 Feb 10;13(2):143. doi: 10.1038/s41419-022-04580-8.

Hashimoto M, Brito SI, Venner A, Pasqualini AL, Yang TL, Allen D, Fuller PM, Anthony TE., Lateral septum modulates cortical state to tune responsivity to threat stimuli., Cell Rep. 2022 Oct 25;41(4):111521. doi: 10.1016/j.celrep.2022.111521.

Behavior

Humby, T., Cross, E. S., Messer, L., Guerrero, S., & Davies, W. (2016), A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis., Psychoneuroendocrinology, 74, 363-370. doi:S0306-4530(16)30216-5 [pii]

Janecek, E., Waindok, P., Bankstahl, M., & Strube, C. (2017)., Abnormal neurobehaviour and impaired memory function as a consequence of toxocara canis- as well as toxocara cati-induced neurotoxocarosis., PLoS Neglected Tropical Diseases, 11(5), e0005594. doi:10.1371/journal.pntd.0005594 [doi]

Voikar, V., Krackow, S., Lipp, H. P., Rau, A., Colacicco, G., & Wolfer, D. P. (2018)., Automated dissection of permanent effects of hippocampal or prefrontal lesions on performance at spatial, working memory and circadian timing tasks of C57BL/6 mice in IntelliCage., Behavioural Brain Research, 352, 8-22. doi:S0166-4328(17)30962-2 [pii]

Laricchiuta, D., Musella, A., Rossi, S., & Centonze, D. (2014), Behavioral and electrophysiological effects of endocannabinoid and dopaminergic systems on salient stimuli., Frontiers in Behavioral Neuroscience, 8, 183. doi:10.3389/fnbeh.2014.00183 [doi]

Heinla, I., Ahlgren, J., Vasar, E., & Voikar, V. (2018)., Behavioural characterization of C57BL/6N and BALB/c female mice in social home cage - effect of mixed housing in complex environment., Physiology & Behavior, 188, 32-41. doi:S0031-9384(18)30032-5 [pii]

Laricchiuta, D., Rojo, M. L., Rodriguez-Gaztelumendi, A., Ferlazzo, F., Petrosini, L., & Fowler, C. J. (2012)., CB1 receptor autoradiographic characterization of the individual differences in approach and avoidance motivation, PloS One, 7(7), e42111. doi:10.1371/journal.pone.0042111 [doi]

Noack, J., Murau, R., & Engelmann, M. (2015)., Consequences of temporary inhibition of the medial amygdala on social recognition memory performance in mice, Frontiers in Neuroscience, 9, 152. doi:10.3389/fnins.2015.00152 [doi]

Tam, S. K., Hasan, S., Choi, H. M., Brown, L. A., Jagannath, A., Hughes, S., . . . Peirson, S. N. (2017)., Constant light desynchronizes olfactory versus object and visuospatial recognition memory performance., The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 37(13), 3555-3567. doi:10.1523/JNEUROSCI.3213-16.2017 [doi]

Laricchiuta, D., Rossi, S., Musella, A., De Chiara, V., Cutuli, D., Centonze, D., & Petrosini, L. (2012)., Differences in spontaneously avoiding or approaching mice reflect differences in CB1-mediated signaling of dorsal striatal transmission., PloS One, 7(3), e33260. doi:10.1371/journal.pone.0033260 [doi]

Reichenbach, N., Herrmann, U., Kahne, T., Schicknick, H., Pielot, R., Naumann, M., . . . Tischmeyer, W. (2015)., Differential effects of dopamine signalling on long-term memory formation and consolidation in rodent brain., Proteome Science, 13, 13-015-0069-2. eCollection 2015. doi:10.1186/s12953-015-0069-2 [doi]

Camats-Perna, Judith; Kalaba, Predrag; Ebner, Karl; Sartori, Simone B; Vuyyuru, Harish; Aher, Nilima Y; Draga?evi?, Vladimir; Singewald, Nicolas; Engelmann, Mario; Lubec, Gert;, Differential Effects of Novel Dopamine Reuptake Inhibitors on Interference With Long-Term Social Memory in Mice., Frontiers in behavioral neuroscience Vol.13, 2019

Laricchiuta, D., Centonze, D., & Petrosini, L. (2013)., Effects of endocannabinoid and endovanilloid systems on aversive memory extinction., Behavioural Brain Research, 256, 101-107. doi:10.1016/j.bbr.2013.08.010 [doi]

Labots, M., Zheng, X., Moattari, G., Ohl, F., & van Lith, H. A. (2016)., Effects of light regime and substrain on behavioral profiles of male C57BL/6 mice in three tests of unconditioned anxiety, Journal of Neurogenetics, 30(3-4), 306-315. doi:10.1080/01677063.2016.1249868 [doi]

Ehmer I, Crown L, van Leeuwen W, Feenstra M, Willuhn I, Denys D., Evidence for Distinct Forms of Compulsivity in the SAPAP3 Mutant-Mouse Model for Obsessive-Compulsive Disorder, eNeuro. 2020 Apr 28;7(2):ENEURO.0245-19.2020. doi: 10.1523/ENEURO.0245-19.2020. Print 2020 Mar/Apr.

de Hoz, L., & Nelken, I. (2014)., Frequency tuning in the behaving mouse: Different bandwidths for discrimination and generalization, PloS One, 9(3), e91676. doi:10.1371/journal.pone.0091676 [doi]

Åhlgren, Johanna; Voikar, Vootele;, Housing mice in the individually ventilated or open cages-Does it matter for behavioral phenotype?, Genes, brain, and behavior Vol.18, 2019

Laricchiuta, D., Saba, L., De Bartolo, P., Caioli, S., Zona, C., & Petrosini, L. (2016), Maintenance of aversive memories shown by fear extinction-impaired phenotypes is associated with increased activity in the amygdaloid-prefrontal circuit., Scientific Reports, 6, 21205. doi:10.1038/srep21205 [doi]

Kulesskaya, N., Karpova, N. N., Ma, L., Tian, L., & Voikar, V. (2014)., Mixed housing with DBA/2 mice induces stress in C57BL/6 mice: Implications for interventions based on social enrichment., Frontiers in Behavioral Neuroscience, 8, 257. doi:10.3389/fnbeh.2014.00257 [doi]

Ahmadlou, M., & Heimel, J. A. (2015)., Preference for concentric orientations in the mouse superior colliculus., Nature Communications, 6, 6773. doi:10.1038/ncomms7773 [doi]

Houben, T., Coomans, C. P., & Meijer, J. H. (2014)., Regulation of circadian and acute activity levels by the murine suprachiasmatic nuclei, PloS One, 9(10), e110172. doi:10.1371/journal.pone.0110172 [doi]

van den Berg, W. E., Lamballais, S., & Kushner, S. A. (2015)., Sex-specific mechanism of social hierarchy in mice., Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 40(6), 1364-1372. doi:10.1038/npp.2014.319 [doi]

Gasser BA, Kurz J, Senn W, Escher G, Mohaupt MG., Stress-induced alterations of social behavior are reversible by antagonism of steroid hormones in C57/BL6 mice, Naunyn Schmiedebergs Arch Pharmacol. 2021 Jan;394(1):127-135. doi: 10.1007/s00210-020-01970-7. Epub 2020 Sep 7.

Odland, Anna U; Jessen, Lea; Kristensen, Jesper L; Fitzpatrick, Ciarán M; Andreasen, Jesper T;, The 5-hydroxytryptamine 2A receptor agonists DOI and 25CN-NBOH decrease marble burying and reverse 8-OH-DPAT-induced deficit in spontaneous alternation, Neuropharmacology Vol., 2019

O'Brien, F. E., O'Connor, R. M., Clarke, G., Donovan, M. D., Dinan, T. G., Griffin, B. T., & Cryan, J. F. (2014)., The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram., Behavioural Brain Research, 261, 17-25. doi:10.1016/j.bbr.2013.11.027 [doi]

Perna, J. C., Wotjak, C. T., Stork, O., & Engelmann, M. (2015)., Timing of presentation and nature of stimuli determine retroactive interference with social recognition memory in mice., Physiology & Behavior, 143, 10-14. doi:10.1016/j.physbeh.2015.02.029 [doi]

de la Zerda SH, Netser S, Magalnik H, Briller M, Marzan D, Glatt S, Abergel Y, Wagner S., Social recognition in laboratory mice requires integration of behaviorally-induced somatosensory, auditory and olfactory cues, Psychoneuroendocrinology. 2022 Sep;143:105859. doi: 10.1016/j.psyneuen.2022.105859. Epub 2022 Jul 5.

Davies JR, Purawijaya DA, Bartlett JM, Robinson ESJ., Impact of Refinements to Handling and Restraint Methods in Mice, Animals (Basel). 2022 Aug 24;12(17):2173. doi: 10.3390/ani12172173.

Kopachev N, Netser S, Wagner S., Sex-dependent features of social behavior differ between distinct laboratory mouse strains and their mixed offspring, iScience. 2022 Jan 5;25(2):103735. doi: 10.1016/j.isci.2022.103735. eCollection 2022 Feb 18.

Steel LCE, Tir S, Tam SKE, Bussell JN, Spitschan M, Foster RG, Peirson SN., Effects of Cage Position and Light Transmission on Home Cage Activity and Circadian Entrainment in Mice, Front Neurosci. 2022 Jan 10;15:832535. doi: 10.3389/fnins.2021.832535. eCollection 2021.

Yaeger JDW, Krupp KT, Summers TR, Summers CH., Contextual generalization of social stress learning is modulated by orexin receptors in basolateral amygdala., Neuropharmacology. 2022 Sep 1;215:109168. doi: 10.1016/j.neuropharm.2022.109168. Epub 2022 Jun 17.

Dunlap KR, Laskin GR, Waddell DS, Black AJ, Steiner JL, Vied C, Gordon BS., Aerobic exercise-mediated changes in the expression of glucocorticoid responsive genes in skeletal muscle differ across the day., Mol Cell Endocrinol. 2022 Jun 15;550:111652. doi: 10.1016/j.mce.2022.111652. Epub 2022 Apr 21.

Trott JM, Hoffman AN, Zhuravka I, Fanselow MS., Conditional and unconditional components of aversively motivated freezing, flight and darting in mice, Elife. 2022 May 26;11:e75663. doi: 10.7554/eLife.75663

Behavioral and learning disabilities

Kordás K, Kis-Varga Á, Varga A, Eldering H, Bulthuis R, Lendvai B, Lévay G, Román V., Measuring sociability of mice using a novel three-chamber apparatus and algorithm of the LABORASâ˘ system, J Neurosci Methods. 2020 Sep 1;343:108841. doi: 10.1016/j.jneumeth.2020.108841. Epub 2020 Jul 1.

Ronda OAHO, van de Heijning BJM, de Bruin A, Thomas RE, Martini I, Koehorst M, Gerding A, Koster MH, Bloks VW, Jurdzinski A, Mulder NL, Havinga R, van der Beek EM, Reijngoud DJ, Kuipers F, Verkade HJ., Spontaneous liver disease in wild-type C57BL/6JOlaHsd mice fed semisynthetic diet, PLoS One. 2020 Sep 21;15(9):e0232069. doi: 10.1371/journal.pone.0232069. eCollection 2020.

Ericsson AC, Hart ML, Kwan J, Lanoue L, Bower LR, Araiza R, Kent Lloyd KC, Franklin CL., Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism, Commun Biol. 2021 Jun 10;4(1):716. doi: 10.1038/s42003-021-02249-0.

Mekada K, Yoshiki A., Substrains matter in phenotyping of C57BL/6 mice, Exp Anim. 2021 May 13;70(2):145-160. doi: 10.1538/expanim.20-0158. Epub 2021 Jan 14.

Bove M, Schiavone S, Tucci P, Sikora V, Dimonte S, Colia AL, Morgese MG, Trabace L., Ketamine administration in early postnatal life as a tool for mimicking Autism Spectrum Disorders core symptoms, Prog Neuropsychopharmacol Biol Psychiatry. 2022 Jul 13;117:110560. doi: 10.1016/j.pnpbp.2022.110560. Epub 2022 Apr 20.

Cardiovascular

Gurgen, D., Kusch, A., Klewitz, R., Hoff, U., Catar, R., Hegner, B., . . . Dragun, D. (2013)., Dragun, D. (2013). Sex-specific mTOR signaling determines sexual dimorphism in myocardial adaptation in normotensive DOCA-salt model., Hypertension, 61(3), 730-736. doi:10.1161/HYPERTENSIONAHA.111.00276 [doi]

Case, A. J., Tian, J., & Zimmerman, M. C. (2017)., Increased mitochondrial superoxide in the brain, but not periphery, sensitizes mice to angiotensin II-mediated hypertension., Redox Biology, 11, 82-90. doi:S2213-2317(16)30268-3 [pii]

Tolonen, A. M., Magga, J., Szabo, Z., Viitala, P., Gao, E., Moilanen, A. M., . . . Serpi, R. (2014)., Inhibition of let-7 microRNA attenuates myocardial remodeling and improves cardiac function postinfarction in mice., Pharmacology Research & Perspectives, 2(4), e00056. doi:10.1002/prp2.56 [doi]

Mutikainen, M., Tuomainen, T., Naumenko, N., Huusko, J., Smirin, B., Laidinen, S., . . . Tavi, P. (2016)., Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha1 induces a cardiac excitation-contraction coupling phenotype without metabolic remodelling., The Journal of Physiology, 594(23), 7049-7071. doi:10.1113/JP272847 [doi]

Hoek-van den Hil, E. F., Keijer, J., Bunschoten, A., Vervoort, J. J., Stankova, B., Bekkenkamp, M., . . . van Schothorst, E. M. (2013)., Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice., PloS One, 8(1), e51588. doi:10.1371/journal.pone.0051588 [doi]

Guilbeau-Frugier, C., Cauquil, M., Karsenty, C., Lairez, O., Dambrin, C., Payre, B., . . . Gales, C. (2018)., Structural evidence for a new elaborate 3D-organization of the cardiomyocyte lateral membrane in adult mammalian cardiac tissues. Cardiovascular Research, doi:10.1093/cvr/cvy256 [doi], Cardiovascular Research, doi:10.1093/cvr/cvy256 [doi]

Tijsen, A. J., van der Made, I., van den Hoogenhof, M. M., Wijnen, W. J., van Deel, E. D., de Groot, N. E., . . . Creemers, E. E. (2014)., The microRNA-15 family inhibits the TGFbeta-pathway in the heart., Cardiovascular Research, 104(1), 61-71. doi:10.1093/cvr/cvu184 [doi]

Thielen NT, Kleinsasser AA, Freeling JL., Myocardial contrast echocardiography assessment of mouse myocardial infarction: comparison of kinetic parameters with conventional methods, PeerJ. 2021 Jun 1;9:e11500. doi: 10.7717/peerj.11500. eCollection 2021.

Schwaerzer GK, Casteel DE, Cividini F, Kalyanaraman H, Zhuang S, Gu Y, Dalton ND, Peterson KL, Dillmann WH, Boss GR, Pilz RB., Constitutive protein kinase G activation exacerbates stress-induced cardiomyopathy, Br J Pharmacol. 2021 May 17. doi: 10.1111/bph.15530. Online ahead of print.

Zhou Z, Liu Z, Gao X, Long Q., Mitochondrial respiration in C57BL/6 substrains varies in response to myocardial infarction, J Bioenerg Biomembr. 2021 Apr;53(2):119-127. doi: 10.1007/s10863-021-09884-6. Epub 2021 Feb 25.

COVID-19

Tan T K, Rijal P, Rahikainen R, Keeble A H, Schimanski L, Hussain S, Harvey R, et al., A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses, bioRxiv 2020.08.31.275701; doi: https://doi.org/10.1101/2020.08.31.275701

Ghebremedhin A, Salam AB, Adu-Addai B, Noonan S, Stratton R, Ahmed MSU, Khantwal C, Martin GR, Lin H, Andrews C, Karanam B, Rudloff U, Lopez H, Jaynes J, Yates C., A Novel CD206 Targeting Peptide Inhibits Bleomycin Induced Pulmonary Fibrosis in Mice, bioRxiv. 2020 Jul 29:2020.07.27.218115. doi: 10.1101/2020.07.27.218115. Preprint.

Schumann S, Kaiser A, Nicoletti F, Mangano K, Fagone P, van Wijk E, Yan Y, Schulz P, Ludescher B, Niedermaier M, von Wegerer J, Rauch P, Setz C, Schubert U, Brysch W., Immune-Modulating Drug MP1032 with SARS-CoV-2 Antiviral Activity In Vitro: A potential Multi-Target Approach for Prevention and Early Intervention Treatment of COVID-19, Int J Mol Sci. 2020 Nov 20;21(22):8803. doi: 10.3390/ijms21228803.

Stanelle-Bertram, S., Schaumburg, B., Kouassi, N. M., Beck, S., Zickler, M., Beythien, G., ... & dos Reis, V. P., SARS-CoV-2 induced CYP19A1 expression in the lung correlates with increased aromatization of testosterone-to-estradiol in male golden hamsters, Research Square, 20 Nov 2020. DOI: 10.21203/rs.3.rs-107474/v1

Singh V, Beer A, Kraus A, et al., Stroke increases the expression of ACE2, the SARS-CoV-2 binding receptor, in murine lungs, bioRxiv 2020.06.24.162941; doi: https://doi.org/10.1101/2020.06.24.162941

Ye G, Gallant JP, Massey C, Shi K, Tai W, Zheng J, Odle AE, Vickers MA, Shang J, Wan Y, Drelich A, Kempaiah KR, Tat V, Perlman S, Du L, Tseng CT, Aihara H, LeBeau AM, Li F., The Development of a Novel Nanobody Therapeutic for SARS-CoV-2, bioRxiv. 2020 Nov 17:2020.11.17.386532. doi: 10.1101/2020.11.17.386532. Preprint.

Chen M, Rosenberg J, Cai X, Hsuan Lee AC, Shi J, Nguyen M, Wignakumar T, Mirle V, Edobor AJ, Fung J, Donington JS, Shanmugarajah K, Lin Y, Chang E, Randall G, Penaloza-MacMaster P, Tian B, Madariaga ML, Huang J., Nanotraps for the containment and clearance of SARS-CoV-2, Matter. 2021 Jun 2;4(6):2059-2082. doi: 10.1016/j.matt.2021.04.005. Epub 2021 Apr 22.

Mirchandani AS, Jenkins SJ, Bain CC, Sanchez-Garcia MA, Lawson H, Coelho P, Murphy F, Griffith DM, Zhang A, Morrison T, Ly T, Arienti S, Sadiku P, Watts ER, Dickinson RS, Reyes L, Cooper G, Clark S, Lewis D, Kelly V, Spanos C, Musgrave KM, Delaney L, Harper I, Scott J, Parkinson NJ, Rostron AJ, Baillie JK, Clohisey S, Pridans C, Campana L, Lewis PS, Simpson AJ, Dockrell DH, Schwarze J, Hirani N, Ratcliffe PJ, Pugh CW, Kranc K, Forbes SJ, Whyte MKB, Walmsley SR., Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation., Nat Immunol. 2022 Jun;23(6):927-939. doi: 10.1038/s41590-022-01216-z. Epub 2022 May 27. Erratum in: Nat Immunol. 2022 Jul 19.

D’Alessio F, Lione L, Salvatori E, Bucci F, Muzi A, Roscilli G…Palombo F., Immunogenicity of COVID-eVax Is Moderately Impacted by Temperature and Molecular Isoforms, bioRxiv 2022.12.29.522202

Diabetes type 2

Roesti ES, Boyle CN, Zeman DT, Sande-Melon M, Storni F, Cabral-Miranda G, Knuth A, Lutz TA, Vogel M, Bachmann MF., Vaccination Against Amyloidogenic Aggregates in Pancreatic Islets Prevents Development of Type 2 Diabetes Mellitus, Vaccines (Basel). 2020 Mar 2;8(1):116. doi: 10.3390/vaccines8010116.

Si R, Cabrera JTO, Tsuji-Hosokawa A, Guo R, Watanabe M, Gao L, Lee YS, Moon JS, Scott BT, Wang J, Ashton AW, Rao JN, Wang JY, Yuan JX, Makino A., HuR/Cx40 downregulation causes coronary microvascular dysfunction in type 2 diabetes, JCI Insight. 2021 Nov 8;6(21):e147982. doi: 10.1172/jci.insight.147982.

Diet induced obesity

Umek, Nejc; Horvat, Simon; Cvetko, Erika; Kreft, Marko; JanĂĄ?ek, Ji?Ă ; KubĂnovĂĄ, Lucie; Stopar Pintari?, Tatjana; ErĹžen, Ida;, 3D analysis of capillary network in skeletal muscle of obese insulin-resistant mice., Histochemistry and cell biology Vol.152, 2019

Duivenvoorde, L. P., van Schothorst, E. M., Swarts, H. M., Kuda, O., Steenbergh, E., Termeulen, S., . . . Keijer, J. (2015), A difference in fatty acid composition of isocaloric high-fat diets alters metabolic flexibility in male C57BL/6JOlaHsd mice., PloS One, 10(6), e0128515. doi:10.1371/journal.pone.0128515 [doi]

Fernández-Calleja, José M S; Bouwman, Lianne M S; Swarts, Hans J M; Billecke, Nils; Oosting, Annemarie; Keijer, Jaap; van Schothorst, Evert M, A Lowly Digestible-Starch Diet after Weaning Enhances Exogenous Glucose Oxidation Rate in Female, but Not in Male, Mice., Nutrients Vol.11, 2019

Eljaafari, A., Robert, M., Chehimi, M., Chanon, S., Durand, C., Vial, G., . . . Pirola, L. (2015), Adipose tissue-derived stem cells from obese subjects contribute to inflammation and reduced insulin response in adipocytes through differential regulation of the Th1/Th17 balance and monocyte activation., Diabetes, 64(7), 2477-2488. doi:10.2337/db15-0162 [doi]

McPherson, N. O., Lane, M., Sandeman, L., Owens, J. A., & Fullston, T. (2017)., An exercise-only intervention in obese fathers restores glucose and insulin regulation in conjunction with the rescue of pancreatic islet cell morphology and MicroRNA expression in male offspring., Nutrients, 9(2), 10.3390/nu9020122. doi:E122 [pii]

Parra-Vargas, M., Sandoval-Rodriguez, A., Rodriguez-Echevarria, R., Dominguez-Rosales, J. A., Santos-Garcia, A., & Armendariz-Borunda, J. (2018)., Delphinidin ameliorates hepatic triglyceride accumulation in human HepG2 cells, but not in diet-induced obese mice., Nutrients, 10(8), 10.3390/nu10081060. doi:E1060 [pii]

Hoek-van den Hil, E. F., van Schothorst, E. M., van der Stelt, I., Swarts, H. J., van Vliet, M., Amolo, T., . . . Keijer, J. (2015), Direct comparison of metabolic health effects of the flavonoids quercetin, hesperetin, epicatechin, apigenin and anthocyanins in high-fat-diet-fed mice., Genes & Nutrition, 10(4), 469-015-0469-z. Epub 2015 May 29. doi:10.1007/s12263-015-0469-z [doi]

Shi, W., Hegeman, M. A., van Dartel, D. A. M., Tang, J., Suarez, M., Swarts, H., . . . Keijer, J. (2017)., Effects of a wide range of dietary nicotinamide riboside (NR) concentrations on metabolic flexibility and white adipose tissue (WAT) of mice fed a mildly obesogenic diet., Molecular Nutrition & Food Research, 61(8), 10.1002/mnfr.201600878. Epub 2017 Apr 13. doi:10.1002/mnfr.201600878 [doi]

Lombardo, G. E., Lepore, S. M., Morittu, V. M., Arcidiacono, B., Colica, C., Procopio, A., . . . Celano, M. (2018)., Effects of oleacein on high-fat diet-dependent steatosis, weight gain, and insulin resistance in mice., Frontiers in Endocrinology, 9, 116. doi:10.3389/fendo.2018.00116 [doi]

Villalpando-Arteaga, E. V., Mendieta-Condado, E., Esquivel-Solis, H., Canales-Aguirre, A. A., Galvez-Gastelum, F. J., Mateos-Diaz, J. C., . . . Marquez-Aguirre, A. L. (2013)., Hibiscus sabdariffa L. aqueous extract attenuates hepatic steatosis through down-regulation of PPAR-gamma and SREBP-1c in diet-induced obese mice., Food & Function, 4(4), 618-626. doi:10.1039/c3fo30270a [doi]

Shi, Wenbiao; Hegeman, Maria A; Doncheva, Atanaska; Bekkenkamp-Grovenstein, Melissa; de Boer, Vincent C J; Keijer, Jaap;, High Dose of Dietary Nicotinamide Riboside Induces Glucose Intolerance and White Adipose Tissue Dysfunction in Mice Fed a Mildly Obesogenic Diet, Nutrients Vol.11, 2019

Kothari, V., Luo, Y., Tornabene, T., O'Neill, A. M., Greene, M. W., Geetha, T., & Babu, J. R. (2017)., High fat diet induces brain insulin resistance and cognitive impairment in mice. Biochimica Et Biophysica Acta, Molecular Basis of Disease, 1863(2), 499-508. doi:S0925-4439(16)30250-2 [pii]

Vial, G., Chauvin, M. A., Bendridi, N., Durand, A., Meugnier, E., Madec, A. M., . . . Rieusset, J. (2015)., Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrial function in liver of a high-fat, high-sucrose diet mice model., Diabetes, 64(6), 2254-2264. doi:10.2337/db14-1220 [doi]

Khan, I. M., Perrard, X. Y., Brunner, G., Lui, H., Sparks, L. M., Smith, S. R., . . . Ballantyne, C. M. (2015)., Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance, International Journal of Obesity (2005), 39(11), 1607-1618. doi:10.1038/ijo.2015.104 [doi]

Hermier, Dominique; Lan, Annaïg; Tellier, Frédérique; Blais, Anne; Culetto, Marta Grauso; Mathé, Véronique; Bellec, Yannick; Gissot, Lionel; Schmidely, Philippe; Faure, Jean-Denis;, Intestinal Availability and Metabolic Effects of Dietary Camelina Sphingolipids during the Metabolic Syndrome Onset in Mice, Journal of agricultural and food chemistry Vol.5, 2020

van der Stelt, I., Hoevenaars, F., Siroka, J., de Ronde, L., Friedecky, D., Keijer, J., & van Schothorst, E. (2017), Metabolic response of visceral white adipose tissue of obese mice exposed for 5 days to human room temperature compared to mouse thermoneutrality., Frontiers in Physiology, 8, 179. doi:10.3389/fphys.2017.00179 [doi]

Derous, D., Kelder, T., van Schothorst, E. M., van Erk, M., Voigt, A., Klaus, S., . . . Radonjic, M. (2015)., Network-based integration of molecular and physiological data elucidates regulatory mechanisms underlying adaptation to high-fat diet., Genes & Nutrition, 10(4), 470-015-0470-6. Epub 2015 May 28. doi:10.1007/s12263-015-0470-6 [doi]

Bouwman, L. M. S., Fernandez-Calleja, J. M. S., Swarts, H. J. M., van der Stelt, I., Oosting, A., Keijer, J., & van Schothorst, E. M. (2018), No adverse programming by post-weaning dietary fructose of body weight, adiposity, glucose tolerance, or metabolic flexibility., Molecular Nutrition & Food Research, 62(2), 10.1002/mnfr.201700315. Epub 2017 Dec 11. doi:10.1002/mnfr.201700315 [doi]

Lombardo, G. E., Arcidiacono, B., De Rose, R. F., Lepore, S. M., Costa, N., Montalcini, T., . . . Celano, M. (2016)., Normocaloric diet restores weight gain and insulin sensitivity in obese mice., Frontiers in Endocrinology, 7, 49. doi:10.3389/fendo.2016.00049 [doi]

Donkers, Joanne M; Kooijman, Sander; Slijepcevic, Davor; Kunst, Roni F; Roscam Abbing, Reinout Lp; Haazen, Lizette; de Waart, Dirk R; Levels, Johannes Hm; Schoonjans, Kristina; Rensen, Patrick Cn; Oude Elferink, Ronald Pj; van de Graaf, Stan Fj;, NTCP deficiency in mice protects against obesity and hepatosteatosis., JCI insight Vol.5, 2019

Lepore, Saverio Massimo; Maggisano, Valentina; Bulotta, Stefania; Mignogna, Chiara; Arcidiacono, Biagio; Procopio, Antonio; Brunetti, Antonio; Russo, Diego; Celano, Marilena, Oleacein Prevents High Fat Diet-Induced Adiposity and Ameliorates Some Biochemical Parameters of Insulin Sensitivity in Mice, Nutrients Vol.11, 2019

Jurrissen, Thomas J; Grunewald, Zachary I; Woodford, Makenzie L; Winn, Nathan C; Ball, James R; Smith, Thomas N; Wheeler, Andrew A; Rawlings, Arthur L; Staveley-OCarroll, Kevin F; Ji, Yan; Fay, William P; Paradis, Pierre; Schiffrin, Ernesto L; Vieira-Potter, Victoria J; Fadel, Paul J; Martinez-Lemus, Luis A; Padilla, Jaume;, Overproduction of endothelin-1 impairs glucose tolerance but does not promote visceral adipose tissue inflammation or limit metabolic adaptations to exercise., American journal of physiology. Endocrinology and metabolism Vol.317, 2019

Duivenvoorde, L. P., van Schothorst, E. M., Derous, D., van der Stelt, I., Masania, J., Rabbani, N., . . . Keijer, J. (2015)., Oxygen restriction as challenge test reveals early high-fat-diet-induced changes in glucose and lipid metabolism., Pflugers Archiv : European Journal of Physiology, 467(6), 1179-1193. doi:10.1007/s00424-014-1553-8 [doi]

Dhandapani, Praveen K; Lyyski, Annina M; Paulin, Lars; Khan, Nahid A; Suomalainen, Anu; Auvinen, Petri; Dufour, Eric; Szibor, Marten; Jacobs, Howard T;, Phenotypic effects of dietary stress in combination with a respiratory chain bypass in mice, Physiological reports Vol.7, 2019

Ronda, Onne A H O; van de Heijning, Bert J M; de Bruin, Alain; Jurdzinski, Angelika; Kuipers, Folkert; Verkade, Henkjan J;, Programming effects of an early life diet containing large phospholipid-coated lipid globules are transient under continuous exposure to a high-fat diet, The British journal of nutrition Vol.122, 2019

Gutman, Roee; Rauch, Maayan; Neuman, Annat; Khamaisi, Hazem; Jonas-Levi, Adi; Konovalova, Yelena; Rytwo, Giora;, Sepiolite Clay Attenuates the Development of Hypercholesterolemia and Obesity in Mice Fed a High-Fat High-Cholesterol Diet., Journal of medicinal food Vol.5, 2019

Voigt, A., Agnew, K., van Schothorst, E. M., Keijer, J., & Klaus, S. (2013)., Short-term, high fat feeding-induced changes in white adipose tissue gene expression are highly predictive for long-term changes., Molecular Nutrition & Food Research, 57(8), 1423-1434. doi:10.1002/mnfr.201200671 [doi]

Fullston, T., Ohlsson-Teague, E. M., Print, C. G., Sandeman, L. Y., & Lane, M. (2016)., Sperm microRNA content is altered in a mouse model of male obesity, but the same suite of microRNAs are not altered in offspring's sperm., PloS One, 11(11), e0166076. doi:10.1371/journal.pone.0166076 [doi]

Pisani, D. F., Ghandour, R. A., Beranger, G. E., Le Faouder, P., Chambard, J. C., Giroud, M., . . . Amri, E. Z. (2014)., The omega6-fatty acid, arachidonic acid, regulates the conversion of white to brite adipocyte through a prostaglandin/calcium mediated pathway., Molecular Metabolism, 3(9), 834-847. doi:10.1016/j.molmet.2014.09.003 [doi]

Hoevenaars, F. P., Bekkenkamp-Grovenstein, M., Janssen, R. J., Heil, S. G., Bunschoten, A., Hoek-van den Hil, E. F., . . . Keijer, J. (2014)., Thermoneutrality results in prominent diet-induced body weight differences in C57BL/6J mice, not paralleled by diet-induced metabolic differences, Molecular Nutrition & Food Research, 58(4), 799-807. doi:10.1002/mnfr.201300285 [doi]

Shi, Wenbiao; Hegeman, Maria A; Doncheva, Atanaska; van der Stelt, Inge; Bekkenkamp-Grovenstein, Melissa; van Schothorst, Evert M; Brenner, Charles; de Boer, Vincent C J; Keijer, Jaap;, Transcriptional Response of White Adipose Tissue to Withdrawal of Vitamin B3, Molecular nutrition & food research Vol.11, 2019

Hoevenaars, Femke P M; Keijer, Jaap; van der Stelt, Inge; Duivenvoorde, Loes P M; Herreman, Laure; van Nes, Robin; FriedeckĂ˝, David; Hegeman, Maria A; van Schothorst, Evert M;, White Adipose Tissue Response of Obese Mice to Ambient Oxygen Restriction at Thermoneutrality: Response Markers Identified, but no WAT Inflammation., Genes Vol.10, 2019

Worley BL, Auen T, Arnold AC, Monia BP, Hempel N, Czyzyk TA., Antisense oligonucleotide-mediated knockdown of Mpzl3 attenuates the negative metabolic effects of diet-induced obesity in mice, Physiol Rep. 2021 May;9(9):e14853. doi: 10.14814/phy2.14853.

Sun P, Bouwman LMS, de Deugd JL, van der Stelt I, Oosting A, Keijer J, van Schothorst EM., Galactose in the Post-Weaning Diet Programs Improved Circulating Adiponectin Concentrations and Skeletal Muscle Insulin Signaling, null

Anagnostopoulos G, Motiño O, Li S, Carbonnier V, Chen H, Sica V, Durand S, Bourgin M, Aprahamian F, Nirmalathasan N, Donne R, Desdouets C, Sola MS, Kotta K, Montégut L, Lambertucci F, Surdez D, Sandrine G, Delattre O, Maiuri MC, Bravo-San Pedro JM, Martins I, Kroemer G. , An obesogenic feedforward loop involving PPARγ, acyl-CoA binding protein and GABAA receptor., Cell Death Dis. 2022 Apr 18;13(4):356. doi: 10.1038/s41419-022-04834-5. Erratum in: Cell Death Dis. 2022 May 3;13(5):430.

Charlot A, Charles A-L, Georg I, Goupilleau F, Debrut L, Pizzimenti M, Mallard J, Pagano AF, Geny B, Zoll J., Beneficial Effects of Ketogenic Diet on Nonalcoholic Steatohepatitis in Obese Mice Model, Biology and Life Sciences Forum. 2022; 12(1):23. https://doi.org/10.3390/IECN2022-12368

General studies

Moore, Scott Emory; Voss, Joachim G; St Pierre Schneider, Barbara;, 17?-estradiol alters mRNA co-expression after murine muscle injury and mild hypobaria., Experimental biology and medicine (Maywood, N.J.) Vol.244, 2019

Sajic, Tatjana; Ciuffa, Rodolfo; Lemos, Vera; Xu, Pan; Leone, Valentina; Li, Chen; Williams, Evan G; Makris, Georgios; Banaei-Esfahani, Amir; Heikenwalder, Mathias; Schoonjans, Kristina; Aebersold, Ruedi;, A new class of protein biomarkers based on subcellular distribution: application to a mouse liver cancer model., Scientific reports Vol.9, 2019

Wenborn, A., Terry, C., Gros, N., Joiner, S., D'Castro, L., Panico, S., . . . Wadsworth, J. D. (2015)., A novel and rapid method for obtaining high titre intact prion strains from mammalian brain., Scientific Reports, 5, 10062. doi:10.1038/srep10062 [doi]

van de Moosdijk AAA, van de Grift YBC, de Man SMA, Zeeman AL, van Amerongen R., A novel Axin2 knock-in mouse model for visualization and lineage tracing of WNT/CTNNB1 responsive cells, Genesis. 2020 Sep;58(9):e23387. doi: 10.1002/dvg.23387. Epub 2020 Jul 9.

Gomez-Pinilla, P. J., Binda, M. M., Lissens, A., Di Giovangiulio, M., van Bree, S. H., Nemethova, A., . . . Boeckxstaens, G. E. (2014), Absence of intestinal inflammation and postoperative ileus in a mouse model of laparoscopic surgery., Neurogastroenterology and Motility : The Official Journal of the European Gastrointestinal Motility Society, 26(9), 1238-1247. doi:10.1111/nmo.12376 [doi]

Lohuis, Mirjam A M; Werkman, Cornelieke C N; Harmsen, Hermie J M; Tietge, Uwe J F; Verkade, Henkjan J;, Absence of Intestinal Microbiota during Gestation and Lactation Does Not Alter the Metabolic Response to a Western-type Diet in Adulthood., Molecular nutrition & food research Vol.63, 2019

Hemmatian, H., Laurent, M. R., Ghazanfari, S., Vanderschueren, D., Bakker, A. D., Klein-Nulend, J., & van Lenthe, G. H. (2017)., Accuracy and reproducibility of mouse cortical bone microporosity as quantified by desktop microcomputed tomography., PloS One, 12(8), e0182996. doi:10.1371/journal.pone.0182996 [doi

Korte SW, Dorfmeyer RA, Franklin CL, Ericsson AC., Acute and long-term effects of antibiotics commonly used in laboratory animal medicine on the fecal microbiota, Vet Res. 2020 Sep 14;51(1):116. doi: 10.1186/s13567-020-00839-0.

Hunter, R. W., Craigie, E., Homer, N. Z., Mullins, J. J., & Bailey, M. A. (2014)., Acute inhibition of NCC does not activate distal electrogenic na+ reabsorption or kaliuresis., American Journal of Physiology.Renal Physiology, 306(4), F457-67. doi:10.1152/ajprenal.00339.2013 [doi]

Gross CM, Kovacs-Kasa A, Meadows ML, Cherian-Shaw M, Fulton DJ, Verin AD., Adenosine and ATP?S protect against bacterial pneumonia-induced acute lung injury, Sci Rep. 2020 Oct 22;10(1):18078. doi: 10.1038/s41598-020-75224-0.

Hoevenaars, F. P., Keijer, J., Herreman, L., Palm, I., Hegeman, M. A., Swarts, H. J., & van Schothorst, E. M. (2014)., Adipose tissue metabolism and inflammation are differently affected by weight loss in obese mice due to either a high-fat diet restriction or change to a low-fat diet., Genes & Nutrition, 9(3), 391-014-0391-9. Epub 2014 Apr 10. doi:10.1007/s12263-014-0391-9 [doi]

Green, Lisa J; Zhou, Hong; Padmanabhan, Vasantha; Shikanov, Ariella;, Adipose-derived stem cells promote survival, growth, and maturation of early-stage murine follicles., Stem cell research & therapy Vol.10, 2019

Hodges EL, Marshall JP, Ashpole NM., Age-dependent hormesis-like effects of the synthetic cannabinoid CP55940 in C57BL/6 mice, NPJ Aging Mech Dis. 2020 Jul 6;6:7. doi: 10.1038/s41514-020-0045-7. eCollection 2020.

Long, D. A., Kolatsi-Joannou, M., Price, K. L., Dessapt-Baradez, C., Huang, J. L., Papakrivopoulou, E., . . . Woolf, A. S. (2013)., Albuminuria is associated with too few glomeruli and too much testosterone., Kidney International, 83(6), 1118-1129. doi:10.1038/ki.2013.45 [doi]

Faustini, Gaia; Marchesan, Elena; Zonta, Laura; Bono, Federica; Bottani, Emanuela; Longhena, Francesca; Ziviani, Elena; Valerio, Alessandra; Bellucci, Arianna, Alpha-Synuclein Preserves Mitochondrial Fusion and Function in Neuronal Cells., Oxidative medicine and cellular longevity Vol.2019, 2019

Dawson, N., M. Kurihara, D.M. Thomson, C.L. Winchester, A. McVie, J.R. Hedde, A.D. Randall, S. Shen, P.A. Seymour, Z.A. Hughes, J. Dunlop, J.T. Brown, N.J. Brandon, B.J. Morris, and J.A. Pratt. 2015., Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1., Transl.Psychiatry. 5:e569.

Huo, Y., Win, S., Than, T. A., Yin, S., Ye, M., Hu, H., & Kaplowitz, N. (2017), Antcin H protects against acute liver injury through disruption of the interaction of c-jun-N-terminal kinase with mitochondria., Antioxidants & Redox Signaling, 26(5), 207-220. doi:10.1089/ars.2016.6833 [doi]

Schwaerzer, Gerburg K; Kalyanaraman, Hema; Casteel, Darren E; Dalton, Nancy D; Gu, Yusu; Lee, Seunghoe; Zhuang, Shunhui; Wahwah, Nisreen; Schilling, Jan M; Patel, Hemal H; Zhang, Qian; Makino, Ayako; Milewicz, Dianna M; Peterson, Kirk L; Boss, Gerry R; Pilz, Renate B, Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog., Nature communications Vol.10, 2019

Gordon, Bradley S; Rossetti, Michael L; Eroshkin, Alexey M;, Arrdc2 and Arrdc3 elicit divergent changes in gene expression in skeletal muscle following anabolic and catabolic stimuli., Physiological genomics Vol.51, 2019

Lerner, Shaul; Anderzhanova, Elmira; Verbitsky, Sima; Eilam, Raya; Kuperman, Yael; Tsoory, Michael; Kuznetsov, Yuri; Brandis, Alexander; Mehlman, Tevie; Mazkereth, Ram; McCarter, Robert; Segal, Menahem; Nagamani, Sandesh C S; Chen, Alon; Erez, Ayelet, ASL Metabolically Regulates Tyrosine Hydroxylase in the Nucleus Locus Coeruleus., Cell reports Vol.29, 2019

Chakrabarti, Sudipta; Roy, Avik; Prorok, Tim; Patel, Dhruv; Dasarathi, Sridevi; Pahan, Kalipada;, Aspirin up-regulates suppressor of cytokine signaling 3 in glial cells via PPAR?, Journal of neurochemistry Vol.151, 2019

Landolt, Lea; Furriol, Jessica; Babickova, Janka; Ahmed, Lavina; Eikrem, Øystein; Skogstrand, Trude; Scherer, Andreas; Suliman, Salwa; Leh, Sabine; Lorens, James B; Gausdal, Gro; Marti, Hans-Peter; Osman, Tarig, AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction, Physiological reports Vol.7, 2019

Hoevenaars, F. P., van Schothorst, E. M., Horakova, O., Voigt, A., Rossmeisl, M., Pico, C., . . . Keijer, J. (2012), BIOCLAIMS standard diet (BIOsd): A reference diet for nutritional physiology., Genes & Nutrition, 7(3), 399-404. doi:10.1007/s12263-011-0262-6 [doi]

Hoevenaars, F.P., E.M. van Schothorst, O. Horakova, A. Voigt, M. Rossmeisl, C. Pico, A. Caimari, J. Kopecky, S. Klaus, and J. Keijer. 2012., BIOCLAIMS standard diet (BIOsd): a reference diet for nutritional physiology., Genes Nutr. 7:399-404.

Palm, I. F., Schram, R. G. A. E., Swarts, H. J. M., van Schothorst, E. M., & Keijer, J. (2017)., Body weight cycling with identical diet composition does not affect energy balance and has no adverse effect on metabolic health parameters, Nutrients, 9(10), 10.3390/nu9101149. doi:E1149 [pii]

Chrobok, N. L., Bol, J. G. J. M., Jongenelen, C. A., Breve, J. J. P., El Alaoui, S., Wilhelmus, M. M. M., . . . van Dam, A. M. (2018)., Characterization of transglutaminase 2 activity inhibitors in monocytes in vitro and their effect in a mouse model for multiple sclerosis, PloS One, 13(4), e0196433. doi:10.1371/journal.pone.0196433 [doi]

Stalinska, J; Zimolag, E; Pianovich, N A; Zapata, A; Lassak, A; Rak, M; Dean, M; Ucar-Bilyeu, D; Wyczechowska, D; Culicchia, F; Marrero, L; Del Valle, L; Sarkaria, J; Peruzzi, F; Jursic, B S; Reiss, K;, Chemically Modified Variants of Fenofibrate with Antiglioblastoma Potential., Translational oncology Vol.12, 2019

Silvennoinen, R., Quesada, H., Kareinen, I., Julve, J., Kaipiainen, L., Gylling, H., . . . Lee-Rueckert, M. (2015), Chronic intermittent psychological stress promotes macrophage reverse cholesterol transport by impairing bile acid absorption in mice., Physiological Reports, 3(5), 10.14814/phy2.12402. doi:10.14814/phy2.12402 [doi]

O'Brien, F. E., Moloney, G. M., Scott, K. A., O'Connor, R. M., Clarke, G., Dinan, T. G., . . . Cryan, J. F. (2015)., Chronic P-glycoprotein inhibition increases the brain concentration of escitalopram: Potential implications for treating depression., Pharmacology Research & Perspectives, 3(6), e00190. doi:10.1002/prp2.190 [doi]

Win, S., Than, T. A., Min, R. W., Aghajan, M., & Kaplowitz, N. (2016), c-jun N-terminal kinase mediates mouse liver injury through a novel sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial src, Hepatology (Baltimore, Md.), 63(6), 1987-2003. doi:10.1002/hep.28486 [doi

Bedussi, B., van Lier, M. G., Bartstra, J. W., de Vos, J., Siebes, M., VanBavel, E., & Bakker, E. N. (2015), Clearance from the mouse brain by convection of interstitial fluid towards the ventricular system., Fluids and Barriers of the CNS, 12, 23-015-0019-5. doi:10.1186/s12987-015-0019-5 [doi]

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Eustace, Andrew D; McNaughton, Emily F; King, Sophie; Kehoe, Oksana; Kungl, Andreas; Mattey, Derek; Nobbs, Angela H; Williams, Neil; Middleton, Jim;, Soluble syndecan-3 binds chemokines, reduces leukocyte migration in vitro and ameliorates disease severity in models of rheumatoid arthritis, Arthritis research & therapy Vol.21, 2019

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Knop, Jelle; van IJzendoorn, Marinus H; Bakermans-Kranenburg, Marian J; JoĂŤls, Marian; van der Veen, Rixt;, The effects of different rearing conditions on sexual maturation and maternal care in heterozygous mineralocorticoid receptor knockout mice., Hormones and behavior Vol.112, 2019

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Beamer E, O'Dea MI, Garvey AA, Smith J, Menéndez-Méndez A, Kelly L, Pavel A, Quinlan S, Alves M, Jimenez-Mateos EM, Tian F, Dempsey E, Dale N, Murray DM, Boylan GB, Molloy EJ, Engel T., Novel Point-of-Care Diagnostic Method for Neonatal Encephalopathy Using Purine Nucleosides, Front Mol Neurosci. 2021 Sep 9;14:732199. doi: 10.3389/fnmol.2021.732199. eCollection 2021.

Doron-Mandel E, Koppel I, Abraham O, Rishal I, Smith TP, Buchanan CN, Sahoo PK, Kadlec J, Oses-Prieto JA, Kawaguchi R, Alber S, Zahavi EE, Di Matteo P, Di Pizio A, Song DA, Okladnikov N, Gordon D, Ben-Dor S, Haffner-Krausz R, Coppola G, Burlingame AL, Jungwirth P, Twiss JL, Fainzilber M., The glycine arginine-rich domain of the RNA-binding protein nucleolin regulates its subcellular localization, EMBO J. 2021 Oct 18;40(20):e107158. doi: 10.15252/embj.2020107158. Epub 2021 Sep 13.

Altshuler A, Amitai-Lange A, Tarazi N, Dey S, Strinkovsky L, Hadad-Porat S, Bhattacharya S, Nasser W, Imeri J, Ben-David G, Abboud-Jarrous G, Tiosano B, Berkowitz E, Karin N, Savir Y, Shalom-Feuerstein R., Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing, Cell Stem Cell. 2021 Jul 1;28(7):1248-1261.e8. doi: 10.1016/j.stem.2021.04.003. Epub 2021 May 12.

Scotece M, Rego-Pérez I, Lechuga-Vieco AV, Cortés AC, Jiménez-Gómez MC, Filgueira-Fernández P, Vaamonde-García C, Enríquez JA, Blanco FJ., Mitochondrial DNA impact on joint damaged process in a conplastic mouse model after being surgically induced with osteoarthritis, Sci Rep. 2021 Apr 27;11(1):9112. doi: 10.1038/s41598-021-88083-0.

Ghouil R, Miron S, Koornneef L, Veerman J, Paul MW, Le Du MH, Sleddens-Linkels E, van Rossum-Fikkert SE, van Loon Y, Felipe-Medina N, Pendas AM, Maas A, Essers J, Legrand P, Baarends WM, Kanaar R, Zinn-Justin S, Zelensky AN., BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination, Nat Commun. 2021 Jul 29;12(1):4605. doi: 10.1038/s41467-021-24871-6.

Barron K, Ogretmen B, Krupenko N., Dietary Folic Acid Alters Metabolism of Multiple Vitamins in a CerS6- and Sex-Dependent Manner, Front Nutr. 2021 Nov 5;8:758403. doi: 10.3389/fnut.2021.758403. eCollection 2021.

Wang Z, Guo K, Gao P, Pu Q, Lin P, Qin S, Xie N, Hur J, Li C, Huang C, Wu M., Microbial and genetic-based framework identifies drug targets in inflammatory bowel disease, Theranostics. 2021 Jun 1;11(15):7491-7506. doi: 10.7150/thno.59196. eCollection 2021.

Pericuesta E, Gutiérrez-Arroyo JL, Sánchez-Calabuig MJ, Gutiérrez-Adán A., Postnatal Catch-Up Growth Programs Telomere Dynamics and Glucose Intolerance in Low Birth Weight Mice, Int J Mol Sci. 2021 Apr 1;22(7):3657. doi: 10.3390/ijms22073657.

Sanman LE, Chen IW, Bieber JM, Steri V, Trentesaux C, Hann B, Klein OD, Wu LF, Altschuler SJ., Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition, Dev Cell. 2021 Feb 8;56(3):356-365.e9. doi: 10.1016/j.devcel.2020.12.020. Epub 2021 Jan 22.

Sever N, Mili?i? G, Bodnar NO, Wu X, Rapoport TA., Mechanism of Lamellar Body Formation by Lung Surfactant Protein B, Mol Cell. 2021 Jan 7;81(1):49-66.e8. doi: 10.1016/j.molcel.2020.10.042. Epub 2020 Nov 25.

Liu Q, Garg P, Hasdemir B, Wang L, Tuscano E, Sever E, Keane E, Hernandez AGL, Yuan TZ, Kwan E, Lai J, Szot G, Paruthiyil S, Axelrod F, K Sato A., Functional GLP-1R antibodies identified from a synthetic GPCR-focused library demonstrate potent blood glucose control, MAbs. 2021 Jan-Dec;13(1):1893425. doi: 10.1080/19420862.2021.1893425.

Kinnear HM, Constance ES, David A, Marsh EE, Padmanabhan V, Shikanov A, Moravek MB., A mouse model to investigate the impact of testosterone therapy on reproduction in transgender men, Hum Reprod. 2019 Oct 2;34(10):2009-2017. doi: 10.1093/humrep/dez177.

Barron K, Ogretmen B, Krupenko N., Ceramide synthase 6 mediates sex-specific metabolic response to dietary folic acid in mice, J Nutr Biochem. 2021 Dec;98:108832. doi: 10.1016/j.jnutbio.2021.108832. Epub 2021 Aug 4.

Ho B, Ryback D, Benson B, Mason CN, Torres PJ, Quinn RA, Thackray VG, Kelley ST., Gut Metabolites Are More Predictive of Disease and Cohoused States than Gut Bacterial Features in a Polycystic Ovary Syndrome-Like Mouse Model, mSystems. 2021 Oct 26;6(5):e0114920. doi: 10.1128/mSystems.01149-20. Epub 2021 Sep 14.

Rossetti ML, Dunlap KR, Salazar G, Hickner RC, Kim JS, Chase BP, Miller BF, Gordon BS., Systemic delivery of a mitochondria targeted antioxidant partially preserves limb muscle mass and grip strength in response to androgen deprivation, Mol Cell Endocrinol. 2021 Sep 15;535:111391. doi: 10.1016/j.mce.2021.111391. Epub 2021 Jul 7.

Gordon BS, Rossetti ML, Casero RA Jr., Spermidine is not an independent factor regulating limb muscle mass in mice following androgen deprivation, Appl Physiol Nutr Metab. 2021 May;46(5):452-460. doi: 10.1139/apnm-2020-0404. Epub 2020 Oct 30.

Sakhneny L, Mueller L, Schonblum A, Azaria S, Burganova G, Epshtein A, Isaacson A, Wilson H, Spagnoli FM, Landsman L., The postnatal pancreatic microenvironment guides beta cell maturation through BMP4 production., Dev Cell. 2021 Oct 11;56(19):2703-2711.e5. doi: 10.1016/j.devcel.2021.08.014. Epub 2021 Sep 8.

van der Stelt I, Shi W, Bekkenkamp-Grovenstein M, Zapata-Pérez R, Houtkooper RH, de Boer VCJ, Hegeman MA, Keijer J., The female mouse is resistant to mild vitamin B(3) deficiency., Eur J Nutr. 2021 Aug 2. doi: 10.1007/s00394-021-02651-8. [Epub ahead of print]

Mittnenzweig M, Mayshar Y, Cheng S, Ben-Yair R, Hadas R, Rais Y, Chomsky E, Reines N, Uzonyi A, Lumerman L, Lifshitz A, Mukamel Z, Orenbuch AH, Tanay A, Stelzer Y., A single-embryo, single-cell time-resolved model for mouse gastrulation., Cell. 2021 May 27;184(11):2825-2842.e22. doi: 10.1016/j.cell.2021.04.004. Epub 2021 Apr 30.

Nicolle L, Casper J, Willimann M, Journot CMA, Detampel P, Einfalt T, Grisch-Chan HM, ThĂśny B, Gerber-Lemaire S, Huwyler J., Development of Covalent Chitosan-Polyethylenimine Derivatives as Gene Delivery Vehicle: Synthesis, Characterization, and Evaluation., Int J Mol Sci. 2021 Apr 7;22(8). pii: 3828. doi: 10.3390/ijms22083828.

Casper J, Nicolle L, Willimann M, Kuzucu EÜ, Tran A, Robin P, Detampel P, Grisch-Chan HM, Thöny B, Huwyler J, Gerber-Lemaire S., Core-Shell Structured Chitosan-Polyethylenimine Nanoparticles for Gene Delivery: Improved Stability, Cellular Uptake, and Transfection Efficiency, null

Deplazes S, Schlegel A, Song Z, Allegri G, Rimann N, Scherer T, Willimann M, Opitz L, Cunningham SC, Alexander IE, Kipar A, Häberle J, Thöny B, Grisch-Chan HM., Intrabiliary infusion of naked DNA vectors targets periportal hepatocytes in mice, null

Mukamel Z, Lifshitz A, Mittnenzweig M, Chomsky E, Schwartzman O, Ben-Kiki O, Zerbib M, Tanay A., DNA methyltransferases 3A and 3B target specific sequences during mouse gastrulation, null

Fahl WE, Cadarso M, Goesch TR., Significant Reduction of Total-Body Irradiation-Induced Death in Mice Treated with PrC-210 24 Hours Postirradiation, Radiat Res. 2022 Sep 1;198(3):263-270. doi: 10.1667/RADE-22-00036.1.

Avagliano C, De Caro C, Cuozzo M, Liguori FM, La Rana G, Micheli L, Di Cesare Mannelli L, Ghelardini C, Paciello O, Russo R., Phaseolus vulgaris extract ameliorates high-fat diet-induced colonic barrier dysfunction and inflammation in mice by regulating peroxisome proliferator-activated receptor expression and butyrate levels, Front Pharmacol. 2022 Aug 11;13:930832. doi: 10.3389/fphar.2022.930832. eCollection 2022.

Russell A, Copio JN, Shi Y, Kang S, Franklin CL, Ericsson AC., Reduced housing density improves statistical power of murine gut microbiota studies, Cell Rep. 2022 May 10;39(6):110783. doi: 10.1016/j.celrep.2022.110783.

Creecy A, Smith C, Wallace JM., Dietary supplements do not improve bone morphology or mechanical properties in young female C57BL/6 mice, Sci Rep. 2022 Jun 13;12(1):9804. doi: 10.1038/s41598-022-14068-2.

Bourgery M, Ekholm E, Hiltunen A, Heino TJ, Pursiheimo JP, Bendre A, Yatkin E, Laitala T, Määttä J, Säämänen AM., Signature of circulating small non-coding RNAs during early fracture healing in mice, Bone Rep. 2022 Oct 18;17:101627. doi: 10.1016/j.bonr.2022.101627.

Genetically modified

Kohler, C., Dinekov, M., & Gotz, J. (2013)., Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice., Neurobiology of Aging, 34(5), 1369-1379. doi:10.1016/j.neurobiolaging.2012.11.010 [doi]

Ataca, D., Caikovski, M., Piersigilli, A., Moulin, A., Benarafa, C., Earp, S. E., . . . Brisken, C. (2016)., Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development, Biology Open, 5(11), 1585-1594. doi:10.1242/bio.019711 [doi]

Dawson, N., Kurihara, M., Thomson, D. M., Winchester, C. L., McVie, A., Hedde, J. R., . . . Pratt, J. A. (2015)., Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated disrupted-in-schizophrenia 1, Translational Psychiatry, 5, e569. doi:10.1038/tp.2015.60 [doi]

Nasser, A., Moller, L. B., Olesen, J. H., Konradsen, L. S., & Andreasen, J. T. (2014)., Anxiety- and depression-like phenotype of hph-1 mice deficient in tetrahydrobiopterin, Neuroscience Research, 89, 44-53. doi:10.1016/j.neures.2014.08.015 [doi]

Marino, M., Papa, S., Crippa, V., Nardo, G., Peviani, M., Cheroni, C., . . . Bendotti, C. (2015)., Differences in protein quality control correlate with phenotype variability in 2 mouse models of familial amyotrophic lateral sclerosis, Neurobiology of Aging, 36(1), 492-504. doi:10.1016/j.neurobiolaging.2014.06.026 [doi]

Grimm, C., Chavez, L., Vilardell, M., Farrall, A. L., Tierling, S., Bohm, J. W., . . . Morkel, M. (2013)., DNA-methylome analysis of mouse intestinal adenoma identifies a tumour-specific signature that is partly conserved in human colon cancer., PLoS Genetics, 9(2), e1003250. doi:10.1371/journal.pgen.1003250 [doi]

Dupont, C., Loos, F., Kong-A-San, J., & Gribnau, J. (2017)., FGF treatment of host embryos injected with ES cells increases rates of chimaerism., Transgenic Research, 26(2), 237-246. doi:10.1007/s11248-016-9997-6 [doi]

Zhou, Y. S., Ihmoda, I. A., Phelps, R. G., Bellamy, C. O., & Turner, A. N. (2015)., Following specific podocyte injury captopril protects against progressive long term renal damage., F1000research, 4, 172. doi:10.12688/f1000research.4030.1 [doi]

Munoz-Ballester, C., Berthier, A., Viana, R., & Sanz, P. (2016), Homeostasis of the astrocytic glutamate transporter GLT-1 is altered in mouse models of lafora disease, Biochimica Et Biophysica Acta, 1862(6), 1074-1083. doi:10.1016/j.bbadis.2016.03.008 [doi]

Fagnan A, Bagger FO, Piqué-Borràs MR, Ignacimouttou C, Caulier A, Lopez CK, Robert E, Uzan B, Gelsi-Boyer V, Aid Z, Thirant C, Moll U, Tauchmann S, Kurtovic-Kozaric A, Maciejewski J, Dierks C, Spinelli O, Salmoiraghi S, Pabst T, Shimoda K, Deleuze V, Lapillonne H, Sweeney C, De Mas V, Leite B, Kadri Z, Malinge S, de Botton S, Micol JB, Kile B, Carmichael CL, Iacobucci I, Mullighan CG, Carroll M, Valent P, Bernard OA, Delabesse E, Vyas P, Birnbaum D, Anguita E, Garçon L, Soler E, Schwaller J, Mercher T., Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers, Blood. 2020 Aug 6;136(6):698-714. doi: 10.1182/blood.2019003062.

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Voikar, V., Kulesskaya, N., Laakso, T., Lauren, J., Strittmatter, S. M., & Airaksinen, M. S. (2013), LRRTM1-deficient mice show a rare phenotype of avoiding small enclosures--a tentative mouse model for claustrophobia-like behaviour., Behavioural Brain Research, 238, 69-78. doi:10.1016/j.bbr.2012.10.013 [doi]

Shen, H., Hyrc, K. L., & Goldberg, M. P. (2013), Maintaining energy homeostasis is an essential component of wld(S)-mediated axon protection., Neurobiology of Disease, 59, 69-79. doi:10.1016/j.nbd.2013.07.007 [doi]

Salminen, A. V., Garrett, L., Schormair, B., Rozman, J., Giesert, F., Niedermeier, K. M., . . . Winkelmann, J. (2017)., Meis1: Effects on motor phenotypes and the sensorimotor system in mice., Disease Models & Mechanisms, 10(8), 981-991. doi:10.1242/dmm.030080 [doi]

Kondo, S., Bottos, A., Allegood, J. C., Masson, R., Maurer, F. G., Genoud, C., . . . Hynes, N. E. (2014)., Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development, PloS One, 9(4), e94114. doi:10.1371/journal.pone.0094114 [doi]

Frank, E., Wu, Y., Piyaratna, N., Body, W. J., Snikeris, P., South, T., . . . Huang, X. F. (2012)., Metabolic parameters and emotionality are little affected in G-protein coupled receptor 12 (Gpr12) mutant mice, PloS One, 7(8), e42395. doi:10.1371/journal.pone.0042395 [doi]

Pasetto, L., Olivari, D., Nardo, G., Trolese, M. C., Bendotti, C., Piccirillo, R., & Bonetto, V. (2018), Micro-computed tomography for non-invasive evaluation of muscle atrophy in mouse models of disease., PloS One, 13(5), e0198089. doi:10.1371/journal.pone.0198089 [doi]

Booth, C. A., Brown, J. T., & Randall, A. D. (2014)., Neurophysiological modification of CA1 pyramidal neurons in a transgenic mouse expressing a truncated form of disrupted-in-schizophrenia 1., The European Journal of Neuroscience, 39(7), 1074-1090. doi:10.1111/ejn.12549 [doi]

Mizrachi, T., Brill, L., Rabie, M., Nevo, Y., Fellig, Y., Zur, M., . . . Vaknin-Dembinsky, A. (2018)., NMO-IgG and AQP4 peptide can induce aggravation of EAMG and immune-mediated muscle weakness., Journal of Immunology Research, 2018, 5389282. doi:10.1155/2018/5389282 [doi]

Hellsten, K. S., Linden, A. M., & Korpi, E. R. (2015)., Paradoxical widespread c-fos expression induced by a GABA agonist in the forebrain of transgenic mice with ectopic expression of the GABA(A) alpha6 subunit., Neuroscience, 293, 123-135. doi:10.1016/j.neuroscience.2015.02.052 [doi]

Berthier, A., Paya, M., Garcia-Cabrero, A. M., Ballester, M. I., Heredia, M., Serratosa, J. M., . . . Sanz, P. (2015), Pharmacological interventions to ameliorate neuropathological symptoms in a mouse model of lafora disease, Molecular Neurobiology, doi:10.1007/s12035-015-9091-8 [doi]

Berthier, A., Paya, M., Garcia-Cabrero, A. M., Ballester, M. I., Heredia, M., Serratosa, J. M., . . . Sanz, P. (2016), Pharmacological interventions to ameliorate neuropathological symptoms in a mouse model of lafora disease., Molecular Neurobiology, 53(2), 1296-1309. doi:10.1007/s12035-015-9091-8 [doi]

Svarcbahs, Reinis; JĂ¤ntti, Maria; KilpelĂ¤inen, Tommi; Julku, Ulrika H; Urvas, Lauri; Kivioja, Saara; Norrbacka, Susanna; MyĂśhĂ¤nen, Timo T;, Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A, Pharmacological research Vol.151, 2019

Mahajan, V. S., Demissie, E., Mattoo, H., Viswanadham, V., Varki, A., Morris, R., & Pillai, S. (2016)., Striking immune phenotypes in gene-targeted mice are driven by a copy-number variant originating from a commercially available C57BL/6 strain., Cell Reports, 15(9), 1901-1909. doi:10.1016/j.celrep.2016.04.080 [doi]

Galliano, E., Potters, J. W., Elgersma, Y., Wisden, W., Kushner, S. A., De Zeeuw, C. I., & Hoebeek, F. E. (2013), Synaptic transmission and plasticity at inputs to murine cerebellar purkinje cells are largely dispensable for standard nonmotor tasks., The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 33(31), 12599-12618. doi:10.1523/JNEUROSCI.1642-13.2013 [doi]

Montero-Barrera, D., Valderrama-Carvajal, H., Terrazas, C. A., Rojas-Hernandez, S., Ledesma-Soto, Y., Vera-Arias, L., . . . Terrazas, L. I. (2015)., The macrophage galactose-type lectin-1 (MGL1) recognizes taenia crassiceps antigens, triggers intracellular signaling, and is critical for resistance to this infection., BioMed Research International, 2015, 615865. doi:10.1155/2015/615865 [doi]

Kool, M. J., van de Bree, J. E., Bodde, H. E., Elgersma, Y., & van Woerden, G. M. (2016)., The molecular, temporal and region-specific requirements of the beta isoform of Calcium/Calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion., Scientific Reports, 6, 26989. doi:10.1038/srep26989 [doi]

Aumailley, L., Roux-Dalvai, F., Kelly, I., Droit, A., & Lebel, M. (2018)., Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional werner syndrome (wrn) mutant protein., PloS One, 13(3), e0193170. doi:10.1371/journal.pone.0193170 [doi]

Martínez-Nieto G, Heljasvaara R, Heikkinen A, Kaski HK, Devarajan R, Rinne O, Henriksson C, Thomson E, von Hertzen C, Miinalainen I, Ruotsalainen H, Pihlajaniemi T, Karppinen SM., Deletion of Col15a1 Modulates the Tumour Extracellular Matrix and Leads to Increased Tumour Growth in the MMTV-PyMT Mouse Mammary Carcinoma Model, Int J Mol Sci. 2021 Sep 15;22(18):9978. doi: 10.3390/ijms22189978.

Zhou Y, Peskett TR, Landles C, Warner JB, Sathasivam K, Smith EJ, Chen S, Wetzel R, Lashuel HA, Bates GP, Saibil HR., Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease, Acta Neuropathol Commun. 2021 Apr 14;9(1):70. doi: 10.1186/s40478-021-01172-z.

Mukherjee D, Gonzales BJ, Ashwal-Fluss R, Turm H, Groysman M, Citri A., Egr2 induction in spiny projection neurons of the ventrolateral striatum contributes to cocaine place preference in mice, Elife. 2021 Mar 16;10:e65228. doi: 10.7554/eLife.65228.

Immunology

Kim, Sang-Soo; Harford, Joe B; Moghe, Manish; Slaughter, Tiffani; Doherty, Caroline; Chang, Esther H;, A tumor-targeting nanomedicine carrying the p53 gene crosses the blood-brain barrier and enhances anti-PD-1 immunotherapy in mouse models of glioblastoma., International journal of cancer Vol.145, 2019

Narra, H. P., Shubitz, L. F., Mandel, M. A., Trinh, H. T., Griffin, K., Buntzman, A. S., . . . Orbach, M. J. (2016)., A coccidioides posadasii CPS1 deletion mutant is avirulent and protects mice from lethal infection., Infection and Immunity, 84(10), 3007-3016. doi:10.1128/IAI.00633-16 [doi]

El-Kenawi, Asmaa; Gatenbee, Chandler; Robertson-Tessi, Mark; Bravo, Rafael; Dhillon, Jasreman; Balagurunathan, Yoganand; Berglund, Anders; Vishvakarma, Naveen; Ibrahim-Hashim, Arig; Choi, Jung; Luddy, Kimberly; Gatenby, Robert; Pilon-Thomas, Shari; Anderson, Alexander; Ruffell, Brian; Gillies, Robert, Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer., British journal of cancer Vol.121, 2019

Koutsoumpli, Georgia; Ip, Peng Peng; Schepel, Ilona; Hoogeboom, Baukje Nynke; Boerma, Annemarie; Daemen, Toos;, Alphavirus-based hepatitis C virus therapeutic vaccines: can universal helper epitopes enhance HCV-specific cytotoxic T lymphocyte responses?, Therapeutic advances in vaccines and immunotherapy Vol.7, 2019

Ip, P. P., Boerma, A., Regts, J., Meijerhof, T., Wilschut, J., Nijman, H. W., & Daemen, T. (2014)., Alphavirus-based vaccines encoding nonstructural proteins of hepatitis C virus induce robust and protective T-cell responses., Molecular Therapy : The Journal of the American Society of Gene Therapy, 22(4), 881-890. doi:10.1038/mt.2013.287 [doi]

Starkey Lewis P, Campana L, Aleksieva N, Cartwright JA, Mackinnon A, O'Duibhir E, Kendall T, Vermeren M, Thomson A, Gadd V, Dwyer B, Aird R, Man TY, Rossi AG, Forrester L, Park BK, Forbes SJ., Alternatively activated macrophages promote resolution of necrosis following acute liver injury, J Hepatol. 2020 Aug;73(2):349-360. doi: 10.1016/j.jhep.2020.02.031. Epub 2020 Mar 11.

Kolomansky A, Kaye I, Ben-Califa N, Gorodov A, Awida Z, Sadovnic O, Ibrahim M, Liron T, Hiram-Bab S, Oster HS, Sarid N, Perry C, Gabet Y, Mittelman M, Neumann D., Anti-CD20-Mediated B Cell Depletion Is Associated With Bone Preservation in Lymphoma Patients and Bone Mass Increase in Mice, Front Immunol. 2020 Oct 19;11:561294. doi: 10.3389/fimmu.2020.561294. eCollection 2020.

Ip, P. P., Boerma, A., Walczak, M., Oosterhuis, K., Haanen, J. B., Schumacher, T. N., . . . Daemen, T. (2015), Antigen design enhances the immunogenicity of semliki forest virus-based therapeutic human papillomavirus vaccines, Gene Therapy, 22(7), 560-567. doi:10.1038/gt.2015.24 [doi]

Le, T. T., Karmouty-Quintana, H., Melicoff, E., Le, T. T., Weng, T., Chen, N. Y., . . . Blackburn, M. R. (2014), Blockade of IL-6 trans signaling attenuates pulmonary fibrosis., Journal of Immunology (Baltimore, Md.: 1950), 193(7), 3755-3768. doi:10.4049/jimmunol.1302470 [doi]

Veiga-Parga, T., Gimenez, F., Mulik, S., Chiang, E. Y., Grogan, J. L., & Rouse, B. T. (2013)., Controlling herpetic stromal keratitis by modulating lymphotoxin-alpha-mediated inflammatory pathways., Microbes and Infection / Institut Pasteur, 15(10-11), 677-687. doi:10.1016/j.micinf.2013.07.001 [doi]

Curato, Caterina; Bernshtein, Biana; Zupancič , Eva; Dufner, Almut; Jaitin, Diego; Giladi, Amir; David, Eyal; Chappell-Maor, Louise; Leshkowitz, Dena; Knobeloch, Klaus-Peter; Amit, Ido; Florindo, Helena F; Jung, Steffen, DC Respond to Cognate T Cell Interaction in the Antigen-Challenged Lymph Node., Frontiers in immunology Vol.10, 2019

Travers, Meghan; Brown, Stephen M; Dunworth, Matthew; Holbert, Cassandra E; Wiehagen, Karla R; Bachman, Kurtis E; Foley, Jackson R; Stone, Meredith L; Baylin, Stephen B; Casero, Robert A; Zahnow, Cynthia A;, DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer., Cancer research Vol.79, 2019

Pujol Lopez, Y., Kenis, G., Stettinger, W., Neumeier, K., de Jonge, S., Steinbusch, H. W., . . . Myint, A. M. (2016)., Effects of prenatal poly I:C exposure on global histone deacetylase (HDAC) and DNA methyltransferase (DNMT) activity in the mouse brain., Molecular Biology Reports, 43(7), 711-717. doi:10.1007/s11033-016-4006-y [doi]

Spencer, A. J., Cottingham, M. G., Jenks, J. A., Longley, R. J., Capone, S., Colloca, S., . . . Hill, A. V. (2014)., Enhanced vaccine-induced CD8+ T cell responses to malaria antigen ME-TRAP by fusion to MHC class ii invariant chain., PloS One, 9(6), e100538. doi:10.1371/journal.pone.0100538 [doi]

Myhill LJ, Stolzenbach S, Mejer H, Jakobsen SR, Hansen TVA, Andersen D, Brix S, Hansen LH, Krych L, Nielsen DS, Nejsum P, Thamsborg SM, Williams AR., Fermentable Dietary Fiber Promotes Helminth Infection and Exacerbates Host Inflammatory Responses, J Immunol. 2020 Jun 1;204(11):3042-3055. doi: 10.4049/jimmunol.1901149. Epub 2020 Apr 13.

Timmermans, S., Bogie, J. F., Vanmierlo, T., Lutjohann, D., Stinissen, P., Hellings, N., & Hendriks, J. J. (2014)., High fat diet exacerbates neuroinflammation in an animal model of multiple sclerosis by activation of the renin angiotensin system., Journal of Neuroimmune Pharmacology : The Official Journal of the Society on NeuroImmune Pharmacology, 9(2), 209-217. doi:10.1007/s11481-013-9502-4 [doi]

Xiao, L., Leusink-Muis, T., Kettelarij, N., van Ark, I., Blijenberg, B., Hesen, N. A., . . . Van't Land, B. (2018)., Human milk oligosaccharide 2'-fucosyllactose improves innate and adaptive immunity in an influenza-specific murine vaccination model., Frontiers in Immunology, 9, 452. doi:10.3389/fimmu.2018.00452 [doi]

Joshi, Shrinidh; Wollenzien, Hannah; Leclerc, Estelle; Jarajapu, Yagna Pr;, Hypoxic regulation of angiotensin-converting enzyme 2 and Mas receptor in human CD34+ cells., Journal of cellular physiology Vol.234, 2019

Sharma-Chawla, Niharika; Stegemann-Koniszewski, Sabine; Christen, Henrike; Boehme, Julia D; Kershaw, Olivia; Schreiber, Jens; GuzmĂĄn, Carlos A; Bruder, Dunja; Hernandez-Vargas, Esteban A;, In vivo Neutralization of Pro-inflammatory Cytokines During Secondary Streptococcus pneumoniae Infection Post Influenza A Virus Infection., Frontiers in immunology Vol.10, 2019

Mastelic Gavillet, B., Eberhardt, C. S., Auderset, F., Castellino, F., Seubert, A., Tregoning, J. S., . . . Siegrist, C. A. (2015)., MF59 mediates its B cell adjuvanticity by promoting T follicular helper cells and thus germinal center responses in adult and early life., Journal of Immunology (Baltimore, Md.: 1950), 194(10), 4836-4845. doi:10.4049/jimmunol.1402071 [doi]

Insua, J. L., Llobet, E., Moranta, D., Perez-Gutierrez, C., Tomas, A., Garmendia, J., & Bengoechea, J. A. (2013)., Modeling klebsiella pneumoniae pathogenesis by infection of the wax moth galleria mellonella., Infection and Immunity, 81(10), 3552-3565. doi:10.1128/IAI.00391-13 [doi]

Dong, W., Bhide, Y., Marsman, S., Holtrop, M., Meijerhof, T., de Vries-Idema, J., . . . Huckriede, A. (2018)., Monophosphoryl lipid A-adjuvanted virosomes with ni-chelating lipids for attachment of conserved viral proteins as cross-protective influenza vaccine., Biotechnology Journal, 13(4), e1700645. doi:10.1002/biot.201700645 [doi]

Fenninger, Franz; Han, Jeffrey; Stanwood, Shawna R; Nohara, Lilian L; Arora, Hitesh; Choi, Kyung Bok; Munro, Lonna; Pfeifer, Cheryl G; Shanina, Iryna; Horwitz, Marc S; Jefferies, Wilfred A;, Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction., Frontiers in immunology Vol.10, 2019

Marín, María Q; Pérez, Patricia; Ljungberg, Karl; Sorzano, Carlos Óscar S; Gómez, Carmen E; Liljeström, Peter; Esteban, Mariano; García-Arriaza, Juan;, Potent Anti-hepatitis C Virus (HCV) T Cell Immune Responses Induced in Mice Vaccinated with DNA-Launched RNA Replicons and Modified Vaccinia Virus Ankara-HCV, Journal of virology Vol.93, 2019

Jaligama, S., Saravia, J., You, D., Yadav, N., Lee, G. I., Shrestha, B., & Cormier, S. A. (2017)., Regulatory T cells and IL10 suppress pulmonary host defense during early-life exposure to radical containing combustion derived ultrafine particulate matter., Respiratory Research, 18(1), 15-016-0487-4. doi:10.1186/s12931-016-0487-4 [doi]

Krueger, Caroline C; Thoms, Franziska; Keller, Elsbeth; Leoratti, Fabiana M S; Vogel, Monique; Bachmann, Martin F;, RNA and Toll-Like Receptor 7 License the Generation of Superior Secondary Plasma Cells at Multiple Levels in a B Cell Intrinsic Fashion, Frontiers in immunology Vol.10, 2019

March, C., Cano, V., Moranta, D., Llobet, E., Perez-Gutierrez, C., Tomas, J. M., . . . Bengoechea, J. A. (2013), Role of bacterial surface structures on the interaction of klebsiella pneumoniae with phagocytes, PloS One, 8(2), e56847. doi:10.1371/journal.pone.0056847 [doi]

Jensen, S. E., Illigen, K. E., Badsberg, J. H., & Haslov, K. R. (2012)., Specificity and detection limit of a dermal temperature histamine sensitization test for absence of residual pertussis toxin in vaccines., Biologicals : Journal of the International Association of Biological Standardization, 40(1), 36-40. doi:10.1016/j.biologicals.2011.09.015 [doi]

Yamamoto, Atsushi; Hester, Joanna; Macklin, Philip S; Kawai, Kento; Uchiyama, Masateru; Biggs, Daniel; Bishop, Tammie; Bull, Katherine; Cheng, Xiaotong; Cawthorne, Eleanor; Coleman, Mathew L; Crockford, Tanya L; Davies, Ben; Dow, Lukas E; Goldin, Rob; Kranc, Kamil; Kudo, Hiromi; Lawson, Hannah; McAuliffe, James; Milward, Kate; Scudamore, Cheryl L; Soilleux, Elizabeth; Issa, Fadi; Ratcliffe, Peter J; Pugh, Chris W;, Systemic silencing of PHD2 causes reversible immune regulatory dysfunction., The Journal of clinical investigation Vol.130, 2019

Tuku B, Stanelle-Bertram S, Sellau J, Beck S, Bai T, Kouassi NM, Preuß A, Hoenow S, Renné T, Lotter H, Gabriel G., Testosterone Protects Against Severe Influenza by Reducing the Pro-Inflammatory Cytokine Response in the Murine Lung, Front Immunol. 2020 Apr 22;11:697. doi: 10.3389/fimmu.2020.00697. eCollection 2020.

Worth AA, Shoop R, Tye K, Feetham CH, D'Agostino G, Dodd GT, Reimann F, Gribble FM, Beebe EC, Dunbar JD, Alexander-Chacko JT, Sindelar DK, Coskun T, Emmerson PJ, Luckman SM., The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling, Elife. 2020 Jul 29;9:e55164. doi: 10.7554/eLife.55164.

van Schaik, E. J., Case, E. D., Martinez, E., Bonazzi, M., & Samuel, J. E. (2017), The SCID mouse model for identifying virulence determinants in coxiella burnetii., Frontiers in Cellular and Infection Microbiology, 7, 25. doi:10.3389/fcimb.2017.00025 [doi]

Shipley FB, Dani N, Xu H, Deister C, Cui J, Head JP, Sadegh C, Fame RM, Shannon ML, Flores VI, Kishkovich T, Jang E, Klein EM, Goldey GJ, He K, Zhang Y, Holtzman MJ, Kirchhausen T, Wyart C, Moore CI, Andermann ML, Lehtinen MK., Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface, Neuron. 2020 Nov 25;108(4):623-639.e10. doi: 10.1016/j.neuron.2020.08.024. Epub 2020 Sep 21.

Detje, C. N., Lienenklaus, S., Chhatbar, C., Spanier, J., Prajeeth, C. K., Soldner, C., . . . Kalinke, U. (2015)., Upon intranasal vesicular stomatitis virus infection, astrocytes in the olfactory bulb are important interferon beta producers that protect from lethal encephalitis., Journal of Virology, 89(5), 2731-2738. doi:10.1128/JVI.02044-14 [doi]

Krueger, Caroline C; Thoms, Franziska; Keller, Elsbeth; Vogel, Monique; Bachmann, Martin F;, Virus-Specific Secondary Plasma Cells Produce Elevated Levels of High-Avidity Antibodies but Are Functionally Short Lived, Frontiers in immunology Vol.10, 2019

Cimica V, Williams S, Adams-Fish D, McMahon C, Narayanan A, Rashid S, Stedman TT., Zika Virus-Like Particle (VLP) vaccine displaying Envelope (E) protein CD loop antigen elicits protective and specific immune response in a murine model, Biochem Biophys Res Commun. 2020 Aug 27;529(3):805-811. doi: 10.1016/j.bbrc.2020.05.161. Epub 2020 Jul 20.

Efimova I, Steinberg I, Zvibel I, Neumann A, Mantelmacher DF, Drucker DJ, Fishman S, Varol C., GIPR Signaling in Immune Cells Maintains Metabolically Beneficial Type 2 Immune Responses in the White Fat From Obese Mice, Front Immunol. 2021 Feb 25;12:643144. doi: 10.3389/fimmu.2021.643144. eCollection 2021.

Ciurkiewicz M, Floess S, Beckstette M, Kummerfeld M, Baumgärtner W, Huehn J, Beineke A., Transcriptome analysis following neurotropic virus infection reveals faulty innate immunity and delayed antigen presentation in mice susceptible to virus-induced demyelination, Brain Pathol. 2021 Nov;31(6):e13000. doi: 10.1111/bpa.13000. Epub 2021 Jul 6.

Ayechu-Muruzabal V, Xiao L, Wehkamp T, van Ark I, Hoogendoorn EJ, Leusink-Muis T, Folkerts G, Garssen J, Willemsen LEM, Van't Land B., A Fermented Milk Matrix Containing Postbiotics Supports Th1- and Th17-Type Immunity In Vitro and Modulates the Influenza-Specific Vaccination Response In Vivo in Association with Altered Serum Galectin Ratios, Vaccines (Basel). 2021 Mar 13;9(3):254. doi: 10.3390/vaccines9030254.

Boelke M, Puff C, Becker K, Hellhammer F, Gusmag F, Marks H, Liebig K, Stiasny K, Dobler G, Baumgärtner W, Schulz C, Becker SC., Enteric Ganglioneuritis, a Common Feature in a Subcutaneous TBEV Murine Infection Model, Microorganisms. 2021 Apr 18;9(4):875. doi: 10.3390/microorganisms9040875.

Karimi MM, Guo Y, Cui X, Pallikonda HA, Horková V, Wang YF, Gil SR, Rodriguez-Esteban G, Robles-Rebollo I, Bruno L, Georgieva R, Patel B, Elliott J, Dore MH, Dauphars D, Krangel MS, Lenhard B, Heyn H, Fisher AG, t?pánek O, Merkenschlager M., The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus, Nat Commun. 2021 Jan 4;12(1):99. doi: 10.1038/s41467-020-20306-w.

Zhang C, Burch M, Wylie K, Herter B, Franklin CL, Ericsson AC., Characterization of the Eukaryotic Virome of Mice from Different Sources, Microorganisms. 2021 Sep 30;9(10):2064. doi: 10.3390/microorganisms9102064.

Sturmlechner I, Zhang C, Sine CC, van Deursen EJ, Jeganathan KB, Hamada N, Grasic J, Friedman D, Stutchman JT, Can I, Hamada M, Lim DY, Lee JH, Ordog T, Laberge RM, Shapiro V, Baker DJ, Li H, van Deursen JM., p21 produces a bioactive secretome that places stressed cells under immunosurveillance, Science. 2021 Oct 29;374(6567):eabb3420. doi: 10.1126/science.abb3420. Epub 2021 Oct 29.

Zhou J, Karshalev E, Mundaca-Uribe R, Esteban-Fernández de Ávila B, Krishnan N, Xiao C, Ventura CJ, Gong H, Zhang Q, Gao W, Fang RH, Wang J, Zhang L., Physical Disruption of Solid Tumors by Immunostimulatory Microrobots Enhances Antitumor Immunity, Adv Mater. 2021 Oct 2:e2103505. doi: 10.1002/adma.202103505. Online ahead of print.

Wedekind MF, Miller KE, Chen CY, Wang PY, Hutzen BJ, Currier MA, Nartker B, Roberts RD, Boon L, Conner J, LaHaye S, Kelly BJ, Gordon D, White P, Mardis ER, Cripe TP., Endogenous retrovirus envelope as a tumor-associated immunotherapeutic target in murine osteosarcoma, iScience. 2021 Jun 19;24(7):102759. doi: 10.1016/j.isci.2021.102759. eCollection 2021 Jul 23.

Fatima N, Patel S, Hussain T., Angiotensin AT2 Receptor is Anti-inflammatory and Reno-Protective in Lipopolysaccharide Mice Model: Role of IL-10, Front Pharmacol. 2021 Apr 15;12:600163. doi: 10.3389/fphar.2021.600163. eCollection 2021.

Ursic K, Kos S, Kamensek U, Cemazar M, Miceska S, Markelc B, Bucek S, Staresinic B, Kloboves Prevodnik V, Heller R, Sersa G., Potentiation of electrochemotherapy effectiveness by immunostimulation with IL-12 gene electrotransfer in mice is dependent on tumor immune status, J Control Release. 2021 Apr 10;332:623-635. doi: 10.1016/j.jconrel.2021.03.009. Epub 2021 Mar 8.

Serrano-Lopez J, Hegde S, Kumar S, Serrano J, Fang J, Wellendorf AM, Roche PA, Rangel Y, Carrington LJ, Geiger H, Grimes HL, Luther S, Maillard I, Sanchez-Garcia J, Starczynowski DT, Cancelas JA., Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics, Elife. 2021 Apr 8;10:e66190. doi: 10.7554/eLife.66190.

Molla B, Heredia M, Sanz P., Modulators of Neuroinflammation Have a Beneficial Effect in a Lafora Disease Mouse Model., Mol Neurobiol. 2021 Jun;58(6):2508-2522. doi: 10.1007/s12035-021-02285-1. Epub 2021 Jan 14.

Arsiwala T, Vogt AS, Barton AE, Manolova V, Funk F, Flühmann B, Bachmann MF., Kupffer Cells and Blood Monocytes Orchestrate the Clearance of Iron-Carbohydrate Nanoparticles from Serum, null

Lacorcia M, Kugyelka R, Spechtenhauser L, Prodjinotho UF, Hamway Y, Spangenberg T, da Costa CP., Praziquantel Reduces Maternal Mortality and Offspring Morbidity by Enhancing Anti-Helminthic Immune Responses, Front Immunol. 2022 Jun 27;13:878029. doi: 10.3389/fimmu.2022.878029. eCollection 2022.

Zhang X, Kracht L, Lerario AM, Dubbelaar ML, Brouwer N, Wesseling EM, Boddeke EWGM, Eggen BJL, Kooistra SM., Epigenetic regulation of innate immune memory in microglia, J Neuroinflammation. 2022 May 14;19(1):111. doi: 10.1186/s12974-022-02463-5.

Ushach I, Zhu R, Rosler E, Pandey RK, De Costa NTS, Pourshahian S, Han Q, Li C, Beigelman L, Gryaznov SM, Yun T., Targeting TLR9 agonists to secondary lymphoid organs induces potent immune responses against HBV infection, Mol Ther Nucleic Acids. 2022 Feb 1;27:1103-1115. doi: 10.1016/j.omtn.2022.01.020. eCollection 2022 Mar 8.

van Loon K, Huijbers EJM, de Haan JD, Griffioen AW., Cancer Vaccination against Extracellular Vimentin Efficiently Adjuvanted with Montanide ISA 720/CpG, Cancers (Basel). 2022 May 24;14(11):2593. doi: 10.3390/cancers14112593.

Edo Á, Calvo-Barreiro L, Eixarch H, Bosch A, Chillón M, Espejo C., Therapeutic Effect of IL-21 Blockage by Gene Therapy in Experimental Autoimmune Encephalomyelitis, Neurotherapeutics. 2022 Sep;19(5):1617-1633. doi: 10.1007/s13311-022-01279-8. Epub 2022 Jul 28.

Zhu L, Myhill LJ, Andersen-Civil AIS, Thamsborg SM, Blanchard A, Williams AR., Garlic-Derived Organosulfur Compounds Regulate Metabolic and Immune Pathways in Macrophages and Attenuate Intestinal Inflammation in Mice, Mol Nutr Food Res. 2022 Apr;66(7):e2101004. doi: 10.1002/mnfr.202101004. Epub 2022 Mar 7.

Infectious disease

Singh V, Beer A, Kraus A, et al., Stroke increases the expression of ACE2, the SARS-CoV-2 binding receptor, in murine lungs, bioRxiv 2020.06.24.162941; doi: https://doi.org/10.1101/2020.06.24.162941

Neuroscience

Myohanen, T. T., Hannula, M. J., Van Elzen, R., Gerard, M., Van Der Veken, P., Garcia-Horsman, J. A., . . . Lambeir, A. M. (2012), A prolyl oligopeptidase inhibitor, KYP-2047, reduces alpha-synuclein protein levels and aggregates in cellular and animal models of parkinson's disease., British Journal of Pharmacology, 166(3), 1097-1113. doi:10.1111/j.1476-5381.2012.01846.x [doi]

Myohanen, T.T., M.J. Hannula, R. Van Elzen, M. Gerard, P. Van Der Veken, J.A. Garcia-Horsman, V. Baekelandt, P.T. Mannisto, and A.M. Lambeir. 2012., A prolyl oligopeptidase inhibitor, KYP-2047, reduces alpha-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease., Br.J.Pharmacol. 166:1097-1113.

Van Zandt, M; Weiss, E; Almyasheva, A; Lipior, S; Maisel, S; Naegele, J R;, Adeno-associated viral overexpression of neuroligin 2 in the mouse hippocampus enhances GABAergic synapses and impairs hippocampal-dependent behaviors., Behavioural brain research Vol.362, 2019

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de Groot, M. W., Dingemans, M. M., Rus, K. H., de Groot, A., & Westerink, R. H. (2014)., Characterization of calcium responses and electrical activity in differentiating mouse neural progenitor cells in vitro, Toxicological Sciences : An Official Journal of the Society of Toxicology, 137(2), 428-435. doi:10.1093/toxsci/kft261 [doi]

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Forsgard, R. A., Korpela, R., Stenman, L. K., Osterlund, P., & Holma, R. (2014), Deoxycholic acid induced changes in electrophysiological parameters and macromolecular permeability in murine small intestine with and without functional enteric nervous system plexuses., Neurogastroenterology and Motility : The Official Journal of the European Gastrointestinal Motility Society, 26(8), 1179-1187. doi:10.1111/nmo.12383 [doi]

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Gorberg V, McCaffery P, Anavi-Goffer S., Different responses of repetitive behaviours in juvenile and young adult mice to Î9âtetrahydrocannabinol and cannabidiol may affect decision making for Tourette syndrome, Br J Pharmacol. 2021 Feb;178(3):614-625. doi: 10.1111/bph.15302. Epub 2020 Dec 2.

Wiebelhaus, J. M., Vunck, S. A., Meltzer, H. Y., & Porter, J. H. (2012)., Discriminative stimulus properties of N-desmethylclozapine, the major active metabolite of the atypical antipsychotic clozapine, in C57BL/6 mice., Behavioural Pharmacology, 23(3), 262-270. doi:10.1097/FBP.0b013e3283534332 [doi]

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Schulz, Jan M; Knoflach, Frederic; Hernandez, Maria-Clemencia; Bischofberger, Josef; Enhanced Dendritic Inhibition and Impaired NMDAR Activation in a Mouse Model of Down Syndrome, Enhanced Dendritic Inhibition and Impaired NMDAR Activation in a Mouse Model of Down Syndrome., The Journal of neuroscience : the official journal of the Society for Neuroscience Vol.39, 2019

Su, C., Sun, F., Cunningham, R. L., Rybalchenko, N., & Singh, M. (2014), ERK5/KLF4 signaling as a common mediator of the neuroprotective effects of both nerve growth factor and hydrogen peroxide preconditioning., Age (Dordrecht, Netherlands), 36(4), 9685-014-9685-5. Epub 2014 Jul 12. doi:10.1007/s11357-014-9685-5 [doi]

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Eakin, K., Y. Li, Y.H. Chiang, B.J. Hoffer, H. Rosenheim, N.H. Greig, and J.P. Miller. 2013., Exendin-4 ameliorates traumatic brain injury-induced cognitive impairment in rats., PLoS One. 8:e82016.

Masullo, Laura; Mariotti, Letizia; Alexandre, Nicolas; Freire-Pritchett, Paula; Boulanger, Jerome; Tripodi, Marco;, Genetically Defined Functional Modules for Spatial Orienting in the Mouse Superior Colliculus, Current biology : CB Vol.29, 2019

Polenghi A, Nieus T, Guazzi S, Gorostiza P, Petrini EM, Barberis A., Kainate Receptor Activation Shapes Short-Term Synaptic Plasticity by Controlling Receptor Lateral Mobility at Glutamatergic Synapses, Cell Rep. 2020 Jun 9;31(10):107735. doi: 10.1016/j.celrep.2020.107735.

Stepien BK, Naumann R, Holtz A, Helppi J, Huttner WB, Vaid S., Lengthening Neurogenic Period during Neocortical Development Causes a Hallmark of Neocortex Expansion, Curr Biol. 2020 Nov 2;30(21):4227-4237.e5. doi: 10.1016/j.cub.2020.08.046. Epub 2020 Sep 3.

Schaafsma, W., Zhang, X., van Zomeren, K. C., Jacobs, S., Georgieva, P. B., Wolf, S. A., . . . Eggen, B. J. (2015)., Long-lasting pro-inflammatory suppression of microglia by LPS-preconditioning is mediated by RelB-dependent epigenetic silencing., Brain, Behavior, and Immunity, 48, 205-221. doi:10.1016/j.bbi.2015.03.013 [doi]

Pakarinen E, Danilova T, VĂľikar V, Chmielarz P, Piepponen P, Airavaara M, Saarma M, Lindahl M., MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System, eNeuro. 2020 Feb 19;7(1):ENEURO.0477-19.2019. doi: 10.1523/ENEURO.0477-19.2019. Print 2020 Jan/Feb.

Evans, C., Cook, S. J., Coleman, M. P., & Gilley, J. (2013), MEK inhibitor U0126 reverses protection of axons from wallerian degeneration independently of MEK-ERK signaling., PloS One, 8(10), e76505. doi:10.1371/journal.pone.0076505 [doi]

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Janecek, E., E. Wilk, K. Schughart, R. Geffers, and C. Strube. 2015., Microarray gene expression analysis reveals major differences between Toxocara canis and Toxocara cati neurotoxocarosis and involvement of T. canis in lipid biosynthetic processes., Int.J.Parasitol. 45:495-503.

Janecek, E., Wilk, E., Schughart, K., Geffers, R., & Strube, C. (2015)., Microarray gene expression analysis reveals major differences between toxocara canis and toxocara cati neurotoxocarosis and involvement of T.canis in lipid biosynthetic processes., International Journal for Parasitology, 45(7), 495-503. doi:10.1016/j.ijpara.2015.02.009 [doi]

Loeffler T, Schilcher I, Flunkert S, Hutter-Paier B., Neurofilament-Light Chain as Biomarker of Neurodegenerative and Rare Diseases With High Translational Value, Front Neurosci. 2020 Jun 11;14:579. doi: 10.3389/fnins.2020.00579. eCollection 2020.

Palencia, G., Garcia, E., Osorio-Rico, L., Trejo-Solis, C., Escamilla-Ramirez, A., & Sotelo, J. (2015)., Neuroprotective effect of thalidomide on MPTP-induced toxicity., Neurotoxicology, 47, 82-87. doi:10.1016/j.neuro.2015.02.004 [doi]

Markova L, Umek N, Horvat S, Hadžić A, Kuroda M, Pintarič TS, Mrak V, Cvetko E., Neurotoxicity of bupivacaine and liposome bupivacaine after sciatic nerve block in healthy and streptozotocin-induced diabetic mice, BMC Vet Res. 2020 Jul 17;16(1):247. doi: 10.1186/s12917-020-02459-4.

Heuer, L., Beyerbach, M., Luhder, F., Beineke, A., & Strube, C. (2015)., Neurotoxocarosis alters myelin protein gene transcription and expression, Parasitology Research, 114(6), 2175-2186. doi:10.1007/s00436-015-4407-1 [doi]

Heuer, L., M. Beyerbach, F. Luhder, A. Beineke, and C. Strube. 2015., Neurotoxocarosis alters myelin protein gene transcription and expression., Parasitol.Res. 114:2175-2186.

Janecek, E., Beineke, A., Schnieder, T., & Strube, C. (2014)., Neurotoxocarosis: Marked preference of toxocara canis for the cerebrum and T. cati for the cerebellum in the paratenic model host mouse, Parasites & Vectors, 7, 194-3305-7-194. doi:10.1186/1756-3305-7-194 [doi]

Janecek, E., A. Beineke, T. Schnieder, and C. Strube. 2014., Neurotoxocarosis: marked preference of Toxocara canis for the cerebrum and T. cati for the cerebellum in the paratenic model host mouse., Parasit.Vectors. 7:194-3305-7-194.

Adalbert, Robert; Kaieda, Akira; Antoniou, Christina; Loreto, Andrea; Yang, Xiuna; Gilley, Jonathan; Hoshino, Takashi; Uga, Keiko; Makhija, Mahindra T; Coleman, Michael P;, Novel HDAC6 Inhibitors Increase Tubulin Acetylation and Rescue Axonal Transport of Mitochondria in a Model of Charcot-Marie-Tooth Type 2F, ACS chemical neuroscience Vol., 2020

Bidinosti, M., Shimshek, D. R., Mollenhauer, B., Marcellin, D., Schweizer, T., Lotz, G. P., . . . Weiss, A. (2012)., Novel one-step immunoassays to quantify alpha-synuclein: Applications for biomarker development and high-throughput screening., The Journal of Biological Chemistry, 287(40), 33691-33705. doi:M112.379792 [pii]

Malik, B., Fernandes, C., Killick, R., Wroe, R., Usardi, A., Williamson, R., . . . Reynolds, C. H. (2012)., Oligomeric amyloid-beta peptide affects the expression of genes involved in steroid and lipid metabolism in primary neurons., Neurochemistry International, 61(3), 321-333. doi:10.1016/j.neuint.2012.05.006 [doi]

Arshad MN, Aaron GB, Naegele JR., Optogenetic Interrogation of ChR2-Expressing GABAergic Interneurons After Transplantation into the Mouse Brain, Methods Mol Biol. 2021;2191:235-259. doi: 10.1007/978-1-0716-0830-2_15.

Gervois, Pascal; Ratajczak, Jessica; Wolfs, Esther; Vangansewinkel, Tim; Dillen, YĂśrg; Merckx, Greet; Bronckaers, Annelies; Lambrichts, Ivo, Preconditioning of Human Dental Pulp Stem Cells with Leukocyte- and Platelet-Rich Fibrin-Derived Factors Does Not Enhance Their Neuroregenerative Effect., Stem cells international Vol.2019, 2019

Bistaffa, Edoardo; Rossi, Martina; De Luca, Chiara Maria Giulia; Cazzaniga, Federico; Carletta, Olga; Campagnani, Ilaria; Tagliavini, Fabrizio; Legname, Giuseppe; Giaccone, Giorgio; Moda, Fabio;, Prion Efficiently Replicates in ?-Synuclein Knockout Mice., Molecular neurobiology Vol.56, 2019

Svarcbahs R, Jäntti M, Kilpeläinen T, Julku UH, Urvas L, Kivioja S, Norrbacka S, Myöhänen TT., Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A, Pharmacol Res. 2020 Jan;151:104558. doi: 10.1016/j.phrs.2019.104558. Epub 2019 Nov 20.

Cabañero D, amírez-López A, Drews E, Schmöle A, Otte DM, Wawrzczak-Bargiela A, Huerga Encabo H, Kummer S, Ferrer-Montiel A, Przewlocki R, Zimmer A, Maldonado R., Protective role of neuronal and lymphoid cannabinoid CB(2) receptors in neuropathic pain, Elife. 2020 Jul 20;9:e55582. doi: 10.7554/eLife.55582.

Gupta, Jyoti; Bromwich, Mark; Radell, Jake; Arshad, Muhammad N; Gonzalez, Selena; Luikart, Bryan W; Aaron, Gloster B; Naegele, Janice R;, Restrained Dendritic Growth of Adult-Born Granule Cells Innervated by Transplanted Fetal GABAergic Interneurons in Mice with Temporal Lobe Epilepsy, eNeuro Vol.6,

Gothelf, Y., Abramov, N., Harel, A., & Offen, D. (2014)., Safety of repeated transplantations of neurotrophic factors-secreting human mesenchymal stromal stem cells., Clinical and Translational Medicine, 3, 21-1326-3-21. eCollection 2014. doi:10.1186/2001-1326-3-21 [doi]

Kros, L., Lindeman, S., Eelkman Rooda, O. H. J., Murugesan, P., Bina, L., Bosman, L. W. J., . . . Hoebeek, F. E. (2017)., Synchronicity and rhythmicity of purkinje cell firing during generalized spike-and-wave discharges in a natural mouse model of absence epilepsy., Frontiers in Cellular Neuroscience, 11, 346. doi:10.3389/fncel.2017.00346 [doi]

Di Lieto, A., Rantamaki, T., Vesa, L., Yanpallewar, S., Antila, H., Lindholm, J., . . . Castren, E. (2012)., The responsiveness of TrkB to BDNF and antidepressant drugs is differentially regulated during mouse development., PloS One, 7(3), e32869. doi:10.1371/journal.pone.0032869 [doi]

Di Lieto, A., T. Rantamaki, L. Vesa, S. Yanpallewar, H. Antila, J. Lindholm, M. Rios, L. Tessarollo, and E. Castren. 2012., The responsiveness of TrkB to BDNF and antidepressant drugs is differentially regulated during mouse development., PLoS One. 7:e32869.

Kostic, Milos; Paridaen, Judith T M L; Long, Katherine R; Kalebic, Nereo; Langen, Barbara; GrĂźbling, Nannette; Wimberger, Pauline; Kawasaki, Hiroshi; Namba, Takashi; Huttner, Wieland B, YAP Activity Is Necessary and Sufficient for Basal Progenitor Abundance and Proliferation in the Developing Neocortex., Cell reports Vol.27, 2019

Spaas J, Franssen WMA, Keytsman C, Blancquaert L, Vanmierlo T, Bogie J, Broux B, Hellings N, van Horssen J, Posa DK, Hoetker D, Baba SP, Derave W, Eijnde BO., Carnosine quenches the reactive carbonyl acrolein in the central nervous system and attenuates autoimmune neuroinflammation, J Neuroinflammation. 2021 Nov 5;18(1):255. doi: 10.1186/s12974-021-02306-9.

Berlamont H, Bruggeman A, Bauwens E, Vandendriessche C, Clarebout E, Xie J, De Bruyckere S, Van Imschoot G, Van Wonterghem E, Ducatelle R, Santens P, Smet A, Haesebrouck F, Vandenbroucke RE., Gastric Helicobacter suis Infection Partially Protects against Neurotoxicity in A 6-OHDA Parkinson's Disease Mouse Model, Int J Mol Sci. 2021 Oct 20;22(21):11328. doi: 10.3390/ijms222111328.

Nguyen VTT, Sallbach J, Dos Santos Guilherme M, Endres K., Influence of Acetylcholine Esterase Inhibitors and Memantine, Clinically Approved for Alzheimer's Dementia Treatment, on Intestinal Properties of the Mouse, Int J Mol Sci. 2021 Jan 20;22(3):1015. doi: 10.3390/ijms22031015.

Spaas J, Van Noten P, Keytsman C, Nieste I, Blancquaert L, Derave W, Eijnde BO., Carnosine and skeletal muscle dysfunction in a rodent multiple sclerosis model, Amino Acids. 2021 Nov;53(11):1749-1761. doi: 10.1007/s00726-021-03086-5. Epub 2021 Oct 12.

Thomson CS, Pundavela J, Perrino MR, Coover RA, Choi K, Chaney KE, Rizvi TA, Largaespada DA, Ratner N., WNT5A inhibition alters the malignant peripheral nerve sheath tumor microenvironment and enhances tumor growth, Oncogene. 2021 Jun;40(24):4229-4241. doi: 10.1038/s41388-021-01773-x. Epub 2021 Jun 2.

Ichwan M, Walker TL, Nicola Z, Ludwig-Müller J, Böttcher C, Overall RW, Adusumilli VS, Bulut M, Sykes AM, Hübner N, Ramirez-Rodriguez G, Ortiz-López L, Lugo-Hernández EA, Kempermann G., Apple Peel and Flesh Contain Pro-neurogenic Compounds, Stem Cell Reports. 2021 Mar 9;16(3):548-565. doi: 10.1016/j.stemcr.2021.01.005. Epub 2021 Feb 11.

Shumate KM, Tas ST, Kavalali ET, Emeson RB., RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission, J Neurochem. 2021 Jul;158(2):182-196. doi: 10.1111/jnc.15372. Epub 2021 May 28.

Mahn M, Saraf-Sinik I, Patil P, Pulin M, Bitton E, Karalis N, Bruentgens F, Palgi S, Gat A, Dine J, Wietek J, Davidi I, Levy R, Litvin A, Zhou F, Sauter K, Soba P, Schmitz D, Lüthi A, Rost BR, Wiegert JS, Yizhar O., Efficient optogenetic silencing of neurotransmitter release with a mosquito rhodopsin, Neuron. 2021 May 19;109(10):1621-1635.e8. doi: 10.1016/j.neuron.2021.03.013. Epub 2021 May 11.

Taylor ZV, Khand B, Porgador A, Monsonego A, Eremenko E., An optimized intracerebroventricular injection of CD4(+) TA cells into mice., STAR Protoc. 2021 Aug 6;2(3):100725. doi: 10.1016/j.xpro.2021.100725. eCollection 2021 Sep 17.

Schroeder S, Hofer SJ, Zimmermann A, Pechlaner R, Dammbrueck C, Pendl T, Marcello GM, Pogatschnigg V, Bergmann M, MĂźller M, Gschiel V, Ristic S, Tadic J, Iwata K, Richter G, Farzi A, ĂĂ§al M, SchĂ¤fer U, Poglitsch M, Royer P, Mekis R, Agreiter M, et al., Dietary spermidine improves cognitive function., Cell Rep. 2021 Apr 13;35(2):108985. doi: 10.1016/j.celrep.2021.108985.

Fustinana MS, et al., State-dependent encoding of exploratory behaviour in the amygdala., Nature. 2021 Apr;592(7853):267-271. doi: 10.1038/s41586-021-03301-z. Epub 2021 Mar 3.

Marshall P, Garton DR, Taira T, Võikar V, Vilenius C, Kulesskaya N, Rivera C, Andressoo JO., Elevated expression of endogenous glial cell line-derived neurotrophic factor impairs spatial memory performance and raises inhibitory tone in the hippocampus., Eur J Neurosci. 2021 Apr;53(8):2469-2482. doi: 10.1111/ejn.15126. Epub 2021 Feb 23.

Bansal R, Nagel M, Stopkova R, Sofer Y, Kimchi T, Stopka P, Spehr M, Ben-Shaul Y., Do all mice smell the same? Chemosensory cues from inbred and wild mouse strains elicit stereotypic sensory representations in the accessory olfactory bulb., BMC Biol. 2021 Jun 28;19(1):133. doi: 10.1186/s12915-021-01064-7.

Steffens SK, Stenberg TH, Wigren HM., Alterations in microglial morphology concentrate in the habitual sleeping period of the mouse, null

Cordaro M, D'Amico R, Fusco R, Genovese T, Peritore AF, Gugliandolo E, Crupi R, Di Paola D, Interdonato L, Impellizzeri D, Cuzzocrea S, Di Paola R, Siracusa R., Actaea racemosa L. Rhizome Protect against MPTP-Induced Neurotoxicity in Mice by Modulating Oxidative Stress and Neuroinflammation, Antioxidants (Basel). 2022 Dec 25;12(1):40. doi: 10.3390/antiox12010040.

Zloto O, Zahavi A, Richard S, Friedman-Gohas M, Weiss S, Goldenberg-Cohen N., Neuroprotective Effect of Azithromycin Following Induction of Optic Nerve Crush in Wild Type and Immunodeficient Mice, Int J Mol Sci. 2022 Oct 6;23(19):11872. doi: 10.3390/ijms231911872.

D'Amico R, Impellizzeri D, Genovese T, Fusco R, Peritore AF, Crupi R, Interdonato L, Franco G, Marino Y, Arangia A, Gugliandolo E, Cuzzocrea S, Di Paola R, Siracusa R, Cordaro M., Açai Berry Mitigates Parkinson's Disease Progression Showing Dopaminergic Neuroprotection via Nrf2-HO1 Pathways, Mol Neurobiol. 2022 Oct;59(10):6519-6533. doi: 10.1007/s12035-022-02982-5. Epub 2022 Aug 15.

Yoles-Frenkel M, Shea SD, Davison IG, Ben-Shaul Y., The Bruce effect: Representational stability and memory formation in the accessory olfactory bulb of the female mouse, Cell Rep. 2022 Aug 23;40(8):111262. doi: 10.1016/j.celrep.2022.111262.

Drummond SE, Burns DP, Maghrani SE, Ziegler O, Healy V, O'Halloran KD., NADPH oxidase 2 is necessary for chronic intermittent hypoxia-induced sternohyoid muscle weakness in adult male mice, Exp Physiol. 2022 Aug;107(8):946-964. doi: 10.1113/EP090536. Epub 2022 Jul 11.

Arshad MN, Oppenheimer S, Jeong J, Buyukdemirtas B, Naegele JR., Hippocampal transplants of fetal GABAergic progenitors regulate adult neurogenesis in mice with temporal lobe epilepsy., Neurobiol Dis. 2022 Nov;174:105879. doi: 10.1016/j.nbd.2022.105879. Epub 2022 Sep 29.

Montaser AB, Kuiri J, Natunen T, Hruška P, Potěšil D, Auriola S, Hiltunen M, Terasaki T, Lehtonen M, Jalkanen A, Huttunen KM., Enhanced drug delivery by a prodrug approach effectively relieves neuroinflammation in mice, Life Sci. 2022 Dec 1;310:121088. doi: 10.1016/j.lfs.2022.121088. Epub 2022 Oct 17.

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Klazas M, Naamneh MS, Zheng W, Lazarovici P., Gabapentin Increases Intra-Epidermal and Peptidergic Nerve Fibers Density and Alleviates Allodynia and Thermal Hyperalgesia in a Mouse Model of Acute Taxol-Induced Peripheral Neuropath, Biomedicines. 2022 Dec 8;10(12):3190. doi: 10.3390/biomedicines10123190.

Oncology

Healy, M. E., Chow, J. D., Byrne, F. L., Breen, D. S., Leitinger, N., Li, C., . . . Hoehn, K. L. (2015)., Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine., Journal of Hepatology, 62(3), 599-606. doi:10.1016/j.jhep.2014.10.024 [doi]

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Bransi, A., Salgado, O. C., Beffinger, M., Milo, K., Silina, K., Yagita, H., . . . van den Broek, M. (2015)., Rational combination of immunotherapies with clinical efficacy in mice with advanced cancer., Cancer Immunology Research, 3(11), 1279-1288. doi:10.1158/2326-6066.CIR-15-0103-T [doi]

Barrett, J. A., Cai, H., Miao, J., Khare, P. D., Gonzalez, P., Dalsing-Hernandez, J., . . . Lebel, F. (2018)., Regulated intratumoral expression of IL-12 using a RheoSwitch therapeutic system((R)) (RTS((R))) gene switch as gene therapy for the treatment of glioma., Cancer Gene Therapy, 25(5-6), 106-116. doi:10.1038/s41417-018-0019-0 [doi]

Suckow, M. A., Wolter, W. R., & Duffield, G. E. (2017)., The impact of environmental light intensity on experimental tumor growth., Anticancer Research, 37(9), 4967-4971. doi:37/9/4967 [pii]

Patel, A., Anderson, J., Kraft, D., Finnon, R., Finnon, P., Scudamore, C. L., . . . Badie, C. (2016), The influence of the CTIP polymorphism, Q418P, on homologous recombination and predisposition to radiation-induced tumorigenesis (mainly rAML) in mice., Radiation Research, 186(6), 638-649. doi:10.1667/RR14495.1 [doi]

Brighenti, E., Giannone, F. A., Fornari, F., Onofrillo, C., Govoni, M., Montanaro, L., . . . Derenzini, M. (2016)., Therapeutic dosages of aspirin counteract the IL-6 induced pro-tumorigenic effects by slowing down the ribosome biogenesis rate., Oncotarget, 7(39), 63226-63241. doi:10.18632/oncotarget.11441 [doi]

O'Rourke, K. P., Loizou, E., Livshits, G., Schatoff, E. M., Baslan, T., Manchado, E., . . . Lowe, S. W. (2017)., Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer., Nature Biotechnology, 35(6), 577-582. doi:10.1038/nbt.3837 [doi]

Hutton C, Heider F, Blanco-Gomez A, Banyard A, Kononov A, Zhang X, Karim S, Paulus-Hock V, Watt D, Steele N, Kemp S, Hogg EKJ, Kelly J, Jackstadt RF, Lopes F, Menotti M, Chisholm L, Lamarca A, Valle J, Sansom OJ, Springer C, Malliri A, Marais R, Pasca di Magliano M, Zelenay S, Morton JP, Jřrgensen C., Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity, Cancer Cell. 2021 Sep 13;39(9):1227-1244.e20. doi: 10.1016/j.ccell.2021.06.017. Epub 2021 Jul 22.

Douguet L, Janho Dit Hreich S, Benzaquen J, Seguin L, Juhel T, Dezitter X, Duranton C, Ryffel B, Kanellopoulos J, Delarasse C, Renault N, Furman C, Homerin G, Féral C, Cherfils-Vicini J, Millet R, Adriouch S, Ghinet A, Hofman P, Vouret-Craviari V., A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy, Nat Commun. 2021 Jan 28;12(1):653. doi: 10.1038/s41467-021-20912-2.

Luna Yolba R, Visentin V, Hervé C, Chiche J, Ricci JE, Méneyrol J, Paillasse MR, Alet N., EVT-701 is a novel selective and safe mitochondrial complex 1 inhibitor with potent anti-tumor activity in models of solid cancers, Pharmacol Res Perspect. 2021 Oct;9(5):e00854. doi: 10.1002/prp2.854.

Cervera-Carrascon V, Quixabeira DCA, Santos JM, Havunen R, Milenova I, Verhoeff J, Heiniö C, Zafar S, Garcia-Vallejo JJ, van Beusechem VW, de Gruijl TD, Kalervo A, Sorsa S, Kanerva A, Hemminki A., Adenovirus Armed With TNFa and IL2 Added to aPD-1 Regimen Mediates Antitumor Efficacy in Tumors Refractory to aPD-1, Front Immunol. 2021 Jul 23;12:706517. doi: 10.3389/fimmu.2021.706517. eCollection 2021.

Sheinboim D, Parikh S, Manich P, Markus I, Dahan S, Parikh R, Stubbs E, Cohen G, Zemser-Werner V, Bell RE, Ruiz SA, Percik R, Brenner R, Leibou S, Vaknine H, Arad G, Gerber Y, Keinan-Boker L, Shimony T, Bikovski L, Goldstein N, Constantini K, Labes S, Mordechai S, Doron H, Lonescu A, Ziv T, Nizri E, Choshen G, Eldar-Finkelman H, Tabach Y, Helman A, Ben-Eliyahu S, Erez N, Perlson E, Geiger T, Ben-Zvi D, Khaled M, Gepner Y, Levy C., An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination, null

Sharp PS, Stylianou M, Arellano LM, Neves JC, Gravagnuolo AM, Dodd A, Barr K, Lozano N, Kisby T, Kostarelos K., Graphene Oxide Nanoscale Platform Enhances the Anti-Cancer Properties of Bortezomib in Glioblastoma Models, Adv Healthc Mater. 2023 Jan;12(3):e2201968. doi: 10.1002/adhm.202201968. Epub 2022 Nov 11.

Meraviglia-Crivelli D, Villanueva H, Zheleva A, Villalba-Esparza M, Moreno B, Menon AP, Calvo A, Cebollero J, Barainka M, de Los Mozos IR, Huesa-Berral C, Pastor F., IL-6/STAT3 signaling in tumor cells restricts the expression of frameshift-derived neoantigens by SMG1 induction, Mol Cancer. 2022 Nov 28;21(1):211. doi: 10.1186/s12943-022-01679-6.

Meraviglia-Crivelli D, Villanueva H, Menon AP, Zheleva A, Moreno B, Villalba-Esparza M, Pastor F., A pan-tumor-siRNA aptamer chimera to block nonsense-mediated mRNA decay inflames and suppresses tumor progression, Mol Ther Nucleic Acids. 2022 Jul 20;29:413-425. doi: 10.1016/j.omtn.2022.07.017. eCollection 2022 Sep 13.

Berger G, Knelson EH, Jimenez-Macias JL, Nowicki MO, Han S, Panagioti E, Lizotte PH, Adu-Berchie K, Stafford A, Dimitrakakis N, Zhou L, Chiocca EA, Mooney DJ, Barbie DA, Lawler SE., STING activation promotes robust immune response and NK cell-mediated tumor regression in glioblastoma models, Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2111003119. doi: 10.1073/pnas.2111003119. Epub 2022 Jul 5.

Schepelmann M, Kupper N, Gushchina V, Mesteri I, Manhardt T, Moritsch S, Müller C, Piatek K, Salzmann M, Vlasaty A, Eferl R, Kallay E., AOM/DSS Induced Colitis-Associated Colorectal Cancer in 14-Month-Old Female Balb/C and C57/Bl6 Mice-A Pilot Study, Int J Mol Sci. 2022 May 9;23(9):5278. doi: 10.3390/ijms23095278.

Salvatori E, Lione L, Compagnone M, Pinto E, Conforti A, Ciliberto G, Aurisicchio L, Palombo F., Neoantigen cancer vaccine augments anti-CTLA-4 efficacy, NPJ Vaccines. 2022 Feb 2;7(1):15. doi: 10.1038/s41541-022-00433-9.

Koch MS, Zdioruk M, Nowicki MO, Griffith AM, Aguilar E, Aguilar LK, Guzik BW, Barone F, Tak PP, Tabatabai G, Lederer JA, Chiocca EA, Lawler S., Systemic high-dose dexamethasone treatment may modulate the efficacy of intratumoral viral oncolytic immunotherapy in glioblastoma models, J Immunother Cancer. 2022 Jan;10(1):e003368. doi: 10.1136/jitc-2021-003368.

Freeling JL, Scholl JL, Eikanger M, Knoblich C, Potts RA, Anderson DJ, Rower JE, Farjoo MH, Zhao H, Pillatzki A, Rezvani K., Pre-clinical safety and therapeutic efficacy of a plant-based alkaloid in a human colon cancer xenograft model., Cell Death Discov. 2022 Mar 28;8(1):135. doi: 10.1038/s41420-022-00936-3.

Osteoporosis

Stephens M, Lopez-Linares K, Aldazabal J, Macias I, Ortuzar N, Bengoetxea H, Bulnes S, Alcorta-Sevillano N, Infante A, Lafuente JV, Rodríguez CI., Murine femur micro-computed tomography and biomechanical datasets for an ovariectomy-induced osteoporosis model., Sci Data. 2021 Sep 15;8(1):240. doi: 10.1038/s41597-021-01012-8.

Surgical

Kunst RF, de Waart DR, Wolters F, Duijst S, Vogels EW, Bolt I, Verheij J, Beuers U, Oude Elferink RPJ, van de Graaf SFJ. , Systemic ASBT inactivation protects against liver damage in obstructive cholestasis in mice, JHEP Rep. 2022 Aug 27;4(11):100573. doi: 10.1016/j.jhepr.2022.100573.

Toxicology

Smeyne, R. J., Breckenridge, C. B., Beck, M., Jiao, Y., Butt, M. T., Wolf, J. C., . . . Botham, P. A. (2016)., Assessment of the effects of MPTP and paraquat on dopaminergic neurons and microglia in the substantia nigra pars compacta of C57BL/6 mice., PloS One, 11(10), e0164094. doi:10.1371/journal.pone.0164094 [doi]

Whitemarsh, R. C., Tepp, W. H., Bradshaw, M., Lin, G., Pier, C. L., Scherf, J. M., . . . Pellett, S. (2013)., Characterization of botulinum neurotoxin A subtypes 1 through 5 by investigation of activities in mice, in neuronal cell cultures, and in vitro., Infection and Immunity, 81(10), 3894-3902. doi:10.1128/IAI.00536-13 [doi]

Heiss, Gregor; Ploetz, Evelyn; Voith von Voithenberg, Lena; Viswanathan, Ramya; Glaser, Samson; Schluesche, Peter; Madhira, Sushi; Meisterernst, Michael; Auble, David T; Lamb, Don C;, Conformational changes and catalytic inefficiency associated with Mot1-mediated TBP-DNA dissociation., Nucleic acids research Vol.47, 2019

Kolomansky A, Hiram-Bab S, Ben-Califa N, Liron T, Deshet-Unger N, Mittelman M, Oster HS, Rauner M, Wielockx B, Neumann D, Gabet Y., Erythropoietin Mediated Bone Loss in Mice Is Dose-Dependent and Mostly Irreversible, Int J Mol Sci. 2020 May 27;21(11):3817. doi: 10.3390/ijms21113817.

Springer, Andrea; Heuer, Lea; Janecek-Erfurth, Elisabeth; Beineke, Andreas; Strube, Christina, Histopathological characterization of Toxocara canis- and T. cati-induced neurotoxocarosis in the mouse model., Parasitology research Vol.118, 2019

Zhou, H., Malik, M. A., Arab, A., Hill, M. T., & Shikanov, A. (2015), Hydrogel based 3-dimensional (3D) system for toxicity and high-throughput (HTP) analysis for cultured murine ovarian follicles., PloS One, 10(10), e0140205. doi:10.1371/journal.pone.0140205 [doi]

Hoek-van den Hil, E. F., van Schothorst, E. M., van der Stelt, I., Hollman, P. C., Keijer, J., & Rietjens, I. M. (2015), Quercetin tests negative for genotoxicity in transcriptome analyses of liver and small intestine of mice., Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association, 81, 34-39. doi:10.1016/j.fct.2015.04.005 [doi]

Myhre, O., Eide, D. M., Kleiven, S., Utkilen, H. C., & Hofer, T. (2018), Repeated five-day administration of L-BMAA, microcystin-LR, or as mixture, in adult C57BL/6 mice - lack of adverse cognitive effects., Scientific Reports, 8(1), 2308-018-20327-y. doi:10.1038/s41598-018-20327-y [doi]

Win, S., Than, T. A., Le, B. H., Garcia-Ruiz, C., Fernandez-Checa, J. C., & Kaplowitz, N. (2015)., Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity., Journal of Hepatology, 62(6), 1367-1374. doi:10.1016/j.jhep.2015.01.032 [doi]

Kendziorski, J. A., Kendig, E. L., Gear, R. B., & Belcher, S. M. (2012)., Strain specific induction of pyometra and differences in immune responsiveness in mice exposed to 17alpha-ethinyl estradiol or the endocrine disrupting chemical bisphenol A, Reproductive Toxicology (Elmsford, N.Y.), 34(1), 22-30. doi:10.1016/j.reprotox.2012.03.001 [doi]

Kendziorski, J. A., & Belcher, S. M. (2015)., Strain-specific induction of endometrial periglandular fibrosis in mice exposed during adulthood to the endocrine disrupting chemical bisphenol A., A. Reproductive Toxicology (Elmsford, N.Y.), 58, 119-130. doi:10.1016/j.reprotox.2015.08.001 [doi]

Meier, D. T., Entrup, L., Templin, A. T., Hogan, M. F., Mellati, M., Zraika, S., . . . Kahn, S. E. (2016), The S20G substitution in hIAPP is more amyloidogenic and cytotoxic than wild-type hIAPP in mouse islets., Diabetologia, 59(10), 2166-2171. doi:10.1007/s00125-016-4045-x [doi]

Dahl H, Eide DM, Tengs T, Duale N, Kamstra JH, Oughton DH, Olsen AK., Perturbed transcriptional profiles after chronic low dose rate radiation in mice, PLoS One. 2021 Aug 24;16(8):e0256667. doi: 10.1371/journal.pone.0256667. eCollection 2021.

Deshpande A, Olaitan AO, Mckelvey AM, Rutherford JT, Hurdle JG, The Ferrous Iron Transporter FeoB1 is Essential for Clostridioides difficile Toxin Production and Pathogenesis in Mice, bioRxiv 2022.03.03.482942

Vaccines

Aminzadeh A, Tiwari MK, Mamah Mustapha SS, Navarrete SJ, Henriksen AB, MĂ¸ller IM, Krogfelt KA, Bjerrum MJ, JĂ¸rgensen R., Detoxification of toxin A and toxin B by copper ion-catalyzed oxidation in production of a toxoid-based vaccine against Clostridioides difficile, Free Radic Biol Med. 2020 Nov 20;160:433-446. doi: 10.1016/j.freeradbiomed.2020.08.021. Epub 2020 Aug 27.

Fratzke AP, Gregory AE, van Schaik EJ, Samuel JE., Coxiella burnetii Whole Cell Vaccine Produces a Th1 Delayed-Type Hypersensitivity Response in a Novel Sensitized Mouse Model, Front Immunol. 2021 Sep 20;12:754712. doi: 10.3389/fimmu.2021.754712. eCollection 2021.