Athymic nude rats
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Wang, P., Song, Y., Weir, M. D., Sun, J., Zhao, L., Simon, C. G., & Xu, H. H. (2016)., A self-setting iPSMSC-alginate-calcium phosphate paste for bone tissue engineering., Dental Materials : Official Publication of the Academy of Dental Materials, 32(2), 252-263. doi:10.1016/j.dental.2015.11.019 [doi]
Dauchy, R. T., Wren, M. A., Dauchy, E. M., Hanifin, J. P., Jablonski, M. R., Warfield, B., . . . Blask, D. E. (2013)., Effect of spectral transmittance through red-tinted rodent cages on circadian metabolism and physiology in nude rats., Journal of the American Association for Laboratory Animal Science : JAALAS, 52(6), 745-755.
King, W., Bendele, A., Marohl, T., & Woodell-May, J. (2017)., Human blood-based anti-inflammatory solution inhibits osteoarthritis progression in a meniscal-tear rat study., Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 35(10), 2260-2268. doi:10.1002/jor.23528 [doi]
Riemenschneider, S. B., Mattia, D. J., Wendel, J. S., Schaefer, J. A., Ye, L., Guzman, P. A., & Tranquillo, R. T. (2016)., Inosculation and perfusion of pre-vascularized tissue patches containing aligned human microvessels after myocardial infarction., Biomaterials, 97, 51-61. doi:10.1016/j.biomaterials.2016.04.031 [doi]
Peredo AP, Jo YK, Duan G, Dodge GR, Lee D, Mauck RL., Mechano-activated biomolecule release in regenerating load-bearing tissue microenvironments, Biomaterials. 2021 Jan;265:120255. doi: 10.1016/j.biomaterials.2020.120255. Epub 2020 Oct 10.
Li, S., Goins, B., Zhang, L., & Bao, A. (2012)., Novel multifunctional theranostic liposome drug delivery system: Construction, characterization, and multimodality MR, near-infrared fluorescent, and nuclear imaging., Bioconjugate Chemistry, 23(6), 1322-1332. doi:10.1021/bc300175d [doi]
Kandalam U, Kawai T, Ravindran G, Brockman R, Romero J, Munro M, Ortiz J, Heidari A, Thomas R, Kuriakose S, Naglieri C, Ejtemai S, Kaltman SI., Predifferentiated Gingival Stem Cell-Induced Bone Regeneration in Rat Alveolar Bone Defect Model, Tissue Eng Part A. 2020 Sep 18. doi: 10.1089/ten.TEA.2020.0052. Online ahead of print.
Xiong, X., Sun, Y., Sattiraju, A., Jung, Y., Mintz, A., Hayasaka, S., & Li, K. C. (2015), Remote spatiotemporally controlled and biologically selective permeabilization of blood-brain barrier. Journal of Controlled Release : Official Journal of the Controlled Release Society, 217, 113-120., doi:10.1016/j.jconrel.2015.08.044 [doi]
Lo, V. C., Akens, M. K., Wise-Milestone, L., Yee, A. J., Wilson, B. C., & Whyne, C. M. (2013)., The benefits of photodynamic therapy on vertebral bone are maintained and enhanced by combination treatment with bisphosphonates and radiation therapy., Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 31(9), 1398-1405. doi:10.1002/jor.22373 [doi]
Vézina A, Manglani M, Morris D, Foster B, McCord M, Song H, Zhang M, Davis D, Zhang W, Bills J, Nagashima K, Shankarappa P, Kindrick J, Walbridge S, Peer CJ, Figg WD, Gilbert MR, McGavern DB, Muldoon LL, Jackson S., Adenosine A2A Receptor Activation Enhances Blood-Tumor Barrier Permeability in a Rodent Glioma Model, Mol Cancer Res. 2021 Dec;19(12):2081-2095. doi: 10.1158/1541-7786.MCR-19-0995. Epub 2021 Sep 14.
Gil-Ranedo J, Gallego-García C, Almendral JM., Viral targeting of glioblastoma stem cells with patient-specific genetic and post-translational p53 deregulations, Cell Rep. 2021 Sep 7;36(10):109673. doi: 10.1016/j.celrep.2021.109673.
Clément A, Doyen M, Fauvelle F, Hossu G, Chen B, Barberi-Heyob M, Hirtz A, Stupar V, Lamiral Z, Pouget C, Gauchotte G, Karcher G, Beaumont M, Verger A, Lemasson B., In vivo characterization of physiological and metabolic changes related to isocitrate dehydrogenase 1 mutation expcression by multiparametric MRI and MRS in a rat model with orthotopically grafted human-derived glioblastoma cell lines, NMR Biomed. 2021 Jun;34(6):e4490. doi: 10.1002/nbm.4490. Epub 2021 Feb 17.
Hormuth DA 2nd, Jarrett AM, Davis T, Yankeelov TE., Towards an Image-Informed Mathematical Model of In Vivo Response to Fractionated Radiation Therapy, Cancers (Basel). 2021 Apr 7;13(8):1765. doi: 10.3390/cancers13081765.
Kandalam U, Kawai T, Ravindran G, Brockman R, Romero J, Munro M, Ortiz J, Heidari A, Thomas R, Kuriakose S, Naglieri C, Ejtemai S, Kaltman SI., Predifferentiated Gingival Stem Cell-Induced Bone Regeneration in Rat Alveolar Bone Defect Model, Tissue Eng Part A. 2021 Mar;27(5-6):424-436. doi: 10.1089/ten.TEA.2020.0052. Epub 2020 Sep 18.
Peredo AP, Jo YK, Duan G, Dodge GR, Lee D, Mauck RL., Mechano-activated biomolecule release in regenerating load-bearing tissue microenvironments, Biomaterials. 2021 Jan;265:120255. doi: 10.1016/j.biomaterials.2020.120255. Epub 2020 Oct 10.
Khan MH, Mishra SK, Zakaria ABM, Mihailović JM, Coman D, Hyder F., Comparison of Lanthanide Macrocyclic Complexes as (23)Na NMR Sensors, Anal Chem. 2022 Feb 8;94(5):2536-2545. doi: 10.1021/acs.analchem.1c04432. Epub 2022 Jan 24.
Immunology
Debing, Y., Mishra, N., Verbeken, E., Ramaekers, K., Dallmeier, K., & Neyts, J. (2016)., A rat model for hepatitis E virus., Disease Models & Mechanisms, 9(10), 1203-1210. doi:dmm.024406 [pii]
Petrovic-Djergovic, D., Popovic, M., Chittiprol, S., Cortado, H., Ransom, R. F., & Partida-Sanchez, S. (2015)., CXCL10 induces the recruitment of monocyte-derived macrophages into kidney, which aggravate puromycin aminonucleoside nephrosis., Clinical and Experimental Immunology, 180(2), 305-315. doi:10.1111/cei.12579 [doi]
Mehrotra, P., Collett, J. A., McKinney, S. D., Stevens, J., Ivancic, C. M., & Basile, D. P. (2017)., IL-17 mediates neutrophil infiltration and renal fibrosis following recovery from ischemia reperfusion: Compensatory role of natural killer cells in athymic rats., American Journal of Physiology.Renal Physiology, 312(3), F385-F397. doi:10.1152/ajprenal.00462.2016 [doi]
Liu, H., Shiryaev, S. A., Chernov, A. V., Kim, Y., Shubayev, I., Remacle, A. G., . . . Shubayev, V. I. (2012)., Immunodominant fragments of myelin basic protein initiate T cell-dependent pain., Journal of Neuroinflammation, 9, 119-2094-9-119. doi:10.1186/1742-2094-9-119 [doi]
Chen, Q., & Shine, H. D. (2013)., Neuroimmune processes associated with wallerian degeneration support neurotrophin-3-induced axonal sprouting in the injured spinal cord., Journal of Neuroscience Research, 91(10), 1280-1291. doi:10.1002/jnr.23257 [doi]
Wheeler, C. J., Seksenyan, A., Koronyo, Y., Rentsendorj, A., Sarayba, D., Wu, H., . . . Irvin, D. K. (2014)., T-lymphocyte deficiency exacerbates behavioral deficits in the 6-OHDA unilateral lesion rat model for parkinson's disease., Journal of Neurology & Neurophysiology, 5(3), 209. doi:209 [pii]
Oncology
Dauchy, R. T., Dauchy, E. M., Mao, L., Belancio, V. P., Hill, S. M., & Blask, D. E. (2012)., A new apparatus and surgical technique for the dual perfusion of human tumor xenografts in situ in nude rats., Comparative Medicine, 62(2), 99-108.
Lemasson, B., Christen, T., Tizon, X., Farion, R., Fondraz, N., Provent, P., . . . Remy, C. (2011)., Assessment of multiparametric MRI in a human glioma model to monitor cytotoxic and anti-angiogenic drug effects., NMR in Biomedicine, 24(5), 473-482. doi:10.1002/nbm.1611 [doi]
Lo, V. C., Akens, M. K., Moore, S., Yee, A. J., Wilson, B. C., & Whyne, C. M. (2012)., Beyond radiation therapy: Photodynamic therapy maintains structural integrity of irradiated healthy and metastatically involved vertebrae in a pre-clinical in vivo model., Breast Cancer Research and Treatment, 135(2), 391-401. doi:10.1007/s10549-012-2146-x [doi]
Chaves C, Declèves X, Taghi M, Menet MC, Lacombe J, Varlet P, Olaciregui NG, Carcaboso AM, Cisternino S., Characterization of the Blood-Brain Barrier Integrity and the Brain Transport of SN-38 in an Orthotopic Xenograft Rat Model of Diffuse Intrinsic Pontine Glioma, Pharmaceutics. 2020 Apr 27;12(5):399. doi: 10.3390/pharmaceutics12050399.
Dauchy, R. T., Xiang, S., Mao, L., Brimer, S., Wren, M. A., Yuan, L., . . . Hill, S. M. (2014)., Circadian and melatonin disruption by exposure to light at night drives intrinsic resistance to tamoxifen therapy in breast cancer., Cancer Research, 74(15), 4099-4110. doi:10.1158/0008-5472.CAN-13-3156 [doi]
Eschbach, R. S., Clevert, D. A., Hirner-Eppeneder, H., Ingrisch, M., Moser, M., Schuster, J., . . . Cyran, C. C. (2017)., Contrast-enhanced ultrasound with VEGFR2-targeted microbubbles for monitoring regorafenib therapy effects in experimental colorectal adenocarcinomas in rats with DCE-MRI and immunohistochemical validation., PloS One, 12(1), e0169323. doi:10.1371/journal.pone.0169323 [doi]
Eschbach, R. S., Fendler, W. P., Kazmierczak, P. M., Hacker, M., Rominger, A., Carlsen, J., . . . Cyran, C. C. (2015)., Correlation of perfusion MRI and 18F-FDG PET imaging biomarkers for monitoring regorafenib therapy in experimental colon carcinomas with immunohistochemical validation., PloS One, 10(2), e0115543. doi:10.1371/journal.pone.0115543 [doi]
Eschbach, R. S., Fendler, W. P., Kazmierczak, P. M., Hacker, M., Rominger, A., Carlsen, J., . . . Cyran, C. C. (2015)., Correlation of perfusion MRI and 18F-FDG PET imaging biomarkers for monitoring regorafenib therapy in experimental colon carcinomas with immunohistochemical validation., PloS One, 10(2), e0115543. doi:10.1371/journal.pone.0115543 [doi]
Rau, R. E., Rodriguez, B. A., Luo, M., Jeong, M., Rosen, A., Rogers, J. H., . . . Goodell, M. A. (2016)., DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia., Blood, 128(7), 971-981. doi:10.1182/blood-2015-11-684225 [doi]
Duong le, T., Wesolowski, G. A., Leung, P., Oballa, R., & Pickarski, M. (2014)., Efficacy of a cathepsin K inhibitor in a preclinical model for prevention and treatment of breast cancer bone metastasis. Molecular Cancer Therapeutics, 13(12), 2898-2909. doi:10.1158/1535-7163.MCT-14-0253 [doi], Molecular Cancer Therapeutics, 13(12), 2898-2909. doi:10.1158/1535-7163.MCT-14-0253 [doi]
Atkins, Ayelet; Burke, Mikhail; Samiezadeh, Saeid; Akens, Margarete K; Hardisty, Michael; Whyne, Cari M;, Elevated Microdamage Spatially Correlates with Stress in Metastatic Vertebrae, Annals of biomedical engineering Vol.47, 2019
Van de Sande, Leen; Willaert, Wouter; Cosyns, Sarah; De Clercq, Kaat; Shariati, Molood; Remaut, Katrien; Ceelen, Wim, Establishment of a rat ovarian peritoneal metastasis model to study pressurized intraperitoneal aerosol chemotherapy (PIPAC)., BMC cancer Vol.19, 2019
Halle, B., Thisgaard, H., Hvidsten, S., Dam, J. H., Aaberg-Jessen, C., Thykjaer, A. S., . . . Kristensen, B. W. (2015)., Estimation of tumor volumes by 11C-MeAIB and 18F-FDG PET in an orthotopic glioblastoma rat model., Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, 56(10), 1562-1568. doi:10.2967/jnumed.115.162511 [doi]
Wise-Milestone, L., Akens, M. K., Rosol, T. J., Hojjat, S. P., Grynpas, M. D., & Whyne, C. M. (2012)., Evaluating the effects of mixed osteolytic/osteoblastic metastasis on vertebral bone quality in a new rat model., Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 30(5), 817-823. doi:10.1002/jor.21577 [doi]
Cyran, C. C., Fu, Y., Rogut, V., Chaopathomkul, B., Wendland, M. F., Shames, D. M., & Brasch, R. C. (2013)., Evaluation of a novel macromolecular cascade-polymer contrast medium for dynamic contrast-enhanced MRI monitoring of antiangiogenic bevacizumab therapy in a human melanoma model., Academic Radiology, 20(10), 1256-1263. doi:10.1016/j.acra.2013.07.010 [doi]
Li, S., Goins, B., Hrycushko, B. A., Phillips, W. T., & Bao, A. (2012)., Feasibility of eradication of breast cancer cells remaining in postlumpectomy cavity and draining lymph nodes following intracavitary injection of radioactive immunoliposomes., Molecular Pharmaceutics, 9(9), 2513-2522. doi:10.1021/mp300132f [doi]
Sakuma, S., Yu, J. Y., Quang, T., Hiwatari, K., Kumagai, H., Kao, S., . . . Pham, W. (2015)., Fluorescence-based endoscopic imaging of thomsen-friedenreich antigen to improve early detection of colorectal cancer. International Journal of Cancer., Journal International Du Cancer, 136(5), 1095-1103. doi:10.1002/ijc.29093 [doi]
Panella, C., Castellvi, Q., Moll, X., Quesada, R., Villanueva, A., Iglesias, M., . . . Burdio, F. (2017)., Focused transhepatic electroporation mediated by hypersaline infusion through the portal vein in rat model. preliminary results on differential conductivity., Radiology and Oncology, 51(4), 415-421. doi:10.1515/raon-2017-0051 [doi]
Shariati, Molood; Zhang, Heyang; Van de Sande, Leen; Descamps, Benedicte; Vanhove, Chris; Willaert, Wouter; Ceelen, Wim; De Smedt, Stefaan C; Remaut, Katrien, High Pressure Nebulization (PIPAC) Versus Injection for the Intraperitoneal Administration of mRNA Complexes, Pharmaceutical research Vol.36, 2019
Thisgaard, H., Halle, B., Aaberg-Jessen, C., Olsen, B. B., Therkelsen, A. S., Dam, J. H., . . . Kristensen, B. W. (2016)., Highly effective auger-electron therapy in an orthotopic glioblastoma xenograft model using convection-enhanced delivery., Theranostics, 6(12), 2278-2291. doi:10.7150/thno.15898 [doi]
Chaumeil, M. M., Ozawa, T., Park, I., Scott, K., James, C. D., Nelson, S. J., & Ronen, S. M. (2012)., Hyperpolarized 13C MR spectroscopic imaging can be used to monitor everolimus treatment in vivo in an orthotopic rodent model of glioblastoma., Neuroimage, 59(1), 193-201. doi:10.1016/j.neuroimage.2011.07.034 [doi]
Tokalov, S. V., Enghardt, W., & Abolmaali, N. (2010)., Improvement of radiation-mediated immunosuppression of human NSCLC tumour xenografts in a nude rat model., Journal of Biomedicine & Biotechnology, 2010, 580531. doi:10.1155/2010/580531 [doi]
Akens, M. K., Wise-Milestone, L., Won, E., Schwock, J., Yee, A. J., Wilson, B. C., & Whyne, C. M. (2014)., In vitro and in vivo effects of photodynamic therapy on metastatic breast cancer cells pre-treated with zoledronic acid., Photodiagnosis and Photodynamic Therapy, 11(3), 426-433. doi:10.1016/j.pdpdt.2014.04.002 [doi]
Verco, James; Johnston, William; Frost, Michael; Baltezor, Michael; Kuehl, Philip J; Lopez, Anita; Gigliotti, Andrew; Belinsky, Steven A; Wolff, Ronald; diZerega, Gere;, Inhaled Submicron Particle Paclitaxel (NanoPac) Induces Tumor Regression and Immune Cell Infiltration in an Orthotopic Athymic Nude Rat Model of Non-Small Cell Lung Cancer, Journal of aerosol medicine and pulmonary drug delivery Vol.32, 2019
Wise-Milestone, L., Akens, M. K., Lo, V. C., Yee, A. J., Wilson, B. C., & Whyne, C. M. (2012)., Local treatment of mixed osteolytic/osteoblastic spinal metastases: Is photodynamic therapy effective?, Breast Cancer Research and Treatment, 133(3), 899-908. doi:10.1007/s10549-011-1854-y [doi]
Kuhn, M. W., Hadler, M. J., Daigle, S. R., Koche, R. P., Krivtsov, A. V., Olhava, E. J., . . . Armstrong, S. A. (2015)., MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition., Haematologica, 100(5), e190-3. doi:10.3324/haematol.2014.115337 [doi]
Kazmierczak, P. M., Burian, E., Eschbach, R., Hirner-Eppeneder, H., Moser, M., Havla, L., . . . Cyran, C. C. (2015)., Monitoring cell death in regorafenib-treated experimental colon carcinomas using annexin-based optical fluorescence imaging validated by perfusion MRI., PloS One, 10(9), e0138452. doi:10.1371/journal.pone.0138452 [doi]
Bechet, D., Auger, F., Couleaud, P., Marty, E., Ravasi, L., Durieux, N., . . . Barberi-Heyob, M. (2015)., Multifunctional ultrasmall nanoplatforms for vascular-targeted interstitial photodynamic therapy of brain tumors guided by real-time MRI., Nanomedicine : Nanotechnology, Biology, and Medicine, 11(3), 657-670. doi:10.1016/j.nano.2014.12.007 [doi]
Li C, Xu X, McMahon N, Alhaj Ibrahim O, Sattar HA, Tichauer KM., Paired-Agent Fluorescence Molecular Imaging of Sentinel Lymph Nodes Using Indocyanine Green as a Control Agent for Antibody-Based Targeted Agents, Contrast Media Mol Imaging. 2019 Jan 3;2019:7561862.
Cyran, C. C., Sennino, B., Fu, Y., Rogut, V., Shames, D. M., Chaopathomkul, B., . . . Raatschen, H. J. (2012)., Permeability to macromolecular contrast media quantified by dynamic MRI correlates with tumor tissue assays of vascular endothelial growth factor (VEGF)., European Journal of Radiology, 81(5), 891-896. doi:10.1016/j.ejrad.2011.07.016 [doi]
Isal, S., Pierson, J., Imbert, L., Clement, A., Collet, C., Pinel, S., . . . Maskali, F. (2018)., PET imaging of (68)ga-NODAGA-RGD, as compared with (18)F-fluorodeoxyglucose, in experimental rodent models of engrafted glioblastoma., EJNMMI Research, 8(1), 51-018-0405-5. doi:10.1186/s13550-018-0405-5 [doi]
Buck, J. R., McKinley, E. T., Fu, A., Abel, T. W., Thompson, R. C., Chambless, L., . . . Manning, H. C. (2015)., Preclinical TSPO ligand PET to visualize human glioma xenotransplants: A preliminary study., PloS One, 10(10), e0141659. doi:10.1371/journal.pone.0141659 [doi]
Hardisty, M. R., Akens, M. K., Hojjat, S. P., Yee, A., & Whyne, C. M. (2012)., Quantification of the effect of osteolytic metastases on bone strain within whole vertebrae using image registration., Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 30(7), 1032-1039. doi:10.1002/jor.22045 [doi]
Li, L., Zhu, L., Ma, C., Lin, L., Yao, J., Wang, L., . . . Wang, L. V. (2017)., Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution., Nature Biomedical Engineering, 1(5), 10.1038/s41551-017-0071. Epub 2017 May 10. doi:0071 [pii]
Shariati M, Lollo G, Matha K, Descamps B, Vanhove C, Van de Sande L, Willaert W, Balcaen L, Vanhaecke F, Benoit JP, Ceelen W, De Smedt SC, Remaut K., Synergy between Intraperitoneal Aerosolization (PIPAC) and Cancer Nanomedicine: Cisplatin-Loaded Polyarginine-Hyaluronic Acid Nanocarriers Efficiently Eradicate Peritoneal Metastasis of Advanced Human Ovarian Cancer, ACS Appl Mater Interfaces. 2020 Jul 1;12(26):29024-29036. doi: 10.1021/acsami.0c05554. Epub 2020 Jun 22.
Ghomashchi S, Whyne CM, Chinnery T, Habach F, Akens MK., Impact of radiofrequency ablation (RFA) on bone quality in a murine model of bone metastases, PLoS One. 2021 Sep 8;16(9):e0256076. doi: 10.1371/journal.pone.0256076. eCollection 2021.
Lücking U, Kosemund D, Böhnke N, Lienau P, Siemeister G, Denner K, Bohlmann R, Briem H, Terebesi I, Bömer U, Schäfer M, Ince S, Mumberg D, Scholz A, Izumi R, Hwang S, von Nussbaum F., Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer, J Med Chem. 2021 Aug 12;64(15):11651-11674. doi: 10.1021/acs.jmedchem.1c01000. Epub 2021 Jul 15.
Chevaleyre C, Kereselidze D, Caillé F, Tournier N, Olaciregui NG, Winkeler A, Declèves X, Jego B, Cisternino S, Auvity S, Truillet C., TSPO PET Imaging as a Potent Non-Invasive Biomarker for Diffuse Intrinsic Pontine Glioma in a Patient-Derived Orthotopic Rat Model, Int J Mol Sci. 2022 Oct 18;23(20):12476. doi: 10.3390/ijms232012476.
Ghomashchi S, Clement A, Whyne CM, Akens MK., Establishment and Image based evaluation of a New Preclinical Rat Model of Osteoblastic Bone Metastases, Clin Exp Metastasis. 2022 Oct;39(5):833-840. doi: 10.1007/s10585-022-10175-6. Epub 2022 Jul 11.
Andreu M, Spurlock M, Hu Z, Sirsy A, Quesada Sanchez LM, Gultekin SH, Bullock R, Gajavelli S., Assessing fetal human neural stem cells tumorigenicity potential in athymic rats with penetrating traumatic brain injury (pTBI), Brain Res. 2022 Sep 15;1791:148002. doi: 10.1016/j.brainres.2022.148002. Epub 2022 Jul 8.
Clément A, Zaragori T, Filosa R, Ovdiichuk O, Beaumont M, Collet C, Roeder E, Martin B, Maskali F, Barberi-Heyob M, Pouget C, Doyen M, Verger A., Multi-tracer and multiparametric PET imaging to detect the IDH mutation in glioma: a preclinical translational in vitro, in vivo, and ex vivo study, Cancer Imaging. 2022 Mar 18;22(1):16. doi: 10.1186/s40644-022-00454-6.
Vézina A, Manglani M, Morris D, Foster B, McCord M, Song H, Zhang M, Davis D, Zhang W, Bills J, Nagashima K, Shankarappa P, Kindrick J, Walbridge S, Peer CJ, Figg WD, Gilbert MR, McGavern DB, Muldoon LL, Jackson S., Adenosine A2A Receptor Activation Enhances Blood-Tumor Barrier Permeability in a Rodent Glioma Model, Mol Cancer Res. 2021 Dec;19(12):2081-2095. doi: 10.1158/1541-7786.MCR-19-0995. Epub 2021 Sep 14.
Transplantation
Chen, W., Liu, X., Chen, Q., Bao, C., Zhao, L., Zhu, Z., & Xu, H. H. K. (2018)., Angiogenic and osteogenic regeneration in rats via calcium phosphate scaffold and endothelial cell co-culture with human bone marrow mesenchymal stem cells (MSCs), human umbilical cord MSCs, human induced pluripotent stem cell-derived MSCs and human embryonic stem cell-derived MSCs., Journal of Tissue Engineering and Regenerative Medicine, 12(1), 191-203. doi:10.1002/term.2395 [doi]
Tremoleda, J. L., Khan, N. S., Mann, V., Racey, S. N., Martin, A. J., Simpson, A. H., & Noble, B. S. (2012)., Assessment of a preclinical model for studying the survival and engraftment of human stem cell derived osteogenic cell populations following orthotopic implantation., Journal of Musculoskeletal & Neuronal Interactions, 12(4), 241-253.
Wang, P., Liu, X., Zhao, L., Weir, M. D., Sun, J., Chen, W., . . . Xu, H. H. (2015)., Bone tissue engineering via human induced pluripotent, umbilical cord and bone marrow mesenchymal stem cells in rat cranium., Acta Biomaterialia, 18, 236-248. doi:10.1016/j.actbio.2015.02.011 [doi]
Yamaleyeva, L. M., Guimaraes-Souza, N. K., Krane, L. S., Agcaoili, S., Gyabaah, K., Atala, A., . . . Yoo, J. J. (2012)., Cell therapy with human renal cell cultures containing erythropoietin-positive cells improves chronic kidney injury. Stem Cells Translational Medicine, 1(5), 373-383, doi:10.5966/sctm.2011-0048 [doi]
Sangadala, S., Yoshioka, K., Enyo, Y., Liu, Y., Titus, L., & Boden, S. D. (2014)., Characterization of a unique motif in LIM mineralization protein-1 that interacts with jun activation-domain-binding protein 1., Molecular and Cellular Biochemistry, 385(1-2), 145-157. doi:10.1007/s11010-013-1823-3 [doi]
Gawlitta, D., Benders, K. E., Visser, J., van der Sar, A. S., Kempen, D. H., Theyse, L. F., . . . Dhert, W. J. (2015)., Decellularized cartilage-derived matrix as substrate for endochondral bone regeneration., Tissue Engineering.Part A, 21(3-4), 694-703. doi:10.1089/ten.TEA.2014.0117 [doi]
Gawlitta, D., Benders, K. E., Visser, J., van der Sar, A. S., Kempen, D. H., Theyse, L. F., . . . Dhert, W. J. (2015)., Decellularized cartilage-derived matrix as substrate for endochondral bone regeneration., Tissue Engineering.Part A, 21(3-4), 694-703. doi:10.1089/ten.TEA.2014.0117 [doi]
Gerbin KA, Mitzelfelt KA, Guan X, Martinson AM, Murry CE., Delta-1 Functionalized Hydrogel Promotes hESC-Cardiomyocyte Graft Proliferation and Maintains Heart Function Post-Injury, Mol Ther Methods Clin Dev. 2020 Apr 18;17:986-998. doi: 10.1016/j.omtm.2020.04.011. eCollection 2020 Jun 12.
Moon, S. H., Ban, K., Kim, C., Kim, S. S., Byun, J., Song, M. K., . . . Yoon, Y. S. (2013)., Development of a novel two-dimensional directed differentiation system for generation of cardiomyocytes from human pluripotent stem cells., International Journal of Cardiology, 168(1), 41-52. doi:10.1016/j.ijcard.2012.09.077 [doi]
Warzecha, J., Seebach, C., Flinspach, A., Wenger, F., Henrich, D., & Marzi, I. (2013)., Effect of sonic hedgehog/beta-TCP composites on bone healing within the critical-sized rat femoral defect., Experimental and Therapeutic Medicine, 5(4), 1035-1039. doi:10.3892/etm.2013.923 [doi]
Seebach, C., Henrich, D., Wilhelm, K., Barker, J. H., & Marzi, I. (2012)., Endothelial progenitor cells improve directly and indirectly early vascularization of mesenchymal stem cell-driven bone regeneration in a critical bone defect in rats., Cell Transplantation, 21(8), 1667-1677. doi:10.3727/096368912X638937 [doi]
Wendel, J. S., Ye, L., Tao, R., Zhang, J., Zhang, J., Kamp, T. J., & Tranquillo, R. T. (2015)., Functional effects of a tissue-engineered cardiac patch from human induced pluripotent stem cell-derived cardiomyocytes in a rat infarct model., Stem Cells Translational Medicine, 4(11), 1324-1332. doi:10.5966/sctm.2015-0044 [doi]
Gowing, G., Shelley, B., Staggenborg, K., Hurley, A., Avalos, P., Victoroff, J., . . . Svendsen, C. N. (2014)., Glial cell line-derived neurotrophic factor-secreting human neural progenitors show long-term survival, maturation into astrocytes, and no tumor formation following transplantation into the spinal cord of immunocompromised rats., Neuroreport, 25(6), 367-372. doi:10.1097/WNR.0000000000000092 [doi]
Zigdon-Giladi, H., Michaeli-Geller, G., Bick, T., Lewinson, D., & Machtei, E. E. (2015)., Human blood-derived endothelial progenitor cells augment vasculogenesis and osteogenesis. Journal of Clinical Periodontology, 42(1), 89-95., doi:10.1111/jcpe.12325 [doi]
Zigdon-Giladi, H., Michaeli-Geller, G., Bick, T., Lewinson, D., & Machtei, E. E. (2015)., Human blood-derived endothelial progenitor cells augment vasculogenesis and osteogenesis. Journal of Clinical Periodontology, 42(1), 89-95., doi:10.1111/jcpe.12325 [doi]
Lim, E. H., Sardinha, J. P., Myers, S., & Stevens, M. (2013)., Latent transforming growth factor-beta1 functionalised electrospun scaffolds promote human cartilage differentiation: Towards an engineered cartilage construct., Archives of Plastic Surgery, 40(6), 676-686. doi:10.5999/aps.2013.40.6.676 [doi]
Lewis, C. S., Supronowicz, P. R., Zhukauskas, R. M., Gill, E., & Cobb, R. R. (2012)., Local antibiotic delivery with demineralized bone matrix., Cell and Tissue Banking, 13(1), 119-127. doi:10.1007/s10561-010-9236-y [doi]
Hamdi, H., Planat-Benard, V., Bel, A., Neamatalla, H., Saccenti, L., Calderon, D., . . . Menasche, P. (2014)., Long-term functional benefits of epicardial patches as cell carriers., Cell Transplantation, 23(1), 87-96. doi:10.3727/096368912X658836 [doi]
Nejadnik, H., Ye, D., Lenkov, O. D., Donig, J. S., Martin, J. E., Castillo, R., . . . Daldrup-Link, H. (2015)., Magnetic resonance imaging of stem cell apoptosis in arthritic joints with a caspase activatable contrast agent., ACS Nano, 9(2), 1150-1160. doi:10.1021/nn504494c [doi]
Nejadnik, H., Ye, D., Lenkov, O. D., Donig, J. S., Martin, J. E., Castillo, R., . . . Daldrup-Link, H. (2015)., Magnetic resonance imaging of stem cell apoptosis in arthritic joints with a caspase activatable contrast agent., ACS Nano, 9(2), 1150-1160. doi:10.1021/nn504494c [doi]
Hong, K. S., Byun, K. H., Seo, J., Lee, H. J., Choi, J. J., Kim, K. S., . . . Chung, H. M. (2014)., Modification to the injection needle to a screw needle improves effective cell delivery in acute myocardial infarction., Biotechnology Letters, 36(4), 859-868. doi:10.1007/s10529-013-1414-0 [doi]
Grealish, S., Heuer, A., Cardoso, T., Kirkeby, A., Jonsson, M., Johansson, J., . . . Parmar, M. (2015)., Monosynaptic tracing using modified rabies virus reveals early and extensive circuit integration of human embryonic stem cell-derived neurons., Stem Cell Reports, 4(6), 975-983. doi:10.1016/j.stemcr.2015.04.011 [doi]
Grealish, S., Heuer, A., Cardoso, T., Kirkeby, A., Jonsson, M., Johansson, J., . . . Parmar, M. (2015)., Monosynaptic tracing using modified rabies virus reveals early and extensive circuit integration of human embryonic stem cell-derived neurons., Stem Cell Reports, 4(6), 975-983. doi:10.1016/j.stemcr.2015.04.011 [doi]
Emgard, M., Piao, J., Aineskog, H., Liu, J., Calzarossa, C., Odeberg, J., . . . Sundstrom, E. (2014)., Neuroprotective effects of human spinal cord-derived neural precursor cells after transplantation to the injured spinal cord., Experimental Neurology, 253, 138-145. doi:10.1016/j.expneurol.2013.12.022 [doi]
Christensen, J., Vonwil, D., & Shastri, V. P. (2015)., Non-invasive in vivo imaging and quantification of tumor growth and metastasis in rats using cells expressing far-red fluorescence protein., PloS One, 10(7), e0132725. doi:10.1371/journal.pone.0132725 [doi]
Bartholomeus, K., Jacobs-Tulleneers-Thevissen, D., Shouyue, S., Suenens, K., In't Veld, P. A., Pipeleers-Marichal, M., . . . Hellemans, K. (2013)., Omentum is better site than kidney capsule for growth, differentiation, and vascularization of immature porcine beta-cell implants in immunodeficient rats., Transplantation, 96(12), 1026-1033. doi:10.1097/TP.0b013e3182a6ee41 [doi]
Robertson, M. J., Dries-Devlin, J. L., Kren, S. M., Burchfield, J. S., & Taylor, D. A. (2014)., Optimizing recellularization of whole decellularized heart extracellular matrix., PloS One, 9(2), e90406. doi:10.1371/journal.pone.0090406 [doi]
Raghavan, S., Miyasaka, E. A., Gilmont, R. R., Somara, S., Teitelbaum, D. H., & Bitar, K. N. (2014)., Perianal implantation of bioengineered human internal anal sphincter constructs intrinsically innervated with human neural progenitor cells., Surgery, 155(4), 668-674. doi:10.1016/j.surg.2013.12.023 [doi]
Yan, X. Z., van den Beucken, J. J., Cai, X., Yu, N., Jansen, J. A., & Yang, F. (2015)., Periodontal tissue regeneration using enzymatically solidified chitosan hydrogels with or without cell loading. Tissue Engineering.Part A, 21(5-6), 1066-1076., doi:10.1089/ten.TEA.2014.0319 [doi]
Epple, Christian; Haumer, Alexander; Ismail, Tarek; Lunger, Alexander; Scherberich, Arnaud; Schaefer, Dirk Johannes; Martin, Ivan;, Prefabrication of a large pedicled bone graft by engineering the germ for de novo vascularization and osteoinduction., Biomaterials Vol.192, 2019
Toussaint, M., Pinel, S., Auger, F., Durieux, N., Thomassin, M., Thomas, E., . . . Barberi-Heyob, M. (2017)., Proton MR spectroscopy and diffusion MR imaging monitoring to predict tumor response to interstitial photodynamic therapy for glioblastoma., Theranostics, 7(2), 436-451. doi:10.7150/thno.17218 [doi]
Clough, B. H., Zeitouni, S., Krause, U., Chaput, C. D., Cross, L. M., Gaharwar, A. K., & Gregory, C. A. (2018)., Rapid osteogenic enhancement of stem cells in human bone marrow using a glycogen-synthease-kinase-3-beta inhibitor improves osteogenic efficacy in vitro and in vivo., Stem Cells Translational Medicine, 7(4), 342-353. doi:10.1002/sctm.17-0229 [doi]
Rajashekhar, G., Ramadan, A., Abburi, C., Callaghan, B., Traktuev, D. O., Evans-Molina, C., . . . March, K. L. (2014)., Regenerative therapeutic potential of adipose stromal cells in early stage diabetic retinopathy., PloS One, 9(1), e84671. doi:10.1371/journal.pone.0084671 [doi]
Gullbrand SE, Kim DH, Ashinsky BG, Bonnevie ED, Smith HE, Mauck RL., Restoration of physiologic loading modulates engineered intervertebral disc structure and function in an in vivo model, JOR Spine. 2020 May 13;3(2):e1086. doi: 10.1002/jsp2.1086. eCollection 2020 Jun.
Ashinsky BG, Gullbrand SE, Bonnevie ED, Wang C, Kim DH, Han L, Mauck RL, Smith HE., Sacrificial Fibers Improve Matrix Distribution and Micromechanical Properties in a Tissue-Engineered Intervertebral Disc, Acta Biomater. 2020 Jul 15;111:232-241. doi: 10.1016/j.actbio.2020.05.019. Epub 2020 May 22.
Seo, J. W., Ang, J., Mahakian, L. M., Tam, S., Fite, B., Ingham, E. S., . . . Ferrara, K. W. (2015)., Self-assembled 20-nm (64)cu-micelles enhance accumulation in rat glioblastoma., Journal of Controlled Release : Official Journal of the Controlled Release Society, 220(Pt A), 51-60. doi:S0168-3659(15)30157-7 [pii]
Yuan, X., Wei, Y., Villasante, A., Ng, J. J. D., Arkonac, D. E., Chao, P. G., & Vunjak-Novakovic, G. (2017), Stem cell delivery in tissue-specific hydrogel enabled meniscal repair in an orthotopic rat model. Biomaterials, 132, 59-71, doi:S0142-9612(17)30213-2 [pii]
Guillaume O, Pérez-Köhler B, Schädl B, Keibl C, Saxenhuber N, Heimel P, Priglinger E, Wolbank S, Redl H, Petter-Puchner A, Fortelny R., Stromal vascular fraction cells as biologic coating of mesh for hernia repair, Hernia. 2020 Dec;24(6):1233-1243. doi: 10.1007/s10029-020-02135-4. Epub 2020 Feb 24.
Shih, Y. R., Phadke, A., Yamaguchi, T., Kang, H., Inoue, N., Masuda, K., & Varghese, S. (2015)., Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment., Acta Biomaterialia, 19, 1-9. doi:10.1016/j.actbio.2015.03.017 [doi]
Cardoso, T., Adler, A. F., Mattsson, B., Hoban, D. B., Nolbrant, S., Wahlestedt, J. N., . . . Parmar, M. (2018)., Target-specific forebrain projections and appropriate synaptic inputs of hESC-derived dopamine neurons grafted to the midbrain of parkinsonian rats., The Journal of Comparative Neurology, 526(13), 2133-2146. doi:10.1002/cne.24500 [doi]
Rota, C., Morigi, M., Cerullo, D., Introna, M., Colpani, O., Corna, D., . . . Remuzzi, G. (2018)., Therapeutic potential of stromal cells of non-renal or renal origin in experimental chronic kidney disease., Stem Cell Research & Therapy, 9(1), 220-018-0960-8. doi:10.1186/s13287-018-0960-8 [doi]
Carwardine, D., Prager, J., Neeves, J., Muir, E. M., Uney, J., Granger, N., & Wong, L. F. (2017)., Transplantation of canine olfactory ensheathing cells producing chondroitinase ABC promotes chondroitin sulphate proteoglycan digestion and axonal sprouting following spinal cord injury., PloS One, 12(12), e0188967. doi:10.1371/journal.pone.0188967 [doi]
Chen, W., Liu, J., Manuchehrabadi, N., Weir, M. D., Zhu, Z., & Xu, H. H. (2013)., Umbilical cord and bone marrow mesenchymal stem cell seeding on macroporous calcium phosphate for bone regeneration in rat cranial defects., Biomaterials, 34(38), 9917-9925. doi:10.1016/j.biomaterials.2013.09.002 [doi]
Rayner MLD, Day AGE, Bhangra KS, Sinden J, Phillips JB., Engineered neural tissue made using clinical-grade human neural stem cells supports regeneration in a long gap peripheral nerve injury model, Acta Biomater. 2021 Nov;135:203-213. doi: 10.1016/j.actbio.2021.08.030. Epub 2021 Aug 26.
Do JL, Allahwerdy S, David RCC, Weinreb RN, Tuszynski MH, Welsbie DS., Optic Nerve Engraftment of Neural Stem Cells, Invest Ophthalmol Vis Sci. 2021 Jul 1;62(9):30. doi: 10.1167/iovs.62.9.30.
Lee UL, Yun S, Cao HL, Ahn G, Shim JH, Woo SH, Choung PH., Bioprinting on 3D Printed Titanium Scaffolds for Periodontal Ligament Regeneration, Cells. 2021 May 28;10(6):1337. doi: 10.3390/cells10061337.
Lee MS, Stebbins MJ, Jiao H, Huang HC, Leiferman EM, Walczak BE, Palecek SP, Shusta EV, Li WJ., Comparative evaluation of isogenic mesodermal and ectomesodermal chondrocytes from human iPSCs for cartilage regeneration, Sci Adv. 2021 May 19;7(21):eabf0907. doi: 10.1126/sciadv.abf0907. Print 2021 May.
Fiorenzano A, Birtele M, Wahlestedt JN, Parmar M., Evaluation of TH-Cre knock-in cell lines for detection and specific targeting of stem cell-derived dopaminergic neurons, Heliyon. 2021 Jan 20;7(1):e06006. doi: 10.1016/j.heliyon.2021.e06006. eCollection 2021 Jan.
Rolph D, Das H., Generation of Myocardial Ischemic Wounds and Healing with Stem Cells, Methods Mol Biol. 2021;2193:141-147. doi: 10.1007/978-1-0716-0845-6_14.
Li H, Jiang H, Li H, Li L, Yan Z, Feng J., Generation of human A9 dopaminergic pacemakers from induced pluripotent stem cells, Mol Psychiatry. 2022 Nov;27(11):4407-4418. doi: 10.1038/s41380-022-01628-1. Epub 2022 May 24.
Olson LC, Redden JT, Gilliam L, Nguyen TM, Vossen JA, Cohen DJ, Schwartz Z, McClure MJ., Human Adipose-Derived Stromal Cells Delivered on Decellularized Muscle Improve Muscle Regeneration and Regulate RAGE and P38 MAPK, Bioengineering (Basel). 2022 Aug 30;9(9):426. doi: 10.3390/bioengineering9090426.
Alekseenko Z, Dias JM, Adler AF, Kozhevnikova M, van Lunteren JA, Nolbrant S, Jeggari A, Vasylovska S, Yoshitake T, Kehr J, Carlén M, Alexeyenko A, Parmar M, Ericson J., Robust derivation of transplantable dopamine neurons from human pluripotent stem cells by timed retinoic acid delivery, Nat Commun. 2022 Jun 1;13(1):3046. doi: 10.1038/s41467-022-30777-8.
Aldrin-Kirk P, Åkerblom M, Cardoso T, Nolbrant S, Adler AF, Liu X, Heuer A, Davidsson M, Parmar M, Björklund T., A novel two-factor monosynaptic TRIO tracing method for assessment of circuit integration of hESC-derived dopamine transplants, Stem Cell Reports. 2022 Jan 11;17(1):159-172. doi: 10.1016/j.stemcr.2021.11.014. Epub 2021 Dec 30.
Björklund A, Nilsson F, Mattsson B, Hoban DB, Parmar M., A Combined α-Synuclein/Fibril (SynFib) Model of Parkinson-Like Synucleinopathy Targeting the Nigrostriatal Dopamine System, J Parkinsons Dis. 2022;12(8):2307-2320. doi: 10.3233/JPD-223452.
Tumor growth
Mokhtari RB, Qorri B, Sambi M, Baluch N, Kumar S, Das B, Szewczuk MR, Yeger H, Cheng HM., 3D Multicellular Stem-Like Human Breast Tumor Spheroids Enhance Tumorigenicity of Orthotopic Xenografts in Athymic Nude Rat Model, Cancers (Basel). 2021 Jun 3;13(11):2784. doi: 10.3390/cancers13112784.
