Developmental and Reproductive Toxicology (DART)
We offer a broad scope and wide range of DART services:
- Fertility (male and/or female)
- Embryo-fetal development/prenatal developmental toxicity study
- Prenatal and postnatal development, including maternal function
- Combined 28-day/reproduction screening
- One- and two-generation reproduction study
- EOGRTS
Developmental Neurotoxicity
Scope and range of services:
- Studies
- OECD 426: Developmental neurotoxicity study
- EPA OPPTS 870.6300: Developmental neurotoxicity study
- Evaluations
- Clinical observations and bodyweight
- Neuropathology (immersion or perfusion fixation)
- Sexual maturation
- Other developmental landmarks
- Behavioral ontogeny
- Motor activity
- Motor and sensory function (auditory startle)
- Learning and memory
Juvenile Animal Studies (JAS)
Scope and range of services:
- Customized study designs
- Species selection and age for intended patient populations
- Consideration of timing of dosing, exposure, monitoring, pharmacological/toxicological differences
- Evaluations
- Routine and target organ toxicological endpoints
- Nervous system
- Reproductive systems
- Skeletal system (growth)
- Neurobehavioral
Inotiv has built an internationally recognized DART and JAS study team through close collaboration with industry-leading experts.