Discovery and Nonregulated Solutions for DMPK

Inotiv offers a broad scope of expertise for drug metabolism and pharmacokinetics (DMPK) studies at all stages of R&D, from lead optimization through new drug application (NDA). Benefit from our long and impeccable regulatory history, world-class team of scientists, and 40+ year track record of providing leading pharma and biotech companies with attentive, decisive analytical services — and high-quality data.

Our stage-dependent drug discovery bundles offer you the solutions you need to provide you with the insights to make informed decisions.

To talk to an expert about our DMPK Services, please click here.

drug-metabolism-pharmacokinetics

In Vivo Discovery Services

At Inotiv, you have access to a broad range of In Vivo Discovery Pharmacokinetics and exploratory toxicology support including:

Leadership team with an average of 25 years of experience
AALAS certified leadership
AAALAC accredited facilities
Boilerplate PK Designs for Rapid Screening
Discrete and Cassette Rapid PK
- Culex enabled/rodent (routine screening PK to bundle with in vitro metabolic clearance data, IVIVC)
- Vascular/Extravascular Dosing
  - Intravenous (IV)
  - Oral (PO)
  - Subcutaneous (SC)
  - Intraperitoneal (IP)
  - Human Papillomavirus (HPV)
  - Intradermal (ID)
    - Manual or Culex
Continuous Infusion
- Rat which is Culex enabled

Rodent In Vivo Drug Disposition Models:

Mechanistic Drug Disposition Study Designs
Bile Duct Cannulated (BDC) Rat
- Clearance mechanisms, excretion
- Culex automated sampling
- Metabolism caging for refrigerated sample collections
Intra-Duodenal Dosing
- BDC or Hepatic Portal Vein (HPV) sampling optional
HPV Dosing/Sampling
- First pass metabolism, clearance mechanism
Tissue Distribution Assessment
- Systemic circulation and tissue exposure

Get More Insight into our In Vivo Services

Obtain Pharmacokinetics, Toxicokinetics, and Modeling Insights for Your Data

Whatever the source of your data, we will perform PK-TK analyses to evaluate dose, DDI potential, bioequivalence/bioavailability, and/or clinical PK projections. You benefit from:

Discovery through regulated PK/TK analyses
IND enabling report preparation (nonclinical pharmacology summary)
Exposure-effect modeling (PK/PD)
Nonclinical pharmacokinetic modeling (pharmacology and toxicology dose design)
Phoenix™ WinNonlin™ validated software
Watson LIMS™ noncompartmental PK analysis (NCA)
Human PK predictions and dose projections (allometric, single species scaling)
Internal and external consultants with diverse PK, PK/PD modeling experience

In Vivo Services In Vivo Services From discovery to regulatory-enabling safety assessments in advanced developmental and reproductive toxicology (DART), we have the in vivo services and associated bioanalysis capabilities you need to find answers.

Surgical Models and MedicalDevice Testing Surgical Models and MedicalDevice Testing Our nonclinical testing services feature veterinary surgeons, state-of-the-art imaging, and a commitment to excellence to advance your medical device.

Histology Histology Our industry-leading histology laboratories support your discovery and nonclinical development projects with a wide range of services. From tissue processing to digital analysis, our team delivers the quality you expect.

Pathology Pathology Access world-class anatomical, clinical, and medical device pathology services, from routine histochemistry, IHC, IF, and ISH to stereology.

Consulting Consulting

Our experts deliver the insights you deserve to get the answers you need, whether in DMPK data analysis, biomarker analysis, or bioequivalence studies.

In Vivo Discovery Services

Obtain Pharmacokinetics, Toxicokinetics, and Modeling Insights for Your Data

Subscribe to updates from Inotiv