Back to Pharmacology and Toxicology Assessment top page

Renal dysfunction resulting from acute kidney injury (AKI) and chronic kidney disease (CKD) is a prevalent clinical condition for which there is a need for effective preventative and therapeutic strategies. Whereas AKI is typically abrupt in nature, CKD develops gradually over time causing a progressive deterioration in renal function. Although temporally distinct, AKI and CKD are closely related and interconnected, with each syndrome representing a risk factor for the other. Furthermore, both AKI and CKD are linked to other clinical disorders such as hypertension and heart disease resulting in cardiorenal syndrome. PBI offers a wide array of animal paradigms that model human conditions of AKI and CKD, including acute renal failure, acute and chronic renal ischemia/reperfusion, nephrotoxicity, and diabetic nephropathy.

Acute Kidney Injury & Failure (AKI / ARF)

ModelSpeciesTop Tier Data
 Unilateral Ureter Occlusion (UUO)Rat & Mouse• Renal Histology (fibrosis)
• Renal Gene Expression
• Kidney Cortex Hydroxyproline
• Blood Pressure (direct and indirect)
• Creatinine Clearance, GFR
• Urinary Protein, KIM1, NGAL, Albumin, MCP-1, Osteopontin
• Serum Creatinine, BUN, Electrolytes
Renal Ischemia/Reperfusion (I/R)Rat & Mouse
Glycerol Induced RhabdomyolysisRat

Nephrotoxicity

ModelSpeciesTop Tier Data
CisplatinMouse• Creatinine Clearance
• Urinary Protein, KIM1, NGAL, Albumin, MCP1
• Serum Creatinine, BUN
Acute StreptozotocinMouse
Puromycin (PAN)Rat

Chronic Kidney Disease & Renal Insufficiency

ModelSpeciesTop Tier Data
Renal Ischemia/ReperfusionRat & Mouse• Creatinine Clearance, GFR
• Urinary Protein, KIM1, NGAL, Albumin
• Serum Creatinine, BUN
• Blood pressure (Direct & Indirect)
• Creatinine Clearance, GFR
• Urinary Protein, KIM1, NGAL, Albumin, MCP-1
• Serum Creatinine, BUN, Electrolytes
• Plasma NT-proBNP, NT-proANP
5/6 NPX + NaCl (pole ablation method)Rat & Mouse
5/6 NPX (renal infarction method)Rat
DOCA + SaltRat
ANGII + L-NAMERat

Autoimmune Kidney Injury

ModelSpeciesTop Tier Data
Nephrotoxic Serum Nephritis
(Anti-Glomerular Basement Membrane Ab)
Mouse• Creatinine Clearance
• Urinary Protein, KIM1, NGAL, Albumin
• Serum Creatinine, BUN
Passive Heymann Nephritis (Anti-Fx1A ab)Rat

Diabetic Nephropathy

ModelSpeciesTop Tier Data
ZSF-1 (±NaCl, ±NPX)Rat• Blood Pressure (Direct & Indirect)
• Creatinine Clearance, GFR
• Urinary Protein, KIM1, NGAL, Osteopontin Albumin
• Serum Creatinine, Bun, Electrolytes Triglycerides, Glucose, HbA1C
• Kidney Histology (fibrosis, macrophages)
• Kidney Profibrotic & Proinflammatory mRNA Expression
• Cardiac Histology (Fibrosis, macrophages)
• Cardiac Gene Expression
• Echocardiography
Zucker Diabetic Fatty (ZDF) Rat
db/db Mouse (±NPX)Mouse
BtBr MouseMouse
Streptozotocin (±NPX)Mouse
(Rat – Under Development)

Related Pages:


Back to Pharmacology and Toxicology Assessment top page