Back to Pharmacology and Toxicology Assessment top page

Effects of peripherally restricted κ opioid receptor agonists on pain-related stimulation and depression of behavior in rats. Negus SS, O’Connell R, Morrissey E, Cheng K, Rice KC. J Pharmacy Exp There. 2012 Mar;340(3):501-9. dos: 10.1124/jpet.111.186783. Pub 2011 Nov 29.

Effects of the δ opioid receptor agonist SNC80 on pain-related depression of intracranial self-stimulation (ICSS) in rats. Negus SS, Rosenberg MB, Altarifi AA, O’Connell RH, Folk JE, Rice KC. J Pain. 2012 Apr; 13(4):317-27. dos: 10.1016/j.jpain.2011.12.003. Pub 2012 Mar 15.

Overexpression of cystatin C in synovium does not reduce synovitis or cartilage degradation in established osteoarthritis. Kyostio-Moore S, Piraino S, Berthelette P, et al. Arthritis Research & Therapy. 2015;17(1):5. doi:10.1186/s13075-015-0519-3.

Nerve growth factor inhibition with tanezumab influences weight-bearing and subsequent cartilage damage in the rat medial meniscal tear model
LaBranche T, Bendele A, Omura B, et al. Ann Rheum Dis. 2016 July(0:1-8).

Animal models of rheumatoid arthritis.
Bendele A. J Musculoskelet Neuronal Interact. 2001 Jun;1(4):377-85.

Animal models of osteoarthritis.
Bendele AM. J Musculoskelet Neuronal Interact. 2001 Jun;1(4):363-76.

Animal models of osteoarthritis in an era of molecular biology.
Bendele AM. J Musculoskelet Neuronal Interact. 2002 Dec;2(6):501-3.

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in a guinea pig.
Kraus VB, Huebner JL, DeGroot J, Bendele A. Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S35-52.

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the rat.
Gerwin N, Bendele AM, Glasson S, Carlson CS. Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S24-34.

Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: confirmation by multivariate analysis that modulation of type II collagen and aggrecan degradation peptides parallels pathologic changes.
Settle S, Vickery L, Nemirovskiy O, Vidmar T, Bendele A, Messing D, Ruminski P, Schnute M, Sunyer T. Arthritis Rheum. 2010 Oct;62(10):3006-15.

CEL-2000: A therapeutic vaccine for rheumatoid arthritis arrests disease development and alters serum cytokine/chemokine patterns in the bovine collagen type II induced arthritis in the DBA mouse model.
Zimmerman DH, Taylor P, Bendele A, Carambula R, Duzant Y, Lowe V, O’Neill SP, Talor E, Rosenthal KS. Int Immunopharmacol. 2010 Apr;10(4):412-21. Epub 2010 Jan 13.

A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models.
Baragi VM, Becher G, Bendele AM, Biesinger R, Bluhm H, Boer J, Deng H, Dodd R, Essers M, Feuerstein T, Gallagher BM Jr, Gege C, Hochgürtel M, Hofmann M, Jaworski A, Jin L, Kiely A, Korniski B, Kroth H, Nix D, Nolte B, Piecha D, Powers TS, Richter F, Schneider M, Steeneck C, Sucholeiki I, Taveras A, Timmermann A, Van Veldhuizen J, Weik J, Wu X, Xia B. Arthritis Rheum. 2009 Jul;60(7):2008-18.

Protective effects of a cathepsin K inhibitor, SB-553484, canine partial medial meniscectomy model of osteoarthritis.
Connor JR, LePage C, Swift BA, Yamashita D, Bendele AM, Maul D, Kumar S. Osteoarthritis Cartilage. 2009 Sep;17(9):1236-43. Epub 2009 Apr 5.

The pattern recognition receptor CD36 is a chondrocyte hypertrophy marker associated with suppression of catabolic responses and promotion of repair responses to inflammatory stimuli.
Cecil DL, Appleton CT, Polewski MD, Mort JS, Schmidt AM, Bendele A, Beier F, Terkeltaub R. J Immunol. 2009 Apr 15;182(8):5024-31.

Prevention of cartilage degeneration in rat model of osteoarthritis by intraarticular treatment with recombinant lubricin.
Flannery CR, Zollner R, Corcoran C, Jones AR, Root A, Rivera-Bermúdez MA, Blanchet T, Gleghorn JP, Bonassar LJ,Bendele AM, Morris EA, Glasson SS. Arthritis Rheum. 2009 Mar;60(3):840-7.

Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells.
Roark CL, French JD, Taylor MA, Bendele AM, Born WK, O’Brien RL. J Immunol. 2007 Oct 15;179(8):5576-83.

Culture-independent analysis of indomethacin-induced alterations in the rat gastrointestinal microbiota.
Dalby AB, Frank DN, St Amand AL, Bendele AM, Pace NR. Appl Environ Microbiol. 2006 Oct;72(10):6707-15.

Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenic mice expressing transmembrane tumor necrosis factor alpha.
Edwards CK 3rd, Bendele AM, Reznikov LI, Fantuzzi G, Chlipala ES, Li L, Moldawer LL, Mountz JD, Li YY, Dinarello CA. Arthritis Rheum. 2006 Sep;54(9):2872-85.

Inhibition of in vitro and in vivo T cell responses by recombinant human Tim-1 extracellular domain proteins.
Mesri M, Smithson G, Ghatpande A, Chapoval A, Shenoy S, Boldog F, Hackett C, Pena CE, Burgess C, Bendele A, Shimkets RA, Starling GC. Int Immunol. 2006 Mar;18(3):473-84. Epub 2006 Feb 15.

Anti-inflammatory activity of an orange peel polymethoxylated flavone, 3′,4′,3,5,6,7,8-heptamethoxyflavone, in the rat carrageenan/paw edema and mouse lipopolysaccharide-challenge assays.
Manthey JA, Bendele P. J Agric Food Chem. 2008 Oct 22;56(20):9399-403. Epub 2008 Sep 25.

Induction of PNAd and N-acetylglucosamine 6-O-sulfotransferases 1 and 2 in mouse collagen-induced arthritis.
Yang J, Rosen SD, Bendele P, Hemmerich S.BMC Immunol. 2006 Jun 13;7:12.

For more information about Publications contact us here.

Back to Pharmacology and Toxicology Assessment top page