Inotiv’s toxicogenomics studies are a powerful tool for the safety assessment of preclinical candidates, as well as novel small molecule and commodity chemicals. Data can be used to:
Our experimental designs for toxicogenomic studies employ dose-response studies — from human-relevant levels to exposure levels used in regulatory studies — with a focus on identifying no-observed-effect level (NOEL) and benchmark doses useful in risk assessments, as well as determining thresholds of toxicological concern.
With a deep background in toxicogenomics and genetic and molecular toxicology, our team conducts studies aimed at identifying cellular and genomic response pathways to xenobiotic exposures.
Our fully integrated capabilities deliver turnkey toxicology solutions that include gene expression profiling integrated into traditional studies. We design studies for:
Inotiv’s scientific staff has the expertise to provide a comprehensive investigative toxicology approach to assess MOA. We integrate genomic profiling into traditional toxicology studies and apply computational tools using a broad spectrum of in vitro and in vivo models.
Our studies provide data in a timely manner to improve your understanding of potential adverse effects. We ensure you understand how the data are relevant to humans to facilitate informed decision-making.
To talk to an expert about our Toxicogenomic Services, please click here.