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Prkdc knockout rats

Prkdc knockout rats publications

ADMET

Harrill JA, Layko D, Nyska A, Hukkanen RR, Manno RA, Grassetti A, Lawson M, Martin G, Budinsky RA, Rowlands JC, Thomas RS., Aryl hydrocarbon receptor knockout rats are insensitive to the pathological effects of repeated oral exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin., J Appl Toxicol. 2016 Jun;36(6):802-14.
Phadnis-Moghe AS, Chen W, Li J, Crawford RB, Bach A, D'Ingillo S, Kovalova N, Suarez-Martinez JE, Kaplan BL, Harrill JA, Budinsky R, Rowlands JC, Thomas RS, Kaminski NE., Immunological characterization of the aryl hydrocarbon receptor (AHR) knockout rat in the presence and absence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)., Toxicology. 2016 Aug 10;368-369:172-182.
Harrill JA, Hukkanen RR, Lawson M, Martin G, Gilger B, Soldatow V, Lecluyse EL, Budinsky RA, Rowlands JC, Thomas RS., Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18

Aging

Bolles, M., Deming, D., Long, K., Agnihothram, S., Whitmore, A., Ferris, M., . . . Baric, R. S. (2011)., A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge, Journal of Virology, 85(23), 12201-12215. doi:10.1128/JVI.06048-11 [doi]
Corsetti, G., Pasini, E., Romano, C., Calvani, R., Picca, A., Marzetti, E., . . . Dioguardi, F. S. (2018)., Body weight loss and tissue wasting in late middle-aged mice on slightly imbalanced Essential/Non-essential amino acids diet., Frontiers in Medicine, 5, 136. doi:10.3389/fmed.2018.00136 [doi]
Rockx, B., Baas, T., Zornetzer, G. A., Haagmans, B., Sheahan, T., Frieman, M., . . . Katze, M. G. (2009), Early upregulation of acute respiratory distress syndrome-associated cytokines promotes lethal disease in an aged-mouse model of severe acute respiratory syndrome coronavirus infection, Journal of Virology, 83(14), 7062-7074. doi:10.1128/JVI.00127-09 [doi]
Barone, R., Macaluso, F., Catanese, P., Marino Gammazza, A., Rizzuto, L., Marozzi, P., . . . Di Felice, V. (2013)., Endurance exercise and conjugated linoleic acid (CLA) supplementation up-regulate CYP17A1 and stimulate testosterone biosynthesis, PloS One, 8(11), e79686. doi:10.1371/journal.pone.0079686 [doi]
Clayton, E. H., Garbow, J. R., & Bayly, P. V. (2011)., Frequency-dependent viscoelastic parameters of mouse brain tissue estimated by MR elastography, Physics in Medicine and Biology, 56(8), 2391-2406. doi:10.1088/0031-9155/56/8/005 [doi]
Cayatte, C., Snell Bennett, A., Rajani, G. M., Hostetler, L., Maynard, S. K., Lazzaro, M., . . . Schneider-Ohrum, K. (2017)., Inferior immunogenicity and efficacy of respiratory syncytial virus fusion protein-based subunit vaccine candidates in aged versus young mice., PloS One, 12(11), e0188708. doi:10.1371/journal.pone.0188708 [doi]
Grizenkova, J., Akhtar, S., Brandner, S., Collinge, J., & Lloyd, S. E. (2014), Microglial Cx3cr1 knockout reduces prion disease incubation time in mice., BMC Neuroscience, 15, 44-2202-15-44. doi:10.1186/1471-2202-15-44 [doi]

Antibody production

Rijal P, Wang BB, Tan TK, Schimanski L, Janesch P, Dong T, McCauley JW, Daniels RS, Townsend AR, Huang KA., Broadly Inhibiting Antineuraminidase Monoclonal Antibodies Induced by Trivalent Influenza Vaccine and H7N9 Infection in Humans, J Virol. 2020 Jan 31;94(4):e01182-19. doi: 10.1128/JVI.01182-19. Print 2020 Jan 31.
McKitrick TR, Goth CK, Rosenberg CS, Nakahara H, Heimburg-Molinaro J, McQuillan AM, Falco R, Rivers NJ, Herrin BR, Cooper MD, Cummings RD., Development of smart anti-glycan reagents using immunized lampreys, Commun Biol. 2020 Feb 28;3(1):91. doi: 10.1038/s42003-020-0819-2.
Boyoglu-Barnum S, Hutchinson GB, Boyington JC, Moin SM, Gillespie RA, Tsybovsky Y, Stephens T, Vaile JR, Lederhofer J, Corbett KS, Fisher BE, Yassine HM, Andrews SF, Crank MC, McDermott AB, Mascola JR, Graham BS, Kanekiyo M., Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses, Nat Commun. 2020 Feb 7;11(1):791. doi: 10.1038/s41467-020-14579-4.
Hemon MF, Lambert NC, Arnoux F, Roudier J, Auger I., PAD4 Immunization Triggers Anti-Citrullinated Peptide Antibodies in Normal Mice: Analysis With Peptide Arrays, Front Immunol. 2022 Mar 31;13:840035. doi: 10.3389/fimmu.2022.840035. eCollection 2022.

Atherosclerosis

Sijbesma JWA, van Waarde A, Kristensen S, Kion I, Tietge UJF, Hillebrands JL, Bulthuis MLC, Buikema H, Nakladal D, Westerterp M, Liu F, Boersma HH, Dierckx RAJO, Slart RHJA, Characterization of a novel model for atherosclerosis imaging: the apolipoprotein E-deficient rat, EJNMMI Res. 2023 Dec 11;13(1):106. doi: 10.1186/s13550-023-01055-5.
Berenji Ardestani S, Eftedal I, Pedersen M, Jeppesen PB, Nørregaard R, Matchkov VV., Endothelial dysfunction in small arteries and early signs  of atherosclerosis in ApoE knockout rats, Sci Rep. 2020 Sep 17;10(1):15296. doi: 10.1038/s41598-020-72338-3.
Berenji Ardestani S, Matchkov VV, Hansen K, Jespersen NR, Pedersen M, Eftedal I., Extensive Simulated Diving Aggravates Endothelial Dysfunction in Male Pro-atherosclerotic ApoE Knockout Rats, Front Physiol. 2020 Dec 23;11:611208. doi: 10.3389/fphys.2020.611208. eCollection 2020.
Wu, Y.; Johnson, G.; Zhao, F.; Wu, Y.; Zhao, G.; Brown, A.; You, S.; Zou, M.-H.; Song, P., Features of Lipid Metabolism in Humanized ApoE Knockin Rat Models, International Journal of Molecular Sciences. 2021; 22(15):8262.
Yang, J. H., Niu, W., Li, Y., & Azadzoi, K. M., Impairment of AMPK-?2 augments detrusor contractions in bladder ischemia, Investigative and Clinical Urology 62, no. 5 (2021): 600.
Nguyen TD, Watanabe A, Burleigh S, Ghaffarzadegan T, Kanklai J, Prykhodko O, Hållenius FF, Nyman M., Monobutyrin and monovalerin improve gut-blood-brain biomarkers and alter gut microbiota composition in high-fat fed apolipoprotein-E-knockout rats., Psychopharmacology (Berl). 2023 Jan;240(1):137-147. doi: 10.1007/s00213-022-06286-3. Epub 2022 Dec 5.
Nakladal, D., Sijbesma, J. W. A., Visser, L. M., Tietge, U. J. F., Slart, R. H. J. A., Deelman, L. E., ... & Buikema, H., Perivascular adipose tissue-derived nitric oxide compensates endothelial dysfunction in aged pre-atherosclerotic apolipoprotein E-deficient rats, Vascular pharmacology (2021): 106945.
Nakladal D, Sijbesma JWA, Visser LM, Tietge UJF, Slart RHJA, Deelman LE, Henning RH, Hillebrands JL, Buikema H., Perivascular adipose tissue-derived nitric oxide compensates endothelial dysfunction in aged pre-atherosclerotic apolipoprotein E-deficient rats., Vascul Pharmacol. 2022 Feb;142:106945. doi: 10.1016/j.vph.2021.106945. Epub 2021 Nov 18.

Autoimmune disease

Kalliokoski, S., Caja, S., Frias, R., Laurila, K., Koskinen, O., Niemela, O., . . . Lindfors, K. (2015), Injection of celiac disease patient sera or immunoglobulins to mice reproduces a condition mimicking early developing celiac disease., Journal of Molecular Medicine (Berlin, Germany), 93(1), 51-62. doi:10.1007/s00109-014-1204-8 [doi]

Cardiovascular

Wu Y, Zhao F, Sure VN, Ibrahim A, Yu C, Carr SM, Song P., Human ApoE2 Endows Stronger Contractility in Rat Cardiomyocytes Enhancing Heart Function, Cells. 2023 Jan 17;12(3):347. doi: 10.3390/cells12030347.
Corsetti G, Romano C, Pasini E, Scarabelli T, Chen-Scarabelli C, Dioguardi FS., Essential Amino Acids-Rich Diet Increases Cardiomyocytes Protection in Doxorubicin-Treated Mice, Nutrients. 2023 May 12;15(10):2287. doi: 10.3390/nu15102287.
Bruce, A. C., & Peirce, S. M. (2012)., Exogenous thrombin delivery promotes collateral capillary arterialization and tissue reperfusion in the murine spinotrapezius muscle ischemia model., Microcirculation (New York, N.Y.: 1994), 19(2), 143-154. doi:10.1111/j.1549-8719.2011.00138.x [doi]
Antonioni A, Dimauro I, Fantini C, Barone R, Macaluso F, Di Felice V, Caporossi D., ÎąB-crystallin response to a pro-oxidant non-cytotoxic environment in murine cardiac cells: An "in vitro" and "in vivo" study, Free Radic Biol Med. 2020 May 20;152:301-312. doi: 10.1016/j.freeradbiomed.2020.03.013. Epub 2020 Mar 26.
Schiviz, A., Magirr, D., Leidenmuhler, P., Schuster, M., Muchitsch, E. M., Hollriegl, W., & Subcommittee on Animal Models. (2014)., Influence of genetic background on bleeding phenotype in the tail-tip bleeding model and recommendations for standardization: Communication from the SSC of the ISTH., Journal of Thrombosis and Haemostasis : JTH, 12(11), 1940-1942. doi:10.1111/jth.12700 [doi]
Kolosowska N, Gotkiewicz M, Dhungana H, Giudice L, Giugno R, Box D, Huuskonen MT, Korhonen P, Scoyni F, Kanninen KM, Ylä-Herttuala S, Turunen TA, Turunen MP, Koistinaho J, Malm T., Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation, J Neuroinflammation. 2020 Jun 19;17(1):194. doi: 10.1186/s12974-020-01870-w.
Stohr, R., Mavilio, M., Marino, A., Casagrande, V., Kappel, B., Mollmann, J., . . . Federici, M. (2015), ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice., Scientific Reports, 5, 9023. doi:10.1038/srep09023 [doi]
Bigelman E, Pasmanik-Chor M, Dassa B, Itkin M, Malitsky S, Dorot O, Pichinuk E, Kleinberg Y, Keren G, Entin-Meer M., Kynurenic acid, a key L-tryptophan-derived metabolite, protects the heart from an ischemic damage, PLoS One. 2023 Aug 24;18(8):e0275550. doi: 10.1371/journal.pone.0275550. eCollection 2023.
De Hoog, V. C., Timmers, L., Van Duijvenvoorde, A., De Jager, S. C., Van Middelaar, B. J., Smeets, M. B., . . . De Kleijn, D. P. (2014), Leucocyte expression of complement C5a receptors exacerbates infarct size after myocardial reperfusion injury, Cardiovascular Research, 103(4), 521-529. doi:10.1093/cvr/cvu153 [doi]
Itzhar A, Yosef G, Eilon-Ashkenazy M, Shmidov Y, Gil H, Lacham-Hartman S, Elyagon S, Etzion S, Bitton R, Cohen S, Etzion Y, Papo N., Potent inhibition of MMP-9 by a novel sustained-release platform attenuates left ventricular remodeling following myocardial infarction, J Control Release. 2023 Dec;364:246-260. doi: 10.1016/j.jconrel.2023.10.033. Epub 2023 Oct 31.
Turner, J. K., McAllister, M. M., Xu, J. L., & Tapping, R. I. (2008)., The resistance of BALB/cJ mice to yersinia pestis maps to the major histocompatibility complex of chromosome 17., Infection and Immunity, 76(9), 4092-4099. doi:10.1128/IAI.00488-08 [doi]

COVID-19

Tan T K, Rijal P, Rahikainen R, Keeble A H, Schimanski L, Hussain S, Harvey R, et al., A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses, bioRxiv 2020.08.31.275701; doi: https://doi.org/10.1101/2020.08.31.275701
Dinnon KH 3rd, Leist SR, Schäfer A, Edwards CE, Martinez DR, Montgomery SA, West A, Yount BL Jr, Hou YJ, Adams LE, Gully KL, Brown AJ, Huang E, Bryant MD, Choong IC, Glenn JS, Gralinski LE, Sheahan TP, Baric RS., A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures, Nature. 2020 Oct;586(7830):560-566. doi: 10.1038/s41586-020-2708-8. Epub 2020 Aug 27.

Gene therapy

Qiu M, Li G, Wang P, Li X, Lai F, Luo R, Liu B, Lin J., aarF domain containing kinase 5 gene promotes invasion and migration of lung cancer cells through ADCK5-SOX9-PTTG1 pathway, Exp Cell Res. 2020 Jul 1;392(1):112002. doi: 10.1016/j.yexcr.2020.112002. Epub 2020 Apr 8.
Lampe, J., Bossow, S., Weiland, T., Smirnow, I., Lehmann, R., Neubert, W., . . . Lauer, U. M. (2013)., An armed oncolytic measles vaccine virus eliminates human hepatoma cells independently of apoptosis., Gene Therapy, 20(11), 1033-1041. doi:10.1038/gt.2013.28 [doi]
Tiwari A, Iida M, Kosnopfel C, Abbariki M, Menegakis A, Fehrenbacher B, Maier J, Schaller M, Brucker SY, Wheeler DL, Harari PM, Rothbauer U, Schittek B, Zips D, Toulany M., Blocking Y-Box Binding Protein-1 through Simultaneous Targeting of PI3K and MAPK in Triple Negative Breast Cancers, Cancers (Basel). 2020 Sep 29;12(10):2795. doi: 10.3390/cancers12102795.
Feichtinger, G. A., Hacobian, A., Hofmann, A. T., Wassermann, K., Zimmermann, A., van Griensven, M., & Redl, H. (2014)., Constitutive and inducible co-expression systems for non-viral osteoinductive gene therapy., European Cells & Materials, 27, 166-84; discussion 184. doi:vol027a13 [pii]
McCarthy GA, Di Niro R, Finan JM, Jain A, Guo Y, Wyatt CR, Guimaraes AR, Waugh TA, Keith D, Morgan TK, Sears RC, Brody JR., Deletion of the mRNA stability factor ELAVL1 (HuR) in pancreatic cancer cells disrupts the tumor microenvironment integrity., NAR Cancer. 2023 Apr 19;5(2):zcad016. doi: 10.1093/narcan/zcad016. eCollection 2023 Jun.
Gentschev, I., Muller, M., Adelfinger, M., Weibel, S., Grummt, F., Zimmermann, M., . . . Szalay, A. A. (2011)., Efficient colonization and therapy of human hepatocellular carcinoma (HCC) using the oncolytic vaccinia virus strain GLV-1h68., PloS One, 6(7), e22069. doi:10.1371/journal.pone.0022069 [doi]
Arruabarrena-Aristorena A, Maag JLV, Kittane S, Cai Y, Karthaus WR, Ladewig E, Park J, Kannan S, Ferrando L, Cocco E, Ho SY, Tan DS, Sallaku M, Wu F, Acevedo B, Selenica P, Ross DS, Witkin M, Sawyers CL, Reis-Filho JS, Verma CS, Jauch R, Koche R, Baselga J, Razavi P, Toska E, Scaltriti M., FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer, Cancer Cell. 2020 Oct 12;38(4):534-550.e9. doi: 10.1016/j.ccell.2020.08.003. Epub 2020 Sep 3.
Yu, L., Liang, Y., Cao, X., Wang, X., Gao, H., Lin, S. Y., . . . Li, K. (2017), Identification of MYST3 as a novel epigenetic activator of ERalpha frequently amplified in breast cancer., Oncogene, 36(20), 2910-2918. doi:10.1038/onc.2016.433 [doi]
Unzu, C., Melero, I., Morales-Kastresana, A., Sampedro, A., Serrano-Mendioroz, I., Azpilikueta, A., . . . Fontanellas, A. (2014), Innate functions of immunoglobulin M lessen liver gene transfer with helper-dependent adenovirus, PloS One, 9(1), e85432. doi:10.1371/journal.pone.0085432 [doi]
Dowaidar, M., Abdelhamid, H. N., Hallbrink, M., Freimann, K., Kurrikoff, K., Zou, X., & Langel, U. (2017)., Magnetic nanoparticle assisted self-assembly of cell penetrating peptides-oligonucleotides complexes for gene delivery, Scientific Reports, 7(1), 9159-017-09803-z. doi:10.1038/s41598-017-09803-z [doi]
Dinami R, Pompili L, Petti E, Porru M, D'Angelo C, Di Vito S, Rizzo A, Campani V, De Rosa G, Bruna A, Serra V, Mano M, Giacca M, Leonetti C, Ciliberto G, Tarsounas M, Stoppacciaro A, Schoeftner S, Biroccio A., MiR-182-3p targets TRF2 and impairs tumor growth of triple-negative breast cancer., EMBO Mol Med. 2023 Jan 11;15(1):e16033. doi: 10.15252/emmm.202216033. Epub 2022 Nov 25.
Kim SS, Doherty C, Moghe M, Rait A, Pirollo KF, Harford JB, Chang EH., Nanomedicine-Based Gene Delivery for a Truncated Tumor Suppressor RB94 Promotes Lung Cancer Immunity, Cancers (Basel). 2022 Oct 18;14(20):5092. doi: 10.3390/cancers14205092.
Ady, J. W., Johnsen, C., Mojica, K., Heffner, J., Love, D., Pugalenthi, A., . . . Fong, Y. (2015)., Oncolytic gene therapy with recombinant vaccinia strain GLV-2b372 efficiently kills hepatocellular carcinoma., Surgery, 158(2), 331-338. doi:10.1016/j.surg.2015.03.044 [doi]
Veiman, K. L., Kunnapuu, K., Lehto, T., Kiisholts, K., Parn, K., Langel, U., & Kurrikoff, K. (2015)., PEG shielded MMP sensitive CPPs for efficient and tumor specific gene delivery in vivo., Journal of Controlled Release : Official Journal of the Controlled Release Society, 209, 238-247. doi:10.1016/j.jconrel.2015.04.038 [doi]
Croessmann, S., Wong, H. Y., Zabransky, D. J., Chu, D., Rosen, D. M., Cidado, J., . . . Park, B. H. (2017)., PIK3CA mutations and TP53 alterations cooperate to increase cancerous phenotypes and tumor heterogeneity., Breast Cancer Research and Treatment, 162(3), 451-464. doi:10.1007/s10549-017-4147-2 [doi]
Hollevoet, K., De Smidt, E., Geukens, N., & Declerck, P. (2018), Prolonged in vivo expression and anti-tumor response of DNA-based anti-HER2 antibodies, Oncotarget, 9(17), 13623-13636. doi:10.18632/oncotarget.24426 [doi]
Kaliberov, S. A., Kaliberova, L. N., Yan, H., Kapoor, V., & Hallahan, D. E. (2016)., Retargeted adenoviruses for radiation-guided gene delivery., Cancer Gene Therapy, 23(9), 303-314. doi:10.1038/cgt.2016.32 [doi]
Shapira, S., Shapira, A., Kazanov, D., Hevroni, G., Kraus, S., & Arber, N. (2017)., Selective eradication of cancer cells by delivery of adenovirus-based toxins., Oncotarget, 8(24), 38581-38591. doi:10.18632/oncotarget.16934 [doi]
Anders, N. M., Liu, J., Wanjiku, T., Giovinazzo, H., Zhou, J., Vaghasia, A., . . . Rudek, M. A. (2016)., Simultaneous quantitative determination of 5-aza-2'-deoxycytidine genomic incorporation and DNA demethylation by liquid chromatography tandem mass spectrometry as exposure-response measures of nucleoside analog DNA methyltransferase inhibitors, Journal of Chromatography.B, Analytical Technologies in the Biomedical and Life Sciences, 1022, 38-45. doi:S1570-0232(16)30178-7 [pii]
Feichtinger, G. A., Hofmann, A. T., Slezak, P., Schuetzenberger, S., Kaipel, M., Schwartz, E., . . . Redl, H. (2014)., Sonoporation increases therapeutic efficacy of inducible and constitutive BMP2/7 in vivo gene delivery., Human Gene Therapy Methods, 25(1), 57-71. doi:10.1089/hgtb.2013.113 [doi]
Abel, T., El Filali, E., Waern, J., Schneider, I. C., Yuan, Q., Munch, R. C., . . . Buchholz, C. J. (2013)., Specific gene delivery to liver sinusoidal and artery endothelial cells, Blood, 122(12), 2030-2038. doi:10.1182/blood-2012-11-468579 [doi]
Hou R, Yu Y, Sluter MN, Li L, Hao J, Fang J, Yang J, Jiang J., Targeting EP2 receptor with multifaceted mechanisms for high-risk neuroblastoma, Cell Rep. 2022 Jun 21;39(12):111000. doi: 10.1016/j.celrep.2022.111000.
Chatterjee S, Naidu GS, Hazan-Halevy I, Grobe H, Ezra A, Sharma P, Goldsmith M, Ramishetti S, Sprinzak D, Zaidel-Bar R, Peer D., Therapeutic gene silencing of CKAP5 leads to lethality in genetically unstable cancer cells., Sci Adv. 2023 Apr 5;9(14):eade4800. doi: 10.1126/sciadv.ade4800. Epub 2023 Apr 5.
Presutti, D., Ceccarelli, M., Micheli, L., Papoff, G., Santini, S., Samperna, S., . . . Tirone, F. (2018)., Tis21-gene therapy inhibits medulloblastoma growth in a murine allograft model., PloS One, 13(3), e0194206. doi:10.1371/journal.pone.0194206 [doi]
Nomikou, N., Feichtinger, G. A., Saha, S., Nuernberger, S., Heimel, P., Redl, H., & McHale, A. P. (2018)., Ultrasound-responsive gene-activated matrices for osteogenic gene therapy using matrix-assisted sonoporation., Journal of Tissue Engineering and Regenerative Medicine, 12(1), e250-e260. doi:10.1002/term.2406 [doi]

General studies

Waugh CM, Mousavizadeh R, Lee J, Screen HRC, Scott A., Mild hypercholesterolemia impacts achilles sub-tendon mechanical properties in young rats, BMC Musculoskelet Disord. 2023 Apr 12;24(1):282. doi: 10.1186/s12891-023-06375-0.
Choi YH, Zhang C, Liu Z, Tu MJ, Yu AX, Yu AM., A Novel Integrated Pharmacokinetic-Pharmacodynamic Model to Evaluate Combination Therapy and Determine In Vivo Synergism, J Pharmacol Exp Ther. 2021 Jun;377(3):305-315. doi: 10.1124/jpet.121.000584. Epub 2021 Mar 12.
Landgraf, L., Christner, C., Storck, W., Schick, I., Krumbein, I., Dahring, H., . . . Hilger, I. (2015), A plasma protein corona enhances the biocompatibility of Au@Fe3O4 janus particles, Biomaterials, 68, 77-88. doi:10.1016/j.biomaterials.2015.07.049 [doi]
Cook Sangar ML, Girard EJ, Hopping G, Yin C, Pakiam F, Brusniak MY, Nguyen E, Ruff R, Gewe MM, Byrnes-Blake K, Nairn NW, Miller DM, Mehlin C, Strand AD, Mhyre AJ, Correnti CE, Strong RK, Simon JA, Olson JM., A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure, Sci Transl Med. 2020 Mar 4;12(533):eaay1041. doi: 10.1126/scitranslmed.aay1041.
Crook ZR, Girard E, Sevilla GP, Merrill M, Friend D, Rupert PB, Pakiam F, Nguyen E, Yin C, Ruff RO, Hopping G, Strand AD, Finton KAK, Coxon M, Mhyre AJ, Strong RK, Olson JM., A TfR-Binding Cystine-Dense Peptide Promotes Blood-Brain Barrier Penetration of Bioactive Molecules, J Mol Biol. 2020 Jun 26;432(14):3989-4009. doi: 10.1016/j.jmb.2020.04.002. Epub 2020 Apr 15.
Joshi S, Montes de Oca I, Maghrabi A, Lopez-Yang C, Quiroz-Olvera J, Garcia CA, Jarajapu YPR., ACE2 gene transfer ameliorates vasoreparative dysfunction in CD34+ cells derived from diabetic older adults, Clin Sci (Lond). 2021 Jan 29;135(2):367-385. doi: 10.1042/CS20201133.
Crum RJ, Capella-Monsonís H, Chang J, Dewey MJ, Kolich BD, Hall KT, El-Mossier SO, Nascari DG, Hussey GS, Badylak SF., Biocompatibility and biodistribution of matrix-bound nanovesicles in vitro and in vivo, Acta Biomater. 2023 Jan 1;155:113-122. doi: 10.1016/j.actbio.2022.11.026. Epub 2022 Nov 22.
Talele S, Zhang W, Chen J, Gupta SK, Burgenske DM, Sarkaria JN, Elmquist WF., Central Nervous System Distribution of the Ataxia-Telangiectasia Mutated Kinase Inhibitor AZD1390: Implications for the Treatment of Brain Tumors, J Pharmacol Exp Ther. 2022 Oct;383(1):91-102. doi: 10.1124/jpet.122.001230. Epub 2022 Aug 5.
Das, S., Haedicke, K., & Grimm, J. (2018)., Cerenkov-activated sticky tag for in vivo fluorescence imaging., Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, 59(1), 58-65. doi:10.2967/jnumed.117.198549 [doi]
Gaffron F, Tilch A, Grüttner C, Kowalski A, Kramer M, Teichgräber U, Hilger AI., Challenges in Tracking of Fluorochrome-Labelled Nanoparticles in Mice via Whole Body NIRF Imaging, Nanomaterials (Basel). 2020 Mar 24;10(3):596. doi: 10.3390/nano10030596.
Rahman, C. V., Ben-David, D., Dhillon, A., Kuhn, G., Gould, T. W., Muller, R., . . . Livne, E. (2014)., Controlled release of BMP-2 from a sintered polymer scaffold enhances bone repair in a mouse calvarial defect model., Journal of Tissue Engineering and Regenerative Medicine, 8(1), 59-66. doi:10.1002/term.1497 [doi]
Deng H, Qiao H, Dai Q, Ma C., Deep learning in photoacoustic imaging: a review, J Biomed Opt. 2021 Apr;26(4):040901. doi: 10.1117/1.JBO.26.4.040901.
Andleeb F, Katta N, Gruslova A, Muralidharan B, Estrada A, McElroy AB, Ullah H, Brenner AJ, Milner TE., Differentiation of Brain Tumor Microvasculature From Normal Vessels Using Optical Coherence Angiography, Lasers Surg Med. 2021 Jun 15. doi: 10.1002/lsm.23446. Online ahead of print.
Altshuler A, Amitai-Lange A, Tarazi N, Dey S, Strinkovsky L, Hadad-Porat S, Bhattacharya S, Nasser W, Imeri J, Ben-David G, Abboud-Jarrous G, Tiosano B, Berkowitz E, Karin N, Savir Y, Shalom-Feuerstein R., Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing, Cell Stem Cell. 2021 Jul 1;28(7):1248-1261.e8. doi: 10.1016/j.stem.2021.04.003. Epub 2021 May 12.
Netser S, Meyer A, Magalnik H, Zylbertal A, de la Zerda SH, Briller M, Bizer A, Grinevich V, Wagner S., Distinct dynamics of social motivation drive differential social behavior in laboratory rat and mouse strains, Nat Commun. 2020 Nov 20;11(1):5908. doi: 10.1038/s41467-020-19569-0.
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Jacobson, O., Li, Q., Chen, H., Niu, G., Kiesewetter, D. O., Xu, L., . . . Chen, X. (2017)., PET-guided evaluation and optimization of internalized antibody-drug conjugates targeting erythropoietin-producing hepatoma A2 receptor., Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, 58(11), 1838-1844. doi:10.2967/jnumed.117.192245 [doi]
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Neuroscience

Berenji Ardestani, Simin; Matchkov, Vladimir V; Eftedal, Ingrid; Pedersen, Michael;, A Single Simulated Heliox Dive Modifies Endothelial Function in the Vascular Wall of ApoE Knockout Male Rats More Than Females., Frontiers in physiology Vol.10, 2019
Phillips, Evan H; Chang, Mandy S; Gorman, Sydney; Qureshi, Hamna J; Ejendal, Karin F K; Kinzer-Ursem, Tamara L; Blaize, A Nicole; Goergen, Craig J;, Angiotensin II Infusion Does Not Cause Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Rats., Journal of vascular research Vol.55, 2018
Cornelissen, Anne; Simsekyilmaz, Sakine; Liehn, Elisa; Rusu, Mihaela; Schaaps, Nicole; Afify, Mamdouh; Florescu, Roberta; Almalla, Mohammad; Borinski, Mauricio; Vogt, Felix;, Apolipoprotein E deficient rats generated via zinc-finger nucleases exhibit pronounced in-stent restenosis., Scientific reports Vol.9, 2019
Rune, Ida; Rolin, Bidda; Lykkesfeldt, Jens; Nielsen, Dennis Sandris; Krych, Lukasz; Kanter, Jenny E; Bornfeldt, Karin E; Kihl, Pernille; Buschard, Karsten; Josefsen, Knud; Fels, Johannes Josef; Mortensen, Alan; Christoffersen, Berit; Kirk, Rikke Kaae; Hansen, Axel Kornerup;, Long-term Western diet fed apolipoprotein E-deficient rats exhibit only modest early atherosclerotic characteristics., Scientific reports Vol.8, 2018
Hohl, Mathias; Linz, Dominik; Fries, Peter; MĂźller, Andreas; Stroeder, Jonas; Urban, Daniel; Speer, Thimoteus; Geisel, JĂźrgen; Hummel, BjĂśrn; Laufs, Ulrich; Schirmer, Stephan H; BĂśhm, Michael; Mahfoud, Felix;, Modulation of the sympathetic nervous system by renal denervation prevents reduction of aortic distensibility in atherosclerosis prone ApoE-deficient rats., Journal of translational medicine Vol.14, 2016
Nguyen TD, Hållenius FF, Lin X, Nyman M, Prykhodko O., Monobutyrin and Monovalerin Affect Brain Short-Chain Fatty Acid Profiles and Tight-Junction Protein Expression in ApoE-Knockout Rats Fed High-Fat Diets, Nutrients. 2020 Apr 24;12(4):1202. doi: 10.3390/nu12041202.

Obesity

Pohjanvirta, R., Karppinen, I., Galbán-Velázquez, S., Esteban, J., Hĺkansson, H., Sankari, S., & Lindén, J., Effects of a high-fat diet and global aryl hydrocarbon receptor deficiency on energy balance and liver retinoid status in male Sprague-Dawley rats, The Journal of Nutritional Biochemistry 95 (2021): 108762.

Oncology

Siddique AB, Kilgore PCSR, Tajmim A, Singh SS, Meyer SA, Jois SD, Cvek U, Trutschl M, Sayed KAE., (-)-Oleocanthal as a Dual c-MET-COX2 Inhibitor for the Control of Lung Cancer, Nutrients. 2020 Jun 11;12(6):1749. doi: 10.3390/nu12061749.
Jiménez-Mora E, Gallego B, Díaz-Gago S, Lasa M, Baquero P, Chiloeches A., (V600E)BRAF Inhibition Induces Cytoprotective Autophagy through AMPK in Thyroid Cancer Cells, Int J Mol Sci. 2021 Jun 3;22(11):6033. doi: 10.3390/ijms22116033.
Masoodi, K. Z., Ramos Garcia, R., Pascal, L. E., Wang, Y., Ma, H. M., O'Malley, K., . . . Wang, Z. (2013)., 5alpha-reductase inhibition suppresses testosterone-induced initial regrowth of regressed xenograft prostate tumors in animal models., Endocrinology, 154(7), 2296-2307. doi:10.1210/en.2012-2077 [doi]
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Marayati R, Bownes LV, Stafman LL, Williams AP, Quinn CH, Atigadda V, Aye JM, Stewart JE, Yoon KJ, Beierle EA., 9-cis-UAB30, a novel rexinoid agonist, decreases tumorigenicity and cancer cell stemness of human neuroblastoma patient-derived xenografts, Transl Oncol. 2021 Jan;14(1):100893. doi: 10.1016/j.tranon.2020.100893. Epub 2020 Sep 30.
Deng, Y., Wang, Z., Zhang, F., Qiao, M., Yan, Z., Wei, Q., . . . Zhang, J. (2016), A blockade of IGF signaling sensitizes human ovarian cancer cells to the anthelmintic niclosamide-induced anti-proliferative and anticancer activities, Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 39(3), 871-888. doi:10.1159/000447797 [doi]
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Zhao Y, Wang C, Goel A., A combined treatment with melatonin and andrographis promotes autophagy and anticancer activity in colorectal cancer, Carcinogenesis. 2022 Apr 25;43(3):217-230. doi: 10.1093/carcin/bgac008.
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Yang, Lu; Li, Yun; Bhattacharya, Arup; Zhang, Yuesheng;, A recombinant human protein targeting HER2 overcomes drug resistance in HER2-positive breast cancer., Science translational medicine Vol.11, 2019
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Santich BH, Cheal SM, Ahmed M, McDevitt MR, Ouerfelli O, Yang G, Veach DR, Fung EK, Patel M, Burnes Vargas D, Malik AA, Guo HF, Zanzonico PB, Monette S, Michel AO, Rudin CM, Larson SM, Cheung NK., A Self-Assembling and Disassembling (SADA) Bispecific Antibody (BsAb) Platform for Curative Two-step Pretargeted Radioimmunotherapy, Clin Cancer Res. 2020 Sep 21. doi: 10.1158/1078-0432.CCR-20-2150. Online ahead of print.
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Pattarawat P, Hunt JT, Poloway J, Archibald CJ, Wang HR., A triple combination gemcitabine?+?romidepsin?+?cisplatin to effectively control triple-negative breast cancer tumor development, recurrence, and metastasis, Cancer Chemother Pharmacol. 2021 Sep;88(3):415-425. doi: 10.1007/s00280-021-04298-y. Epub 2021 May 27.
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Li M, Li J, Guo X, Pan H, Zhou Q., Absence of HTATIP2 Expression in A549 Lung Adenocarcinoma Cells Promotes Tumor Plasticity in Response to Hypoxic Stress, Cancers (Basel). 2020 Jun 11;12(6):1538. doi: 10.3390/cancers12061538.
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Ziegler, J., Bastian, A., Lerner, M., Bailey-Downs, L., Saunders, D., Smith, N., . . . Towner, R. A. (2017)., AG488 as a therapy against gliomas., Oncotarget, 8(42), 71833-71844. doi:10.18632/oncotarget.18284 [doi]
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