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Adjuvant-induced arthritis

Haque M, Singh AK, Ouseph MM, Ahmed S., Regulation of Synovial Inflammation and Tissue Destruction by Guanylate Binding Protein 5 in Synovial Fibroblasts From Patients With Rheumatoid Arthritis and Rats With Adjuvant-Induced Arthritis, Arthritis Rheumatol. 2021 Jun;73(6):943-954. doi: 10.1002/art.41611. Epub 2021 Apr 20.

Halpert G, Halperin Sheinfeld M, Monteran L, Sharif K, Volkov A, Nadler R, Schlesinger A, Barshak I, Kalechman Y, Blank M, Shoenfeld Y, Amital H., The tellurium-based immunomodulator, AS101 ameliorates adjuvant-induced arthritis in rats, Clin Exp Immunol. 2021 Mar;203(3):375-384. doi: 10.1111/cei.13553. Epub 2020 Dec 8.

Ong ST, Bajaj S, Tanner MR, Chang SC, Krishnarjuna B, Ng XR, Morales RAV, Chen MW, Luo D, Patel D, Yasmin S, Ng JJH, Zhuang Z, Nguyen HM, El Sahili A, Lescar J, Patil R, Charman SA, Robins EG, Goggi JL, Tan PW, Sadasivam P, Ramasamy B, Hartimath SV, Dhawan V, Bednenko J, Colussi P, Wulff H, Pennington MW, Kuyucak S, Norton RS, Beeton C, Chandy KG., Modulation of Lymphocyte Potassium Channel K(V)1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin, ACS Pharmacol Transl Sci. 2020 May 14;3(4):720-736. doi: 10.1021/acsptsci.0c00035. eCollection 2020 Aug 14.

Yu R, Song D, DuBois DC, Almon RR, Jusko WJ., Modeling Combined Anti-Inflammatory Effects of Dexamethasone and Tofacitinib in Arthritic Rats, AAPS J. 2019 Jul 24;21(5):93. doi: 10.1208/s12248-019-0362-6.

Meka RR, Venkatesha SH, Acharya B, Moudgil KD., Peptide-targeted liposomal delivery of dexamethasone for arthritis therapy, Nanomedicine (Lond). 2019 Jun;14(11):1455-1469. doi: 10.2217/nnm-2018-0501. Epub 2019 Apr 2.

Fechtner S, Singh AK, Srivastava I, Szlenk CT, Muench TR, Natesan S, Ahmed S., Cannabinoid Receptor 2 Agonist JWH-015 Inhibits Interleukin-1?-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts and in Adjuvant Induced Arthritis Rat via Glucocorticoid Receptor, Front Immunol. 2019 May 8;10:1027. doi: 10.3389/fimmu.2019.01027. eCollection 2019.

Katri A, D?browska A, Löfvall H, Ding M, Karsdal MA, Andreassen KV, Thudium CS, Henriksen K., Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model, Arthritis Res Ther. 2019 Feb 22;21(1):68. doi: 10.1186/s13075-019-1819-9.

ADMET

Pohjanvirta R, Mahiout S., Aryl hydrocarbon receptor is indispensable for Î˛-naphthoflavone-induced novel food avoidance and may be involved in LiCl-triggered conditioned taste aversion in rats., Physiol Behav. 2019 May 15;204:58-64.

Harrill JA, Layko D, Nyska A, Hukkanen RR, Manno RA, Grassetti A, Lawson M, Martin G, Budinsky RA, Rowlands JC, Thomas RS., Aryl hydrocarbon receptor knockout rats are insensitive to the pathological effects of repeated oral exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin., J Appl Toxicol. 2016 Jun;36(6):802-14.

Phadnis-Moghe AS, Chen W, Li J, Crawford RB, Bach A, D'Ingillo S, Kovalova N, Suarez-Martinez JE, Kaplan BL, Harrill JA, Budinsky R, Rowlands JC, Thomas RS, Kaminski NE., Immunological characterization of the aryl hydrocarbon receptor (AHR) knockout rat in the presence and absence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)., Toxicology. 2016 Aug 10;368-369:172-182.

Harrill JA, Hukkanen RR, Lawson M, Martin G, Gilger B, Soldatow V, Lecluyse EL, Budinsky RA, Rowlands JC, Thomas RS., Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18

Fuchs H, Kishimoto W, Gansser D, Tanswell P, Ishiguro N., Brain penetration of WEB 2086 (Apafant) and dantrolene in Mdr1a (P-glycoprotein) and Bcrp knockout rats., Drug Metab Dispos. 2014 Oct;42(10):1761-5.

Zamek-Gliszczynski MJ, Bedwell DW, Bao JQ, Higgins JW., Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics., Drug Metab Dispos. 2012 Sep;40(9):1825-33.

Huang L, Li X, Roberts J, Janosky B, Lin MH., Differential role of P-glycoprotein and breast cancer resistance protein in drug distribution into brain, CSF and peripheral nerve tissues in rats., Xenobiotica. 2015;45(6):547-55

Miyake T., Estimating Efflux Transporter-Mediated Disposition of Molecules beyond the Rule of Five (bRo5) Using Transporter Gene Knockout Rats., Biol Pharm Bull. 2020 Mar 1;43(3):384-392.

Kimura H, Yagi Y, Mikamo M, Maeda K, Kagawa S, Arimitsu K, Higashi T, Nishii R, Ono M, Nakamoto Y, Togashi K, Kusuhara H, Saji H., Evaluation of transporter-mediated hepatobiliary transport of newly developed 18F-labeled pitavastatin derivative, PTV-F1, in rats by PET imaging., Drug Metab Pharmacokinet. 2019 Oct;34(5):317-324

Sato S, Tohyama K, Kosugi Y., Investigation of MDR1-overexpressing cell lines to derive a quantitative prediction approach for brain disposition using in vitro efflux activities., Eur J Pharm Sci. 2020 Jan 15;142:105119.

Ganguly S, Panetta JC, Roberts JK, Schuetz EG., Ketamine Pharmacokinetics and Pharmacodynamics Are Altered by P-Glycoprotein and Breast Cancer Resistance Protein Efflux Transporters in Mice., Drug Metab Dispos. 2018 Jul;46(7):1014-1022

Zamek-Gliszczynski MJ, Goldstein KM, Paulman A, Baker TK, Ryan TP., Minor compensatory changes in SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats do not detract from their utility in the study of transporter-mediated pharmacokinetics., Drug Metab Dispos. 2013 Jun;41(6):1174-8.

Bridges CC, Zalups RK, Joshee L., Toxicological significance of renal Bcrp: Another potential transporter in the elimination of mercuric ions from proximal tubular cells., Toxicol Appl Pharmacol. 2015 Jun 1;285(2):110-7.

Cheng Y, Chen S, Freeden C, Chen W, Zhang Y, Abraham P, Nelson DM, Humphreys WG, Gan J, Lai Y., Bile Salt Homeostasis in Normal and Bsep Gene Knockout Rats with Single and Repeated Doses of Troglitazone., J Pharmacol Exp Ther. 2017 Sep;362(3):385-394.

Cheng Y, Freeden C, Zhang Y, Abraham P, Shen H, Wescott D, Humphreys WG, Gan J, Lai Y., Biliary excretion of pravastatin and taurocholate in rats with bile salt export pump (Bsep) impairment., Biopharm Drug Dispos. 2016 Jul;37(5):276-86.

Haines C, Chatham LR, Vardy A, Elcombe CR, Foster JR, Lake BG., Comparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16Îą-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats., Xenobiotica. 2019 Feb;49(2):227-238.

Haines C, Chatham LR, Vardy A, Elcombe CR, Foster JR, Lake BG., Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16Îą-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats., Toxicology. 2018 May 1;400-401:20-27

Forbes KP, Kouranova E, Tinker D, Janowski K, Cortner D, McCoy A, Cui X., Creation and Preliminary Characterization of Pregnane X Receptor and Constitutive Androstane Receptor Knockout Rats., Drug Metab Dispos. 2017 Oct;45(10):1068-1076

Okuda Y, Kushida M, Sumida K, Nagahori H, Nakamura Y, Higuchi H, Kawamura S, Lake BG, Cohen SM, Yamada T., Editor's Highlight: Mode of Action Analysis for Rat Hepatocellular Tumors Produced by the Synthetic Pyrethroid Momfluorothrin: Evidence for Activation of the Constitutive Androstane Receptor and Mitogenicity in Rat Hepatocytes., Toxicol Sci. 2017 Aug 1;158(2):412-430

Wiemann C, Goettel M, Vardy A, Elcombe BM, Elcombe CR, Chatham LR, Wang H, Li L, Buesen R, Honarvar N, Treumann S, Marxfeld H, Groeters S, Lake BG., Metazachlor: Mode of action analysis for rat liver tumour formation and human relevance., Toxicology. 2019 Oct 1;426:152282.

Miyake T., Estimating Efflux Transporter-Mediated Disposition of Molecules beyond the Rule of Five (bRo5) Using Transporter Gene Knockout Rats., Biol Pharm Bull. 2020 Mar 1;43(3):384-392.

Fuchs, Holger; Kishimoto, Wataru; Gansser, Dietmar; Tanswell, Paul; Ishiguro, Naoki;, Brain penetration of WEB 2086 (Apafant) and dantrolene in Mdr1a (P-glycoprotein) and Bcrp knockout rats., Drug metabolism and disposition: the biological fate of chemicals Vol.42, 2014

Suzuki, Motoya; Komura, Hiroshi; Yoshikawa, Tomonori; Enya, Seiji; Nagao, Akemi; Takubo, Hiroaki; Kogayu, Motohiro;, Characterization of gastrointestinal absorption of digoxin involving influx and efflux transporter in rats: application of mdr1a knockout (-/-) rats into absorption study of multiple transporter substrate., Xenobiotica; the fate of foreign compounds in biological systems Vol.44, 2014

Zamek-Gliszczynski, Maciej J; Bedwell, David W; Bao, Jing Q; Higgins, J William;, Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics., Drug metabolism and disposition: the biological fate of chemicals Vol.40, 2012

Huang, Liyue; Li, Xingwen; Roberts, Jonathan; Janosky, Brett; Lin, Min-Hwa Jasmine;, Differential role of P-glycoprotein and breast cancer resistance protein in drug distribution into brain, CSF and peripheral nerve tissues in rats., Xenobiotica; the fate of foreign compounds in biological systems Vol.45, 2015

Miyake, Taiji;, Estimating Efflux Transporter-Mediated Disposition of Molecules beyond the Rule of Five (bRo5) Using Transporter Gene Knockout Rats., Biological & pharmaceutical bulletin Vol.43, 2020

Fujii, Shinobu; Setoguchi, Chikako; Kawazu, Kouichi; Hosoya, Ken-ichi;, Functional Characterization of Carrier-Mediated Transport of Pravastatin across the Blood-Retinal Barrier in Rats., Drug metabolism and disposition: the biological fate of chemicals Vol.43, 2015

Fujii, Shinobu; Setoguchi, Chikako; Kawazu, Kouichi; Hosoya, Ken-ichi;, Impact of P-glycoprotein on blood-retinal barrier permeability: comparison of blood-aqueous humor and blood-brain barrier using mdr1a knockout rats., Investigative ophthalmology & visual science Vol.55, 2014

Dumas, Noé; Moulin-Sallanon, Marcelle; Fender, Pascal; Tournier, Benjamin B; Ginovart, Nathalie; Charnay, Yves; Millet, Philippe;, In Vivo Quantification of 5-HT2A Brain Receptors in Mdr1a KO Rats with 123I-R91150 Single-Photon Emission Computed Tomography., Molecular imaging Vol.14, 2015

Sato, Sho; Tohyama, Kimio; Kosugi, Yohei;, Investigation of MDR1-overexpressing cell lines to derive a quantitative prediction approach for brain disposition using in vitro efflux activities., European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Vol.142, 2020

Nagaya, Yoko; Nozaki, Yoshitane; Takenaka, Osamu; Watari, Ryuji; Kusano, Kazutomi; Yoshimura, Tsutomu; Kusuhara, Hiroyuki;, Investigation of utility of cerebrospinal fluid drug concentration as a surrogate for interstitial fluid concentration using microdialysis coupled with cisternal cerebrospinal fluid sampling in wild-type and Mdr1a(-/-) rats., Drug metabolism and pharmacokinetics Vol.31, 2016

Ganguly, Samit; Panetta, John C; Roberts, Jessica K; Schuetz, Erin G;, Ketamine Pharmacokinetics and Pharmacodynamics Are Altered by P-Glycoprotein and Breast Cancer Resistance Protein Efflux Transporters in Mice., Drug metabolism and disposition: the biological fate of chemicals Vol.46, 2018

Zamek-Gliszczynski, Maciej J; Goldstein, Keith M; Paulman, April; Baker, Thomas K; Ryan, Timothy P;, Minor compensatory changes in SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats do not detract from their utility in the study of transporter-mediated pharmacokinetics., Drug metabolism and disposition: the biological fate of chemicals Vol.41, 2013

Al-Ali, Ahmed A Abdulhussein; Quach, Jeffrey Rong Chao; Bundgaard, Christoffer; Steffansen, Bente; Holm, RenĂŠ; Nielsen, Carsten Uhd;, Polysorbate 20 alters the oral bioavailability of etoposide in wild type and mdr1a deficient Sprague-Dawley rats., International journal of pharmaceutics Vol.543, 2018

Nielsen, Carsten Uhd; Abdulhussein, Ahmed A; Colak, Dilan; Holm, René;, Polysorbate 20 increases oral absorption of digoxin in wild-type Sprague Dawley rats, but not in mdr1a(-/-) Sprague Dawley rats., International journal of pharmaceutics Vol.513, 2016

Nicolas, Jean-Marie; Chanteux, Hugues; Nicolaï, Johan; Brouta, Frédéric; Viot, Delphine; Rosseels, Marie-Luce; Gillent, Eric; Bonnaillie, Pierre; Mathy, François-Xavier; Long, Jeff; Helmer, Eric;, Role of P-glycoprotein in the brain disposition of seletalisib: Evaluation of the potential for drug-drug interactions., European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Vol.142, 2020

Dulin, Jennifer N; Moore, Meredith L; Grill, Raymond J;, The dual cyclooxygenase/5-lipoxygenase inhibitor licofelone attenuates p-glycoprotein-mediated drug resistance in the injured spinal cord., Journal of neurotrauma Vol.30, 2013

Liu, Xingrong; Cheong, Jonathan; Ding, Xiao; Deshmukh, Gauri;, Use of cassette dosing approach to examine the effects of P-glycoprotein on the brain and cerebrospinal fluid concentrations in wild-type and P-glycoprotein knockout rats., Drug metabolism and disposition: the biological fate of chemicals Vol.42, 2014

Strupp, Christian; Bomann, Werner H; Spézia, François; Gervais, Frédéric; Forster, Roy; Richert, Lysiane; Singh, Pramila;, A human relevance investigation of PPARÎą-mediated key events in the hepatocarcinogenic mode of action of propaquizafop in rats., Regulatory toxicology and pharmacology : RTP Vol.95, 2018

Forbes, Kevin P; Kouranova, Evguenia; Tinker, Daniel; Janowski, Karen; Cortner, Doug; McCoy, Aaron; Cui, Xiaoxia;, Creation and Preliminary Characterization of Pregnane X Receptor and Constitutive Androstane Receptor Knockout Rats., Drug metabolism and disposition: the biological fate of chemicals Vol.45, 2017

Haines C, Chatham LR, Vardy A, Elcombe CR, Foster JR, Lake BG., Comparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16?-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats., Xenobiotica. 2019 Feb;49(2):227-238.

Haines C, Chatham LR, Vardy A, Elcombe CR, Foster JR, Lake BG., Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16?-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats., Toxicology. 2018 May 1;400-401:20-27.

Hunter SR, Vonk A, Mullen Grey AK, Riddick DS., Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase., Drug Metab Dispos. 2017 Feb;45(2):118-129.

Chiang M, Back HM, Lee JB, Oh S, Guo T, Girgis S, Park C, Haroutounian S, Kagan L., Pharmacokinetic Modeling of the Impact of P-glycoprotein on Ondansetron Disposition in the Central Nervous System, Pharm Res. 2020 Sep 28;37(10):205. doi: 10.1007/s11095-020-02929-2.

Tsartsalis S, Tournier BB, Millet P., In vivo absolute quantification of striatal and extrastriatal D(2/3) receptors with [(123)I]epidepride SPECT, EJNMMI Res. 2020 Jun 16;10(1):66. doi: 10.1186/s13550-020-00650-0.

Ganguly S, Finkelstein D, Shaw TI, Michalek RD, Zorn KM, Ekins S, et al., Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters, PLoS ONE 16(7): e0253852. 2021.

Aging

Bolles, M., Deming, D., Long, K., Agnihothram, S., Whitmore, A., Ferris, M., . . . Baric, R. S. (2011)., A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge, Journal of Virology, 85(23), 12201-12215. doi:10.1128/JVI.06048-11 [doi]

Corsetti, G., Pasini, E., Romano, C., Calvani, R., Picca, A., Marzetti, E., . . . Dioguardi, F. S. (2018)., Body weight loss and tissue wasting in late middle-aged mice on slightly imbalanced Essential/Non-essential amino acids diet., Frontiers in Medicine, 5, 136. doi:10.3389/fmed.2018.00136 [doi]

Rockx, B., Baas, T., Zornetzer, G. A., Haagmans, B., Sheahan, T., Frieman, M., . . . Katze, M. G. (2009), Early upregulation of acute respiratory distress syndrome-associated cytokines promotes lethal disease in an aged-mouse model of severe acute respiratory syndrome coronavirus infection, Journal of Virology, 83(14), 7062-7074. doi:10.1128/JVI.00127-09 [doi]

Barone, R., Macaluso, F., Catanese, P., Marino Gammazza, A., Rizzuto, L., Marozzi, P., . . . Di Felice, V. (2013)., Endurance exercise and conjugated linoleic acid (CLA) supplementation up-regulate CYP17A1 and stimulate testosterone biosynthesis, PloS One, 8(11), e79686. doi:10.1371/journal.pone.0079686 [doi]

Clayton, E. H., Garbow, J. R., & Bayly, P. V. (2011)., Frequency-dependent viscoelastic parameters of mouse brain tissue estimated by MR elastography, Physics in Medicine and Biology, 56(8), 2391-2406. doi:10.1088/0031-9155/56/8/005 [doi]

Cayatte, C., Snell Bennett, A., Rajani, G. M., Hostetler, L., Maynard, S. K., Lazzaro, M., . . . Schneider-Ohrum, K. (2017)., Inferior immunogenicity and efficacy of respiratory syncytial virus fusion protein-based subunit vaccine candidates in aged versus young mice., PloS One, 12(11), e0188708. doi:10.1371/journal.pone.0188708 [doi]

Grizenkova, J., Akhtar, S., Brandner, S., Collinge, J., & Lloyd, S. E. (2014), Microglial Cx3cr1 knockout reduces prion disease incubation time in mice., BMC Neuroscience, 15, 44-2202-15-44. doi:10.1186/1471-2202-15-44 [doi]

Jiang R, Gao J, Shen J, Zhu X, Wang H, Feng S, Huang C, Shen H, Liu H., Glycyrrhizic Acid Improves Cognitive Levels of Aging Mice by Regulating T/B Cell Proliferation, Front Aging Neurosci. 2020 Oct 7;12:570116. doi: 10.3389/fnagi.2020.570116. eCollection 2020.

Thunhorst, R. L., Beltz, T., & Johnson, A. K. (2014)., Age-related declines in thirst and salt appetite responses in male fischer 344xBrown norway rats., Physiology & Behavior, 135, 180-188. doi:10.1016/j.physbeh.2014.06.010 [doi]

Ding, Q., Ash, C., Mracek, T., Merry, B., & Bing, C. (2012)., Caloric restriction increases adiponectin expression by adipose tissue and prevents the inhibitory effect of insulin on circulating adiponectin in rats., The Journal of Nutritional Biochemistry, 23(8), 867-874. doi:10.1016/j.jnutbio.2011.04.011 [doi]

Barsony, J., Manigrasso, M. B., Xu, Q., Tam, H., & Verbalis, J. G. (2013)., Chronic hyponatremia exacerbates multiple manifestations of senescence in male rats., Age (Dordrecht, Netherlands), 35(2), 271-288. doi:10.1007/s11357-011-9347-9 [doi]

Wu, L. W., Wang, Y. L., Christensen, J. M., Khalifian, S., Schneeberger, S., Raimondi, G., . . . Brandacher, G. (2014)., Donor age negatively affects the immunoregulatory properties of both adipose and bone marrow derived mesenchymal stem cells., Transplant Immunology, 30(4), 122-127. doi:10.1016/j.trim.2014.03.001 [doi]

LaCroix, A. S., Duenwald-Kuehl, S. E., Brickson, S., Akins, T. L., Diffee, G., Aiken, J., . . . Lakes, R. S. (2013)., Effect of age and exercise on the viscoelastic properties of rat tail tendon., Annals of Biomedical Engineering, 41(6), 1120-1128. doi:10.1007/s10439-013-0796-4 [doi]

Zhang, C., & Gao, Y. (2014)., Effects of aging on the lateral transmission of force in rat skeletal muscle., Journal of Biomechanics, 47(5), 944-948. doi:10.1016/j.jbiomech.2014.01.026 [doi]

Morgan, D., Mitzelfelt, J. D., Koerper, L. M., & Carter, C. S. (2012)., Effects of morphine on thermal sensitivity in adult and aged rats., The Journals of Gerontology.Series A, Biological Sciences and Medical Sciences, 67(7), 705-713. doi:10.1093/gerona/glr210 [doi]

Sittig, L. J., Herzing, L. B., Xie, H., Batra, K. K., Shukla, P. K., & Redei, E. E. (2012)., Excess folate during adolescence suppresses thyroid function with permanent deficits in motivation and spatial memory., Genes, Brain, and Behavior, 11(2), 193-200. doi:10.1111/j.1601-183X.2011.00749.x [doi]

Kang, C., Chung, E., Diffee, G., & Ji, L. L. (2013)., Exercise training attenuates aging-associated mitochondrial dysfunction in rat skeletal muscle: Role of PGC-1alpha., Experimental Gerontology, 48(11), 1343-1350. doi:10.1016/j.exger.2013.08.004 [doi]

Wright, K. J., Thomas, M. M., Betik, A. C., Belke, D., & Hepple, R. T. (2014)., Exercise training initiated in late middle age attenuates cardiac fibrosis and advanced glycation end-product accumulation in senescent rats., Experimental Gerontology, 50, 9-18. doi:10.1016/j.exger.2013.11.006 [doi]

VanGuilder Starkey, H. D., Bixler, G. V., Sonntag, W. E., & Freeman, W. M. (2013)., Expression of NgR1-antagonizing proteins decreases with aging and cognitive decline in rat hippocampus., Cellular and Molecular Neurobiology, 33(4), 483-488. doi:10.1007/s10571-013-9929-4 [doi]

Mattson, D. L., Kunert, M. P., Kaldunski, M. L., Greene, A. S., Roman, R. J., Jacob, H. J., & Cowley, A. W.,Jr. (2004)., Influence of diet and genetics on hypertension and renal disease in dahl salt-sensitive rats., Physiological Genomics, 16(2), 194-203. doi:10.1152/physiolgenomics.00151.2003 [doi]

Selvaratnam, J., Paul, C., & Robaire, B. (2015)., Male rat germ cells display age-dependent and cell-specific susceptibility in response to oxidative stress challenges., Biology of Reproduction, doi:biolreprod.115.131318 [pii]

Nieves-Martinez, E., Haynes, K., Childers, S. R., Sonntag, W. E., & Nicolle, M. M. (2012)., Muscarinic receptor/G-protein coupling is reduced in the dorsomedial striatum of cognitively impaired aged rats., Behavioural Brain Research, 227(1), 258-264. doi:10.1016/j.bbr.2011.10.048 [doi]

Durbin, S. M., Jackson, J. R., Ryan, M. J., Gigliotti, J. C., Alway, S. E., & Tou, J. C. (2014)., Resveratrol supplementation preserves long bone mass, microstructure, and strength in hindlimb-suspended old male rats., Journal of Bone and Mineral Metabolism, 32(1), 38-47. doi:10.1007/s00774-013-0469-2 [doi]

McQuail, J. A., & Nicolle, M. M. (2015)., Spatial reference memory in normal aging fischer 344 x brown norway F1 hybrid rats., Neurobiology of Aging, 36(1), 323-333. doi:10.1016/j.neurobiolaging.2014.06.030 [doi]

MacPhail, R. C., Farmer, J. D., & Jarema, K. A. (2012)., Toluene effects on the motor activity of adolescent, young-adult, middle-age and senescent male brown norway rats., Neurotoxicology, 33(1), 111-118. doi:10.1016/j.neuro.2011.12.006 [doi]

Beccari, S., Valero, J., Maletic-Savatic, M., & Sierra, A. (2017)., A simulation model of neuroprogenitor proliferation dynamics predicts age-related loss of hippocampal neurogenesis but not astrogenesis., Scientific Reports, 7(1), 16528-017-16466-3. doi:10.1038/s41598-017-16466-3 [doi]

Bauernfeind, F., Niepmann, S., Knolle, P. A., & Hornung, V. (2016)., Aging-associated TNF production primes inflammasome activation and NLRP3-related metabolic disturbances., Journal of Immunology (Baltimore, Md.: 1950), 197(7), 2900-2908. doi:10.4049/jimmunol.1501336 [doi]

Panagiotou, M., Vyazovskiy, V. V., Meijer, J. H., & Deboer, T. (2017)., Differences in electroencephalographic non-rapid-eye movement sleep slow-wave characteristics between young and old mice, Scientific Reports, 7, 43656. doi:10.1038/srep43656 [doi]

Wolf, G., Lotan, A., Lifschytz, T., Ben-Ari, H., Kreisel Merzel, T., Tatarskyy, P., . . . Lerer, B. (2017)., Differentially severe cognitive effects of compromised cerebral blood flow in aged mice: Association with myelin degradation and microglia activation., Frontiers in Aging Neuroscience, 9, 191. doi:10.3389/fnagi.2017.00191 [doi]

Panagiotou, M., Papagiannopoulos, K., Rohling, J. H. T., Meijer, J. H., & Deboer, T. (2018)., How old is your brain? slow-wave activity in non-rapid-eye-movement sleep as a marker of brain rejuvenation after long-term exercise in mice., Frontiers in Aging Neuroscience, 10, 233. doi:10.3389/fnagi.2018.00233 [doi]

Nitzan, Keren; Benhamron, Sandrine; Valitsky, Michael; Kesner, Eyal E; Lichtenstein, Michal; Ben-Zvi, Ayal; Ella, Ezra; Segalstein, Yehudit; Saada, Ann; Lorberboum-Galski, Haya; Rosenmann, Hanna;, Mitochondrial Transfer Ameliorates Cognitive Deficits, Neuronal Loss, and Gliosis in Alzheimers Disease Mice, Journal of Alzheimer's disease : JAD Vol.72, 2019

Davis, H. M., Aref, M. W., Aguilar-Perez, A., Pacheco-Costa, R., Allen, K., Valdez, S., . . . Plotkin, L. I. (2018)., x43 overexpression in osteocytes prevents osteocyte apoptosis and preserves cortical bone quality in aging mice., JBMR Plus, 2(4), 206-216. doi:10.1002/jbm4.10035 [doi]

Kubik, L. L., Landis, R. W., Remmer, H., Bergin, I. L., & Philbert, M. A. (2015)., 1,3-dinitrobenzene induces age- and region-specific oxidation to mitochondria-related proteins in brain., Toxicological Sciences : An Official Journal of the Society of Toxicology, 145(1), 48-58. doi:10.1093/toxsci/kfv015 [doi]

Shahaduzzaman, M., Golden, J. E., Green, S., Gronda, A. E., Adrien, E., Ahmed, A., . . . Willing, A. E. (2013), A single administration of human umbilical cord blood T cells produces long-lasting effects in the aging hippocampus, Age (Dordrecht, Netherlands), 35(6), 2071-2087. doi:10.1007/s11357-012-9496-5 [doi]

Pabon, M. M., Jernberg, J. N., Morganti, J., Contreras, J., Hudson, C. E., Klein, R. L., & Bickford, P. C. (2012), A spirulina-enhanced diet provides neuroprotection in an alpha-synuclein model of parkinson's disease., . PloS One, 7(9), e45256. doi:10.1371/journal.pone.0045256 [doi]

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Shetty, P. K., Sadgrove, M. P., Galeffi, F., & Turner, D. A. (2012)., Pyruvate incubation enhances glycogen stores and sustains neuronal function during subsequent glucose deprivation., Neurobiology of Disease, 45(1), 177-187. doi:10.1016/j.nbd.2011.08.002 [doi]

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Kim, John T; Kasukonis, Benjamin; Dunlap, Grady; Perry, Richard; Washington, Tyrone; Wolchok, Jeffrey C, Regenerative Repair of Volumetric Muscle Loss Injury is Sensitive to Age, Part A Vol.10, 2019

Meconi, A., Lui, E., & Marrone, D. F. (2015)., Sustained arc expression in adult-generated granule cells., Neuroscience Letters, 603, 66-70. doi:10.1016/j.neulet.2015.07.029 [doi]

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Wiley JL, Barrus DG, Farquhar CE, Lefever TW, Gamage TF., Sex, species and age: Effects of rodent demographics on the pharmacology of ?(9)-tetrahydrocanabinol, Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 2;106:110064. doi: 10.1016/j.pnpbp.2020.110064. Epub 2020 Aug 15.

Moro F, Pischiutta F, Portet A, Needham EJ, Norton EJ, Ferdinand JR, Vegliante G, Sammali E, Pascente R, Caruso E, Micotti E, Tolomeo D, di Marco Barros R, Fraunberger E, Wang KKW, Esser MJ, Menon DK, Clatworthy MR, Zanier ER., Ageing is associated with maladaptive immune response and worse outcome after traumatic brain injury, Brain Commun. 2022 Feb 16;4(2):fcac036. doi: 10.1093/braincomms/fcac036.

Hernandez CM, Jackson NL, Hernandez AR, McMahon LL., Impairments in Fear Extinction Memory and Basolateral Amygdala Plasticity in the TgF344-AD Rat Model of Alzheimer's Disease Are Distinct from Nonpathological Aging, 35998297

Li H, McLaurin KA, Mactutus CF, Likins B, Huang W, Chang SL, Booze RM., Intraneuronal β-Amyloid Accumulation: Aging HIV-1 Human and HIV-1 Transgenic Rat Brain, 35746739

Ikeda Y, Zabbarova I, de Rijk M, Kanai A, Wolf-Johnston A, Weiss JP, Jackson E, Birder L., Effects of vasopressin receptor agonists on detrusor smooth muscle tone in young and aged bladders: Implications for nocturia treatment, 35789681

Smith LA, Goodman AM, McMahon LL., Dentate Granule Cells Are Hyperexcitable in the TgF344-AD Rat Model of Alzheimer's Disease, 35685246

Anandakrishnan R, Tobey H, Nguyen S, Sandoval O, Klein BG, Costa BM., Cranial manipulation affects cholinergic pathway gene expression in aged rats, 34995434

Fowler C, Goerzen D, Madularu D, Devenyi GA, Chakravarty MM, Near J., Longitudinal characterization of neuroanatomical changes in the Fischer 344 rat brain during normal aging and between sexes, 34775212

Alcoholism

Lopez-Jimenez, A., Walter, N. A., Gine, E., Santos, A., Echeverry-Alzate, V., Buhler, K. M., . . . Lopez-Moreno, J. A. (2013)., A spontaneous deletion of alpha-synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: Effects on alcohol consumption., Synapse (New York, N.Y.), 67(6), 280-289. doi:10.1002/syn.21639 [doi]

Laitakari A, Tapio J, MĂ¤kelĂ¤ KA, Herzig KH, Dengler F, Gylling H, Walkinshaw G, Myllyharju J, Dimova EY, Serpi R, Koivunen P., HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD, J Mol Med (Berl). 2020 May;98(5):719-731. doi: 10.1007/s00109-020-01903-0. Epub 2020 Apr 15.

Boschen KE, Ptacek TS, Berginski ME, Simon JM, Parnell SE., Transcriptomic analyses of gastrulation-stage mouse embryos with differential susceptibility to alcohol, Dis Model Mech. 2021 Jun 1;14(6):dmm049012. doi: 10.1242/dmm.049012. Epub 2021 Jun 17.

Koskela M, Piepponen TP, Andressoo JO, Võikar V, Airavaara M., Female C57BL/6J Mice Show Alcohol-Seeking Behaviour after Withdrawal from Prolonged Alcohol Consumption in the Social Environment., Alcohol Alcohol. 2021 Apr 24. pii: agab032. doi: 10.1093/alcalc/agab032. [Epub ahead of print]

Tice AL, Laudato JA, Fadool DA, Gordon BS, Steiner JL., Acute binge alcohol alters whole body metabolism and the time-dependent expression of skeletal muscle-specific metabolic markers for multiple days in mice, Am J Physiol Endocrinol Metab. 2022 Sep 1;323(3):E215-E230. doi: 10.1152/ajpendo.00026.2022. Epub 2022 Jul 6.

Gil de Biedma-Elduayen L, Giménez-Gómez P, Morales-Puerto N, Vidal R, Núñez-de la Calle C, Gutiérrez-López MD, O'Shea E, Colado MI., Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61-8048 after chronic intermittent ethanol in mice, Br J Pharmacol. 2022 Jul;179(14):3711-3726. doi: 10.1111/bph.15825. Epub 2022 Mar 7.

Pinson MR, Tseng AM, Adams A, Lehman TE, Chung K, Gutierrez J, Larin KV, Chambers C, Miranda RC; Collaborative Initiative on Fetal Alcohol Spectrum Disorders., Prenatal alcohol exposure contributes to negative pregnancy outcomes by altering fetal vascular dynamics and the placental transcriptome, Alcohol Clin Exp Res. 2022 Jun;46(6):1036-1049. doi: 10.1111/acer.14846. Epub 2022 May 9.

Ghosh A, Muthuraju S, Badal S, Wooden J, Leasure JL, Roman G, Das J., Differential Expression of Presynaptic Munc13-1 and Munc13-2 in Mouse Hippocampus Following Ethanol Drinking, Neuroscience. 2022 Apr 1;487:166-183. doi: 10.1016/j.neuroscience.2022.02.008. Epub 2022 Feb 12.

Allergic encephalomyelitis

Bardou, I., Kaercher, R. M., Brothers, H. M., Hopp, S. C., Royer, S., & Wenk, G. L. (2014)., Age and duration of inflammatory environment differentially affect the neuroimmune response and catecholaminergic neurons in the midbrain and brainstem., Neurobiology of Aging, 35(5), 1065-1073. doi:10.1016/j.neurobiolaging.2013.11.006 [doi]

Davis, C. M., Cobuzzi, J. L., & Riley, A. L. (2012)., Assessment of the aversive effects of peripheral mu opioid receptor agonism in fischer 344 and lewis rats., Pharmacology, Biochemistry, and Behavior, 101(2), 181-186. doi:10.1016/j.pbb.2012.01.001 [doi]

Hopp, S. C., D'Angelo, H. M., Royer, S. E., Kaercher, R. M., Crockett, A. M., Adzovic, L., & Wenk, G. L. (2015)., Calcium dysregulation via L-type voltage-dependent calcium channels and ryanodine receptors underlies memory deficits and synaptic dysfunction during chronic neuroinflammation, Journal of Neuroinflammation, 12, 56-015-0262-3. doi:10.1186/s12974-015-0262-3 [doi]

Steward, O., Sharp, K. G., Yee, K. M., Hatch, M. N., & Bonner, J. F. (2014)., Characterization of ectopic colonies that form in widespread areas of the nervous system with neural stem cell transplants into the site of a severe spinal cord injury, The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 34(42), 14013-14021. doi:10.1523/JNEUROSCI.3066-14.2014 [doi]

Lee, T. C., Greene-Schloesser, D., Payne, V., Diz, D. I., Hsu, F. C., Kooshki, M., . . . Robbins, M. E. (2012)., Chronic administration of the angiotensin-converting enzyme inhibitor, ramipril, prevents fractionated whole-brain irradiation-induced perirhinal cortex-dependent cognitive impairment., Radiation Research, 178(1), 46-56. doi:10.1667/RR2731.1 [pii]

Ramadan, E., Basselin, M., Chang, L., Chen, M., Ma, K., & Rapoport, S. I. (2012)., Chronic lithium feeding reduces upregulated brain arachidonic acid metabolism in HIV-1 transgenic rat, ournal of Neuroimmune Pharmacology : The Official Journal of the Society on NeuroImmune Pharmacology, 7(3), 701-713. doi:10.1007/s11481-012-9381-0 [doi]

Bardou, I., Brothers, H. M., Kaercher, R. M., Hopp, S. C., & Wenk, G. L. (2013)., Differential effects of duration and age on the consequences of neuroinflammation in the hippocampus., Neurobiology of Aging, 34(10), 2293-2301. doi:10.1016/j.neurobiolaging.2013.03.034 [doi]

Festa, L., Gutoskey, C. J., Graziano, A., Waterhouse, B. D., & Meucci, O. (2015), Induction of interleukin-1beta by human immunodeficiency virus-1 viral proteins leads to increased levels of neuronal ferritin heavy chain, synaptic injury, and deficits in flexible attention., The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 35(29), 10550-10561. doi:10.1523/JNEUROSCI.4403-14.2015 [doi]

Trama, A. M., Holzknecht, Z. E., Thomas, A. D., Su, K. Y., Lee, S. M., Foltz, E. E., . . . Parker, W. (2012)., Lymphocyte phenotypes in wild-caught rats suggest potential mechanisms underlying increased immune sensitivity in post-industrial environments, Cellular & Molecular Immunology, 9(2), 163-174. doi:10.1038/cmi.2011.61 [doi]

Shuster, K. A., Hish, G. A., Selles, L. A., Chowdhury, M. A., Wiggins, R. C., Dysko, R. C., & Bergin, I. L. (2013)., Naturally occurring disseminated group B streptococcus infections in postnatal rats., Comparative Medicine, 63(1), 55-61.

Haick, A. K., Rzepka, J. P., Brandon, E., Balemba, O. B., & Miura, T. A. (2014)., Neutrophils are needed for an effective immune response against pulmonary rat coronavirus infection, but also contribute to pathology., The Journal of General Virology, 95(Pt 3), 578-590. doi:10.1099/vir.0.061986-0 [doi]

Faridi, M. H., Altintas, M. M., Gomez, C., Duque, J. C., Vazquez-Padron, R. I., & Gupta, V. (2013)., Small molecule agonists of integrin CD11b/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury., Biochimica Et Biophysica Acta, 1830(6), 3696-3710. doi:10.1016/j.bbagen.2013.02.018 [doi]

Li, M. D., Cao, J., Wang, S., Wang, J., Sarkar, S., Vigorito, M., . . . Chang, S. L. (2013)., Transcriptome sequencing of gene expression in the brain of the HIV-1 transgenic rat., PloS One, 8(3), e59582. doi:10.1371/journal.pone.0059582 [doi]

Alpha synuclein

Zaltieri, M., Grigoletto, J., Longhena, F., Navarria, L., Favero, G., Castrezzati, S., . . . Bellucci, A. (2015)., Alpha-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons., Journal of Cell Science, 128(13), 2231-2243. doi:10.1242/jcs.157867 [doi]

Liron, T., Raphael, B., Hiram-Bab, S., Bab, I. A., & Gabet, Y. (2018), Bone loss in C57BL/6J-OlaHsd mice, a substrain of C57BL/6J carrying mutated alpha-synuclein and multimerin-1 genes., . Journal of Cellular Physiology, 233(1), 371-377. doi:10.1002/jcp.25895 [doi]

Mahul-Mellier, A. L., Fauvet, B., Gysbers, A., Dikiy, I., Oueslati, A., Georgeon, S., . . . Lashuel, H. A. (2014)., c-abl phosphorylates alpha-synuclein and regulates its degradation: Implication for alpha-synuclein clearance and contribution to the pathogenesis of parkinson's disease., Human Molecular Genetics, 23(11), 2858-2879. doi:10.1093/hmg/ddt674 [doi]

Jonsson, O., Steffen, A. C., Sundquist, V. S., Janson, J., Martinsson, S., Maatta, U., & Emanuelsson, A. B. (2013)., Capillary microsampling and analysis of 4-microl blood, plasma and serum samples to determine human alpha-synuclein elimination rate in mice, Bioanalysis, 5(4), 449-462. doi:10.4155/bio.12.337 [doi]

Weihofen, Andreas; Liu, YuTing; Arndt, Joseph W; Huy, Christian; Quan, Chao; Smith, Benjamin A; Baeriswyl, Jean-Luc; Cavegn, Nicole; Senn, Luzia; Su, Lihe; Marsh, Galina; Auluck, Pavan K; Montrasio, Fabio; Nitsch, Roger M; Hirst, Warren D; Cedarbaum, Jesse M; Pepinsky, R Blake; Grimm, Jan; Weinreb, Paul H, Development of an aggregate-selective, human-derived ?-synuclein-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinsons disease models., Neurobiology of disease Vol.124, 2019

Weihofen, A., Liu, Y., Arndt, J. W., Huy, C., Quan, C., Smith, B. A., . . . Weinreb, P. H. (2018)., Development of an aggregate-selective, human-derived alpha-synuclein antibody BIIB054 that ameliorates disease phenotypes in parkinson's disease models, Neurobiology of Disease, doi:S0969-9961(18)30448-0 [pii]

Pelkonen, A., Kallunki, P., & Yavich, L. (2013), Effects of exogenous alpha-synuclein on stimulated dopamine overflow in dorsal striatum, Neuroscience Letters, 554, 141-145. doi:10.1016/j.neulet.2013.08.072 [doi]

Garcia-Reitboeck, P., Anichtchik, O., Dalley, J. W., Ninkina, N., Tofaris, G. K., Buchman, V. L., & Spillantini, M. G. (2013), Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra., Experimental Neurology, 248, 541-545. doi:10.1016/j.expneurol.2013.07.015 [doi]

Emanuele, M., Esposito, A., Camerini, S., Antonucci, F., Ferrara, S., Seghezza, S., . . . Chieregatti, E. (2016)., Exogenous alpha-synuclein alters pre- and post-synaptic activity by fragmenting lipid rafts., Ebiomedicine, 7, 191-204. doi:10.1016/j.ebiom.2016.03.038 [doi]

Chadchankar, H., Ihalainen, J., Tanila, H., & Yavich, L. (2012)., Methylphenidate modifies overflow and presynaptic compartmentalization of dopamine via an alpha-synuclein-dependent mechanism., The Journal of Pharmacology and Experimental Therapeutics, 341(2), 484-492. doi:10.1124/jpet.111.189225 [doi]

Burtscher J, Copin JC, Sandi C, Lashuel HA., Pronounced ?-Synuclein Pathology in a Seeding-Based Mouse Model Is Not Sufficient to Induce Mitochondrial Respiration Deficits in the Striatum and Amygdala, eNeuro. 2020 Aug 17;7(4):ENEURO.0110-20.2020. doi: 10.1523/ENEURO.0110-20.2020. Print 2020 Jul/Aug.

Bar, R., Boehm-Cagan, A., Luz, I., Kleper-Wall, Y., & Michaelson, D. M. (2017)., The effects of apolipoprotein E genotype, alpha-synuclein deficiency, and sex on brain synaptic and alzheimer's disease-related pathology, Alzheimer's & Dementia (Amsterdam, Netherlands), 10, 1-11. doi:10.1016/j.dadm.2017.08.003 [doi]

Fassler M, Benaim C, George J., A Single Chain Fragment Variant Binding Misfolded Alpha-Synuclein Exhibits Neuroprotective and Antigen-Specific Anti-Inflammatory Properties, Cells. 2022 Nov 29;11(23):3822. doi: 10.3390/cells11233822.

Eteläinen TS, Kilpeläinen TP, Ignatius A, Auno S, De Lorenzo F, Uhari-Väänänen JK, Julku UH, Myöhänen TT., Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model, Neuropharmacology. 2022 Nov 1;218:109213. doi: 10.1016/j.neuropharm.2022.109213. Epub 2022 Aug 12.

Alzheimer's disease

Emam S, Nasrollahpour M, Colarusso B, Cai X, Grant S, Kulkarni P, Ekenseair A, Gharagouzloo C, Ferris CF, Sun NX., Detection of presymptomatic Alzheimer's disease through breath biomarkers, Alzheimers Dement (Amst). 2020 Oct 14;12(1):e12088. doi: 10.1002/dad2.12088. eCollection 2020.

Kulkarni P, Grant S, Morrison TR, Cai X, Iriah S, Kristal BS, Honeycutt J, Brenhouse H, Hartner JC, Madularu D, Ferris CF., Characterizing the human APOE epsilon 4 knock-in transgene in female and male rats with multimodal magnetic resonance imaging, Brain Res. 2020 Nov 15;1747:147030. doi: 10.1016/j.brainres.2020.147030. Epub 2020 Jul 31.

Antibody production

Rijal P, Wang BB, Tan TK, Schimanski L, Janesch P, Dong T, McCauley JW, Daniels RS, Townsend AR, Huang KA., Broadly Inhibiting Antineuraminidase Monoclonal Antibodies Induced by Trivalent Influenza Vaccine and H7N9 Infection in Humans, J Virol. 2020 Jan 31;94(4):e01182-19. doi: 10.1128/JVI.01182-19. Print 2020 Jan 31.

McKitrick TR, Goth CK, Rosenberg CS, Nakahara H, Heimburg-Molinaro J, McQuillan AM, Falco R, Rivers NJ, Herrin BR, Cooper MD, Cummings RD., Development of smart anti-glycan reagents using immunized lampreys, Commun Biol. 2020 Feb 28;3(1):91. doi: 10.1038/s42003-020-0819-2.

Boyoglu-Barnum S, Hutchinson GB, Boyington JC, Moin SM, Gillespie RA, Tsybovsky Y, Stephens T, Vaile JR, Lederhofer J, Corbett KS, Fisher BE, Yassine HM, Andrews SF, Crank MC, McDermott AB, Mascola JR, Graham BS, Kanekiyo M., Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses, Nat Commun. 2020 Feb 7;11(1):791. doi: 10.1038/s41467-020-14579-4.

Kolehmainen P, Huttunen M, Iakubovskaia A, Maljanen A, Tauriainen S, Yatkin E...Julkunen I., Coronavirus spike protein-specific antibodies indicate frequent infections and reinfections in infancy and among BNT162b2-vaccinated healthcare workers, null

Nogal B, McCoy LE, van Gils MJ, Cottrell CA, Voss JE, Andrabi R, Pauthner M, Liang CH, Messmer T, Nedellec R, Shin M, Turner HL, Ozorowski G, Sanders RW, Burton DR, Ward AB., HIV envelope trimer-elicited autologous neutralizing antibodies bind a region overlapping the N332 glycan supersite, Sci Adv. 2020 Jun 5;6(23):eaba0512. doi: 10.1126/sciadv.aba0512. eCollection 2020 Jun.

Schorcht A, van den Kerkhof TLGM, Cottrell CA, Allen JD, Torres JL, Behrens AJ, Schermer EE, Burger JA, de Taeye SW, Torrents de la PeĂąa A, Bontjer I, Gumbs S, Ozorowski G, LaBranche CC, de Val N, Yasmeen A, Klasse PJ, Montefiori DC, Moore JP, Schuitemaker H, Crispin M, van Gils MJ, Ward AB, Sanders RW., Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers, J Virol. 2020 Nov 23;94(24):e01214-20. doi: 10.1128/JVI.01214-20. Print 2020 Nov 23.

Hemon MF, Lambert NC, Arnoux F, Roudier J, Auger I., PAD4 Immunization Triggers Anti-Citrullinated Peptide Antibodies in Normal Mice: Analysis With Peptide Arrays, 35432329

Atherosclerosis

Riemer K, Rowland EM, Broughton-Venner J, Leow CH, Tang M, Weinberg PD., Contrast Agent-Free Assessment of Blood Flow and Wall Shear Stress in the Rabbit Aorta using Ultrasound Image Velocimetry, 34876322

Nguyen TD, Watanabe A, Burleigh S, Ghaffarzadegan T, Kanklai J, Prykhodko O, Hållenius FF, Nyman M., Monobutyrin and monovalerin improve gut-blood-brain biomarkers and alter gut microbiota composition in high-fat fed apolipoprotein-E-knockout rats., 36104381

Nakladal D, Sijbesma JWA, Visser LM, Tietge UJF, Slart RHJA, Deelman LE, Henning RH, Hillebrands JL, Buikema H., Perivascular adipose tissue-derived nitric oxide compensates endothelial dysfunction in aged pre-atherosclerotic apolipoprotein E-deficient rats., Vascul Pharmacol. 2022 Feb;142:106945. doi: 10.1016/j.vph.2021.106945. Epub 2021 Nov 18.

Zabriskie MS, Wang C, Wang S, Alexander MD., Apolipoprotein E knockout rabbit model of intracranial atherosclerotic disease, Animal Model Exp Med. 2020 Jun 21;3(2):208-213. doi: 10.1002/ame2.12125. eCollection 2020 Jun.

Riemer K, Rowland EM, Leow CH, Tang MX, Weinberg PD., Determining Haemodynamic Wall Shear Stress in the Rabbit Aorta In Vivo Using Contrast-Enhanced Ultrasound Image Velocimetry, Ann Biomed Eng. 2020 Jun;48(6):1728-1739. doi: 10.1007/s10439-020-02484-2. Epub 2020 Mar 4.

Koike T, Koike Y, Yang D, Guo Y, Rom O, Song J, Xu J, Chen Y, Wang Y, Zhu T, Garcia-Barrio MT, Fan J, Chen YE, Zhang J., Human apolipoprotein A-II reduces atherosclerosis in knock-in rabbits, Atherosclerosis. 2021 Jan;316:32-40. doi: 10.1016/j.atherosclerosis.2020.11.028. Epub 2020 Nov 28.

Devine R, Goudie MJ, Singha P, Schmiedt C, Douglass M, Brisbois EJ, Handa H., Mimicking the Endothelium: Dual Action Heparinized Nitric Oxide Releasing Surface, ACS Appl Mater Interfaces. 2020 May 6;12(18):20158-20171. doi: 10.1021/acsami.9b22277. Epub 2020 Apr 22.

Berenji Ardestani S, Matchkov VV, Hansen K, Jespersen NR, Pedersen M, Eftedal I., Extensive Simulated Diving Aggravates Endothelial Dysfunction in Male Pro-atherosclerotic ApoE Knockout Rats, Front Physiol. 2020 Dec 23;11:611208. doi: 10.3389/fphys.2020.611208. eCollection 2020.

Berenji Ardestani S, Eftedal I, Pedersen M, Jeppesen PB, Nørregaard R, Matchkov VV., Endothelial dysfunction in small arteries and early signsÂ of atherosclerosis in ApoE knockout rats, Sci Rep. 2020 Sep 17;10(1):15296. doi: 10.1038/s41598-020-72338-3.

Wu, Y.; Johnson, G.; Zhao, F.; Wu, Y.; Zhao, G.; Brown, A.; You, S.; Zou, M.-H.; Song, P., Features of Lipid Metabolism in Humanized ApoE Knockin Rat Models, International Journal of Molecular Sciences. 2021; 22(15):8262.

Nakladal, D., Sijbesma, J. W. A., Visser, L. M., Tietge, U. J. F., Slart, R. H. J. A., Deelman, L. E., ... & Buikema, H., Perivascular adipose tissue-derived nitric oxide compensates endothelial dysfunction in aged pre-atherosclerotic apolipoprotein E-deficient rats, Vascular pharmacology (2021): 106945.

Yang, J. H., Niu, W., Li, Y., & Azadzoi, K. M., Impairment of AMPK-?2 augments detrusor contractions in bladder ischemia, Investigative and Clinical Urology 62, no. 5 (2021): 600.

Naito, Noritsugu; Ukita, Rei; Wilbs, Jonas; Wu, Kan; Lin, Xiaojie; Carleton, Neil M.; Roberts, Kalliope; Jiang, Shaoyi; Heinis, Christian; Cook, Keith E., Combination of polycarboxybetaine coating and factor XII inhibitor reduces clot formation while preserving normal tissue coagulation during extracorporeal life support, Biomaterials. 2021.

Autism

Schiavi S, Carbone E, Melancia F, Buzzelli V, Manduca A, Campolongo P, Pallottini V, Trezza V., Perinatal supplementation with omega-3 fatty acids corrects the aberrant social and cognitive traits observed in a genetic model of autism based on FMR1 deletion in rats, Nutr Neurosci. 2020 Sep 11:1-14. doi: 10.1080/1028415X.2020.1819107. Online ahead of print.

Barnett BR, Casey CP, Torres-Velázquez M, Rowley PA, Yu JJ., Convergent brain microstructure across multiple genetic models of schizophrenia and autism spectrum disorder: A feasibility study, Magn Reson Imaging. 2020 Jul;70:36-42. doi: 10.1016/j.mri.2020.04.002. Epub 2020 Apr 13.

Scott KE, Kazazian K, Mann RS, Möhrle D, Schormans AL, Schmid S, Allman BL., Loss of Cntnap2 in the Rat Causes Autism-Related Alterations in Social Interactions, Stereotypic Behavior, and Sensory Processing, Autism Res. 2020 Oct;13(10):1698-1717. doi: 10.1002/aur.2364. Epub 2020 Sep 11.

Autoimmune disease

Kalliokoski, S., Caja, S., Frias, R., Laurila, K., Koskinen, O., Niemela, O., . . . Lindfors, K. (2015), Injection of celiac disease patient sera or immunoglobulins to mice reproduces a condition mimicking early developing celiac disease., Journal of Molecular Medicine (Berlin, Germany), 93(1), 51-62. doi:10.1007/s00109-014-1204-8 [doi]

Cohen, M. D., Vaughan, J. M., Garrett, B., Prophete, C., Horton, L., Sisco, M., . . . Chen, L. C. (2015)., Acute high-level exposure to WTC particles alters expression of genes associated with oxidative stress and immune function in the lung, Journal of Immunotoxicology, 12(2), 140-153. doi:10.3109/1547691X.2014.914609 [doi]

Koshy, S., Huq, R., Tanner, M. R., Atik, M. A., Porter, P. C., Khan, F. S., . . . Beeton, C. (2014)., Blocking KV1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma, The Journal of Biological Chemistry, 289(18), 12623-12632. doi:10.1074/jbc.M113.517037 [doi]

Chang, J. C., Leung, J., Tang, T., Holzknecht, Z. E., Hartwig, M. G., Duane Davis, R., . . . Lin, S. S. (2014)., Cromolyn ameliorates acute and chronic injury in a rat lung transplant model., The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 33(7), 749-757. doi:10.1016/j.healun.2014.03.004 [doi]

Karimian Pour, N., & Piquette-Miller, M. (2018)., Endotoxin modulates the expression of renal drug transporters in HIV-1 transgenic rats, Journal of Pharmacy & Pharmaceutical Sciences : A Publication of the Canadian Society for Pharmaceutical Sciences, Societe Canadienne Des Sciences Pharmaceutiques, 21(1s), 117s-129s. doi:10.18433/jpps30017 [doi]

Farah, I. O., Holt-Gray, C., Cameron, J. A., Tucci, M., Cason, Z., & Benghuzzi, H. (2015)., Health impact of retinoic acid (ATRA) on ovalbumin-sensitized F344 rat lung and improvement of tissue pathology by citral., Biomedical Sciences Instrumentation, 51, 362-369.

Farah, I. O., Holt-Gray, C., Cameron, J. A., Tucci, M., & Benghuzzi, H. (2017), Histopathological analysis of the F344 rat lung upon exposure to retenoic acid, ovalbumin, mold spores and citral., Biomedical Sciences Instrumentation, 53, 120-127.

Brenner, M., Laragione, T., Shah, A., Mello, A., Remmers, E. F., Wilder, R. L., & Gulko, P. S. (2012)., Identification of two new arthritis severity loci that regulate levels of autoantibodies, interleukin-1beta, and joint damage in pristane- and collagen-induced arthritis., Arthritis and Rheumatism, 64(5), 1369-1378. doi:10.1002/art.33468 [doi]

Farah, I. O., Holt-Gray, C., Cameron, J. A., Tucci, M., & Benghuzzi, H. (2017)., Impact of atra on ovalbumin and mold-sensitized F344 rats and reversal of health-related implications by citral, Biomedical Sciences Instrumentation, 53, 320-327.

Farah, I. O., Holt-Gray, C., Cameron, J. A., Tucci, M., Cason, Z., & Benghuzzi, H. (2016)., Impact of triple combinations of retinoic acid, mold spores and citral on the F344 rat lung tissue pathology., Biomedical Sciences Instrumentation, 52, 104-111.

Chang, J. C., Leung, J. H., Tang, T., Hartwig, M. G., Holzknecht, Z. E., Parker, W., . . . Lin, S. S. (2012), In the face of chronic aspiration, prolonged ischemic time exacerbates obliterative bronchiolitis in rat pulmonary allografts., American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 12(11), 2930-2937. doi:10.1111/j.1600-6143.2012.04215.x [doi]

Nally, J. E., Wilson-Welder, J. H., Hornsby, R. L., Palmer, M. V., & Alt, D. P. (2018), Inbred rats as a model to study persistent renal leptospirosis and associated cellular immune responsiveness., Frontiers in Cellular and Infection Microbiology, 8, 66. doi:10.3389/fcimb.2018.00066 [doi]

Mao, X., Sarkar, S., & Chang, S. L. (2013)., Involvement of the NLRP3 inflammasome in the modulation of an LPS-induced inflammatory response during morphine tolerance., Drug and Alcohol Dependence, 132(1-2), 38-46. doi:10.1016/j.drugalcdep.2012.12.022 [doi]

Trama, A. M., Holzknecht, Z. E., Thomas, A. D., Su, K. Y., Lee, S. M., Foltz, E. E., . . . Parker, W. (2012)., Lymphocyte phenotypes in wild-caught rats suggest potential mechanisms underlying increased immune sensitivity in post-industrial environments., Cellular & Molecular Immunology, 9(2), 163-174. doi:10.1038/cmi.2011.61 [doi]

Whelan, A. O., Flick-Smith, H. C., Homan, J., Shen, Z. T., Carpenter, Z., Khoshkenar, P., . . . Oyston, P. C. F. (2018)., Protection induced by a francisella tularensis subunit vaccine delivered by glucan particles., PloS One, 13(10), e0200213. doi:10.1371/journal.pone.0200213 [doi]

Aplin, A. C., Ligresti, G., Fogel, E., Zorzi, P., Smith, K., & Nicosia, R. F. (2014)., Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by toll-like receptors., Angiogenesis, 17(1), 147-161. doi:10.1007/s10456-013-9384-3 [doi]

Sikalidis, A. K., Fitch, M. D., & Fleming, S. E. (2013)., Risk of colonic cancer is not higher in the obese lep(ob) mouse model compared to lean littermates, Pathology Oncology Research : POR, 19(4), 867-874. doi:10.1007/s12253-013-9656-7 [doi]

Campisi, J., Sharkey, C., Johnson, J. D., Asea, A., Maslanik, T., Bernstein-Hanley, I., & Fleshner, M. (2012)., Stress-induced facilitation of host response to bacterial challenge in F344 rats is dependent on extracellular heat shock protein 72 and independent of alpha beta T cells., Stress (Amsterdam, Netherlands), 15(6), 637-646. doi:10.3109/10253890.2011.653596 [doi]

Farah, I. O., Holt-Gray, C., Cameron, J. A., Tucci, M., Cason, Z., & Benghuzzi, H. (2015), The negative impact of combining retinoic acid (ATRA) and mold spores on F344 rat lung and improvement of tissue pathology by citral., Biomedical Sciences Instrumentation, 51, 370-377.

Trama, A. M., Holzknecht, Z. E., Thomas, A. D., Su, K. Y., Lee, S. M., Foltz, E. E., . . . Parker, W. (2012)., Lymphocyte phenotypes in wild-caught rats suggest potential mechanisms underlying increased immune sensitivity in post-industrial environments., Cellular & Molecular Immunology, 9(2), 163-174. doi:10.1038/cmi.2011.61 [doi]

Reese SR, Wilson NA, Huang Y, Ptak L, Degner KR, Xiang D, Redfield RR, Zhong W, Panzer SE., B-cell Deficiency Attenuates Transplant Glomerulopathy in a Rat Model of Chronic Active Antibody-mediated Rejection., Transplantation. 2021 Jul 1;105(7):1516-1529. doi: 10.1097/TP.0000000000003530.

Background for induced and genetically-modified models

Massi L, Hagihara KM, Courtin J, Hinz J, Müller C, Fustiñana MS, Xu C, Karalis N, Lüthi A., Disynaptic specificity of serial information flow for conditioned fear, 36652513

Ye H, Chen C, Wu H, Zheng K, Martín-Adrados B, Caparros E, Francés R, Nelson LJ, Gómez Del Moral M, Asensio I, Vaquero J, Bañares R, Ávila MA, Andrade RJ, Isabel Lucena M, Martínez-Chantar ML, Reeves HL, Masson S, Blumberg RS, Gracia-Sancho J, Nevzorova YA, Martínez-Naves E, Cubero FJ., Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy, 35145060

Hashimoto M, Brito SI, Venner A, Pasqualini AL, Yang TL, Allen D, Fuller PM, Anthony TE., Lateral septum modulates cortical state to tune responsivity to threat stimuli., 36288710

Behavior

Humby, T., Cross, E. S., Messer, L., Guerrero, S., & Davies, W. (2016), A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis., Psychoneuroendocrinology, 74, 363-370. doi:S0306-4530(16)30216-5 [pii]

Janecek, E., Waindok, P., Bankstahl, M., & Strube, C. (2017)., Abnormal neurobehaviour and impaired memory function as a consequence of toxocara canis- as well as toxocara cati-induced neurotoxocarosis., PLoS Neglected Tropical Diseases, 11(5), e0005594. doi:10.1371/journal.pntd.0005594 [doi]

Voikar, V., Krackow, S., Lipp, H. P., Rau, A., Colacicco, G., & Wolfer, D. P. (2018)., Automated dissection of permanent effects of hippocampal or prefrontal lesions on performance at spatial, working memory and circadian timing tasks of C57BL/6 mice in IntelliCage., Behavioural Brain Research, 352, 8-22. doi:S0166-4328(17)30962-2 [pii]

Laricchiuta, D., Musella, A., Rossi, S., & Centonze, D. (2014), Behavioral and electrophysiological effects of endocannabinoid and dopaminergic systems on salient stimuli., Frontiers in Behavioral Neuroscience, 8, 183. doi:10.3389/fnbeh.2014.00183 [doi]

Heinla, I., Ahlgren, J., Vasar, E., & Voikar, V. (2018)., Behavioural characterization of C57BL/6N and BALB/c female mice in social home cage - effect of mixed housing in complex environment., Physiology & Behavior, 188, 32-41. doi:S0031-9384(18)30032-5 [pii]

Laricchiuta, D., Rojo, M. L., Rodriguez-Gaztelumendi, A., Ferlazzo, F., Petrosini, L., & Fowler, C. J. (2012)., CB1 receptor autoradiographic characterization of the individual differences in approach and avoidance motivation, PloS One, 7(7), e42111. doi:10.1371/journal.pone.0042111 [doi]

Noack, J., Murau, R., & Engelmann, M. (2015)., Consequences of temporary inhibition of the medial amygdala on social recognition memory performance in mice, Frontiers in Neuroscience, 9, 152. doi:10.3389/fnins.2015.00152 [doi]

Tam, S. K., Hasan, S., Choi, H. M., Brown, L. A., Jagannath, A., Hughes, S., . . . Peirson, S. N. (2017)., Constant light desynchronizes olfactory versus object and visuospatial recognition memory performance., The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 37(13), 3555-3567. doi:10.1523/JNEUROSCI.3213-16.2017 [doi]

Laricchiuta, D., Rossi, S., Musella, A., De Chiara, V., Cutuli, D., Centonze, D., & Petrosini, L. (2012)., Differences in spontaneously avoiding or approaching mice reflect differences in CB1-mediated signaling of dorsal striatal transmission., PloS One, 7(3), e33260. doi:10.1371/journal.pone.0033260 [doi]

Reichenbach, N., Herrmann, U., Kahne, T., Schicknick, H., Pielot, R., Naumann, M., . . . Tischmeyer, W. (2015)., Differential effects of dopamine signalling on long-term memory formation and consolidation in rodent brain., Proteome Science, 13, 13-015-0069-2. eCollection 2015. doi:10.1186/s12953-015-0069-2 [doi]

Camats-Perna, Judith; Kalaba, Predrag; Ebner, Karl; Sartori, Simone B; Vuyyuru, Harish; Aher, Nilima Y; Draga?evi?, Vladimir; Singewald, Nicolas; Engelmann, Mario; Lubec, Gert;, Differential Effects of Novel Dopamine Reuptake Inhibitors on Interference With Long-Term Social Memory in Mice., Frontiers in behavioral neuroscience Vol.13, 2019

Laricchiuta, D., Centonze, D., & Petrosini, L. (2013)., Effects of endocannabinoid and endovanilloid systems on aversive memory extinction., Behavioural Brain Research, 256, 101-107. doi:10.1016/j.bbr.2013.08.010 [doi]

Labots, M., Zheng, X., Moattari, G., Ohl, F., & van Lith, H. A. (2016)., Effects of light regime and substrain on behavioral profiles of male C57BL/6 mice in three tests of unconditioned anxiety, Journal of Neurogenetics, 30(3-4), 306-315. doi:10.1080/01677063.2016.1249868 [doi]

Ehmer I, Crown L, van Leeuwen W, Feenstra M, Willuhn I, Denys D., Evidence for Distinct Forms of Compulsivity in the SAPAP3 Mutant-Mouse Model for Obsessive-Compulsive Disorder, eNeuro. 2020 Apr 28;7(2):ENEURO.0245-19.2020. doi: 10.1523/ENEURO.0245-19.2020. Print 2020 Mar/Apr.

de Hoz, L., & Nelken, I. (2014)., Frequency tuning in the behaving mouse: Different bandwidths for discrimination and generalization, PloS One, 9(3), e91676. doi:10.1371/journal.pone.0091676 [doi]

Åhlgren, Johanna; Voikar, Vootele;, Housing mice in the individually ventilated or open cages-Does it matter for behavioral phenotype?, Genes, brain, and behavior Vol.18, 2019

Laricchiuta, D., Saba, L., De Bartolo, P., Caioli, S., Zona, C., & Petrosini, L. (2016), Maintenance of aversive memories shown by fear extinction-impaired phenotypes is associated with increased activity in the amygdaloid-prefrontal circuit., Scientific Reports, 6, 21205. doi:10.1038/srep21205 [doi]

Kulesskaya, N., Karpova, N. N., Ma, L., Tian, L., & Voikar, V. (2014)., Mixed housing with DBA/2 mice induces stress in C57BL/6 mice: Implications for interventions based on social enrichment., Frontiers in Behavioral Neuroscience, 8, 257. doi:10.3389/fnbeh.2014.00257 [doi]

Ahmadlou, M., & Heimel, J. A. (2015)., Preference for concentric orientations in the mouse superior colliculus., Nature Communications, 6, 6773. doi:10.1038/ncomms7773 [doi]

Houben, T., Coomans, C. P., & Meijer, J. H. (2014)., Regulation of circadian and acute activity levels by the murine suprachiasmatic nuclei, PloS One, 9(10), e110172. doi:10.1371/journal.pone.0110172 [doi]

van den Berg, W. E., Lamballais, S., & Kushner, S. A. (2015)., Sex-specific mechanism of social hierarchy in mice., Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 40(6), 1364-1372. doi:10.1038/npp.2014.319 [doi]

Gasser BA, Kurz J, Senn W, Escher G, Mohaupt MG., Stress-induced alterations of social behavior are reversible by antagonism of steroid hormones in C57/BL6 mice, Naunyn Schmiedebergs Arch Pharmacol. 2021 Jan;394(1):127-135. doi: 10.1007/s00210-020-01970-7. Epub 2020 Sep 7.

Odland, Anna U; Jessen, Lea; Kristensen, Jesper L; Fitzpatrick, Ciarán M; Andreasen, Jesper T;, The 5-hydroxytryptamine 2A receptor agonists DOI and 25CN-NBOH decrease marble burying and reverse 8-OH-DPAT-induced deficit in spontaneous alternation, Neuropharmacology Vol., 2019

O'Brien, F. E., O'Connor, R. M., Clarke, G., Donovan, M. D., Dinan, T. G., Griffin, B. T., & Cryan, J. F. (2014)., The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram., Behavioural Brain Research, 261, 17-25. doi:10.1016/j.bbr.2013.11.027 [doi]

Perna, J. C., Wotjak, C. T., Stork, O., & Engelmann, M. (2015)., Timing of presentation and nature of stimuli determine retroactive interference with social recognition memory in mice., Physiology & Behavior, 143, 10-14. doi:10.1016/j.physbeh.2015.02.029 [doi]

Duncan, M. J., Prochot, J. R., Cook, D. H., Tyler Smith, J., & Franklin, K. M. (2013), Influence of aging on Bmal1 and Per2 expression in extra-SCN oscillators in hamster brain., Brain Research, 1491, 44-53. doi:10.1016/j.brainres.2012.11.008 [doi]

Duncan, M. J., Franklin, K. M., Peng, X., Yun, C., & Legan, S. J. (2014), Roles of exercise and arousal in blockade of the luteinizing hormone surge., hysiology & Behavior, 131, 7-16. doi:10.1016/j.physbeh.2014.04.006 [doi]

Piekarski, D. J., Jarjisian, S. G., & Zucker, I. (2012)., Winter day lengths counteract stimulatory effects of apomorphine and yohimbine on sexual behavior of male syrian hamsters., Chronobiology International, 29(7), 850-856. doi:10.3109/07420528.2012.699125 [doi]

Meade GM, Charron LS, Kilburn LW, Pei Z, Wang HY, Robinson S., A Model of Negative Emotional Contagion Between Male-Female Rat Dyads: Effects of Voluntary Exercise on Stress-Induced Behavior and BDNF-TrkB Signaling, Physiol Behav. 2020 Dec 12:113286. doi: 10.1016/j.physbeh.2020.113286. Online ahead of print.

Ottenheimer DJ, Bari BA, Sutlief E, Fraser KM, Kim TH, Richard JM, Cohen JY, Janak PH., A quantitative reward prediction error signal in the ventral pallidum, Nat Neurosci. 2020 Oct;23(10):1267-1276. doi: 10.1038/s41593-020-0688-5. Epub 2020 Aug 10.

Yu XW, Pandey K, Katzman AC, Alberini CM., A role for CIM6P/IGF2 receptor in memory consolidation and enhancement, Elife. 2020 May 5;9:e54781. doi: 10.7554/eLife.54781.

Nentwig, Todd B; Starr, E Margaret; Chandler, L Judson; Glover, Elizabeth J;, Absence of compulsive drinking phenotype in adult male rats exposed to ethanol in a binge-like pattern during adolescence., Alcohol (Fayetteville, N.Y.) Vol.79, 2019

Lynch, Caroline A; Porter, Brandon; Butler, Tracy R;, Access to voluntary running wheel exercise: Prevention of anxiety-like behavior in chronically stressed rats, but potentiation of ethanol intake/preference., Physiology & behavior Vol.206, 2019

Visser, A. K., Meerlo, P., Ettrup, A., Knudsen, G. M., Bosker, F. J., den Boer, J. A., . . . van Waarde, A. (2014)., Acute social defeat does not alter cerebral 5-HT2A receptor binding in male wistar rats, Synapse (New York, N.Y.), 68(9), 379-386. doi:10.1002/syn.21750 [doi]

Kendricks DR, Boomhower SR, Arnold MA, Glenn DJ, Newland MC., Adolescent methylmercury exposure alters short-term remembering, but not sustained attention, in male Long-Evans rats, Neurotoxicology. 2020 May;78:186-194. doi: 10.1016/j.neuro.2020.03.009. Epub 2020 Mar 19.

Stevenson ME, Miller CC, Owen HA, Swain RA., Aerobic exercise increases sprouting angiogenesis in the male rat motor cortex, Brain Struct Funct. 2020 Nov;225(8):2301-2314. doi: 10.1007/s00429-020-02100-y. Epub 2020 Sep 12.

Nagaya, N., Acca, G. M., & Maren, S. (2015)., Allopregnanolone in the bed nucleus of the stria terminalis modulates contextual fear in rats., Frontiers in Behavioral Neuroscience, 9, 205. doi:10.3389/fnbeh.2015.00205 [doi]

Acca, G. M., Mathew, A. S., Jin, J., Maren, S., & Nagaya, N. (2017), Allopregnanolone induces state-dependent fear via the bed nucleus of the stria terminalis., Hormones and Behavior, 89, 137-144. doi:S0018-506X(16)30395-6 [pii]

Kamal, A., Van der Harst, J. E., Kapteijn, C. M., Baars, A. J., Spruijt, B. M., & Ramakers, G. M. (2010)., Announced reward counteracts the effects of chronic social stress on anticipatory behavior and hippocampal synaptic plasticity in rats., Experimental Brain Research, 201(4), 641-651. doi:10.1007/s00221-009-2083-z [doi]

van der Harst, J. E., Baars, A. M., & Spruijt, B. M. (2005)., Announced rewards counteract the impairment of anticipatory behaviour in socially stressed rats, Behavioural Brain Research, 161(2), 183-189. doi:S0166-4328(05)00075-6 [pii]

Hudson AR, Santora VJ, Petroski RE, Almos TA, Anderson G, Barido R, Basinger J, Bellows CL, Bookser BC, Broadbent NJ, Cabebe C, Chai CK, Chen M, Chow S, Chung M, Heger L, Danks AM, Freestone GC, Gitnick D, Gupta V, Hoffmaster C, Kaplan AP, Kennedy MR, Lee D, Limberis J, Ly K, Mak CC, Masatsugu B, Morse AC, Na J, Neul D, Nikpur J, Renick J, Sebring K, Sevidal S, Tabatabaei A, Wen J, Xia S, Yan Y, Yoder ZW, Zook D, Peters M, Breitenbucher JG., Azetidine-based selective glycine transporter-1 (GlyT1) inhibitors with memory enhancing properties, Bioorg Med Chem Lett. 2020 Jul 15;30(14):127214. doi: 10.1016/j.bmcl.2020.127214. Epub 2020 Apr 25.

Skelly, M. J., Chappell, A. M., Ariwodola, O. J., & Weiner, J. L. (2016)., Behavioral and neurophysiological evidence that lateral paracapsular GABAergic synapses in the basolateral amygdala contribute to the acquisition and extinction of fear learning., Neurobiology of Learning and Memory, 127, 10-16. doi:10.1016/j.nlm.2015.11.006 [doi]

Sellinger EP, Kougias DG, Drzewiecki CM, Juraska JM., Behavioral effects in adult rats exposed to low doses of a phthalate mixture during the perinatal or adolescent period, Neurotoxicol Teratol. 2020 May-Jun;79:106886. doi: 10.1016/j.ntt.2020.106886. Epub 2020 Apr 18.

Deal AL, Bass CE, Grinevich VP, Delbono O, Bonin KD, Weiner JL, Budygin EA., Bidirectional Control of Alcohol-drinking Behaviors Through Locus Coeruleus Optoactivation, Neuroscience. 2020 Sep 1;443:84-92. doi: 10.1016/j.neuroscience.2020.07.024. Epub 2020 Jul 21.

Makhijani VH, Irukulapati P, Van Voorhies K, Fortino B, Besheer J., Central amygdala mineralocorticoid receptors modulate alcohol self-administration, Neuropharmacology. 2020 Dec 15;181:108337. doi: 10.1016/j.neuropharm.2020.108337. Epub 2020 Sep 29.

Wakabayashi, Ken T; Feja, Malte; Baindur, Ajay N; Bruno, Michael J; Bhimani, Rohan V; Park, Jinwoo; Hausknecht, Kathryn; Shen, Roh-Yu; Haj-Dahmane, Samir; Bass, Caroline E;, Chemogenetic activation of ventral tegmental area GABA neurons, but not mesoaccumbal GABA terminals, disrupts responding to reward-predictive cues., Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Vol.44, 2019

Waddell, J., & Mooney, S. M. (2017), Choline and working memory training improve cognitive deficits caused by prenatal exposure to ethanol, Nutrients, 9(10), 10.3390/nu9101080. doi:E1080 [pii]

Waddell J, Hill E, Tang S, Jiang L, Xu S, Mooney SM., Choline Plus Working Memory Training Improves Prenatal Alcohol-Induced Deficits in Cognitive Flexibility and Functional Connectivity in Adulthood in Rats, Nutrients. 2020 Nov 14;12(11):3513. doi: 10.3390/nu12113513.

Kellis DM, Kaigler KF, Witherspoon E, Fadel JR, Wilson MA., Cholinergic neurotransmission in the basolateral amygdala during cued fear extinction, Neurobiol Stress. 2020 Nov 30;13:100279. doi: 10.1016/j.ynstr.2020.100279. eCollection 2020 Nov.

Giacobbo BL, Doorduin J, Moraga-Amaro R, Nazario LR, Schildt A, Bromberg E, Dierckx RAJO, de Vries EFJ., Chronic harmine treatment has a delayed effect on mobility in control and socially defeated rats, Psychopharmacology (Berl). 2020 Jun;237(6):1595-1606. doi: 10.1007/s00213-020-05483-2. Epub 2020 Feb 22.

Bardgett ME, Downnen T, Crane C, Baltes Thompson EC, Muncie B, Steffen SA, Yates JR, Pauly JR., Chronic risperidone administration leads to greater amphetamine-induced conditioned place preference, Neuropharmacology. 2020 Nov 15;179:108276. doi: 10.1016/j.neuropharm.2020.108276. Epub 2020 Aug 16.

Miller, M. M., Meyer, A. E., Sprowles, J. L., & Sable, H. J. (2017)., Cocaine self-administration in male and female rats perinatally exposed to PCBs: Evaluating drug use in an animal model of environmental contaminant exposure, Experimental and Clinical Psychopharmacology, 25(2), 114-124. doi:10.1037/pha0000113 [doi]

Miller, M. M., Sprowles, J. L. N., Voeller, J. N., Meyer, A. E., & Sable, H. J. K. (2017)., Cocaine sensitization in adult long-evans rats perinatally exposed to polychlorinated biphenyls, Neurotoxicology and Teratology, 62, 34-41. doi:S0892-0362(17)30023-5 [pii]

Nelson, Nnamdi G; Law, Wen Xuan; Weingarten, Michael J; Carnevale, Lauren N; Das, Aditi; Liang, Nu-Chu;, Combined ? 9-tetrahydrocannabinol and moderate alcohol administration: effects on ingestive behaviors in adolescent male rats, Psychopharmacology Vol.236, 2019

Sims SK, Rizzo A, Howard K, Farrand A, Boger H, Adkins DL., Comparative Enhancement of Motor Function and BDNF Expression Following Different Brain Stimulation Approaches in an Animal Model of Ischemic Stroke, Neurorehabil Neural Repair. 2020 Oct;34(10):925-935. doi: 10.1177/1545968320952798. Epub 2020 Sep 10.

Avila C, Kucinski A, Sarter M., Complex Movement Control in a Rat Model of Parkinsonian Falls: Bidirectional Control by Striatal Cholinergic Interneurons, J Neurosci. 2020 Jul 29;40(31):6049-6067. doi: 10.1523/JNEUROSCI.0220-20.2020. Epub 2020 Jun 18.

Wilson DA, Fleming G, Vervoordt SM, Coureaud G., Cortical processing of configurally perceived odor mixtures, Brain Res. 2020 Feb 15;1729:146617. doi: 10.1016/j.brainres.2019.146617. Epub 2019 Dec 19.

Trask S, Reis DS, Ferrara NC, Helmstetter FJ., Decreased cued fear discrimination learning in female rats as a function of estrous phase, Learn Mem. 2020 May 15;27(6):254-257. doi: 10.1101/lm.051185.119. Print 2020 Jun.

Baumgartner HM, Cole SL, Olney JJ, Berridge KC., Desire or Dread from Nucleus Accumbens Inhibitions: Reversed by Same-Site Optogenetic Excitations, J Neurosci. 2020 Mar 25;40(13):2737-2752. doi: 10.1523/JNEUROSCI.2902-19.2020. Epub 2020 Feb 19.

Woon EP, Seibert TA, Urbanczyk PJ, Ng KH, Sangha S., Differential effects of prior stress on conditioned inhibition of fear and fear extinction, Behav Brain Res. 2020 Mar 2;381:112414. doi: 10.1016/j.bbr.2019.112414. Epub 2019 Dec 28.

DeLarge AF, Winsauer PJ., Effects of â9-THC on memory in ovariectomized and intact female rats, Horm Behav. 2020 Nov 23;127:104883. doi: 10.1016/j.yhbeh.2020.104883. Online ahead of print.

Randall, Patrick A; Fortino, Brayden; Huynh, Y Wendy; Thompson, Brady M; Larsen, Christopher E; Callen, Mackenzie P; Barrett, Scott T; Murray, Jennifer E; Bevins, Rick A; Besheer, Joyce;, Effects of nicotine conditioning history on alcohol and methamphetamine self-administration in rats, Pharmacology, biochemistry, and behavior Vol.179, 2019

Lamb, R J; Ginsburg, Brett C; Greig, Alexander; Schindler, Charles W;, Effects of rat strain and method of inducing ethanol drinking on Pavlovian-Instrumental-Transfer with ethanol-paired conditioned stimuli, Alcohol (Fayetteville, N.Y.) Vol.79, 2019

Goode, T. D., Leong, K. C., Goodman, J., Maren, S., & Packard, M. G. (2016), Enhancement of striatum-dependent memory by conditioned fear is mediated by beta-adrenergic receptors in the basolateral amygdala., Neurobiology of Stress, 3, 74-82. doi:10.1016/j.ynstr.2016.02.004 [doi]

Neal, S., Kent, M., Bardi, M., & Lambert, K. G. (2018), Enriched environment exposure enhances social interactions and oxytocin responsiveness in male long-evans rats., Frontiers in Behavioral Neuroscience, 12, 198. doi:10.3389/fnbeh.2018.00198 [doi]

Scarola SJ, Bardi M., Environmental enrichment modulates inflammation during development in long-evans rats (Rattus norvegicus), Dev Psychobiol. 2020 Jun 23. doi: 10.1002/dev.22007. Online ahead of print.

Kirry, Adam J; Durigan, Deven J; Twining, Robert C; Gilmartin, Marieke R;, Estrous cycle stage gates sex differences in prefrontal muscarinic control of fear memory formation., Neurobiology of learning and memory Vol.161, 2019

DeAngeli, N. E., Todd, T. P., Chang, S. E., Yeh, H. H., Yeh, P. W., & Bucci, D. J. (2015), Exposure to kynurenic acid during adolescence increases sign-tracking and impairs long-term potentiation in adulthood., Frontiers in Behavioral Neuroscience, 8, 451. doi:10.3389/fnbeh.2014.00451 [doi]

Goode, T. D., Holloway-Erickson, C. M., & Maren, S. (2017)., Extinction after fear memory reactivation fails to eliminate renewal in rats, Neurobiology of Learning and Memory, 142(Pt A), 41-47. doi:S1074-7427(17)30035-7 [pii]

Giustino, T. F., Fitzgerald, P. J., & Maren, S. (2016)., Fear expression suppresses medial prefrontal cortical firing in rats., PloS One, 11(10), e0165256. doi:10.1371/journal.pone.0165256 [doi]

Jin, J., & Maren, S. (2015), Fear renewal preferentially activates ventral hippocampal neurons projecting to both amygdala and prefrontal cortex in rats, Scientific Reports, 5, 8388. doi:10.1038/srep08388 [doi]

Zanni G, DeSalle MJ, Deutsch HM, Barr GA, Eisch AJ., Female and male rats readily consume and prefer oxycodone to water in a chronic, continuous access, two-bottle oral voluntary paradigm, Neuropharmacology. 2020 May 1;167:107978. doi: 10.1016/j.neuropharm.2020.107978. Epub 2020 Jan 27.

Messanvi, F; Perkins, A; du Hoffmann, J; Chudasama, Y;, Fronto-temporal galanin modulates impulse control, Psychopharmacology Vol.12, 2019

Agrawal J, Dwivedi Y., GABA(A) Receptor Subunit Transcriptional Regulation, Expression Organization, and Mediated Calmodulin Signaling in Prefrontal Cortex of Rats Showing Testosterone-Mediated Impulsive Behavior, Front Neurosci. 2020 Nov 6;14:600099. doi: 10.3389/fnins.2020.600099. eCollection 2020.

Marek, R., Jin, J., Goode, T. D., Giustino, T. F., Wang, Q., Acca, G. M., . . . Sah, P. (2018)., Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear., Nature Neuroscience, 21(3), 384-392. doi:10.1038/s41593-018-0073-9 [doi]

Santollo J, Edwards AA., How predictive is body weight on fluid intake in rats? It depends on sex, Physiol Behav. 2021 Feb 1;229:113262. doi: 10.1016/j.physbeh.2020.113262. Epub 2020 Nov 21.

Guarraci FA, Ali M, Gonzalez CMF, Lucero D, Clemons LW, Davis LK, Henneman EL, Odell SE, Meerts SH., I. Antidepressants and sexual behavior: Weekly ketamine injections increase sexual behavior initially in female and male rats, Pharmacol Biochem Behav. 2020 Dec;199:173039. doi: 10.1016/j.pbb.2020.173039. Epub 2020 Sep 11.

Poland, R. S., Hahn, Y., Knapp, P. E., Beardsley, P. M., & Bowers, M. S. (2016)., Ibudilast attenuates expression of behavioral sensitization to cocaine in male and female rats., Neuropharmacology, 109, 281-292. doi:10.1016/j.neuropharm.2016.06.024 [doi]

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LeCocq MR, Sun S, Chaudhri N., The Role of Context Conditioning in the Reinstatement of Responding to an Alcohol-Predictive Conditioned Stimulus., Behav Brain Res. 2021 Nov 28:113686. doi: 10.1016/j.bbr.2021.113686. [Epub ahead of print]

Natale NR, Kent M, Fox N, Vavra D, Lambert K., Neurobiological effects of a probiotic-supplemented diet in chronically stressed male Long-Evans rats: Evidence of enhanced resilience., IBRO Neurosci Rep. 2021 Nov 6;11:207-215. doi: 10.1016/j.ibneur.2021.10.004. eCollection 2021 Dec.

GonzĂĄlez VV, Seitz BM, Formaker R, Blaisdell AP., Elements of a compound elicit little conditioned reinforcement., J Exp Psychol Anim Learn Cogn. 2021 Nov 29. doi: 10.1037/xan0000296. [Epub ahead of print]

Anekonda VT, Thompson BW, Ho JM, Roberts ZS, Edwards MM, Nguyen HK, Dodson AD, Wolden-Hanson T, Chukri DW, Herbertson AJ, Graham JL, Havel PJ, Wietecha TA, O'Brien KD, Blevins JE., Hindbrain Administration of Oxytocin Reduces Food Intake, Weight Gain and Activates Catecholamine Neurons in the Hindbrain Nucleus of the Solitary Tract in Rats., J Clin Med. 2021 Oct 29;10(21). pii: 5078. doi: 10.3390/jcm10215078.

Kinley BL, Kyne RF, Lawton-Stone TS, Walker DM, Paul MJ., Long-term consequences of peri-adolescent social isolation on social preference, anxiety-like behaviour, and vasopressin neural circuitry of male and female rats., Eur J Neurosci. 2021 Nov 8. doi: 10.1111/ejn.15520. [Epub ahead of print]

Leon Z, Shah K, Bailey LS, Karkhanis AN, Sirohi S., Patterned Feeding of a Hyper-Palatable Food (Oreo Cookies) Reduces Alcohol Drinking in Rats., Front Behav Neurosci. 2021 Oct 20;15:725856. doi: 10.3389/fnbeh.2021.725856. eCollection 2021.

East BS, Fleming G, Vervoordt S, Shah P, Sullivan RM, Wilson DA., Basolateral amygdala to posterior piriform cortex connectivity ensures precision in learned odor threat., Sci Rep. 2021 Nov 5;11(1):21746. doi: 10.1038/s41598-021-01320-4.

Vandaele Y, Ottenheimer DJ, Janak PH., Dorsomedial Striatal Activity Tracks Completion of Behavioral Sequences in Rats., eNeuro. 2021 Nov 18;8(6). pii: ENEURO.0279-21.2021. doi: 10.1523/ENEURO.0279-21.2021. Print 2021 Nov-Dec.

Opendak M, Raineki C, Perry RE, Rincón-Cortés M, Song SC, Zanca RM, Wood E, Packard K, Hu S, Woo J, Martinez K, Vinod KY, Brown RW, Deehan GA Jr, Froemke RC, Serrano PA, Wilson DA, Sullivan RM., Bidirectional control of infant rat social behavior via dopaminergic innervation of the basolateral amygdala., Neuron. 2021 Dec 15;109(24):4018-4035.e7. doi: 10.1016/j.neuron.2021.09.041. Epub 2021 Oct 26.

Bercum FM, Navarro Gomez MJ, Saddoris MP., Elevated fear responses to threatening cues in rats with early life stress is associated with greater excitability and loss of gamma oscillations in ventral-medial prefrontal cortex., Neurobiol Learn Mem. 2021 Nov;185:107541. doi: 10.1016/j.nlm.2021.107541. Epub 2021 Oct 20.

Patwell R, Yang H, Pandey SC, Glover EJ., An operant ethanol self-administration paradigm that discriminates between appetitive and consummatory behaviors reveals distinct behavioral phenotypes in commonly used rat strains., Neuropharmacology. 2021 Dec 15;201:108836. doi: 10.1016/j.neuropharm.2021.108836. Epub 2021 Oct 12.

Mu L, Liu X, Yu H, Hu M, Friedman V, Kelly TJ, Zhao L, Liu QS., Ibudilast attenuates cocaine self-administration and prime- and cue-induced reinstatement of cocaine seeking in rats., Neuropharmacology. 2021 Dec 15;201:108830. doi: 10.1016/j.neuropharm.2021.108830. Epub 2021 Oct 7.

Fourman S, Buesing D, Girvin S, Nashawi H, Ulrich-Lai YM., Limited cheese intake reduces HPA axis and behavioral stress responses in male rats., Physiol Behav. 2021 Dec 1;242:113614. doi: 10.1016/j.physbeh.2021.113614. Epub 2021 Oct 1.

Trask S, Ferrara NC, Grisales K, Helmstetter FJ., Optogenetic inhibition of either the anterior or posterior retrosplenial cortex disrupts retrieval of a trace, but not delay, fear memory., Neurobiol Learn Mem. 2021 Nov;185:107530. doi: 10.1016/j.nlm.2021.107530. Epub 2021 Sep 27.

Cortez I, Brocardo PS, Leasure JL., Changes in Affective Behavior and Oxidative Stress after Binge Alcohol in Male and Female Rats., Brain Sci. 2021 Sep 21;11(9). pii: 1250. doi: 10.3390/brainsci11091250.

Lawrence-Sidebottom D, Schmidt MA, Harvey DO, Van Dongen HPA, Davis CJ., Floor vibrations for motivation and feedback in the rat vibration actuating search task., PLoS One. 2021 Sep 27;16(9):e0257980. doi: 10.1371/journal.pone.0257980. eCollection 2021.

Ferrara NC, Trask S, Pullins SE, Helmstetter FJ., Regulation of learned fear expression through the MgN-amygdala pathway., Neurobiol Learn Mem. 2021 Nov;185:107526. doi: 10.1016/j.nlm.2021.107526. Epub 2021 Sep 23.

Northcutt KV, Leal-Medina TS, Yoon YS., Early postnatal hypothyroidism reduces juvenile play behavior, but prenatal hypothyroidism compensates for these effects., Physiol Behav. 2021 Nov 1;241:113594. doi: 10.1016/j.physbeh.2021.113594. Epub 2021 Sep 15.

Gemzik ZM, Donahue MM, Griffin AL., Optogenetic suppression of the medial septum impairs working memory maintenance., Learn Mem. 2021 Sep 15;28(10):361-370. doi: 10.1101/lm.053348.120. Print 2021 Oct.

Amarante LM, Laubach M., Coherent theta activity in the medial and orbital frontal cortices encodes reward value., Elife. 2021 Sep 10;10. pii: e63372. doi: 10.7554/eLife.63372.

Fournier DI, Cheng HY, Tavakkoli A, Gulledge AT, Bucci DJ, Todd TP., Retrosplenial cortex inactivation during retrieval, but not encoding, impairs remotely acquired auditory fear conditioning in male rats., Neurobiol Learn Mem. 2021 Nov;185:107517. doi: 10.1016/j.nlm.2021.107517. Epub 2021 Sep 6.

Tryon SC, Sakamoto IM, Kellis DM, Kaigler KF, Wilson MA., Individual Differences in Conditioned Fear and Extinction in Female Rats., Front Behav Neurosci. 2021 Aug 18;15:740313. doi: 10.3389/fnbeh.2021.740313. eCollection 2021.

Angelyn H, Loney GC, Meyer PJ., Nicotine Enhances Goal-Tracking in Ethanol and Food Pavlovian Conditioned Approach Paradigms., Front Neurosci. 2021 Aug 18;15:561766. doi: 10.3389/fnins.2021.561766. eCollection 2021.

Nwachukwu K, Rhoads E, Meek S, Bardi M., Back to nature: herbal treatment, environmental enrichment, and social play can protect against unpredictable chronic stress in Long-Evans rats (Rattus norvegicus)., Psychopharmacology (Berl). 2021 Oct;238(10):2999-3012. doi: 10.1007/s00213-021-05917-5. Epub 2021 Aug 1.

Wooden JI, Spinetta MJ, Nguyen T, O'Leary CI, Leasure JL., A Sensitive Homecage-Based Novel Object Recognition Task for Rodents., Front Behav Neurosci. 2021 Jun 11;15:680042. doi: 10.3389/fnbeh.2021.680042. eCollection 2021.

Rajalingam D, Nymoen I, Nyberg H, Nielsen MB, Einarsen SV, Gjerstad J., Workplace bullying increases the risk of anxiety through a stress-induced Î˛2-adrenergic receptor mechanism: a multisource study employing an animal model, cell culture experiments and human data., Int Arch Occup Environ Health. 2021 Nov;94(8):1905-1915. doi: 10.1007/s00420-021-01718-7. Epub 2021 Jun 2.

George BE, Barth SH, Kuiper LB, Holleran KM, Lacy RT, Raab-Graham KF, Jones SR., Enhanced heroin self-administration and distinct dopamine adaptations in female rats., Neuropsychopharmacology. 2021 Sep;46(10):1724-1733. doi: 10.1038/s41386-021-01035-0. Epub 2021 May 26.

Gonzalez ST, Marty V, Spigelman I, Reise SP, Fanselow MS., Impact of stress resilience and susceptibility on fear learning, anxiety, and alcohol intake., Neurobiol Stress. 2021 May 6;15:100335. doi: 10.1016/j.ynstr.2021.100335. eCollection 2021 Nov.

Santollo J, Edwards AA, Howell JA, Myers KE., Bidirectional effects of estradiol on the control of water intake in female rats., Horm Behav. 2021 Jul;133:104996. doi: 10.1016/j.yhbeh.2021.104996. Epub 2021 May 18.

Taylor-Yeremeeva EM, Wisser SC, Chakoma TL, Aldrich SJ, Denney AE, Donahue EK, Adelman JS, Ihle PCJ, Robinson S., Appetitive and aversive sensory preconditioning in rats is impaired by disruption of the postrhinal cortex., Neurobiol Learn Mem. 2021 Sep;183:107461. doi: 10.1016/j.nlm.2021.107461. Epub 2021 May 17.

Bach EC, Morgan JW, Ewin SE, Barth SH, Raab-Graham KF, Weiner JL., Chronic Ethanol Exposures Leads to a Negative Affective State in Female Rats That Is Accompanied by a Paradoxical Decrease in Ventral Hippocampus Excitability., Front Neurosci. 2021 Apr 30;15:669075. doi: 10.3389/fnins.2021.669075. eCollection 2021.

Moschak TM, Carelli RM., A sex-dependent role for the prelimbic cortex in impulsive action both before and following early cocaine abstinence., Neuropsychopharmacology. 2021 Aug;46(9):1565-1573. doi: 10.1038/s41386-021-01024-3. Epub 2021 May 10.

Guarraci FA, Davis LK, Henneman EL, Toro E, Odell SE, Le N, Navarro JM, Valdivia HS, Williams I, Credeur M, Gore AC., Daily GnRH agonist treatment delays the development of reproductive physiology and behavior in male rats., Horm Behav. 2021 Jun;132:104982. doi: 10.1016/j.yhbeh.2021.104982. Epub 2021 May 3.

Totty MS, Warren N, Huddleston I, Ramanathan KR, Ressler RL, Oleksiak CR, Maren S., Behavioral and brain mechanisms mediating conditioned flight behavior in rats., Sci Rep. 2021 Apr 15;11(1):8215. doi: 10.1038/s41598-021-87559-3.

Ressler RL, Goode TD, Kim S, Ramanathan KR, Maren S., Covert capture and attenuation of a hippocampus-dependent fear memory., Nat Neurosci. 2021 May;24(5):677-684. doi: 10.1038/s41593-021-00825-5. Epub 2021 Apr 1.

Drzewiecki CM, Willing J, Cortes LR, Juraska JM., Adolescent stress during, but not after, pubertal onset impairs indices of prepulse inhibition in adult rats., Dev Psychobiol. 2021 Jul;63(5):837-850. doi: 10.1002/dev.22111. Epub 2021 Feb 24.

Holstein SE, Barkell GA, Young MR., Caffeine increases alcohol self-administration, an effect that is independent of dopamine D(2) receptor function., Alcohol. 2021 Mar;91:61-73. doi: 10.1016/j.alcohol.2020.12.004. Epub 2021 Jan 9.

Gabriel DBK, Liley AE, Freels TG, Simon NW., Dopamine receptors regulate preference between high-effort and high-risk rewards., Psychopharmacology (Berl). 2021 Apr;238(4):991-1004. doi: 10.1007/s00213-020-05745-z. Epub 2021 Jan 7.

West RK, Rodgers SP, Leasure JL., Neural Perturbations Associated With Recurrent Binge Alcohol in Male and Female Rats., Alcohol Clin Exp Res. 2021 Feb;45(2):365-374. doi: 10.1111/acer.14529. Epub 2020 Dec 29.

McQuown S, Paes D, Baumgärtel K, Prickaerts J, Peters M., Pharmacological inhibition of phosphodiesterase 7 enhances consolidation processes of spatial memory., Neurobiol Learn Mem. 2021 Jan;177:107357. doi: 10.1016/j.nlm.2020.107357. Epub 2020 Dec 3.

Leyrer-Jackson JM, Holter M, Overby PF, Newbern JM, Scofield MD, Olive MF, Gipson CD., Accumbens Cholinergic Interneurons Mediate Cue-Induced Nicotine Seeking and Associated Glutamatergic Plasticity., eNeuro. 2021 Feb 9;8(1). pii: ENEURO.0276-20.2020. doi: 10.1523/ENEURO.0276-20.2020. Print 2021 Jan-Feb.

Glover EJ, Khan F, Clayton-Stiglbauer K, Chandler LJ., Impact of sex, strain, and age on blood ethanol concentration and behavioral signs of intoxication during ethanol vapor exposure., Neuropharmacology. 2021 Feb 15;184:108393. doi: 10.1016/j.neuropharm.2020.108393. Epub 2020 Nov 19.

Stevenson ME, Nazario AS, Czyz AM, Owen HA, Swain RA., Motor learning rapidly increases synaptogenesis and astrocytic structural plasticity in the rat cerebellum., Neurobiol Learn Mem. 2021 Jan;177:107339. doi: 10.1016/j.nlm.2020.107339. Epub 2020 Nov 10.

Wakabayashi KT, Feja M, Leigh MPK, Baindur AN, Suarez M, Meyer PJ, Bass CE., Chemogenetic Activation of Mesoaccumbal Gamma-Aminobutyric Acid Projections Selectively Tunes Responses to Predictive Cues When Reward Value Is Abruptly Decreased., Biol Psychiatry. 2021 Feb 15;89(4):366-375. doi: 10.1016/j.biopsych.2020.08.017. Epub 2020 Aug 28.

Glushchak K, Ficarro A, Schoenfeld TJ., High-fat diet and acute stress have different effects on object preference tests in rats during adolescence and adulthood., Behav Brain Res. 2021 Feb 5;399:112993. doi: 10.1016/j.bbr.2020.112993. Epub 2020 Nov 2.

Dutcher AM, Truong KV, Miller DD, Allred RP, Nudi E, Jones TA., Training in a cooperative bimanual skilled reaching task, the popcorn retrieval task, improves unimanual function after motor cortical infarcts in rats., Behav Brain Res. 2021 Jan 1;396:112900. doi: 10.1016/j.bbr.2020.112900. Epub 2020 Sep 14.

Leyrer-Jackson JM, Overby PF, Bull A, Marusich JA, Gipson CD., Strain and sex matters: Differences in nicotine self-administration between outbred and recombinase-driver transgenic rat lines., Exp Clin Psychopharmacol. 2021 Aug;29(4):375-384. doi: 10.1037/pha0000376. Epub 2020 Apr 16.

de la Zerda SH, Netser S, Magalnik H, Briller M, Marzan D, Glatt S, Abergel Y, Wagner S., Social recognition in laboratory mice requires integration of behaviorally-induced somatosensory, auditory and olfactory cues, 35816892

Davies JR, Purawijaya DA, Bartlett JM, Robinson ESJ., Impact of Refinements to Handling and Restraint Methods in Mice, 36077894

Kopachev N, Netser S, Wagner S., Sex-dependent features of social behavior differ between distinct laboratory mouse strains and their mixed offspring, 35098101

Steel LCE, Tir S, Tam SKE, Bussell JN, Spitschan M, Foster RG, Peirson SN., Effects of Cage Position and Light Transmission on Home Cage Activity and Circadian Entrainment in Mice, 35082600

Yaeger JDW, Krupp KT, Summers TR, Summers CH., Contextual generalization of social stress learning is modulated by orexin receptors in basolateral amygdala., 35724928

Dunlap KR, Laskin GR, Waddell DS, Black AJ, Steiner JL, Vied C, Gordon BS., Aerobic exercise-mediated changes in the expression of glucocorticoid responsive genes in skeletal muscle differ across the day., 35461977

Trott JM, Hoffman AN, Zhuravka I, Fanselow MS., Conditional and unconditional components of aversively motivated freezing, flight and darting in mice, 35616523

Salazar BH, Hoffman KA, Fraizer AM, Humes F, Hogan MK, Horner MA, Yadegar T, Trusler S, Hamilton GF, Horner PJ., Rigor and reproducibility in analysis of rodent behavior utilizing the forelimb reaching task following a cervical spinal cord injury, 36395979

Broadfoot CK, Lenell C, Kelm-Nelson CA, Ciucci MR., Effects of social isolation on 50-kHz ultrasonic vocalizations, affective state, cognition, and neurotransmitter concentrations in the ventral tegmental and locus coeruleus of adult rats, 36241070

Vandaele Y, Janak PH., Lack of action monitoring as a prerequisite for habitual and chunked behavior: Behavioral and neural correlates, 36636348

Guarraci FA, Avendano L, Kelly M, Estoesta C, Sencherey B, Valdivia HS, Gale A, Yepez L, Belfield JB, Carter KM, Williams N, Gore AC., Chronic periadolescent leuprolide exposure affects the development of reproductive physiology and behavior of female and male rats differently, but both mature after treatment termination, 36609535

Drzewiecki CM, Brinks AS, Sellinger EP, Doshi AD, Koh JY, Juraska JM., Brief postnatal exposure to bisphenol A affects apoptosis and gene expression in the medial prefrontal cortex and social behavior in rats with sex specificity, 36442689

Murphy HM, Kalinina AI, Wideman CH., Effects of Chronic Oral Administration of Midazolam on Memory and Circadian Rhythms in Rats, 36302539

Grieves RM, Shinder ME, Rosow LK, Kenna MS, Taube JS., The Neural Correlates of Spatial Disorientation in Head Direction Cells, 36635237

Pinizzotto CC, Dreyer KM, Aje OA, Caffrey RM, Madhira K, Kritzer MF., Spontaneous Object Exploration in a Recessive Gene Knockout Model of Parkinson's Disease: Development and Progression of Object Recognition Memory Deficits in Male Pink1-/- Rats, 36560930

Kendricks DR, Bhattacharya S, Reed MN, Newland MC., Impacts of neonatal methylmercury on behavioral flexibility and learning in spatial discrimination reversal and visual signal detection tasks, 36055519

White SR, Laubach M., The rostral medial frontal cortex is crucial for engagement in consummatory behavior, 35771511

Behavioral and learning disabilities

Kordás K, Kis-Varga Á, Varga A, Eldering H, Bulthuis R, Lendvai B, Lévay G, Román V., Measuring sociability of mice using a novel three-chamber apparatus and algorithm of the LABORASâ˘ system, J Neurosci Methods. 2020 Sep 1;343:108841. doi: 10.1016/j.jneumeth.2020.108841. Epub 2020 Jul 1.

Ronda OAHO, van de Heijning BJM, de Bruin A, Thomas RE, Martini I, Koehorst M, Gerding A, Koster MH, Bloks VW, Jurdzinski A, Mulder NL, Havinga R, van der Beek EM, Reijngoud DJ, Kuipers F, Verkade HJ., Spontaneous liver disease in wild-type C57BL/6JOlaHsd mice fed semisynthetic diet, PLoS One. 2020 Sep 21;15(9):e0232069. doi: 10.1371/journal.pone.0232069. eCollection 2020.

Amin B, Robinson RAS., Dataset of quantitative proteomic analysis to understand aging processes in rabbit liver, Data Brief. 2020 May 15;31:105701. doi: 10.1016/j.dib.2020.105701. eCollection 2020 Aug.

Ericsson AC, Hart ML, Kwan J, Lanoue L, Bower LR, Araiza R, Kent Lloyd KC, Franklin CL., Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism, Commun Biol. 2021 Jun 10;4(1):716. doi: 10.1038/s42003-021-02249-0.

Mekada K, Yoshiki A., Substrains matter in phenotyping of C57BL/6 mice, Exp Anim. 2021 May 13;70(2):145-160. doi: 10.1538/expanim.20-0158. Epub 2021 Jan 14.

Bove M, Schiavone S, Tucci P, Sikora V, Dimonte S, Colia AL, Morgese MG, Trabace L., Ketamine administration in early postnatal life as a tool for mimicking Autism Spectrum Disorders core symptoms, 35460811

Biomedical research

Ton MLH, Keitley D, Theeuwes B, Guibentif C, Ahnfelt-Rønne J, Andreassen TK...Göttgens B., Rabbit development as a model for single cell comparative genomics, null

Rozema NB, Procissi D, Bertolino N, Viola KL, Nandwana V, Abdul N, Pribus S, Dravid V, Klein WL, Disterhoft JF, Weiss C., AÎ˛ oligomer induced cognitive impairment and evaluation of ACU193-MNS-based MRI in rabbit, Alzheimers Dement (N Y). 2020 Oct 10;6(1):e12087. doi: 10.1002/trc2.12087. eCollection 2020.

Hamilton NJI, Lee DDH, Gowers KHC, Butler CR, Maughan EF, Jevans B, Orr JC, McCann CJ, Burns AJ, MacNeil S, Birchall MA, O'Callaghan C, Hynds RE, Janes SM., Bioengineered airway epithelial grafts with mucociliary function based on collagen IV- and laminin-containing extracellular matrix scaffolds, Eur Respir J. 2020 Jun 18;55(6):1901200. doi: 10.1183/13993003.01200-2019. Print 2020 Jun.

Comolli J, Schnellbacher R, Beaufrere H, Blas-Machado U, Quandt J, Mayer J, Divers SJ., Comparison of endoscopic endotracheal intubation and the v-gel supraglottic airway device for spontaneously ventilating New Zealand White Rabbits undergoing ovariohysterectomy, Vet Rec. 2020 Nov 14;187(10):e84. doi: 10.1136/vr.105746. Epub 2020 Jul 20.

Gordon AC, Gates VL, White SB, Harris KR, Procissi D, Zhang Z, Li W, Samaan D, Nicolai JR, Mouli SK, Sato KT, Ryu RK, Omary RA, Salem R, Lewandowski RJ, Larson AC., Correlation and Agreement of Yttrium-90 Positron Emission Tomography/Computed Tomography with ExÂ Vivo Radioembolization Microsphere Deposition in the Rabbit VX2 Liver Tumor Model, J Vasc Interv Radiol. 2021 Jan;32(1):23-32.e1. doi: 10.1016/j.jvir.2020.09.016. Epub 2020 Nov 12.

Bertolino N, Procissi D, Disterhoft JF, Weiss C., Detection of memory- and learning-related brain connectivity changes following trace eyeblink-conditioning using resting-state functional magnetic resonance imaging in the awake rabbit, J Comp Neurol. 2020 Sep 25. doi: 10.1002/cne.25042. Online ahead of print.

GĂśk C, Plain F, Robertson AD, Howie J, Baillie GS, Fraser NJ, Fuller W., Dynamic Palmitoylation of the Sodium-Calcium Exchanger Modulates Its Structure, Affinity for Lipid-Ordered Domains, and Inhibition by XIP, Cell Rep. 2020 Jun 9;31(10):107697. doi: 10.1016/j.celrep.2020.107697.

Luthra A, Montezuma-Rusca JM, La Vake CJ, LeDoyt M, Delgado KN, Davenport TC, Fiel-Gan M, Caimano MJ, Radolf JD, Hawley KL., Evidence that immunization with TP0751, a bipartite Treponema pallidum lipoprotein with an intrinsically disordered region and lipocalin fold, fails to protect in the rabbit model of experimental syphilis, PLoS Pathog. 2020 Sep 16;16(9):e1008871. doi: 10.1371/journal.ppat.1008871. eCollection 2020 Sep.

Shangguan AJ, Zhou K, Yang J, Eresen A, Wang B, Sun C, Pan L, Hu S, Khan AT, Mouli SK, Yaghmai V, Zhang Z., Intraprocedural Transcatheter Intraarterial Perfusion (TRIP)-MRI for Evaluation of Irreversible Electroporation Therapy Response in a Rabbit Liver Tumor Model, Clin Exp Gastroenterol. 2020 Nov 6;13:543-553. doi: 10.2147/CEG.S269163. eCollection 2020.

Amemiya K, Zeng X, Bearss JJ, Cote CK, Soffler C, Bernhards RC, Dankmeyer JL, Ribot WJ, Trevino SR, Welkos SL, Worsham PL, Waag DM., Laser Scanning Confocal Microscopy Was Used to Validate the Presence of Burkholderia Pseudomallei or B. Mallei in Formalin-Fixed Paraffin Embedded Tissues, Trop Med Infect Dis. 2020 Apr 29;5(2):65. doi: 10.3390/tropicalmed5020065.

Li XH, Vance GM, Cartwright J, Cao JP, Wilson RA, Castro-Borges W., Mapping the epitopes of Schistosoma japonicum esophageal gland proteins for incorporation into vaccine constructs, PLoS One. 2020 Feb 27;15(2):e0229542. doi: 10.1371/journal.pone.0229542. eCollection 2020.

Okba NMA, Widjaja I, van Dieren B, Aebischer A, van Amerongen G, de Waal L, Stittelaar KJ, Schipper D, Martina B, van den Brand JMA, Beer M, Bosch BJ, Haagmans BL., Particulate multivalent presentation of the receptor binding domain induces protective immune responses against MERS-CoV, Emerg Microbes Infect. 2020 Dec;9(1):1080-1091. doi: 10.1080/22221751.2020.1760735.

Petraitiene R, Petraitis V, Kavaliauskas P, Maung BBW, Khan F, Naing E, Aung T, Zigmantaite V, Grigaleviciute R, Kucinskas A, Stakauskas R, Georgiades BN, Mazur CA, Hayden JA, Satlin MJ, Walsh TJ., Pharmacokinetics and Efficacy of Ceftazidime-Avibactam in the Treatment of Experimental Pneumonia Caused by Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae in Persistently Neutropenic Rabbits, Antimicrob Agents Chemother. 2020 Mar 24;64(4):e02157-19. doi: 10.1128/AAC.02157-19. Print 2020 Mar 24.

Amin B, Ford KI, Robinson RAS., Quantitative proteomics to study aging in rabbit liver, Mech Ageing Dev. 2020 Apr;187:111227. doi: 10.1016/j.mad.2020.111227. Epub 2020 Feb 29.

Bailey TW, Dos Santos AP, do Nascimento NC, Xie S, Thimmapuram J, Sivasankar MP, Cox A., RNA sequencing identifies transcriptional changes in the rabbit larynx in response to low humidity challenge, BMC Genomics. 2020 Dec 11;21(1):888. doi: 10.1186/s12864-020-07301-7.

Pan L, Sun C, Zhou K, Figini M, Wang B, Shangguan J, Hu S, Yang J, Xing W, Wang J, Velichko Y, Yaghmai V, Zhang Z., Transcatheter Intraarterial Perfusion MRI Approaches to Differentiate Reversibly Electroporated Penumbra From Irreversibly Electroporated Zones in Rabbit Liver, Acad Radiol. 2020 Dec;27(12):1727-1733. doi: 10.1016/j.acra.2020.01.008. Epub 2020 Feb 6.

Cannes do Nascimento N, Dos Santos AP, Sivasankar MP, Cox A., Unraveling the molecular pathobiology of vocal fold systemic dehydration using an in vivo rabbit model, PLoS One. 2020 Jul 31;15(7):e0236348. doi: 10.1371/journal.pone.0236348. eCollection 2020.

Gordon AC, White SB, Gates VL, Procissi D, Harris KR, Yang Y, Zhang Z, Li W, Lyu T, Huang X, Omary RA, Salem R, Lewandowski RJ, Larson AC., Yttrium-90 Radioembolization and Tumor Hypoxia: Gas-challenge BOLD Imaging in the VX2 Rabbit Model of Hepatocellular Carcinoma, Acad Radiol. 2020 Jun 7:S1076-6332(20)30204-X. doi: 10.1016/j.acra.2020.04.012. Online ahead of print.

Pilipenko, Iuliia; Korzhikov-Vlakh, Viktor; Valtari, Annika; Anufrikov, Yurii; Kalinin, Stanislav; Ruponen, Marika; Krasavin, Mikhail; Urtti, Arto; Tennikova, Tatiana, Mucoadhesive properties of nanogels based on stimuli-sensitive glycosaminoglycan-graft-pNIPAAm copolymers, International Journal of Biological Macromolecules. 2021.

Anton-Sales, Irene; Roig-Sanchez, Soledad; Traeger, Kamelia; Weis, Christine; Laromaine, Anna; Turon, Pau; Roig, Anna, In vivo soft tissue reinforcement with bacterial nanocellulose, Biomaterials Science. 2021.

Chua, Corrine Ying Xuan; Liu, Hsuan-Chen; Di Trani, Nicola; Susnjar, Antonia; Ho, Jeremy; Scorrano, Giovanni; Rhudy, Jessica; Sizovs, Antons; Lolli, Graziano; Hernandez, Nathanael; Nucci, Maria Concetta; Cicalo, Roberto; Ferrari, Mauro; Grattoni, Alessandro, Carbon fiber reinforced polymers for implantable medical devices, Biomaterials. 2021.

Pertici, Irene; Bianchi, Giulio; Bongini, Lorenzo; Cojoc, Dan; Taft, Manuel H.; Manstein, Dietmar J.; Lombardi, Vincenzo; Bianco, Pasquale, Muscle myosin performance measured with a synthetic nanomachine reveals a class-specific Ca2+-sensitivity of the frog myosin II isoform, The Journal of Physiology. 2021.

do Nascimento, Naila Cannes; dos Santos, Andrea Pires; Mohallem, Rodrigo; Aryal, Uma K.; Xie, Jun; Cox, Abigail; Sivasankar, M. Preeti, Furosemide-induced systemic dehydration alters the proteome of rabbit vocal folds, Journal of Proteomics. 2021.

Tseng, Chun-Che; Dean, Shirley; Davies, Brian A.; Azmi, Ishara F.; Pashkova, Natalya; Payne, Johanna A.; Staffenhagen, Jennifer; West, Matt; Piper, Robert C.; Odorizzi, Greg; Katzmann, David J., Bro1 stimulates Vps4 to promote intralumenal vesicle formation during multivesicular body biogenesis, Journal of Cell Biology. 2021.

O'Shaughnessy, Danielle; Grande, Daniel; El-Neemany, Diana; Sajjan, Sujata; Pillalamarri, Nirmala; Shalom, Dara; Winkler, Harvey, Evaluation of the histological and biomechanical properties of poly-4-hydroxybutyrate scaffold for pelvic organ prolapse, compared with polypropylene mesh in a rabbit model, International Urogynecology Journal. 2021.

Carcinogenesis

Santos, J. M., Havunen, R., Siurala, M., Cervera-Carrascon, V., Tahtinen, S., Sorsa, S., . . . Hemminki, A. (2017), Adenoviral production of interleukin-2 at the tumor site removes the need for systemic postconditioning in adoptive cell therapy., International Journal of Cancer, 141(7), 1458-1468. doi:10.1002/ijc.30839 [doi]

Salzwedel, A. O., Han, J., LaRocca, C. J., Shanley, R., Yamamoto, M., & Davydova, J. (2018)., Combination of interferon-expressing oncolytic adenovirus with chemotherapy and radiation is highly synergistic in hamster model of pancreatic cancer, Oncotarget, 9(26), 18041-18052. doi:10.18632/oncotarget.24710 [doi]

Opoku-Acheampong, A. B., Penugonda, K., & Lindshield, B. L. (2016)., Effect of saw palmetto supplements on androgen-sensitive LNCaP human prostate cancer cell number and syrian hamster flank organ growth., Evidence-Based Complementary and Alternative Medicine : ECAM, 2016, 8135135. doi:10.1155/2016/8135135 [doi]

Nistal-Villan, E., Bunuales, M., Poutou, J., Gonzalez-Aparicio, M., Bravo-Perez, C., Quetglas, J. I., . . . Hernandez-Alcoceba, R. (2015)., Enhanced therapeutic effect using sequential administration of antigenically distinct oncolytic viruses expressing oncostatin M in a syrian hamster orthotopic pancreatic cancer model., Molecular Cancer, 14, 210-015-0479-x. doi:10.1186/s12943-015-0479-x [doi]

Woods, S. E., Ek, C., Shen, Z., Feng, Y., Ge, Z., Muthupalani, S., . . . Fox, J. G. (2016), Male syrian hamsters experimentally infected with helicobacter spp. of the H. bilis cluster develop MALT-associated gastrointestinal lymphomas., Helicobacter, 21(3), 201-217. doi:10.1111/hel.12265 [doi]

Siurala, M., Bramante, S., Vassilev, L., Hirvinen, M., Parviainen, S., Tahtinen, S., . . . Hemminki, A. (2015), Oncolytic adenovirus and doxorubicin-based chemotherapy results in synergistic antitumor activity against soft-tissue sarcoma., International Journal of Cancer, 136(4), 945-954. doi:10.1002/ijc.29048 [doi]

LaRocca, C. J., Han, J., Gavrikova, T., Armstrong, L., Oliveira, A. R., Shanley, R., . . . Davydova, J. (2015)., Oncolytic adenovirus expressing interferon alpha in a syngeneic syrian hamster model for the treatment of pancreatic cancer., Surgery, 157(5), 888-898. doi:10.1016/j.surg.2015.01.006 [doi]

Havunen, R., Siurala, M., Sorsa, S., Gronberg-Vaha-Koskela, S., Behr, M., Tahtinen, S., . . . Hemminki, A. (2016)., Oncolytic adenoviruses armed with tumor necrosis factor alpha and interleukin-2 enable successful adoptive cell therapy., Molecular Therapy Oncolytics, 4, 77-86. doi:10.1016/j.omto.2016.12.004 [doi]

Muhanna, N., Jin, C. S., Huynh, E., Chan, H., Qiu, Y., Jiang, W., . . . Zheng, G. (2015)., Phototheranostic porphyrin nanoparticles enable visualization and targeted treatment of head and neck cancer in clinically relevant models., Theranostics, 5(12), 1428-1443. doi:10.7150/thno.13451 [doi]

Pal, R., Shilagard, T., Yang, J., Villarreal, P., Brown, T., Qiu, S., . . . Vargas, G. (2016)., Remodeling of the epithelial-connective tissue interface in oral epithelial dysplasia as visualized by noninvasive 3D imaging., Cancer Research, 76(16), 4637-4647. doi:10.1158/0008-5472.CAN-16-0252 [doi]

Jin, J., Guo, L., VonTungeln, L., Vanlandingham, M., Cerniglia, C. E., & Chen, H. (2018), Smokeless tobacco impacts oral microbiota in a syrian golden hamster cheek pouch carcinogenesis model., Anaerobe, 52, 29-42. doi:S1075-9964(18)30095-7 [pii]

Kim, C. S., Ingato, D., Wilder-Smith, P., Chen, Z., & Kwon, Y. J. (2018)., Stimuli-disassembling gold nanoclusters for diagnosis of early stage oral cancer by optical coherence tomography., Nano Convergence, 5(1), 3-018-0134-5. Epub 2018 Jan 26. doi:10.1186/s40580-018-0134-5 [doi]

Carcinogenicity

Bull, R. J., Kolisetty, N., Zhang, X., Muralidhara, S., Quinones, O., Lim, K. Y., . . . Cummings, B. S. (2012)., Absorption and disposition of bromate in F344 rats., Toxicology, 300(1-2), 83-91. doi:10.1016/j.tox.2012.06.002 [doi]

Qian, G., Tang, L., Guo, X., Wang, F., Massey, M. E., Su, J., . . . Wang, J. S. (2014)., Aflatoxin B1 modulates the expression of phenotypic markers and cytokines by splenic lymphocytes of male F344 rats., Journal of Applied Toxicology : JAT, 34(3), 241-249. doi:10.1002/jat.2866 [doi]

Richie, J. P.,Jr, Das, A., Calcagnotto, A. M., Aliaga, C. A., & El-Bayoumy, K. (2012)., Age related changes in selenium and glutathione levels in different lobes of the rat prostate., Experimental Gerontology, 47(3), 223-228. doi:10.1016/j.exger.2011.11.015 [doi]

Patlolla, J. M., Zhang, Y., Li, Q., Steele, V. E., & Rao, C. V. (2012)., Anti-carcinogenic properties of omeprazole against human colon cancer cells and azoxymethane-induced colonic aberrant crypt foci formation in rats., International Journal of Oncology, 40(1), 170-175. doi:10.3892/ijo.2011.1214 [doi]

Hailey, J. R., Nold, J. B., Brown, R. H., Cullen, J. M., Holder, J. C., Jordan, H. L., . . . Miller, R. T. (2014)., Biliary proliferative lesions in the sprague-dawley rat: Adverse/non-adverse., Toxicologic Pathology, 42(5), 844-854. doi:10.1177/0192623313499976 [doi]

Jiang, Y., Djuric, Z., Sen, A., Ren, J., Kuklev, D., Waters, I., . . . Brenner, D. E. (2014)., Biomarkers for personalizing omega-3 fatty acid dosing., Cancer Prevention Research (Philadelphia, Pa.), 7(10), 1011-1022. doi:10.1158/1940-6207.CAPR-14-0134 [doi]

Robinson, A., Johnson, N. M., Strey, A., Taylor, J. F., Marroquin-Cardona, A., Mitchell, N. J., . . . Phillips, T. D. (2012)., Calcium montmorillonite clay reduces urinary biomarkers of fumonisin B(1) exposure in rats and humans., Food Additives & Contaminants.Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment, 29(5), 809-818. doi:10.1080/19440049.2011.651628 [doi]

Peiffer, D. S., Zimmerman, N. P., Wang, L. S., Ransom, B. W., Carmella, S. G., Kuo, C. T., . . . Stoner, G. D. (2014)., Chemoprevention of esophageal cancer with black raspberries, their component anthocyanins, and a major anthocyanin metabolite, protocatechuic acid., Cancer Prevention Research (Philadelphia, Pa.), 7(6), 574-584. doi:10.1158/1940-6207.CAPR-14-0003 [doi]

Ravillah, D., Mohammed, A., Qian, L., Brewer, M., Zhang, Y., Biddick, L., . . . Rao, C. V. (2014)., Chemopreventive effects of an HDAC2-selective inhibitor on rat colon carcinogenesis and APCmin/+ mouse intestinal tumorigenesis., The Journal of Pharmacology and Experimental Therapeutics, 348(1), 59-68. doi:10.1124/jpet.113.208645 [doi]

Janakiram, N. B., Mohammed, A., Ravillah, D., Choi, C. I., Zhang, Y., Desai, D., . . . Rao, C. V. (2013)., Chemopreventive effects of PBI-se, a selenium-containing analog of PBIT, on AOM-induced aberrant crypt foci in F344 rats, Oncology Reports, 30(2), 952-960. doi:10.3892/or.2013.2483 [doi]

Janakiram, N. B., Mohammed, A., Zhang, Y., Brewer, M., Bryant, T., Lightfoot, S., . . . Rao, C. V. (2013)., Chemopreventive efficacy of raloxifene, bexarotene, and their combination on the progression of chemically induced colon adenomas to adenocarcinomas in rats., Cancer Prevention Research (Philadelphia, Pa.), 6(12), 1251-1261. doi:10.1158/1940-6207.CAPR-13-0249 [doi]

Cruz, M. D., Wali, R. K., Bianchi, L. K., Radosevich, A. J., Crawford, S. E., Jepeal, L., . . . Roy, H. K. (2014), Colonic mucosal fatty acid synthase as an early biomarker for colorectal neoplasia: Modulation by obesity and gender., Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 23(11), 2413-2421. doi:10.1158/1055-9965.EPI-14-0026 [doi]

Vellimana, A. K., Recinos, V. R., Hwang, L., Fowers, K. D., Li, K. W., Zhang, Y., . . . Tyler, B. M. (2013)., Combination of paclitaxel thermal gel depot with temozolomide and radiotherapy significantly prolongs survival in an experimental rodent glioma model., Journal of Neuro-Oncology, 111(3), 229-236. doi:10.1007/s11060-012-1014-1 [doi]

Johnson, N. M., Egner, P. A., Baxter, V. K., Sporn, M. B., Wible, R. S., Sutter, T. R., . . . Roebuck, B. D. (2014)., Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold., Cancer Prevention Research (Philadelphia, Pa.), 7(7), 658-665. doi:10.1158/1940-6207.CAPR-13-0430 [doi]

Sosna, J., Havivi, E., Khan, W., Appelbaum, L., Nyska, A., & Domb, A. J. (2014), Computed tomography of lipiodol-loaded biodegradable pasty polymer for implant visualization, Contrast Media & Molecular Imaging, 9(3), 246-251. doi:10.1002/cmmi.1560 [doi]

Canene-Adams, K., Sfanos, K. S., Liang, C. T., Yegnasubramanian, S., Nelson, W. G., Brayton, C., & De Marzo, A. M. (2013)., Dietary chemoprevention of PhIP induced carcinogenesis in male fischer 344 rats with tomato and broccoli., PloS One, 8(11), e79842. doi:10.1371/journal.pone.0079842 [doi]

Djuric, Z., Aslam, M. N., Simon, B. R., Sen, A., Jiang, Y., Ren, J., . . . Brenner, D. E. (2017)., Effects of fish oil supplementation on prostaglandins in normal and tumor colon tissue: Modulation by the lipogenic phenotype of colon tumors., he Journal of Nutritional Biochemistry, 46, 90-99. doi:S0955-2863(16)30803-8 [pii]

Archibong, A. E., Ramesh, A., Inyang, F., Niaz, M. S., Hood, D. B., & Kopsombut, P. (2012)., Endocrine disruptive actions of inhaled benzo(a)pyrene on ovarian function and fetal survival in fisher F-344 adult rats., Reproductive Toxicology (Elmsford, N.Y.), 34(4), 635-643. doi:10.1016/j.reprotox.2012.09.003 [doi]

Bhattacharya, A., Li, Y., Shi, Y., & Zhang, Y. (2013)., Enhanced inhibition of urinary bladder cancer growth and muscle invasion by allyl isothiocyanate and celecoxib in combination., Carcinogenesis, 34(11), 2593-2599. doi:10.1093/carcin/bgt280 [doi]

Fang, M., Guo, W. R., Park, Y., Kang, H. G., & Zarbl, H. (2015), Enhancement of NAD(+)-dependent SIRT1 deacetylase activity by methylselenocysteine resets the circadian clock in carcinogen-treated mammary epithelial cells, Oncotarget, 6(40), 42879-42891. doi:10.18632/oncotarget.6002 [doi]

Yang, L., Wang, L. S., Chen, X. L., Gatalica, Z., Qiu, S., Liu, Z., . . . Xie, J. (2012)., Hedgehog signaling activation in the development of squamous cell carcinoma and adenocarcinoma of esophagus., International Journal of Biochemistry and Molecular Biology, 3(1), 46-57.

Gato, W. E., Hales, D. B., & Means, J. C. (2012), Hepatic gene expression analysis of 2-aminoanthracene exposed fisher-344 rats reveal patterns indicative of liver carcinoma and type 2 diabetes., The Journal of Toxicological Sciences, 37(5), 1001-1016. doi:DN/JST.JSTAGE/jts/37.1001 [pii]

Wheeler, K. T., Payne, V., D'Agostino, R. B.,Jr, Walb, M. C., Munley, M. T., Metheny-Barlow, L. J., & Robbins, M. E. (2014)., Impact of breathing 100% oxygen on radiation-induced cognitive impairment., Radiation Research, 182(5), 580-585. doi:10.1667/RR13643.1 [doi]

Farah, I. O., Holt Gray, C., Cameron, J. A., Tucci, M. A., Cason, Z., & Benghuzzi, H. A. (2014), Impact of paired combinations of retinoic acid (atra) and ovalbumin on f344 rat lung tissues and improvement of related pathology by citral., Biomedical Sciences Instrumentation, 50, 423-430.

Qian, G., Wang, F., Tang, L., Massey, M. E., Mitchell, N. J., Su, J., . . . Wang, J. S. (2013)., Integrative toxicopathological evaluation of aflatoxin B(1) exposure in F344 rats., Toxicologic Pathology, 41(8), 1093-1105. doi:10.1177/0192623313477256 [doi]

Boyle, M. C., Crabbs, T. A., Wyde, M. E., Painter, J. T., Hill, G. D., Malarkey, D. E., . . . Nyska, A. (2012)., Intestinal lymphangiectasis and lipidosis in rats following subchronic exposure to indole-3-carbinol via oral gavage., Toxicologic Pathology, 40(4), 561-576. doi:10.1177/0192623311436178 [doi]

Ren, X., Graham, J. C., Jing, L., Mikheev, A. M., Gao, Y., Lew, J. P., . . . Zarbl, H. (2013)., Mapping of Mcs30, a new mammary carcinoma susceptibility quantitative trait locus (QTL30) on rat chromosome 12: Identification of fry as a candidate mcs gene, PloS One, 8(9), e70930. doi:10.1371/journal.pone.0070930 [doi]

Rondini, E. A., & Bennink, M. R. (2012)., Microarray analyses of genes differentially expressed by diet (black beans and soy flour) during azoxymethane-induced colon carcinogenesis in rats., Journal of Nutrition and Metabolism, 2012, 351796. doi:10.1155/2012/351796 [doi]

Burns, K. M., & Melnick, R. L. (2012)., MTBE: Recent carcinogenicity studies., International Journal of Occupational and Environmental Health, 18(1), 66-69. doi:10.1179/107735212X13293200778947 [doi]

Djamali, A., Reese, S., Hafez, O., Vidyasagar, A., Jacobson, L., Swain, W., . . . Torrealba, J. R. (2012), Nox2 is a mediator of chronic CsA nephrotoxicity., American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 12(8), 1997-2007. doi:10.1111/j.1600-6143.2012.04081.x [doi]

Veeranki, O. L., Bhattacharya, A., Marshall, J. R., & Zhang, Y. (2013)., Organ-specific exposure and response to sulforaphane, a key chemopreventive ingredient in broccoli: Implications for cancer prevention., The British Journal of Nutrition, 109(1), 25-32. doi:10.1017/S0007114512000657 [doi]

Shi, N., Jin, F., Zhang, X., Clinton, S. K., Pan, Z., & Chen, T. (2014), Overexpression of human beta-defensin 2 promotes growth and invasion during esophageal carcinogenesis, Oncotarget, 5(22), 11333-11344. doi:2416 [pii]

Peng, X., Li, W., Johnson, W. D., Torres, K. E., & McCormick, D. L. (2015), Overexpression of lipocalins and pro-inflammatory chemokines and altered methylation of PTGS2 and APC2 in oral squamous cell carcinomas induced in rats by 4-nitroquinoline-1-oxide, PloS One, 10(1), e0116285. doi:10.1371/journal.pone.0116285 [doi]

Qian, G., Tang, L., Wang, F., Guo, X., Massey, M. E., Williams, J. H., . . . Wang, J. S. (2013)., Physiologically based toxicokinetics of serum aflatoxin B1-lysine adduct in F344 rats., Toxicology, 303, 147-151. doi:10.1016/j.tox.2012.10.020 [doi]

Nicastro, H. L., Grubbs, C. J., Margaret Juliana, M., Bode, A. M., Kim, M. S., Lu, Y., . . . Lubet, R. A. (2014)., Preventive effects of NSAIDs, NO-NSAIDs, and NSAIDs plus difluoromethylornithine in a chemically induced urinary bladder cancer model., Cancer Prevention Research (Philadelphia, Pa.), 7(2), 246-254. doi:10.1158/1940-6207.CAPR-13-0164 [doi]

Bhattacharya, P., & Keating, A. F. (2012), Protective role for ovarian glutathione S-transferase isoform pi during 7,12-dimethylbenz[a]anthracene-induced ovotoxicity., Toxicology and Applied Pharmacology, 260(2), 201-208. doi:10.1016/j.taap.2012.02.014 [doi]

Qian, G., Tang, L., Lin, S., Xue, K. S., Mitchell, N. J., Su, J., . . . Wang, J. S. (2016)., Sequential dietary exposure to aflatoxin B1 and fumonisin B1 in F344 rats increases liver preneoplastic changes indicative of a synergistic interaction., Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association, 95, 188-195. doi:10.1016/j.fct.2016.07.017 [doi]

Jimenez-Andrade, J. M., Mantyh, W. G., Bloom, A. P., Freeman, K. T., Ghilardi, J. R., Kuskowski, M. A., & Mantyh, P. W. (2012), The effect of aging on the density of the sensory nerve fiber innervation of bone and acute skeletal pain., Neurobiology of Aging, 33(5), 921-932. doi:10.1016/j.neurobiolaging.2010.08.008 [doi]

Hassoun, E., Cearfoss, J., Mamada, S., Al-Hassan, N., Brown, M., Heimberger, K., & Liu, M. C. (2014)., The effects of mixtures of dichloroacetate and trichloroacetate on induction of oxidative stress in livers of mice after subchronic exposure., Journal of Toxicology and Environmental Health.Part A, 77(6), 313-323. doi:10.1080/15287394.2013.864576 [doi]

Bhattacharya, A., Li, Y., Geng, F., Munday, R., & Zhang, Y. (2012)., The principal urinary metabolite of allyl isothiocyanate, N-acetyl-S-(N-allylthiocarbamoyl)cysteine, inhibits the growth and muscle invasion of bladder cancer., Carcinogenesis, 33(2), 394-398. doi:10.1093/carcin/bgr283 [doi]

Gato, W. E., McGee, S. R., Hales, D. B., & Means, J. C. (2014)., Time-dependent regulation of apoptosis by AEN and BAX in response to 2-aminoanthracene dietary consumption., Toxicology International, 21(1), 57-64. doi:10.4103/0971-6580.128796 [doi]

Wali, R. K., Kunte, D. P., De La Cruz, M., Tiwari, A. K., Brasky, J., Weber, C. R., . . . Roy, H. K. (2012)., Topical polyethylene glycol as a novel chemopreventive agent for oral cancer via targeting of epidermal growth factor response., PloS One, 7(6), e38047. doi:10.1371/journal.pone.0038047 [doi]

COVID-19

Tan T K, Rijal P, Rahikainen R, Keeble A H, Schimanski L, Hussain S, Harvey R, et al., A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses, bioRxiv 2020.08.31.275701; doi: https://doi.org/10.1101/2020.08.31.275701

Dinnon KH 3rd, Leist SR, Schäfer A, Edwards CE, Martinez DR, Montgomery SA, West A, Yount BL Jr, Hou YJ, Adams LE, Gully KL, Brown AJ, Huang E, Bryant MD, Choong IC, Glenn JS, Gralinski LE, Sheahan TP, Baric RS., A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures, Nature. 2020 Oct;586(7830):560-566. doi: 10.1038/s41586-020-2708-8. Epub 2020 Aug 27.

Leist SR, Dinnon KH 3rd, Schäfer A, Tse LV, Okuda K, Hou YJ, West A, Edwards CE, Sanders W, Fritch EJ, Gully KL, Scobey T, Brown AJ, Sheahan TP, Moorman NJ, Boucher RC, Gralinski LE, Montgomery SA, Baric RS., A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice, Cell. 2020 Nov 12;183(4):1070-1085.e12. doi: 10.1016/j.cell.2020.09.050. Epub 2020 Sep 23.

Schäfer A, Muecksch F, Lorenzi JCC, Leist SR, Cipolla M, Bournazos S, Schmidt F, Maison RM, Gazumyan A, Martinez DR, Baric RS, Robbiani DF, Hatziioannou T, Ravetch JV, Bieniasz PD, Bowen RA, Nussenzweig MC, Sheahan TP., Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo, J Exp Med. 2021 Mar 1;218(3):e20201993. doi: 10.1084/jem.20201993.

van Doremalen N, Lambe T, Spencer A, Belij-Rammerstorfer S, Purushotham JN, Port JR, Avanzato V, Bushmaker T, Flaxman A, Ulaszewska M, Feldmann F, Allen ER, Sharpe H, Schulz J, Holbrook M, Okumura A, Meade-White K, PĂŠrez-PĂŠrez L, Bissett C, Gilbride C, Williamson BN, Rosenke R, Long D, Ishwarbhai A, Kailath R, Rose L, Morris S, Powers C, Lovaglio J, Hanley PW, Scott D, Saturday G, de Wit E, Gilbert SC, Munster VJ., ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques, bioRxiv. 2020 May 13:2020.05.13.093195. doi: 10.1101/2020.05.13.093195. Preprint.

van Doremalen N, Lambe T, Spencer A, Belij-Rammerstorfer S, Purushotham JN, Port JR, Avanzato VA, Bushmaker T, Flaxman A, Ulaszewska M, Feldmann F, Allen ER, Sharpe H, Schulz J, Holbrook M, Okumura A, Meade-White K, PĂŠrez-PĂŠrez L, Edwards NJ, Wright D, Bissett C, Gilbride C, Williamson BN, Rosenke R, Long D, Ishwarbhai A, Kailath R, Rose L, Morris S, Powers C, Lovaglio J, Hanley PW, Scott D, Saturday G, de Wit E, Gilbert SC, Munster VJ., ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques, Nature. 2020 Oct;586(7830):578-582. doi: 10.1038/s41586-020-2608-y. Epub 2020 Jul 30.

Menachery VD, Gralinski LE, Mitchell HD, Dinnon KH 3rd, Leist SR, Yount BL Jr, McAnarney ET, Graham RL, Waters KM, Baric RS., Combination Attenuation Offers Strategy for Live Attenuated Coronavirus Vaccines, J Virol. 2018 Aug 16;92(17):e00710-18. doi: 10.1128/JVI.00710-18. Print 2018 Sep 1.

Graham SP, McLean RK, Spencer AJ, Belij-Rammerstorfer S, Wright D, Ulaszewska M, Edwards JC, Hayes JWP, Martini V, Thakur N, Conceicao C, Dietrich I, Shelton H, Waters R, Ludi A, Wilsden G, Browning C, Bialy D, Bhat S, Stevenson-Leggett P, Hollinghurst P, Gilbride C, Pulido D, Moffat K, Sharpe H, Allen E, Mioulet V, Chiu C, Newman J, Asfor AS, Burman A, Crossley S, Huo J, Owens RJ, Carroll M, Hammond JA, Tchilian E, Bailey D, Charleston B, Gilbert SC, Tuthill TJ, Lambe T., Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19, NPJ Vaccines. 2020 Jul 27;5:69. doi: 10.1038/s41541-020-00221-3. eCollection 2020.

Li W, Schäfer A, Kulkarni SS, Liu X, Martinez DR, Chen C, Sun Z, Leist SR, Drelich A, Zhang L, Ura ML, Berezuk A, Chittori S, Leopold K, Mannar D, Srivastava SS, Zhu X, Peterson EC, Tseng CT, Mellors JW, Falzarano D, Subramaniam S, Baric RS, Dimitrov DS., High Potency of a Bivalent Human V(H) Domain in SARS-CoV-2 Animal Models, Cell. 2020 Oct 15;183(2):429-441.e16. doi: 10.1016/j.cell.2020.09.007. Epub 2020 Sep 4.

Duško Lainšček, Tina Fink, Vida Forstnerič, Iva Hafner-Bratkovič, Sara Orehek, Žiga Strmšek, Mateja Manček-Keber, Peter Pečan, Hana Esih, Špela Malenšek, Jana Aupič, Petra Dekleva, Tjaša Plaper, Sara Vidmar, Lucija Kadunc, Mojca Benčina, Neža Omersa, Gregor Anderluh, Florence Pojer, Kelvin Lau, David Hacker, Bruno Correia, David Peterhoff, Ralf Wagner, View ORCID ProfileRoman Jerala, Immune response to vaccine candidates based on different types of nanoscaffolded RBD domain of the SARS-CoV-2 spike protein, bioRxiv 2020.08.28.244269; doi: https://doi.org/10.1101/2020.08.28.244269

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