BSEP knockout rats
Related publications
ADMET
Cheng Y, Chen S, Freeden C, Chen W, Zhang Y, Abraham P, Nelson DM, Humphreys WG, Gan J, Lai Y., Bile Salt Homeostasis in Normal and Bsep Gene Knockout Rats with Single and Repeated Doses of Troglitazone., J Pharmacol Exp Ther. 2017 Sep;362(3):385-394.
Cheng Y, Freeden C, Zhang Y, Abraham P, Shen H, Wescott D, Humphreys WG, Gan J, Lai Y., Biliary excretion of pravastatin and taurocholate in rats with bile salt export pump (Bsep) impairment., Biopharm Drug Dispos. 2016 Jul;37(5):276-86.
Metabolism
Grzelak N, Kaczmarek D, Mrówczyński W., Comparison of the effects of BDNF/TRKB signalling on metabolic biomarkers in the liver of sedentary and trained rats with normal and knockout BDNF genotypes., Front Physiol. 2023 Dec 13;14:1268648. doi: 10.3389/fphys.2023.1268648
Neuroscience
Shirayama, Yukihiko; Yang, Chun; Zhang, Ji-chun; Ren, Qian; Yao, Wei; Hashimoto, Kenji;, Alterations in brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain regions of a learned helplessness rat model and the antidepressant effects of a TrkB agonist and antagonist., European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology Vol.25, 2015
Paredes, D. A., Jalloh, A., Catlow, B. J., Jaishankar, A., Seo, S., Jimenez, D. V., ... & McKay, R. D., Bdnf deficiency in the neonatal hippocampus contributes to global dna hypomethylation and adult behavioral changes, Brain research 1754 (2021): 147254.
Martis, Lena-Sophie; Wiborg, Ove; Holmes, Megan C; Harris, Anjanette P;, BDNF+/- rats exhibit depressive phenotype and altered expression of genes relevant in mood disorders., Genes, brain, and behavior Vol.18, 2019
Ren, Q; Ma, M; Yang, C; Zhang, J-C; Yao, W; Hashimoto, K;, BDNF-TrkB signaling in the nucleus accumbens shell of mice has key role in methamphetamine withdrawal symptoms., Translational psychiatry Vol.5, 2015
Geist, Phillip A; Dulka, Brooke N; Barnes, Abigail; Totty, Michael; Datta, Subimal;, BNDF heterozygosity is associated with memory deficits and alterations in cortical and hippocampal EEG power., Behavioural brain research Vol.332, 2017
Gururajan, A; Hill, R A; van den Buuse, M;, Brain-derived neurotrophic factor heterozygous mutant rats show selective cognitive changes and vulnerability to chronic corticosterone treatment., Neuroscience Vol.284, 2015
Garner, Jennifer M; Chambers, Jonathan; Barnes, Abigail K; Datta, Subimal;, Changes in Brain-Derived Neurotrophic Factor Expression Influence Sleep-Wake Activity and Homeostatic Regulation of Rapid Eye Movement Sleep., Sleep Vol.41, 2018
Xia, Chunmei; Shen, Shanwei; Hashmi, Fiza; Qiao, Li-Ya;, Colitis-induced bladder afferent neuronal activation is regulated by BDNF through PLCÎł pathway., Experimental neurology Vol.285, 2016
Liu, Miao; Kay, Jarren C; Shen, Shanwei; Qiao, Li-Ya;, Endogenous BDNF augments NMDA receptor phosphorylation in the spinal cord via PLCÎł, PKC, and PI3K/Akt pathways during colitis., Journal of neuroinflammation Vol.12, 2015
Sapio, Matthew R; Iadarola, Michael J; LaPaglia, Danielle M; Lehky, Tanya; Thurm, Audrey E; Danley, Kristen M; Fuhr, Shannon R; Lee, Mark D; Huey, Amanda E; Sharp, Stephen J; Tsao, Jack W; Yanovski, Jack A; Mannes, Andrew J; Han, Joan C;, Haploinsufficiency of the brain-derived neurotrophic factor gene is associated with reduced pain sensitivity., Pain Vol.160, 2019
Grzelak N, Krutki P, Bączyk M, Kaczmarek D, Mrówczyński W., Influence of altered serum and muscle concentrations of BDNF on electrophysiological properties of spinal motoneurons in wild-type and BDNF-knockout rats., Sci Rep. 2023 Mar 20;13(1):4571. doi: 10.1038/s41598-023-31703-8.
St Laurent, Robyn; Helm, Samuel R; Glenn, Melissa J;, Reduced cocaine-seeking behavior in heterozygous BDNF knockout rats., Neuroscience letters Vol.544, 2013
Yang, Bangkun; Yang, Chun; Ren, Qian; Zhang, Ji-Chun; Chen, Qian-Xue; Shirayama, Yukihiko; Hashimoto, Kenji;, Regional differences in the expression of brain-derived neurotrophic factor (BDNF) pro-peptide, proBDNF and preproBDNF in the brain confer stress resilience., European archives of psychiatry and clinical neuroscience Vol.266, 2016
Harris, A P; Lennen, R J; Brydges, N M; Jansen, M A; Pernet, C R; Whalley, H C; Marshall, I; Baker, S; Basso, A M; Day, M; Holmes, M C; Hall, J;, The role of brain-derived neurotrophic factor in learned fear processing: an awake rat fMRI study., Genes, brain, and behavior Vol.15, 2016
