Society of Toxicology | ToxExpo 2023

March 19-23, 2023
Nashville, TN
Booth #709

Toxicologists and scientists will attend the annual ToxExpo virtually to communicate industry-leading ideas and best practices. With live, semi-live, and on-demand offerings, attendees will have access to more than 70 scientific and featured sessions, dedicated networking spaces to connect with friends and colleagues, and service and product providers through the ToxExpo exhibits.

View the Conference Website
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Exhibitor Hosted Sessions

Monday, March 20, 2023
3:00pm-4:00pm — Room 101C Music City Center
“Aneugen or Clastogen: Mode of Action Determination for Genotoxicity Assessment”
Presented by Dr. Shambhu Roy and Dr. Pavan Gollapudi

Wednesday, March 22, 2023
9:00am-10:00am — Room 101C Music City Center
“Broad Application of Duplex Sequencing to Genomic Safety Assessment”
Presented by Dr. Todd Auman and Dr. Cheryl Hobbs (Inotiv) and Dr. Jesse Salk (TwinStrand Biosciences)

Poster Presentations and Symposia

Monday, March 20, 2023
Poster Session: Regulation/Policy
9:00am-10:45am — Tox Expo Hall C
Abstract 3177/Poster P292: Evaluation of Skin Sensitization Classification Rules to Reflect Human Potency
Authors: Herzler M, Abedini J, To KT, Allen DG, Api AM, Germolec D, Gordon J, Kleinstreuer NC, Ko H, Matheson J, Thierse H, Truax J, Vanselow J, Strickland J
Abstract 3181/Poster P296: Evaluating New Chemicals in the US under the Toxic Substances Control Act: Application of New Approach Methods to Evaluate Eye Irritation
Authors: Beardslee RA, Salazar KD, van der Zalm A, Camacho IA, Brunner R, Raabe H, Allen D, Daniel A, Kleinstreuer NC, O'Dell L, Clippinger A, Scarano L, Lowit A

Poster Session: DNA Damage and Repair
10:45am-12:30pm — Tox Expo Hall C
Abstract 3250/Poster P367: Usefulness of 3D HepG2 Liver Spheroid Model for Genotoxicity Assessment of Chemicals and Pharmaceuticals
Presenting Author: Dr. Shambhu Roy

Poster Session: Ocular Toxicology
10:45am-12:30pm — Tox Expo Hall C
Abstract 3137/Poster P245: Three-Phase Testing of Agrochemical Formulations: Developing a Defined Approach for Eye Irritation Potential
Authors: Daniel AB, van der Zalm AJ, Clippinger AJ, Kleinstreuer NC, Allen DG

Poster Session: Biotransformation/Cytochrome P450
10:45am-12:30pm — Tox Expo Hall C
Abstract 3271/Poster P390: Mechanistic Insights from Profiling Chemical-Mediated Transcription Factor Transactivation with the Integration of Cytochrome P450 Metabolism
Authors: Medvedev A, Karmaus AL, Hull V, Reinke EN, Daniel AB, Allen DG, Kleinstreuer NC, Casey W

Poster Session: Computational Toxicology I
2:30pm-4:15pm — Tox Expo Hall C
Agnes Karmaus (Inotiv, contractor supporting NICEATM) is session chair.
Abstract 3064/Poster P169: OPERA Models Supporting Regulatory Needs
Authors: Mansouri K, Martin T, Chang X, Williams A, Kleinstreuer N
Abstract 3089/Poster P194: DASS App: A Web Application for Applying Defined Approaches for Skin Sensitization to Predict Hazard and Potency Categorization
Authors: To KT, Strickland J, Borrel A, Truax J, Allen DG, Kleinstreuer NC

Tuesday, March 21, 2023
Poster Session: Computational Toxicology II
9:00am-10:45am — Tox Expo Hall C
Abstract 3669/Poster P154: Combining NAM Data and IVIVE for Evaluating Potential Inhalation Toxicity
Authors: Chang X, Reinke EN, Daniel AB, Allen DG, Mumtaz MM, Kleinstreuer NC
Abstract 3670/Poster P155: Integrating Population Enzyme Variability into Physiologically Based Kinetic Models of Parent Chemicals and Metabolites
Authors: Hull V, Hines D, Unnikrishnan A, Karmaus AL, Allen DG, Dorne JC, Erickson J, Combs P, Ferguson S, Kleinstreuer NC, Mansouri K
Abstract 3695/Poster P180: Annotations for ToxCast and Tox21 High-Throughput Screening Assays: Facilitating Assay Interpretation and Data Use
Authors: Karmaus AL, Borrel A, Feshuk M, Harrill A, Wittwehr C, Kleinstreuer NC

Symposium Session: Achieving Successful Reproducibility for Next-Generation Toxicological Methods
1:00pm-2:30pm — Room 202
Agnes Karmaus (Inotiv, contractor supporting NICEATM) is session chair.
Abstract 1139: Leveraging In Vivo Variability to Assess Performance of Predictive Models and the Role of Reanalysis to Build Confidence via Consensus
Author: Karmaus A

Poster Session: Alternatives to Mammalian Models II
2:30pm-4:15pm — Tox Expo Hall C
Abstract 3624/Poster P106: Validation of the Electrophilic Allergen Screening Assay (EASA) to Detect Substances That Impact the Initial Key Event in the Adverse Outcome Pathway for Skin Sensitization
Authors: Gordon J, Truax J, Borrel A, Reinke EN, Adams V, Rua D, Petersen E, Uhl R, Allen DG, Kleinstreuer NC, Strickland J
Abstract 3627/Poster P109: Application of Defined Approaches for Skin Sensitization for Chemicals of Federal Agency Interest
Authors: Strickland J, Truax J, To KT, Reinke EN, Gulledge T, Johnson VJ, Allen DG, Kleinstreuer NC, Germolec D
Abstract 3634/Poster P116: Peer Review Report of the EpiSensA Skin Sensitization Assay
Authors: Reinke EN, Corsini E, Ono A, Fukuyama T, Ashikaga T, Gerberick GF
Abstract 3643/Poster P125: Methods2AOP: An International Collaboration to Integrate Assay Annotations into the AOP Key Event Descriptions
Authors: Wittwehr C, Chang X, Bisson W, Edwards SW, Ferguson S, Harrill A, Hogberg HT, Karmaus AL, Batista-Leite S, Lekka E, Kleinstreuer NC, Markey KJ, Masci AM, Mennecozzi M, Mortensen HM, O'Brien JM, Reinke EN, Schmitt C, Tucker NN, Virvilis V

Poster Session: Bioinformatics
2:30pm-4:15pm — Tox Expo Hall C
Abstract 3740/Poster P226: Applying In Silico Toxicity Models across the Tox21 Chemical Universe
Authors: Lee S, Borrel A, To KT, Li T, Liu Z, Tong W, Benfenati E, Roncaglioni A, Manganaro A, Mansouri K, Kleinstreuer NC
Abstract 3742/Poster P228: V2: Exploring the Environmental Chemical Universe
Authors: Borrel A, Unnikrishnan A, Allen DG, Kleinstreuer NC
Abstract 3744/Poster P230: Integrated Chemical Environment: An Advanced Platform Aiding NAM-Based Chemical Assessments
Authors: Unnikrishnan A, Karmaus AL, Hull V, Chang X, Borrel A, To KT, Daniel AB, Cooper S, Phillips J, McAfee E, Allen DG, Casey W, Kleinstreuer NC

Platform Session: Mixtures Toxicology
3:00pm-4:30pm — Room 205
Abstract 2039: Mapping a Path to Disease: Quantifying the Risk of Exposure to Environmental Chemical Mixtures via a Common Molecular Target Using a Geospatial Modeling Approach
Authors: Eccles KM, Karmaus AL, Kleinstreuer NC, Parham F, Wambaugh JF, Messier KP

Workshop Session: Computational Visualization Tools for Communicating Large, Complex Data
3:00pm-4:30pm — Room 202
Kim To (Inotiv, contractor supporting NICEATM) is session co-chair.

Wednesday, March 22, 2023
Poster Session: Biological Modeling
9:00am-10:45am — Tox Expo Hall C
Abstract 4326/Poster P191: Risk-Based, Geospatially Informed Prioritization of Potentially Cardiotoxic Chemicals
Authors: Krishna S, Chang X, Eccles KM, Messier K, Kleinstreuer NC

Poster Session: Skin and Dermal Toxicity
10:45am-12:30pm — Tox Expo Hall C
Abstract 4454/Poster P327: The Skin Allergy Risk Assessment-Integrated Chemical Environment (SARA-ICE) Model for UN GHS Classification: An Evaluation and Application in Case Studies
Authors: Reynolds G, Reynolds J, Gilmour N, Strickland J, Reinke E, Germolec D, Truax J, Allen D, Maxwell G, Kleinstreuer N

Thursday, March 23, 2023
Poster Session: Late-Breaking 6
8:30am-11:30am — Tox Expo Hall A1
Abstract 5167/Poster P268: Comparative Evaluation of Different Plating Methodologies and Sources of Induced S9 Metabolic Activation on the Mutagenic Potential of N-Nitrosodipropylamine Using the Ames Test
Presenting Author: Dr. Pavan Gollapudi



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