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Webinar: Longitudinal Clinical Observations and Motor Coordination Assessments of the SOD1G93A Rat Model of Amyotrophic Lateral Sclerosis (ALS)

July 22, 2024 | 11:00am EDT

Presented by: Dr. Jessica Ramadhin – Field Applications Scientist, Taconic Biosciences, Dr. Christopher M. Butt – Senior Director-Neuroscience, Inotiv

Amyotrophic Lateral Sclerosis (ALS) is a debilitating neurodegenerative disease with limited treatment options and unmet medical needs. These high patient needs drive significant basic and drug discovery research, which requires relevant preclinical models.

In this webinar, Dr. Jessica Ramadhin will introduce the SOD1 rat model, which expresses human SOD1 with the G93A mutation and develops various motor phenotypes. Senior Director of Neuroscience at Inotiv Boulder, Dr. Chris Butt, will then review new data generated in the model along with results from a 16-week longitudinal study in the SOD1 rat, including loss of motor coordination and progressive clinical degeneration, which correlate to the presence of the clinically relevant biomarker neurofilament light, a measure of neuronal damage. Join us for a discussion of relevant assays and endpoints for drug discovery research using this model.

Webinar Topics include:

  • Discuss the development of a rat model that expresses human SOD1 with the
    G93A mutation and why the G93A mutation is relevant to ALS
  • Explore the disease phenotype of the SOD1G93A rat model
  • Provide insight into how variability in disease phenotype of the SOD1G93A rat
    model is addressed in study planning

Please join us for this topical event and together, let's achieve your research goals!

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